ES2816630T3 - Composiciones de flagelina y usos - Google Patents
Composiciones de flagelina y usos Download PDFInfo
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- ES2816630T3 ES2816630T3 ES15827248T ES15827248T ES2816630T3 ES 2816630 T3 ES2816630 T3 ES 2816630T3 ES 15827248 T ES15827248 T ES 15827248T ES 15827248 T ES15827248 T ES 15827248T ES 2816630 T3 ES2816630 T3 ES 2816630T3
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Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10202426B2 (en) * | 2014-07-30 | 2019-02-12 | Genome Protection, Inc. | Flagellin compositions and uses |
| JP6762030B2 (ja) | 2014-11-20 | 2020-09-30 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 異なる核酸アジュバントの組み合わせによる、新規Ｔｈ１誘導性アジュバントおよびその用途 |
| UY37816A (es) | 2017-07-20 | 2019-02-28 | Spogen Biotech Inc | Polipéptidos bioactivos para mejorar la protección, crecimiento y productividad en plantas |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| US11660331B2 (en) | 2017-11-09 | 2023-05-30 | The Scripps Research Institute | Heroin vaccine |
| JP7037930B2 (ja) * | 2017-12-19 | 2022-03-17 | 株式会社小糸製作所 | 車両の運転支援装置、命令表示装置及び車両用灯具。 |
| CN109879940A (zh) * | 2017-12-25 | 2019-06-14 | 苏州和锐生物科技有限公司 | 鞭毛g多肽、抗体捕获器件及试剂盒 |
| CN112203675A (zh) * | 2018-04-24 | 2021-01-08 | 基因组保护股份有限公司 | 用于改善虚弱和衰老的方法 |
| WO2020110154A1 (en) * | 2018-11-30 | 2020-06-04 | Bharat Biotech International Limited | A chimeric therapeutic vaccine |
| US20220024991A1 (en) * | 2018-12-07 | 2022-01-27 | Genome Protection, Inc. | Engineered flagellin-derived compositions and uses |
| CN111718417B (zh) * | 2019-03-19 | 2022-10-14 | 宁波鲲鹏生物科技有限公司 | 含有荧光蛋白片段的融合蛋白及其用途 |
| KR102169663B1 (ko) * | 2019-03-28 | 2020-10-26 | 가톨릭대학교 산학협력단 | 플라젤린으로부터 유도된 tlr5 작용제를 유효성분으로 포함하는 이식편대숙주질환의 예방 또는 치료용 조성물 |
| JP2022529781A (ja) | 2019-04-17 | 2022-06-24 | コンパス パスファインダー リミテッド | サイロシビンによるうつ病及び他の様々な障害の治療 |
| CN110157655B (zh) * | 2019-05-22 | 2021-06-01 | 中国兽医药品监察所 | 一种无毒性气肿疽梭菌基因工程亚单位疫苗用菌种及其应用 |
| WO2021041822A1 (en) * | 2019-08-30 | 2021-03-04 | Genome Protection. Inc. | Methods of increasing vaccine efficacy |
| US12240813B2 (en) | 2020-05-19 | 2025-03-04 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
| JP7598660B2 (ja) * | 2020-06-04 | 2024-12-12 | ザ カトリック ユニバーシティ オブ コリア インダストリー－アカデミック コーオペレイション ファウンデーション | フラジェリン由来のｔｌｒ５アゴニストを有効成分として含む抗がん剤組成物 |
| TWI746188B (zh) * | 2020-09-28 | 2021-11-11 | 中山醫學大學 | 篩選治療腦炎藥物之平台及其方法 |
| US20220226465A1 (en) | 2021-01-18 | 2022-07-21 | ConserV Bioscience | Coronavirus Immunogenic Compositions, Methods and Uses Thereof |
| KR20240027752A (ko) * | 2021-06-30 | 2024-03-04 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 플라겔린의 폐 전달을 위한 에어로졸 조성물 |
| KR102483177B1 (ko) * | 2021-07-09 | 2022-12-29 | 전남대학교산학협력단 | 탈-면역 플라젤린 및 이를 포함하는 백신 조성물 |
| KR102514849B1 (ko) * | 2021-10-28 | 2023-03-28 | 전남대학교산학협력단 | 수지상 세포를 표적하는 신규한 펩타이드, 및 이를 포함하는 암 치료용 조성물 |
| IL317229A (en) * | 2022-06-01 | 2025-01-01 | Flag Bio Inc | RNA helpers, methods and uses thereof |
| WO2024035137A1 (ko) * | 2022-08-10 | 2024-02-15 | 주식회사 메디스팬 | 바실러스 서브틸리스 플라젤린 변이체 및 이의 용도 |
| US20240173397A1 (en) * | 2022-11-29 | 2024-05-30 | George Mason University | Limiting viral infection and replication in stem cells |
