AU2014296626B2 - Multipartite signaling proteins and uses thereof - Google Patents

Multipartite signaling proteins and uses thereof Download PDF

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Publication number
AU2014296626B2
AU2014296626B2 AU2014296626A AU2014296626A AU2014296626B2 AU 2014296626 B2 AU2014296626 B2 AU 2014296626B2 AU 2014296626 A AU2014296626 A AU 2014296626A AU 2014296626 A AU2014296626 A AU 2014296626A AU 2014296626 B2 AU2014296626 B2 AU 2014296626B2
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fusion protein
multimerization
binding
natural cell
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AU2014296626A1 (en
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Alexander ASTRAKHAN
Michael CERTO
Jordan JARJOUR
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Assigned to REGENERON PHARMACEUTICALS, INC. reassignment REGENERON PHARMACEUTICALS, INC. Request for Assignment Assignors: 2SEVENTY BIO, INC.
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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AU2014296626A 2013-07-29 2014-07-23 Multipartite signaling proteins and uses thereof Active AU2014296626B2 (en)

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US201361859697P 2013-07-29 2013-07-29
US61/859,697 2013-07-29
US201461934092P 2014-01-31 2014-01-31
US61/934,092 2014-01-31
PCT/US2014/047852 WO2015017214A1 (en) 2013-07-29 2014-07-23 Multipartite signaling proteins and uses thereof

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EP3925618A1 (en) 2013-07-29 2021-12-22 2seventy bio, Inc. Multipartite signaling proteins and uses thereof
EP3087101B1 (en) * 2013-12-20 2024-06-05 Novartis AG Regulatable chimeric antigen receptor
AU2014368383B2 (en) * 2013-12-20 2020-01-16 Cellectis Method of engineering multi-input signal sensitive T cell for immunotherapy
ES2792849T3 (es) 2014-02-10 2020-11-12 Univ Emory Expresión de polipéptido químico con receptores de linfocitos variables en células inmunes y usos para tratar el cáncer
GB201506423D0 (en) 2015-04-15 2015-05-27 Tc Biopharm Ltd Gamma delta T cells and uses thereof
ES2692206T3 (es) 2014-11-26 2018-11-30 Miltenyi Biotec Gmbh Inmunoterapia combinada de receptores de reconocimiento de antígenos y células hematopoyéticas para el tratamiento de enfermedades
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