AU2015233006B2 - Sildenafil solutions and methods of making and using same - Google Patents

Sildenafil solutions and methods of making and using same Download PDF

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Publication number
AU2015233006B2
AU2015233006B2 AU2015233006A AU2015233006A AU2015233006B2 AU 2015233006 B2 AU2015233006 B2 AU 2015233006B2 AU 2015233006 A AU2015233006 A AU 2015233006A AU 2015233006 A AU2015233006 A AU 2015233006A AU 2015233006 B2 AU2015233006 B2 AU 2015233006B2
Authority
AU
Australia
Prior art keywords
pharmaceutical composition
composition according
sildenafil citrate
liquid carrier
ethanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2015233006A
Other languages
English (en)
Other versions
AU2015233006A1 (en
Inventor
Morris ABOOHI
Moshe Rogosnitzky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vigorous Solutions Ltd
Original Assignee
Vigorous Solutions Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54145440&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2015233006(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vigorous Solutions Ltd filed Critical Vigorous Solutions Ltd
Publication of AU2015233006A1 publication Critical patent/AU2015233006A1/en
Application granted granted Critical
Publication of AU2015233006B2 publication Critical patent/AU2015233006B2/en
Priority to AU2018250378A priority Critical patent/AU2018250378B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01Q—ANTENNAS, i.e. RADIO AERIALS
    • H01Q5/00—Arrangements for simultaneous operation of antennas on two or more different wavebands, e.g. dual-band or multi-band arrangements
    • H01Q5/50—Feeding or matching arrangements for broad-band or multi-band operation
    • H01Q5/55—Feeding or matching arrangements for broad-band or multi-band operation for horn or waveguide antennas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01Q—ANTENNAS, i.e. RADIO AERIALS
    • H01Q1/00—Details of, or arrangements associated with, antennas
    • H01Q1/27—Adaptation for use in or on movable bodies
    • H01Q1/28—Adaptation for use in or on aircraft, missiles, satellites, or balloons
    • H01Q1/288—Satellite antennas
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01Q—ANTENNAS, i.e. RADIO AERIALS
    • H01Q1/00—Details of, or arrangements associated with, antennas
    • H01Q1/36—Structural form of radiating elements, e.g. cone, spiral, umbrella; Particular materials used therewith

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Astronomy & Astrophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Remote Sensing (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Aviation & Aerospace Engineering (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2015233006A 2014-03-19 2015-03-19 Sildenafil solutions and methods of making and using same Ceased AU2015233006B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2018250378A AU2018250378B2 (en) 2014-03-19 2018-10-16 Sildenafil solutions and methods of making and using same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461955299P 2014-03-19 2014-03-19
US61/955,299 2014-03-19
PCT/IB2015/052014 WO2015140748A2 (en) 2014-03-19 2015-03-19 Sildenafil solutions and methods of making and using same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018250378A Division AU2018250378B2 (en) 2014-03-19 2018-10-16 Sildenafil solutions and methods of making and using same

Publications (2)

Publication Number Publication Date
AU2015233006A1 AU2015233006A1 (en) 2016-11-03
AU2015233006B2 true AU2015233006B2 (en) 2018-07-19

Family

ID=54145440

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2015233006A Ceased AU2015233006B2 (en) 2014-03-19 2015-03-19 Sildenafil solutions and methods of making and using same
AU2018250378A Ceased AU2018250378B2 (en) 2014-03-19 2018-10-16 Sildenafil solutions and methods of making and using same

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2018250378A Ceased AU2018250378B2 (en) 2014-03-19 2018-10-16 Sildenafil solutions and methods of making and using same

Country Status (25)