| WO2025172452A1 (en) * | 2024-02-14 | 2025-08-21 | Institut National de la Santé et de la Recherche Médicale | Combination for treating bacterial infection due to pseudomonas aeruginosa antibiotic-resistant strain |
| JP1793517S (ja) * | 2024-08-22 | 2025-04-21 | 船舶用推進機用リモートコントローラー |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3007812A (en) | 1957-02-11 | 1961-11-07 | Allied Chem | Water-repellent compositions, method of water-proofing porous surfaces therewith, and resulting water-repellent surfaces |
| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US5399494A (en) | 1983-03-04 | 1995-03-21 | The University Of Maryland System | Vibrio cholerae strain CVD103Hgr, method of making same, and vaccines derived therefrom |
| US6130082A (en) | 1988-05-05 | 2000-10-10 | American Cyanamid Company | Recombinant flagellin vaccines |
| EP0449958B9 (en) * | 1988-12-19 | 2003-05-28 | American Cyanamid Company | Meningococcal class 1 outer-membrane protein vaccine |
| WO1992005816A1 (de) | 1990-09-28 | 1992-04-16 | Gebrüder Sulzer Aktiengesellschaft | Hohlnadel zur medizinischen verwendung und verfahren zur herstellung derartiger hohlnadeln |
| EP0967279B1 (en) | 1992-03-02 | 2008-01-02 | Novartis Vaccines and Diagnostics S.r.l. | Helicobacter pylori cytotoxin useful for vaccines and diagnostics |
| US5693476A (en) | 1995-02-24 | 1997-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of screening for compounds capable of modulating vesicular release |
| US20020009747A1 (en) | 1997-08-25 | 2002-01-24 | Freda Diane Miller | Methods and reagents for identifying modulators of neuronal apoptosis |
| US5994409A (en) | 1997-12-09 | 1999-11-30 | U.S. Bioscience, Inc. | Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds |
| US6586008B1 (en) * | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
| WO2001040280A2 (en) | 1999-11-29 | 2001-06-07 | Inotek Corporation | Composition and method for treating a microbial infection |
| CN1447819B (zh) | 2000-01-31 | 2011-06-22 | 妙甯公司 | 人cyr61 |
| US7300749B2 (en) | 2000-02-17 | 2007-11-27 | Millennium Pharmaceuticals, Inc. | Molecules of the pyrin domain protein family and uses thereof |
| WO2002044363A1 (en) | 2000-11-28 | 2002-06-06 | Genesis Research And Development Corporation Limited | Methods for modulating apoptotic cell death |
| US8703146B2 (en) | 2001-04-20 | 2014-04-22 | Institute For Systems Biology | Toll-like receptor 5 ligands and methods of use |
| ATE463505T1 (de) | 2001-04-20 | 2010-04-15 | Inst Systems Biology | Toll-ähnlichen-rezeptor-5-liganden und verwendungsverfahren |
| CA2462638A1 (en) | 2001-10-02 | 2003-04-10 | University Of Chicago | Methods and compositions for modulating apoptosis |
| US7078165B2 (en) | 2003-03-27 | 2006-07-18 | Institut Pasteur | Method for modulating Nod1 activity, use of a MTP related molecule for modulating Nod1 activity, and therapeutic applications thereof |
| US7638485B2 (en) | 2003-12-02 | 2009-12-29 | Cleveland Biolabs, Inc. | Modulating apoptosis |
| WO2005056041A2 (en) | 2003-12-02 | 2005-06-23 | Cleveland Clinic Foundation | METHODS OF INHIBITING APOPTOSIS USING LATENT TGFβ |
