AU2015296555B2 - Flagellin compositons and uses - Google Patents
Flagellin compositons and uses Download PDFInfo
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- AU2015296555B2 AU2015296555B2 AU2015296555A AU2015296555A AU2015296555B2 AU 2015296555 B2 AU2015296555 B2 AU 2015296555B2 AU 2015296555 A AU2015296555 A AU 2015296555A AU 2015296555 A AU2015296555 A AU 2015296555A AU 2015296555 B2 AU2015296555 B2 AU 2015296555B2
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| CN109879940A (zh) * | 2017-12-25 | 2019-06-14 | 苏州和锐生物科技有限公司 | 鞭毛g多肽、抗体捕获器件及试剂盒 |
| EA202092530A1 (ru) * | 2018-04-24 | 2021-02-01 | Джиноум Протекшн, Инк. | Способы облегчения старческой астении и старения |
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| CN111718417B (zh) * | 2019-03-19 | 2022-10-14 | 宁波鲲鹏生物科技有限公司 | 含有荧光蛋白片段的融合蛋白及其用途 |
| KR102169663B1 (ko) * | 2019-03-28 | 2020-10-26 | 가톨릭대학교 산학협력단 | 플라젤린으로부터 유도된 tlr5 작용제를 유효성분으로 포함하는 이식편대숙주질환의 예방 또는 치료용 조성물 |
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| CN110157655B (zh) * | 2019-05-22 | 2021-06-01 | 中国兽医药品监察所 | 一种无毒性气肿疽梭菌基因工程亚单位疫苗用菌种及其应用 |
| CN114502573A (zh) * | 2019-08-30 | 2022-05-13 | 基因组保护股份有限公司 | 提高疫苗功效的方法 |
| CN118754841A (zh) | 2020-05-19 | 2024-10-11 | 赛本爱尔兰有限公司 | 氘化的色胺衍生物和使用方法 |
| KR102720967B1 (ko) * | 2020-06-04 | 2024-10-23 | 가톨릭대학교 산학협력단 | 플라젤린으로부터 유도된 tlr5 작용제를 유효성분으로 포함하는 면역관문억제제의 항암 효과 증진용 약학 조성물 |
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| KR102483177B1 (ko) * | 2021-07-09 | 2022-12-29 | 전남대학교산학협력단 | 탈-면역 플라젤린 및 이를 포함하는 백신 조성물 |
| KR102514849B1 (ko) * | 2021-10-28 | 2023-03-28 | 전남대학교산학협력단 | 수지상 세포를 표적하는 신규한 펩타이드, 및 이를 포함하는 암 치료용 조성물 |
| IL317229A (en) * | 2022-06-01 | 2025-01-01 | Flag Bio Inc | RNA helpers, methods and uses thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090246303A1 (en) * | 2003-12-02 | 2009-10-01 | Gudkov Andrei V | Method for Reducing The Effects of Chemotherapy Using Flagellin Related Polypeptides |
| CN102965386A (zh) * | 2011-09-02 | 2013-03-13 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 一种重组细菌鞭毛蛋白衍生多肽的制备和活性鉴定方法 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3007812A (en) | 1957-02-11 | 1961-11-07 | Allied Chem | Water-repellent compositions, method of water-proofing porous surfaces therewith, and resulting water-repellent surfaces |
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US5399494A (en) | 1983-03-04 | 1995-03-21 | The University Of Maryland System | Vibrio cholerae strain CVD103Hgr, method of making same, and vaccines derived therefrom |
| US6130082A (en) | 1988-05-05 | 2000-10-10 | American Cyanamid Company | Recombinant flagellin vaccines |
| ES2070312T5 (es) * | 1988-12-19 | 2003-05-16 | American Cyanamid Co | Vacuna de proteina de membrana exterior meningococica de clase 1. |
| ES2088014T3 (es) | 1990-09-28 | 1996-08-01 | Sulzer Innotec Ag | Aguja hueca para utilizacion medica y procedimiento para la fabricacion de este tipo de agujas huecas. |
| CA2383007A1 (en) | 1992-03-02 | 1993-09-16 | Chiron S.P.A. | Helicobacter pylori proteins useful for vaccines and diagnostics |
| US5693476A (en) | 1995-02-24 | 1997-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of screening for compounds capable of modulating vesicular release |
| US20020009747A1 (en) | 1997-08-25 | 2002-01-24 | Freda Diane Miller | Methods and reagents for identifying modulators of neuronal apoptosis |
| US5994409A (en) | 1997-12-09 | 1999-11-30 | U.S. Bioscience, Inc. | Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds |
| US6586008B1 (en) * | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
| AU4709401A (en) | 1999-11-29 | 2001-06-12 | Inotek Corporation | Composition and method for treating a microbial infection |
| CA2398660A1 (en) | 2000-01-31 | 2001-08-02 | Munin Corporation | Human cyr61 |
| US7300749B2 (en) | 2000-02-17 | 2007-11-27 | Millennium Pharmaceuticals, Inc. | Molecules of the pyrin domain protein family and uses thereof |
| AU2002216500A1 (en) | 2000-11-28 | 2002-06-11 | Genesis Research And Development Corporation Limited | Methods for modulating apoptotic cell death |