Country Link
US (2) US9968609B2 (cg-RX-API-DMAC10.html)
EP (2) EP3119201B1 (cg-RX-API-DMAC10.html)
JP (1) JP6744821B2 (cg-RX-API-DMAC10.html)
KR (1) KR20160137584A (cg-RX-API-DMAC10.html)
CN (1) CN106132204B (cg-RX-API-DMAC10.html)
AU (2) AU2015233006B2 (cg-RX-API-DMAC10.html)
CA (1) CA2942628C (cg-RX-API-DMAC10.html)
CL (1) CL2016002318A1 (cg-RX-API-DMAC10.html)
CY (1) CY1120187T1 (cg-RX-API-DMAC10.html)
DK (1) DK3119201T3 (cg-RX-API-DMAC10.html)
EA (1) EA032819B1 (cg-RX-API-DMAC10.html)
ES (1) ES2668915T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20180773T1 (cg-RX-API-DMAC10.html)
HU (1) HUE038431T2 (cg-RX-API-DMAC10.html)
IL (1) IL247840B (cg-RX-API-DMAC10.html)
LT (1) LT3119201T (cg-RX-API-DMAC10.html)
MX (1) MX371276B (cg-RX-API-DMAC10.html)
NO (1) NO2723977T3 (cg-RX-API-DMAC10.html)
PL (1) PL3119201T3 (cg-RX-API-DMAC10.html)
PT (1) PT3119201T (cg-RX-API-DMAC10.html)
RS (1) RS57206B1 (cg-RX-API-DMAC10.html)
SG (2) SG11201607507VA (cg-RX-API-DMAC10.html)
SI (1) SI3119201T1 (cg-RX-API-DMAC10.html)
SM (1) SMT201800268T1 (cg-RX-API-DMAC10.html)
WO (1) WO2015140748A2 (cg-RX-API-DMAC10.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO2723977T3 (cg-RX-API-DMAC10.html) 2014-03-19 2018-03-10
JP6902372B2 (ja) * 2017-02-28 2021-07-14 ヱスビー食品株式会社 苦味抑制用組成物
JP2021509114A (ja) * 2017-12-26 2021-03-18 エフティーエフ ファーマ プライベート リミテッド Ｐｄｅ ｖ阻害剤のための液体経口処方物
CA3137260A1 (en) * 2019-04-18 2020-10-22 Ellamed Ip & Services Pte. Ltd. Liquid sildenafil citrate compositions
CA3157765A1 (en) * 2019-11-12 2021-05-20 Richard Lawrence Type v phosphodiesterase inhibitor compositions, methods of making them and methods of using them in preventing or treating elevated pulmonary vascular pressure or pulmonary hemorrhage

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US5785984A (en) * 1993-02-05 1998-07-28 Kao Corporation Taste-modifying method and bitterness-decreasing method
WO2001035926A2 (en) * 1999-11-18 2001-05-25 Natco Pharma Limited An improved pharmaceutical composition for treating male erectile dysfunction
US20090239883A1 (en) * 1999-11-02 2009-09-24 Pfizer Inc Treatment of Pulmonary Hypertension
US20100022496A1 (en) * 2006-09-22 2010-01-28 Philippe Perovitch Galenical form for the administration of active ingredients by transmucous means
US20100297223A1 (en) * 2007-12-19 2010-11-25 Abbott Gmbh & Co. Kg Pharmaceutical dosage form comprising a liquid or flowable core composition

