MX2023000773A - Ensayo de cuantificacion de peptido para diferenciar quininogeno de alto peso molecular (hmwk) de longitud completa y hmwk escindido. - Google Patents

Ensayo de cuantificacion de peptido para diferenciar quininogeno de alto peso molecular (hmwk) de longitud completa y hmwk escindido.

Info

Publication number
MX2023000773A
MX2023000773A MX2023000773A MX2023000773A MX2023000773A MX 2023000773 A MX2023000773 A MX 2023000773A MX 2023000773 A MX2023000773 A MX 2023000773A MX 2023000773 A MX2023000773 A MX 2023000773A MX 2023000773 A MX2023000773 A MX 2023000773A
Authority
MX
Mexico
Prior art keywords
hmwk
molecular weight
high molecular
weight kininogen
cleaved
Prior art date
Application number
MX2023000773A
Other languages
English (en)
Inventor
Guodong Zhang
Ryan Faucette
Daniel J Sexton
Jiang Wu
Gul M Mustafa
Mark Szewc
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of MX2023000773A publication Critical patent/MX2023000773A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/224—Haemostasis or coagulation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Acá se divulgan métodos para diferenciar quininógeno de alto peso molecular (HMWK) de longitud completa y HMWK escindido en una muestra. Dichos métodos pueden comprender tratar una muestra biológica con una proteasa para generar una pluralidad de péptidos digeridos, y medir uno o más péptidos originales, los cuales son indicadores de HMWK escindido y/o de HMWK de longitud completa.
MX2023000773A 2015-12-15 2018-06-15 Ensayo de cuantificacion de peptido para diferenciar quininogeno de alto peso molecular (hmwk) de longitud completa y hmwk escindido. MX2023000773A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562267734P 2015-12-15 2015-12-15

Publications (1)

Publication Number Publication Date
MX2023000773A true MX2023000773A (es) 2023-02-22

Family

ID=57794352

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018007493A MX2018007493A (es) 2015-12-15 2016-12-15 Ensayo de cuantificacion de peptido para diferenciar quininogeno de alto peso molecular (hmwk) de longitud completa y hmwk escindido.
MX2023000773A MX2023000773A (es) 2015-12-15 2018-06-15 Ensayo de cuantificacion de peptido para diferenciar quininogeno de alto peso molecular (hmwk) de longitud completa y hmwk escindido.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018007493A MX2018007493A (es) 2015-12-15 2016-12-15 Ensayo de cuantificacion de peptido para diferenciar quininogeno de alto peso molecular (hmwk) de longitud completa y hmwk escindido.

Country Status (14)

Country Link
US (2) US11668718B2 (es)
EP (1) EP3390439A1 (es)
JP (3) JP7092669B2 (es)
KR (1) KR20180134838A (es)
CN (1) CN108602877A (es)
AU (2) AU2016372159B2 (es)
BR (1) BR112018012165A2 (es)
CA (1) CA3008621A1 (es)
CO (1) CO2018007216A2 (es)
EA (1) EA201891414A1 (es)
IL (2) IL297850B1 (es)
MX (2) MX2018007493A (es)
NZ (1) NZ743482A (es)
WO (1) WO2017106504A1 (es)

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047323A (en) * 1986-01-22 1991-09-10 Temple University Of The Commonwealth System Of Higher Education Method for detecting human kininogen using monoclonal antibodies thereto
JP2603487B2 (ja) 1987-11-26 1997-04-23 大日本製薬株式会社 ガンに罹患している疑いのあるヒトをスクリーニングする方法
JPH08208692A (ja) 1994-09-28 1996-08-13 Sumitomo Pharmaceut Co Ltd 新規な細胞接着抑制ペプチド誘導体
JP3073439B2 (ja) 1996-02-08 2000-08-07 雪印乳業株式会社 骨形成促進及び骨吸収防止剤
EP1044012B1 (en) 1998-11-10 2006-05-03 Temple University of the Commonwealth System of Higher Education Inhibition of angiogenesis by peptide analogs of high molecular weight kininogen domain 5
US20060154319A1 (en) 1999-04-29 2006-07-13 Flodgaard Hans J Inhibition of bradykinin release
WO2001034195A1 (en) 1999-11-12 2001-05-17 Temple University Of The Commonwealth System Of Higher Education Inhibition of angiogenesis by antibodies against high molecular weight kininogen domain 5
US20050124794A1 (en) 2002-03-15 2005-06-09 Mccrae Keith Cell surface tropomyosin as a target of angiogenesis inhibition
CN1858243A (zh) 2005-04-30 2006-11-08 安徽省生物医学研究所 一种预测血管紧张素ii受体拮抗剂类降压药药物作用的方法及其应用
EP2216651A4 (en) 2007-10-18 2010-12-01 Miyazaki Prefectural Ind Suppo BIOMARKER FOR THE DIAGNOSIS OF A HEPATIC DISEASE
WO2010004962A1 (ja) 2008-07-07 2010-01-14 日本臓器製薬株式会社 線維筋痛症の検査法
GB0821721D0 (en) 2008-11-27 2008-12-31 Hansa Medical Ab Antimicrobial therapy
EP3578664A1 (en) 2009-03-30 2019-12-11 Nordic Bioscience A/S Collagen iv neo-epitope fibrosis assay
JP5714285B2 (ja) 2010-09-29 2015-05-07 株式会社プロトセラ 妊娠高血圧症候群マーカーおよびそれを用いた診断
CN102558329A (zh) 2010-12-10 2012-07-11 中国人民解放军军事医学科学院生物医学分析中心 一组特异性多肽及其在制备肺癌早期诊断试剂中的用途
NZ631543A (en) 2012-03-28 2017-03-31 Sanofi Sa Antibodies to bradykinin b1 receptor ligands
RS57890B1 (sr) * 2013-01-20 2019-01-31 Dyax Corp Procena i tretman poremećaja posredovanih bradikininom
JP2016188761A (ja) 2013-08-23 2016-11-04 国立研究開発法人国立国際医療研究センター 糖尿病腎症の発症または発症リスクの検出方法及びキット
KR20230054745A (ko) * 2013-10-21 2023-04-25 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 시스템 바이오마커를 결정하기 위한 검정법
WO2015120036A1 (en) * 2014-02-04 2015-08-13 University Of Virginia Patent Foundation Compositions and methods for analysis of protein sequences and post-translational modifications
CN104345154B (zh) 2014-08-22 2016-10-26 北京蛋白质组研究中心 一种检测多肿瘤相关“多肽-蛋白组合式标志物”的双抗体夹心试剂盒
CN104155457B (zh) 2014-08-22 2016-11-16 北京蛋白质组研究中心 一种结直肠癌相关“多肽-蛋白组合式标志物”检测试剂盒
WO2016081413A1 (en) 2014-11-17 2016-05-26 The Rockefeller University Compositions and methods for use in diagnosis of alzheimer's disease

