AU2015329778B2 - Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV) - Google Patents
Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV) Download PDFInfo
- Publication number
- AU2015329778B2 AU2015329778B2 AU2015329778A AU2015329778A AU2015329778B2 AU 2015329778 B2 AU2015329778 B2 AU 2015329778B2 AU 2015329778 A AU2015329778 A AU 2015329778A AU 2015329778 A AU2015329778 A AU 2015329778A AU 2015329778 B2 AU2015329778 B2 AU 2015329778B2
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- substituted
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1417707.5 | 2014-10-07 | ||
| GBGB1417707.5A GB201417707D0 (en) | 2014-10-07 | 2014-10-07 | Pharmaceutical compounds |
| PCT/GB2015/052920 WO2016055780A1 (en) | 2014-10-07 | 2015-10-06 | Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (rsv) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2015329778A1 AU2015329778A1 (en) | 2017-05-04 |
| AU2015329778A8 AU2015329778A8 (en) | 2017-05-18 |
| AU2015329778B2 true AU2015329778B2 (en) | 2020-04-23 |
Family
ID=51946966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015329778A Active AU2015329778B2 (en) | 2014-10-07 | 2015-10-06 | Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV) |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US10106539B2 (enExample) |
| EP (1) | EP3204375B1 (enExample) |
| JP (1) | JP6695334B2 (enExample) |
| KR (2) | KR20230116097A (enExample) |
| CN (1) | CN107108557B (enExample) |
| AR (1) | AR102181A1 (enExample) |
| AU (1) | AU2015329778B2 (enExample) |
| BR (1) | BR112017007311B1 (enExample) |
| CA (1) | CA2963740C (enExample) |
| CL (1) | CL2017000839A1 (enExample) |
| CO (1) | CO2017004603A2 (enExample) |
| CY (1) | CY1121564T1 (enExample) |
| DK (1) | DK3204375T3 (enExample) |
| ES (1) | ES2718976T3 (enExample) |
| GB (1) | GB201417707D0 (enExample) |
| HR (1) | HRP20190808T1 (enExample) |
| HU (1) | HUE043553T2 (enExample) |
| LT (1) | LT3204375T (enExample) |
| MX (1) | MX373233B (enExample) |
| NZ (1) | NZ731323A (enExample) |
| PE (1) | PE20170949A1 (enExample) |
| PL (1) | PL3204375T3 (enExample) |
| PT (1) | PT3204375T (enExample) |
| RS (1) | RS58706B1 (enExample) |
| RU (1) | RU2734248C2 (enExample) |
| SG (1) | SG11201702766YA (enExample) |
| SI (1) | SI3204375T1 (enExample) |
| SM (1) | SMT201900249T1 (enExample) |
| TR (1) | TR201903362T4 (enExample) |
| TW (1) | TWI718107B (enExample) |
| WO (1) | WO2016055780A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016197908A1 (zh) * | 2015-06-08 | 2016-12-15 | 南京明德新药研发股份有限公司 | 咪唑衍生物及其中间体的制备方法和晶型 |
| WO2018025043A1 (en) | 2016-08-04 | 2018-02-08 | ReViral Limited | Pyrimidine derivatives and their use in treating or preventing a respiratory syncytial virus infection |
| GB201711704D0 (en) * | 2017-07-20 | 2017-09-06 | Reviral Ltd | Pharmaceutical compounds |
| GB201721812D0 (en) * | 2017-12-22 | 2018-02-07 | Reviral Ltd | Pharmaceutical compounds |
| CN116077494A (zh) * | 2023-01-11 | 2023-05-09 | 黑龙江中医药大学 | 一种治疗呼吸道合胞病毒的药物组合物及其制备方法 |
| WO2024174953A1 (zh) * | 2023-02-21 | 2024-08-29 | 苏州隆博泰药业有限公司 | 苯并咪唑类衍生物及其医药用途 |
| WO2024252355A1 (en) | 2023-06-08 | 2024-12-12 | Pfizer Inc. | Pediatric dosing regimens comprising a fusion inhibitor for the treatment of rsv |
