AU2016219170B2 - Antibody therapeutics that bind CTLA4 - Google Patents

Antibody therapeutics that bind CTLA4 Download PDF

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Publication number
AU2016219170B2
AU2016219170B2 AU2016219170A AU2016219170A AU2016219170B2 AU 2016219170 B2 AU2016219170 B2 AU 2016219170B2 AU 2016219170 A AU2016219170 A AU 2016219170A AU 2016219170 A AU2016219170 A AU 2016219170A AU 2016219170 B2 AU2016219170 B2 AU 2016219170B2
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AU
Australia
Prior art keywords
seq
ser
gly
chain variable
antibody
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Ceased
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AU2016219170A
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AU2016219170A1 (en
Inventor
John Dixon Gray
Heyue Zhou
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Sorrento Therapeutics Inc
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Sorrento Therapeutics Inc
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Priority to AU2021282431A priority Critical patent/AU2021282431A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2016219170A 2015-02-13 2016-02-12 Antibody therapeutics that bind CTLA4 Ceased AU2016219170B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021282431A AU2021282431A1 (en) 2015-02-13 2021-12-08 Antibody therapeutics that bind CTLA4

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562116353P 2015-02-13 2015-02-13
US62/116,353 2015-02-13
PCT/US2016/017713 WO2016130898A2 (en) 2015-02-13 2016-02-12 Antibody therapeutics that bind ctla4

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021282431A Division AU2021282431A1 (en) 2015-02-13 2021-12-08 Antibody therapeutics that bind CTLA4

Publications (2)

Publication Number Publication Date
AU2016219170A1 AU2016219170A1 (en) 2017-09-21
AU2016219170B2 true AU2016219170B2 (en) 2021-09-09

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2016219170A Ceased AU2016219170B2 (en) 2015-02-13 2016-02-12 Antibody therapeutics that bind CTLA4
AU2021282431A Abandoned AU2021282431A1 (en) 2015-02-13 2021-12-08 Antibody therapeutics that bind CTLA4

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2021282431A Abandoned AU2021282431A1 (en) 2015-02-13 2021-12-08 Antibody therapeutics that bind CTLA4

Country Status (13)

Country Link
US (3) US10202453B2 (enExample)
EP (3) EP3256165B1 (enExample)
JP (3) JP6917902B2 (enExample)
KR (1) KR20180006367A (enExample)
CN (2) CN108271359B (enExample)
AR (1) AR103675A1 (enExample)
AU (2) AU2016219170B2 (enExample)
CA (1) CA2976446A1 (enExample)
ES (1) ES2882157T3 (enExample)
IL (3) IL292578A (enExample)
MX (3) MX384026B (enExample)
TW (1) TW201636369A (enExample)
WO (2) WO2016130986A1 (enExample)

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CA2976446A1 (en) 2016-08-18
WO2016130986A1 (en) 2016-08-18
JP2021054857A (ja) 2021-04-08
MX384026B (es) 2025-03-14
IL292578A (en) 2022-06-01
MX2021007947A (es) 2021-08-16
CN114014930A (zh) 2022-02-08
AU2016219170A1 (en) 2017-09-21
US20190127469A1 (en) 2019-05-02
TW201636369A (zh) 2016-10-16
KR20180006367A (ko) 2018-01-17
JP2018508573A (ja) 2018-03-29
WO2016130898A3 (en) 2016-10-20
EP3949984A1 (en) 2022-02-09
IL253963B (en) 2021-07-29
EP3256165A4 (en) 2018-10-24
US11155623B2 (en) 2021-10-26
US20220002415A1 (en) 2022-01-06
US10202453B2 (en) 2019-02-12
IL284336A (en) 2021-07-29
JP2022084942A (ja) 2022-06-07
IL253963A0 (en) 2017-10-31
WO2016130898A2 (en) 2016-08-18
JP6917902B2 (ja) 2021-08-11
ES2882157T3 (es) 2021-12-01
EP4151231A1 (en) 2023-03-22
CN108271359B (zh) 2021-11-09
AU2021282431A1 (en) 2021-12-23
IL284336B (en) 2022-06-01
AR103675A1 (es) 2017-05-24
CN108271359A (zh) 2018-07-10
US20160237154A1 (en) 2016-08-18
MX2022011935A (es) 2022-10-20
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EP3256165B1 (en) 2021-07-14
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