| WO2005056054A2 (en) | 2003-12-02 | 2005-06-23 | Cleveland Clinic Foundation | METHODS OF INHIBITING APOPTOSIS USING INDUCERS OF NF-κB |
| AU2004296828B2 (en) * | 2003-12-02 | 2011-07-07 | Cleveland Clinic Foundation | Methods of protecting against radiation using flagellin |
| US20050266391A1 (en) | 2004-01-15 | 2005-12-01 | Bennett Brydon L | Methods for preserving tissue |
| WO2006039701A1 (en) | 2004-10-01 | 2006-04-13 | University Of South Florida | Flagellin-based adjuvants and vaccines |
| JP5094407B2 (ja) | 2004-12-16 | 2012-12-12 | ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ | Ｙｅｒｓｉｎｉａｐｅｓｔｉｓの免疫療法におけるフラジェリンの使用 |
| EP1838340B1 (en) | 2004-12-22 | 2018-04-04 | Cleveland Clinic Foundation | Flagellin related polypeptides and uses thereof |
| WO2007030581A2 (en) | 2005-09-09 | 2007-03-15 | Oregon Health & Science University | Neuroprotectants |
| US20070269406A1 (en) | 2005-12-14 | 2007-11-22 | Ichim Thomas E | Transcatheter tumor immunoembolization |
| US20090081157A1 (en) | 2006-01-09 | 2009-03-26 | Richard Syd Kornbluth | Immunostimulatory Combinations for Vaccine Adjuvants |
| EP2114427B1 (en) | 2007-01-30 | 2014-06-25 | New York University | Peptides for treatment of conditions associated with nitric oxide |
| WO2008157473A1 (en) | 2007-06-15 | 2008-12-24 | Immurx, Inc. | Use of tlr agonists and/or type 1 interferons to alleviate toxicity of tnf-r agonist therapeutic regimens |
| CA2695385A1 (en) | 2007-07-31 | 2009-02-05 | Atul Bedi | Polypeptide-nucleic acid conjugate for immunoprophylaxis or immunotherapy for neoplastic or infectious disorders |
| KR101811965B1 (ko) | 2007-11-07 | 2017-12-22 | 셀덱스 쎄라퓨틱스, 인크. | 인간 수지상 및 상피 세포 205(ｄｅｃ-205)에 결합하는 항체 |
| WO2009102818A1 (en) | 2008-02-11 | 2009-08-20 | Cleveland Biolabs, Inc. | Method for reducing the effects of chemotheraphy using flagellin related polypeptides |
| CN102170911B (zh) * | 2008-08-01 | 2014-07-02 | 克里夫兰生物实验室公司 | 用于治疗再灌注损伤的方法 |
| US8486408B2 (en) * | 2008-10-03 | 2013-07-16 | Emory University | Methods for the treatment of graft-versus-host disease |
| BRPI1010937A2 (pt) | 2009-05-21 | 2019-09-24 | Astrazeneca Ab | composto, uso de um composto, e, método para tratar câncer |
| AU2010290896B2 (en) | 2009-09-02 | 2014-07-03 | Glaxosmithkline Biologicals S.A. | Immunogenic compositions including TLR activity modulators |
| CA2777198C (en) * | 2009-10-06 | 2018-07-24 | Panacela Labs, Inc. | Use of toll-like receptor and agonist for treating cancer |
| EP2547362B1 (en) * | 2010-03-17 | 2021-08-25 | Cornell University | Disrupted adenovirus-based vaccine against drugs of abuse |
| US9683020B2 (en) * | 2011-08-01 | 2017-06-20 | Emory University | VLPS containing ligands and methods related thereto |
| CN102965386A (zh) * | 2011-09-02 | 2013-03-13 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 一种重组细菌鞭毛蛋白衍生多肽的制备和活性鉴定方法 |
| CN102772795B (zh) * | 2012-08-06 | 2015-07-29 | 中国人民解放军疾病预防控制所 | 布鲁氏菌鞭毛蛋白bmeii1112在制备布鲁氏菌亚单位疫苗中的应用 |
| US10202426B2 (en) * | 2014-07-30 | 2019-02-12 | Genome Protection, Inc. | Flagellin compositions and uses |
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