| WO2025120500A1 (en) | 2023-12-06 | 2025-06-12 | Pfizer Inc. | Benzodiazepine compounds as n-protein inhibitors |
| CN122580320A (zh) | 2024-01-16 | 2026-08-14 | 辉瑞大药厂 | 作为n-蛋白抑制剂的苯二氮䓬吡唑甲酰胺类 |
| WO2025248535A1 (en) * | 2024-05-29 | 2025-12-04 | Zydus Lifesciences Limited | Novel spirocyclic compounds to treat viral infections |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013068769A1 (en) * | 2011-11-10 | 2013-05-16 | Re:Viral Ltd | Pharmaceutical compounds |
| WO2014184163A1 (en) * | 2013-05-14 | 2014-11-20 | F. Hoffmann-La Roche Ag | Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
| WO2015022263A1 (en) * | 2013-08-12 | 2015-02-19 | F. Hoffmann-La Roche Ag | Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
| WO2015022301A1 (en) * | 2013-08-15 | 2015-02-19 | F. Hoffmann-La Roche Ag | Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57102863A (en) * | 1980-12-16 | 1982-06-26 | Takeda Chem Ind Ltd | Spiroindolinone and its preparation |
| RU2184735C2 (ru) * | 1998-01-23 | 2002-07-10 | Санкио Компани, Лимитед | Производные спиропиперидина, лекарственное средство, способ профилактики или лечения |
| EP1418175A1 (en) * | 1999-06-28 | 2004-05-12 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
| US6774134B2 (en) | 2000-12-20 | 2004-08-10 | Bristol-Myers Squibb Company | Heterocyclic substituted 2-methyl-benzimidazole antiviral agents |
| US6919331B2 (en) | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| US7205328B2 (en) * | 2002-10-21 | 2007-04-17 | Irm Llc | Oxindoles with anti-HIV activity |
| JO2355B1 (en) | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| US7390798B2 (en) | 2004-09-13 | 2008-06-24 | Merck & Co., Inc. | Carboxamide spirolactam CGRP receptor antagonists |
| EP1802637B1 (en) | 2004-10-13 | 2008-10-15 | Merck & Co., Inc. | Cgrp receptor antagonists |
| US20100278835A1 (en) | 2009-03-10 | 2010-11-04 | Astrazeneca Uk Limited | Novel compounds 660 |
| AU2013334001B2 (en) | 2012-10-16 | 2017-07-20 | Janssen Sciences Ireland Uc | RSV antiviral compounds |
| KR20160007629A (ko) * | 2013-05-14 | 2016-01-20 | 에프. 호프만-라 로슈 아게 | 호흡기 세포융합 바이러스 감염의 치료 및 예방을 위한 아자-옥소-인돌 |
| KR20160030271A (ko) * | 2013-08-12 | 2016-03-16 | 에프. 호프만-라 로슈 아게 | 호흡기 세포융합 바이러스 감염의 치료 및 예방을 위한 아자-옥소-인돌 |
| KR20160030569A (ko) * | 2013-08-15 | 2016-03-18 | 에프. 호프만-라 로슈 아게 | 호흡기 세포융합 바이러스 감염의 치료 및 예방을 위한 신규한 아자-옥소-인돌 |
-
2014
- 2014-10-07 GB GBGB1417707.5A patent/GB201417707D0/en not_active Ceased
-
2015
- 2015-10-06 CN CN201580066385.4A patent/CN107108557B/zh active Active
- 2015-10-06 DK DK15782033.3T patent/DK3204375T3/en active
- 2015-10-06 NZ NZ731323A patent/NZ731323A/en unknown
- 2015-10-06 KR KR1020237025697A patent/KR20230116097A/ko active Pending
- 2015-10-06 RU RU2017113026A patent/RU2734248C2/ru active
- 2015-10-06 AR ARP150103215A patent/AR102181A1/es not_active Application Discontinuation
- 2015-10-06 CA CA2963740A patent/CA2963740C/en active Active
- 2015-10-06 HU HUE15782033A patent/HUE043553T2/hu unknown
- 2015-10-06 PT PT15782033T patent/PT3204375T/pt unknown
- 2015-10-06 SI SI201530634T patent/SI3204375T1/sl unknown
- 2015-10-06 ES ES15782033T patent/ES2718976T3/es active Active
