AU2015342818B2 - Methods for treating ocular diseases - Google Patents

Methods for treating ocular diseases Download PDF

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Publication number
AU2015342818B2
AU2015342818B2 AU2015342818A AU2015342818A AU2015342818B2 AU 2015342818 B2 AU2015342818 B2 AU 2015342818B2 AU 2015342818 A AU2015342818 A AU 2015342818A AU 2015342818 A AU2015342818 A AU 2015342818A AU 2015342818 B2 AU2015342818 B2 AU 2015342818B2
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bcva
compared
mammal
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AU2015342818A1 (en
Inventor
Margarita GEKKIEVA
Peter SALLSTIG
Werner Schmidt
James WARBURTON
Andreas WEICHSELBERGER
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Novartis AG
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Novartis AG
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Priority to AU2018278870A priority Critical patent/AU2018278870B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2015342818A 2014-11-07 2015-11-06 Methods for treating ocular diseases Active AU2015342818B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2018278870A AU2018278870B2 (en) 2014-11-07 2018-12-11 Methods for treating ocular diseases
AU2020220210A AU2020220210B2 (en) 2014-11-07 2020-08-21 Methods for treating ocular diseases

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462076770P 2014-11-07 2014-11-07
US62/076,770 2014-11-07
US201462088061P 2014-12-05 2014-12-05
US62/088,061 2014-12-05
PCT/US2015/059575 WO2016073918A1 (en) 2014-11-07 2015-11-06 Methods for treating ocular diseases

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018278870A Division AU2018278870B2 (en) 2014-11-07 2018-12-11 Methods for treating ocular diseases

Publications (2)

Publication Number Publication Date
AU2015342818A1 AU2015342818A1 (en) 2017-05-11
AU2015342818B2 true AU2015342818B2 (en) 2019-01-03

Family

ID=54697654

Family Applications (6)

Application Number Title Priority Date Filing Date
AU2015342818A Active AU2015342818B2 (en) 2014-11-07 2015-11-06 Methods for treating ocular diseases
AU2015342815A Active AU2015342815B2 (en) 2014-11-07 2015-11-06 Stable protein solution formulation containing high concentration of an anti-VEGF antibody
AU2018274882A Active AU2018274882B2 (en) 2014-11-07 2018-12-04 Stable protein solution formulation containing high concentration of an anti-VEGF antibody
AU2018278870A Active AU2018278870B2 (en) 2014-11-07 2018-12-11 Methods for treating ocular diseases
AU2020220210A Active AU2020220210B2 (en) 2014-11-07 2020-08-21 Methods for treating ocular diseases
AU2020244614A Active AU2020244614B2 (en) 2014-11-07 2020-10-05 Stable protein solution formulation containing high concentration of an anti-VEGF antibody

Family Applications After (5)

Application Number Title Priority Date Filing Date
AU2015342815A Active AU2015342815B2 (en) 2014-11-07 2015-11-06 Stable protein solution formulation containing high concentration of an anti-VEGF antibody
AU2018274882A Active AU2018274882B2 (en) 2014-11-07 2018-12-04 Stable protein solution formulation containing high concentration of an anti-VEGF antibody
AU2018278870A Active AU2018278870B2 (en) 2014-11-07 2018-12-11 Methods for treating ocular diseases
AU2020220210A Active AU2020220210B2 (en) 2014-11-07 2020-08-21 Methods for treating ocular diseases
AU2020244614A Active AU2020244614B2 (en) 2014-11-07 2020-10-05 Stable protein solution formulation containing high concentration of an anti-VEGF antibody

Country Status (24)

Country Link
US (5) US10035850B2 (enExample)
EP (2) EP3215123A1 (enExample)
JP (6) JP6667519B2 (enExample)
KR (4) KR20240161204A (enExample)
CN (4) CN114081951A (enExample)
AU (6) AU2015342818B2 (enExample)
BR (2) BR112017008093A2 (enExample)
CA (2) CA2966646A1 (enExample)
CL (2) CL2017001117A1 (enExample)
CO (1) CO2017004596A2 (enExample)
EA (1) EA201790989A1 (enExample)
EC (1) ECSP17034829A (enExample)
GT (1) GT201700096A (enExample)
IL (5) IL251642B (enExample)
MX (3) MX383808B (enExample)
MY (2) MY183807A (enExample)
NZ (1) NZ730821A (enExample)
PE (1) PE20170780A1 (enExample)
PH (3) PH12021550147A1 (enExample)
RU (1) RU2722643C2 (enExample)
SG (3) SG10201913565RA (enExample)
TN (1) TN2017000128A1 (enExample)
TW (4) TWI705827B (enExample)
WO (2) WO2016073915A1 (enExample)

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