| US8703146B2 (en) | 2001-04-20 | 2014-04-22 | Institute For Systems Biology | Toll-like receptor 5 ligands and methods of use |
| WO2002085933A1 (en) | 2001-04-20 | 2002-10-31 | The Institute For Systems Biology | Toll-like receptor 5 ligands and methods of use |
| WO2003028659A2 (en) | 2001-10-02 | 2003-04-10 | University Of Chicago | Methods and compositions for modulating apoptosis |
| US7078165B2 (en) | 2003-03-27 | 2006-07-18 | Institut Pasteur | Method for modulating Nod1 activity, use of a MTP related molecule for modulating Nod1 activity, and therapeutic applications thereof |
| WO2005056041A2 (en) | 2003-12-02 | 2005-06-23 | Cleveland Clinic Foundation | METHODS OF INHIBITING APOPTOSIS USING LATENT TGFβ |
| WO2005056054A2 (en) | 2003-12-02 | 2005-06-23 | Cleveland Clinic Foundation | METHODS OF INHIBITING APOPTOSIS USING INDUCERS OF NF-κB |
| EP1706133B1 (en) | 2003-12-02 | 2010-10-06 | Cleveland Clinic Foundation | Methods of protecting against radiation using flagellin |
| US7638485B2 (en) | 2003-12-02 | 2009-12-29 | Cleveland Biolabs, Inc. | Modulating apoptosis |
| US20050266391A1 (en) | 2004-01-15 | 2005-12-01 | Bennett Brydon L | Methods for preserving tissue |
| US7404963B2 (en) | 2004-10-01 | 2008-07-29 | The University Of South Florida | Flagellin-based adjuvants and vaccines |
| EP1824510B1 (en) | 2004-12-16 | 2012-10-31 | Wake Forest University Health Sciences | Use of flagellin in the immunotherapy of yersinia pestis |
| EP2460534A1 (en) | 2004-12-22 | 2012-06-06 | Cleveland Clinic Foundation | Flagellin related polypeptides and uses thereof |
| WO2007030581A2 (en) | 2005-09-09 | 2007-03-15 | Oregon Health & Science University | Neuroprotectants |
| WO2007070623A2 (en) | 2005-12-14 | 2007-06-21 | Medistem Laboratories, Inc. | Transcatheter tumor immunoembolization |
| EP2441846A3 (en) | 2006-01-09 | 2012-07-25 | The Regents Of the University of California | Immunostimulatory combinations of TNFRSF, TLR, NLR, RHR, purinergic receptor, and cytokine receptor agoinsts for vaccines and tumor immunotherapy |
| WO2008094275A1 (en) | 2007-01-30 | 2008-08-07 | New York University | Peptides for treatment of conditions associated with nitric oxide |
| KR20100034010A (ko) | 2007-06-15 | 2010-03-31 | 임뮤룩스, 인코포레이티드 | Ｔｎｆｒ 효능제 치료 요법의 독성을 경감시키기 위한 ｔｌｒ 효능제 및／또는 타입 1 인터페론의 용도 |
| MX2010001194A (es) | 2007-07-31 | 2010-07-30 | Univ Louisiana State | Conjugado de polipeptido-acido nucleico para inmunoprofilaxis o inmunoterapia para desordenes neoplasicos o infecciones. |
| EA201692127A1 (ru) | 2007-11-07 | 2017-08-31 | Селлдекс Терапьютикс Инк. | Антитела, связывающиеся с человеческим dec-205 |
| EP2320948B1 (en) * | 2008-08-01 | 2013-03-06 | Cleveland Biolabs, Inc. | Methods for treating reperfusion injuries |
| US8486408B2 (en) * | 2008-10-03 | 2013-07-16 | Emory University | Methods for the treatment of graft-versus-host disease |
| BRPI1010937A2 (pt) | 2009-05-21 | 2019-09-24 | Astrazeneca Ab | composto, uso de um composto, e, método para tratar câncer |
| NZ598654A (en) | 2009-09-02 | 2014-05-30 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| KR20120104177A (ko) | 2009-10-06 | 2012-09-20 | 파나셀라 랩스, 아이엔씨. | 암을 치료하기 위한 톨 유사 수용체 및 효능제의 용도 |
| CN102892429B (zh) * | 2010-03-17 | 2016-08-31 | 康奈尔大学 | 基于被破坏的腺病毒的抗滥用药物疫苗 |
| CN103945863A (zh) * | 2011-08-01 | 2014-07-23 | 爱默蕾大学 | 包含配体的vlp及其相关方法 |
| CN102772795B (zh) * | 2012-08-06 | 2015-07-29 | 中国人民解放军疾病预防控制所 | 布鲁氏菌鞭毛蛋白bmeii1112在制备布鲁氏菌亚单位疫苗中的应用 |
| KR20170031251A (ko) * | 2014-07-30 | 2017-03-20 | 클리브랜드 바이오랩스, 아이엔씨. | 플라젤린 조성물 및 용도 |
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2015
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090246303A1 (en) * | 2003-12-02 | 2009-10-01 | Gudkov Andrei V | Method for Reducing The Effects of Chemotherapy Using Flagellin Related Polypeptides |
| CN102965386A (zh) * | 2011-09-02 | 2013-03-13 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 一种重组细菌鞭毛蛋白衍生多肽的制备和活性鉴定方法 |
Non-Patent Citations (1)
| Title |
|---|
| SMITH K D ET AL, "Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility", NATURE IMMUNOLOGY,, (2003-12-01), vol. 4, no. 12, pages 1247 - 1253 * |
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