Also Published As

Publication number Publication date
IL259995B1 (en) 2023-01-01
IL297850B1 (en) 2024-06-01
IL259995B2 (en) 2023-05-01
EA201891414A1 (ru) 2019-02-28
JP7092669B2 (ja) 2022-06-28
IL259995A (en) 2018-07-31
CO2018007216A2 (es) 2018-09-20
JP2022141640A (ja) 2022-09-29
EP3390439A1 (en) 2018-10-24
AU2016372159A1 (en) 2018-07-05
JP7425117B2 (ja) 2024-01-30
US11668718B2 (en) 2023-06-06
US20230408528A1 (en) 2023-12-21
KR20180134838A (ko) 2018-12-19
AU2022204058A1 (en) 2022-06-30
IL297850A (en) 2023-01-01
CN108602877A (zh) 2018-09-28
JP2019505185A (ja) 2019-02-28
AU2016372159B2 (en) 2022-03-24
BR112018012165A2 (pt) 2018-12-04
JP2024026847A (ja) 2024-02-28
WO2017106504A8 (en) 2017-07-13
WO2017106504A1 (en) 2017-06-22
US20210025898A1 (en) 2021-01-28
MX2018007493A (es) 2018-09-18
NZ743482A (en) 2023-04-28
CA3008621A1 (en) 2017-06-22

Similar Documents

Publication Publication Date Title
AU2019201173B2 (en) Novel polypeptides
EA201892489A1 (ru) Число мишеней для мультиплексной оптимизированной амплификации с несоответствиями (moma)
BR112016016916A2 (pt) método de tratamento de angiodema hereditário (hae)
GB2520885A (en) Methods for discovering therapeutic targets
PH12017501967A1 (en) Maize plant dbn9936 and method for use in detecting nucleic acid sequence thereof
MX2020010147A (es) Metodos para predecir el riesgo de neumonia intersticial.
MX2017000083A (es) Compuestos de platino, composiciones y usos de estos.
EA201590994A1 (ru) Способ увеличения гидродинамического объема полипептида путем присоединения карбоксиконцевого пептида гонадотропина
WO2011115819A3 (en) Small molecule inhibitors of muc1 and methods of identifying the same
PH12015502849B1 (en) Biomarkers for cognitive dysfunction diseases and method for detecting cognitive dysfunction disease using biomarkers
EP4297036A3 (en) Method for predicting the off-target binding of a peptide which binds to a target peptide presented by a major histocompatibility complex
BR112018067536A2 (pt) sistema de transpóson e métodos de uso
IL250646A0 (en) A process for conjugating a peptide or protein with a reagent containing a leaving group that includes a peg moiety
MX2018012550A (es) Composiciones y metodos para la deteccion de proteinas de celulas huesped.
MX2017008096A (es) Pestivirus.
BR112017020308A2 (pt) udp-glicosiltransferases
CY1114618T1 (el) Βιολογικα δραστικα πεπτιδια που περιεχουν καρβοξυτελικη αργινινη
BR112015000125A2 (pt) moléculas, vetor, células, processo, proteína, método para expressar um polipeptídeo mbip, polipeptídeos, anticorpo ou fragmento de anticorpo e sequência de nucleotídeos
BR112015004629A2 (pt) polipeptídeos de clostridium difficile como vacinas
PT3365685T (pt) Imunoensaio para detetar cininogénio de elevada massa molecular clivado
WO2014043170A8 (en) Consumable cryopreserved cells transiently overexpressing gene(s) encoding drug transporter protein(s) and/or drug metabolizing enzyme(s)
PH12017501957A1 (en) Herbicide-tolerant maize plant dbn9858, and nucleotide sequence and method for detecting same
BR112016015537A2 (pt) métodos e kits para detectar a presença de sequência polinucleotídea da e. histolytica em amostra
ECSP109947A (es) Péptido (dn81) optimizado inhibitorio de la entrada del virus del dengue
CL2011003063A1 (es) Metodo de alto rendimiento para la deteccion de la presencia de dos o mas proteinas de interes con secuencias de aminoacidos conocidas en una muestra de planta, y procedimiento para mantener el genotipo de una variedad de la planta transgenica.