AU2016318773B2 - Genetic engineering of macrophages for immunotherapy - Google Patents

Genetic engineering of macrophages for immunotherapy Download PDF

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Publication number
AU2016318773B2
AU2016318773B2 AU2016318773A AU2016318773A AU2016318773B2 AU 2016318773 B2 AU2016318773 B2 AU 2016318773B2 AU 2016318773 A AU2016318773 A AU 2016318773A AU 2016318773 A AU2016318773 A AU 2016318773A AU 2016318773 B2 AU2016318773 B2 AU 2016318773B2
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cell
protein
cells
vector
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AU2016318773A1 (en
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Courtney Crane
Michael C. Jensen
Nicole Lieberman
Kara WHITE MOYES
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Seattle Children's Hospital
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Seattle Childrens Hospital dba Seattle Childrens Research Inst
Seattle Children's Hospital
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/17—Monocytes; Macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
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    • A—HUMAN NECESSITIES
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
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    • C12N2510/00—Genetically modified cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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AU2016318773A 2015-09-09 2016-09-07 Genetic engineering of macrophages for immunotherapy Active AU2016318773B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562216224P 2015-09-09 2015-09-09
US62/216,224 2015-09-09
US201662361348P 2016-07-12 2016-07-12
US62/361,348 2016-07-12
PCT/US2016/050552 WO2017044487A1 (en) 2015-09-09 2016-09-07 Genetic engineering of macrophages for immunotherapy

Publications (2)

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AU2016318773A1 AU2016318773A1 (en) 2018-04-12
AU2016318773B2 true AU2016318773B2 (en) 2024-08-01

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US (3) US10525082B2 (enExample)
EP (1) EP3347026A4 (enExample)
JP (3) JP6959909B2 (enExample)
CN (1) CN108243607A (enExample)
AU (1) AU2016318773B2 (enExample)
CA (1) CA2997912A1 (enExample)
HK (1) HK1257460A1 (enExample)
SG (1) SG10201913151TA (enExample)
WO (1) WO2017044487A1 (enExample)

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