AU2014364589B2 - Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof - Google Patents

Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof Download PDF

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Publication number
AU2014364589B2
AU2014364589B2 AU2014364589A AU2014364589A AU2014364589B2 AU 2014364589 B2 AU2014364589 B2 AU 2014364589B2 AU 2014364589 A AU2014364589 A AU 2014364589A AU 2014364589 A AU2014364589 A AU 2014364589A AU 2014364589 B2 AU2014364589 B2 AU 2014364589B2
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Australia
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peptide
residues
amino acid
staple
lipids
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AU2014364589A
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AU2014364589A1 (en
Inventor
Peter G. Schultz
Weijun Shen
Pengyu YANG
Huafei ZOU
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Scripps Research Institute
California Institute for Biomedical Research
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Scripps Research Institute
California Institute for Biomedical Research
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
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  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
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  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
AU2014364589A 2013-12-18 2014-12-17 Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof Active AU2014364589B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361917816P 2013-12-18 2013-12-18
US61/917,816 2013-12-18
PCT/US2014/070977 WO2015095406A1 (en) 2013-12-18 2014-12-17 Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof

Publications (2)

Publication Number Publication Date
AU2014364589A1 AU2014364589A1 (en) 2016-07-07
AU2014364589B2 true AU2014364589B2 (en) 2020-02-27

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Country Status (8)

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US (5) US10039809B2 (https=)
EP (2) EP4212180A1 (https=)
JP (1) JP6572497B2 (https=)
KR (1) KR102455171B1 (https=)
CN (1) CN106456589B (https=)
AU (1) AU2014364589B2 (https=)
CA (1) CA2933701C (https=)
WO (1) WO2015095406A1 (https=)

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CN108697768B (zh) 2015-12-23 2022-07-22 约翰霍普金斯大学 长效glp-1r激动剂作为神经系统病状和神经退行性病状的治疗方法
WO2017116204A1 (ko) 2015-12-31 2017-07-06 한미약품 주식회사 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체
CN106046145B (zh) * 2016-04-22 2022-11-04 深圳市图微安创科技开发有限公司 Glp-1r/gcgr双靶点激动剂多肽治疗脂肪肝病、高脂血症和动脉硬化
KR102005457B1 (ko) 2016-06-29 2019-07-30 한미약품 주식회사 글루카곤 유도체, 이의 결합체, 및 이를 포함하는 조성물, 및 이의 치료적 용도
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AU2018237139A1 (en) * 2017-03-22 2019-10-17 The Regents Of The University Of California Modified oligonucleotides and therapeutic uses thereof
US20200164078A1 (en) * 2017-07-17 2020-05-28 Technische Universiteit Eindhoven Applicable chemical composition comprising an agent conjugated to a hydrophobic moiety and a carrier
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CN113024635B (zh) * 2019-12-25 2023-12-19 中国医学科学院药物研究所 一类订书肽化合物及其药物组合物的用途
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TW202241491A (zh) * 2020-12-16 2022-11-01 丹麥商西蘭製藥公司 Ｇｌｐ－１／ｇｌｐ－２雙重促效劑之醫藥組合物
WO2022156189A1 (zh) * 2021-01-22 2022-07-28 深圳市图微安创科技开发有限公司 多肽化合物在预防或治疗炎症性肠病及其相关的肠纤维化中的应用
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