AU2015256997B2 - NOX inhibitor and NFkB inhibitor containing methoxyflavone - Google Patents
NOX inhibitor and NFkB inhibitor containing methoxyflavone Download PDFInfo
- Publication number
- AU2015256997B2 AU2015256997B2 AU2015256997A AU2015256997A AU2015256997B2 AU 2015256997 B2 AU2015256997 B2 AU 2015256997B2 AU 2015256997 A AU2015256997 A AU 2015256997A AU 2015256997 A AU2015256997 A AU 2015256997A AU 2015256997 B2 AU2015256997 B2 AU 2015256997B2
- Authority
- AU
- Australia
- Prior art keywords
- group
- methoxyflavones
- hydroxy
- dimethoxyflavone
- tetramethoxyflavone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- ZAIANDVQAMEDFL-UHFFFAOYSA-N 3-methoxy-2-phenylchromen-4-one Chemical compound O1C2=CC=CC=C2C(=O)C(OC)=C1C1=CC=CC=C1 ZAIANDVQAMEDFL-UHFFFAOYSA-N 0.000 title claims abstract description 199
- YEHDMSUNJUONMW-UHFFFAOYSA-N methoxyflavone Natural products COC1=CC=CC=C1C1=CC(=O)C2=CC=CC=C2O1 YEHDMSUNJUONMW-UHFFFAOYSA-N 0.000 title claims abstract description 54
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- ZXJJBDHPUHUUHD-UHFFFAOYSA-N 4',5,7-Trimethoxyflavone Chemical compound C1=CC(OC)=CC=C1C1=CC(=O)C2=C(OC)C=C(OC)C=C2O1 ZXJJBDHPUHUUHD-UHFFFAOYSA-N 0.000 claims description 40
- 238000000034 method Methods 0.000 claims description 39
- CLXVBVLQKLQNRQ-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5,7-dimethoxychromen-4-one Chemical compound C=1C(OC)=CC(OC)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 CLXVBVLQKLQNRQ-UHFFFAOYSA-N 0.000 claims description 37
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 31
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- ALGDHWVALRSLBT-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-3,5,7-trimethoxychromen-4-one Chemical compound C=1C(OC)=CC(OC)=C(C(C=2OC)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 ALGDHWVALRSLBT-UHFFFAOYSA-N 0.000 claims description 27
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| JP2017145221A (ja) * | 2016-02-18 | 2017-08-24 | 株式会社レーネ | Ｔａｕタンパク質凝集阻害剤 |
| JP6909559B2 (ja) * | 2016-03-31 | 2021-07-28 | 株式会社アンチエイジングコミュニケーション | Ｏｐｈ活性増強剤 |
| JP6462755B2 (ja) * | 2017-04-04 | 2019-01-30 | 丸善製薬株式会社 | 脳の機能改善剤および脳の機能改善用飲食品 |
| TWI646943B (zh) * | 2017-12-08 | 2019-01-11 | 財團法人自行車暨健康科技工業研究發展中心 | Method for screening for muscular dysfunction through functional fitness |
| KR102032739B1 (ko) * | 2018-01-31 | 2019-10-16 | 한림대학교 산학협력단 | 신규한 크리신 유도체 화합물을 유효성분으로 포함하는 당뇨합병증의 예방 또는 치료용 약학 조성물 |
| CN110237066B (zh) * | 2018-03-07 | 2022-03-29 | 上海市生物医药技术研究院 | 3-甲氧基黄酮及其衍生物在制备治疗或预防肾病的药物中的应用 |
| CN108904489A (zh) * | 2018-06-19 | 2018-11-30 | 杭州勃锐思莫生物医药科技有限责任公司 | 5,7-甲氧基3,4’羟基黄酮的抗呼吸道炎症性疾病的用途 |