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DE69426176T2 (de) * 1993-02-05 2001-04-05 Kao Corp., Tokio/Tokyo Verfahren zur geschmacksmodifizierung und verfahren zur verminderung eines bitteren geschmack
US6548490B1 (en) 1997-10-28 2003-04-15 Vivus, Inc. Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
TWI223598B (en) 1998-06-22 2004-11-11 Pfizer Ireland Pharmaceuticals An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate
US6531114B1 (en) 1999-04-06 2003-03-11 Wm. Wrigley Jr. Company Sildenafil citrate chewing gum formulations and methods of using the same
US6552024B1 (en) 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
CN100558407C (zh) 2000-02-04 2009-11-11 柳署弘 制备含有胆汁酸的澄清水溶液剂型
EP1301186A1 (en) 2000-07-19 2003-04-16 Lavipharm Laboratories, Inc. Sildenafil citrate solid dispersions having high water solubility
US20030216407A1 (en) 2002-01-31 2003-11-20 Pfizer Inc. Use of PDE5 inhibitors in the treatment of scarring
US7611728B2 (en) 2003-09-05 2009-11-03 Supernus Pharmaceuticals, Inc. Osmotic delivery of therapeutic compounds by solubility enhancement
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CA2552003A1 (en) 2004-01-05 2005-07-28 Teva Pharmaceutical Industries Ltd. Methods for the production of sildenafil base and citrate salt
CN1925860A (zh) * 2004-01-05 2007-03-07 特瓦制药工业有限公司 制备西地那非碱及其柠檬酸盐的方法
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US7556487B2 (en) 2006-03-29 2009-07-07 Intergum Gida Sinayi ve Ticaret A.S. Apparatus for making center-filled chewing gum pieces
EP2008530B1 (de) 2007-06-19 2011-01-19 Symrise AG Aromakomposition zum Verringern oder Unterdrücken von unerwünschtem bitteren und adstringierenden Eindruck
WO2009125415A1 (en) 2008-04-07 2009-10-15 Hetero Research Foundation Amorphous form of sildenafil citrate
FR2939321B1 (fr) 2008-12-05 2011-08-26 Philippe Perovitch Dispositif de conditionnement et d'administration de principes actifs en solution hydro-alcoolique.
US8642270B2 (en) 2009-02-09 2014-02-04 Vm Institute Of Research Prognostic biomarkers to predict overall survival and metastatic disease in patients with triple negative breast cancer
DE102010049708A1 (de) * 2010-10-28 2012-05-03 Hexal Ag Orale pharmazeutische Filmformulierung für bitter schmeckende Arzneistoffe
CA2858364C (en) * 2011-12-05 2018-07-24 Foye Opawale Oral spray formulations and methods for administration of sildenafil
GB2497933B (en) 2011-12-21 2014-12-24 Londonpharma Ltd Drug delivery technology
HK1207562A1 (en) * 2012-01-18 2016-02-05 苏州泰飞尔医药有限公司 High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions
US9186361B2 (en) 2013-03-15 2015-11-17 Novartis Ag Compounds and compositions for the treatment of parasitic diseases
NO2723977T3 (cg-RX-API-DMAC10.html) 2014-03-19 2018-03-10

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5785984A (en) * 1993-02-05 1998-07-28 Kao Corporation Taste-modifying method and bitterness-decreasing method
US20090239883A1 (en) * 1999-11-02 2009-09-24 Pfizer Inc Treatment of Pulmonary Hypertension
WO2001035926A2 (en) * 1999-11-18 2001-05-25 Natco Pharma Limited An improved pharmaceutical composition for treating male erectile dysfunction
US20100022496A1 (en) * 2006-09-22 2010-01-28 Philippe Perovitch Galenical form for the administration of active ingredients by transmucous means
US20100297223A1 (en) * 2007-12-19 2010-11-25 Abbott Gmbh & Co. Kg Pharmaceutical dosage form comprising a liquid or flowable core composition

Also Published As

Publication number Publication date
US20170049776A1 (en) 2017-02-23
IL247840B (en) 2019-03-31
US10211534B2 (en) 2019-02-19
RS57206B1 (sr) 2018-07-31
PT3119201T (pt) 2018-06-15
CL2016002318A1 (es) 2017-03-24
AU2018250378A1 (en) 2018-11-08
CN106132204A (zh) 2016-11-16
MX371276B (es) 2020-01-23
CA2942628C (en) 2022-06-07
US20180233823A1 (en) 2018-08-16
JP2017508764A (ja) 2017-03-30
EA032819B1 (ru) 2019-07-31
EA201691871A1 (ru) 2017-03-31
US9968609B2 (en) 2018-05-15
CA2942628A1 (en) 2015-09-24
AU2018250378B2 (en) 2020-05-14
KR20160137584A (ko) 2016-11-30
AU2015233006A1 (en) 2016-11-03
EP3119201A4 (en) 2017-03-15
PL3119201T3 (pl) 2018-08-31
WO2015140748A3 (en) 2015-12-17
SG10201808038TA (en) 2018-10-30
LT3119201T (lt) 2018-05-10
CY1120187T1 (el) 2018-12-12
EP3119201B1 (en) 2018-03-14
SG11201607507VA (en) 2016-10-28
CN106132204B (zh) 2019-08-20
DK3119201T3 (en) 2018-05-28
MX2016012154A (es) 2016-12-15
EP3119201A2 (en) 2017-01-25
EP3372083A1 (en) 2018-09-12
ES2668915T3 (es) 2018-05-23
WO2015140748A2 (en) 2015-09-24
HUE038431T2 (hu) 2018-10-29
HRP20180773T1 (hr) 2018-06-15
NO2723977T3 (cg-RX-API-DMAC10.html) 2018-03-10
SI3119201T1 (en) 2018-07-31
JP6744821B2 (ja) 2020-08-19
SMT201800268T1 (it) 2018-07-17

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