- 2015-10-06 MX MX2017004425A patent/MX373233B/es active IP Right Grant
- 2015-10-06 JP JP2017519320A patent/JP6695334B2/ja active Active
- 2015-10-06 LT LTEP15782033.3T patent/LT3204375T/lt unknown
- 2015-10-06 PL PL15782033T patent/PL3204375T3/pl unknown
- 2015-10-06 EP EP15782033.3A patent/EP3204375B1/en active Active
- 2015-10-06 SM SM20190249T patent/SMT201900249T1/it unknown
- 2015-10-06 US US15/517,290 patent/US10106539B2/en active Active
- 2015-10-06 SG SG11201702766YA patent/SG11201702766YA/en unknown
- 2015-10-06 WO PCT/GB2015/052920 patent/WO2016055780A1/en not_active Ceased
- 2015-10-06 HR HRP20190808TT patent/HRP20190808T1/hr unknown
- 2015-10-06 RS RS20190515A patent/RS58706B1/sr unknown
- 2015-10-06 PE PE2017000576A patent/PE20170949A1/es unknown
- 2015-10-06 KR KR1020177012311A patent/KR102561796B1/ko active Active
- 2015-10-06 BR BR112017007311-0A patent/BR112017007311B1/pt active IP Right Grant
- 2015-10-06 TR TR2019/03362T patent/TR201903362T4/tr unknown
- 2015-10-06 AU AU2015329778A patent/AU2015329778B2/en active Active
- 2015-10-07 TW TW104133092A patent/TWI718107B/zh active
-
2017
- 2017-04-06 CL CL2017000839A patent/CL2017000839A1/es unknown
- 2017-05-05 CO CONC2017/0004603A patent/CO2017004603A2/es unknown
-
2019
- 2019-04-11 CY CY20191100403T patent/CY1121564T1/el unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013068769A1 (en) * | 2011-11-10 | 2013-05-16 | Re:Viral Ltd | Pharmaceutical compounds |
| WO2014184163A1 (en) * | 2013-05-14 | 2014-11-20 | F. Hoffmann-La Roche Ag | Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
| WO2015022263A1 (en) * | 2013-08-12 | 2015-02-19 | F. Hoffmann-La Roche Ag | Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
| WO2015022301A1 (en) * | 2013-08-15 | 2015-02-19 | F. Hoffmann-La Roche Ag | Novel aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
Also Published As
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| Publication | Publication Date | Title |
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| DK3204375T3 (en) | Spiro indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV) | |
| DK2776416T3 (en) | Pharmaceutical compounds | |
| US12384764B2 (en) | Pharmaceutical compounds | |
| EP4178964A1 (en) | Benzodiazepine derivatives useful in treating a respiratory syncytial virus infection | |
| EP4048665A1 (en) | Benzodiazepine derivatives for treating a respiratory syncytial virus (rsv) infection | |
| WO2022008912A1 (en) | Benzodiazepine derivatives useful in treating a respiratory syncytial virus infection | |
| ES2905650T3 (es) | Compuestos farmacéuticos | |
| WO2018025043A1 (en) | Pyrimidine derivatives and their use in treating or preventing a respiratory syncytial virus infection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TH | Corrigenda |
Free format text: IN VOL 31 , NO 17 , PAGE(S) 2583 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME REVIRAL LTD , APPLICATION NO. 2015329778, UNDER INID (71) CORRECT THE APPLICANT NAME TO REVIRAL LIMITED |
|
| FGA | Letters patent sealed or granted (standard patent) | ||
| PC | Assignment registered |
Owner name: PFIZER INC. Free format text: FORMER OWNER(S): REVIRAL LIMITED |