| JP7229513B2 (ja) * | 2018-10-16 | 2023-02-28 | 丸善製薬株式会社 | 脳の機能改善剤および脳の機能改善用飲食品 |
| CN109288834A (zh) * | 2018-11-28 | 2019-02-01 | 武汉科技大学 | 5-甲氧基黄酮在制备无义突变通读药物中的应用 |
| WO2020178267A1 (en) * | 2019-03-04 | 2020-09-10 | Universite D'aix-Marseille | Nox inhibitors for preventing epileptic seizures |
| CN110357846B (zh) * | 2019-07-11 | 2021-06-15 | 上海健康医学院 | 一种黄酮并单萜类化合物及其制备方法和应用 |
| US20230021051A1 (en) * | 2019-12-26 | 2023-01-19 | Maruzen Pharmaceuticals Co., Ltd. | Composition Containing Black Ginger Extract and Composition for Oral Administration |
| CN111374970B (zh) * | 2020-03-17 | 2023-05-30 | 广西壮族自治区中医药研究院 | 一种具有抗结肠炎活性的组合物及其应用 |
| CN111617076B (zh) * | 2020-06-24 | 2021-09-28 | 江苏吴中医药集团有限公司 | 一种含有盐酸阿比多尔的复方药物组合物及其用途 |
| JP7081843B2 (ja) * | 2020-10-26 | 2022-06-07 | 株式会社東洋新薬 | 自律神経調節剤 |
| WO2022137964A1 (ja) * | 2020-12-23 | 2022-06-30 | 国立大学法人大阪大学 | 軟骨・骨・関節疾患の予防または治療用医薬組成物および軟骨・骨・関節疾患の予防または治療用薬剤のスクリーニング方法 |
| WO2023144742A1 (en) | 2022-01-26 | 2023-08-03 | Universidade De Aveiro | Ionic-liquid-based formulations for the prevention or treatment of neurological diseases |
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| BR0210391A (pt) * | 2001-06-12 | 2004-06-15 | Elan Pharm Inc | Composto, métodos de tratar um paciente que tenha ou de prevenir um paciente de contrair uma doença ou condição e de preparar um composto, e, uso de um composto |
| JP2007314468A (ja) * | 2006-05-25 | 2007-12-06 | Meiji Milk Prod Co Ltd | 小胞体ストレス制御化合物とそれを有効成分とする医薬組成物 |
| JP2009051790A (ja) * | 2007-08-29 | 2009-03-12 | Maruzen Pharmaceut Co Ltd | 抗酸化剤、抗老化剤、抗炎症剤、育毛剤、抗肥満剤、及び美白剤、並びに化粧料及び美容用飲食品 |
| JP5756264B2 (ja) * | 2010-05-06 | 2015-07-29 | 日本タブレット株式会社 | キサンチンオキシダーゼ阻害剤、キサンチンオキシダーゼ及び５α−レダクターゼ阻害剤、並びに該阻害剤を含有する医薬組成物 |
| KR101811303B1 (ko) * | 2011-07-26 | 2017-12-26 | 에스케이하이닉스 주식회사 | 반도체 집적회로 및 그의 구동 방법 |
| JP2013144659A (ja) * | 2012-01-16 | 2013-07-25 | Nippon Tablet Kk | ５α−レダクターゼ阻害剤、並びに該阻害剤を含有する飲食品類、化粧料組成物、医薬組成物 |
| KR101528023B1 (ko) * | 2012-05-16 | 2015-06-15 | 연세대학교 산학협력단 | 캠페리아 파비플로라 추출물 또는 플라본계 화합물을 함유하는 근육 질환 예방 및 치료용 또는 근 기능 개선용 조성물 |
| JP2013241354A (ja) * | 2012-05-18 | 2013-12-05 | Oriza Yuka Kk | ホスホジエステラーゼ２阻害剤 |
| JP2013253047A (ja) * | 2012-06-07 | 2013-12-19 | Kinki Univ | 血液レオロジー改善剤、並びに該血液レオロジー改善剤を含有する飲食品類及び医薬組成物 |
| WO2013185301A1 (zh) * | 2012-06-13 | 2013-12-19 | Jin Yongri | 黄酮及二氢黄酮衍生物在制备镇静、催眠药物中的用途 |
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| CA2948127A1 (en) | 2015-11-12 |
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| CN106456597A (zh) | 2017-02-22 |
| TW201625574A (zh) | 2016-07-16 |
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