AU2014291683B2 - Indole-3-carbinol derivatives - Google Patents

Indole-3-carbinol derivatives Download PDF

Info

Publication number
AU2014291683B2
AU2014291683B2 AU2014291683A AU2014291683A AU2014291683B2 AU 2014291683 B2 AU2014291683 B2 AU 2014291683B2 AU 2014291683 A AU2014291683 A AU 2014291683A AU 2014291683 A AU2014291683 A AU 2014291683A AU 2014291683 B2 AU2014291683 B2 AU 2014291683B2
Authority
AU
Australia
Prior art keywords
indole
carboxylic acid
butyl ester
reaction
acid tert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2014291683A
Other languages
English (en)
Other versions
AU2014291683A1 (en
Inventor
Bipin Dhanajibhai GADHIYA
Rajiv Indravadan Modi
Niravkumar Sureshbhai SAGAR
Chandan Hardhan Singh
Sunilkumar Ramsuratbhai TIVARI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cadila Pharmaceuticals Ltd
Original Assignee
Cadila Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Pharmaceuticals Ltd filed Critical Cadila Pharmaceuticals Ltd
Publication of AU2014291683A1 publication Critical patent/AU2014291683A1/en
Application granted granted Critical
Publication of AU2014291683B2 publication Critical patent/AU2014291683B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
AU2014291683A 2013-07-16 2014-07-11 Indole-3-carbinol derivatives Ceased AU2014291683B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2370/MUM/2013 2013-07-16
PCT/IB2014/063031 WO2015008202A1 (en) 2013-07-16 2014-07-11 Indole-3-carbinol derivatives
IN2370MU2013 IN2013MU02370A (enExample) 2013-07-16 2014-07-11

Publications (2)

Publication Number Publication Date
AU2014291683A1 AU2014291683A1 (en) 2016-02-18
AU2014291683B2 true AU2014291683B2 (en) 2017-11-02

Family

ID=52345790

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014291683A Ceased AU2014291683B2 (en) 2013-07-16 2014-07-11 Indole-3-carbinol derivatives

Country Status (9)

Country Link
US (1) US9708258B2 (enExample)
EP (1) EP3022177B1 (enExample)
JP (1) JP6293271B2 (enExample)
AU (1) AU2014291683B2 (enExample)
CA (1) CA2918277C (enExample)
EA (1) EA030692B1 (enExample)
ES (1) ES2671998T3 (enExample)
IN (1) IN2013MU02370A (enExample)
WO (1) WO2015008202A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104906086A (zh) * 2015-06-24 2015-09-16 安徽四正医药科技有限公司 吲哚-3-甲醇、二吲哚甲烷及其衍生物用于治疗肾小球肾炎药物的应用
US20210315909A1 (en) 2018-07-11 2021-10-14 Arrys Therapeutics, Inc. Polymorphic compounds and uses thereof
US20210353648A1 (en) * 2018-09-27 2021-11-18 Arrys Therapeutics, Inc. Grapiprant unit dosage forms

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002060382A (ja) * 2000-08-22 2002-02-26 Ajinomoto Co Inc モナティンの立体異性体及びその使用、並びにモナティン類の製造方法及びそのための中間体
GB0614068D0 (en) * 2006-07-14 2006-08-23 Glaxo Group Ltd Compounds
US7807705B2 (en) 2007-05-18 2010-10-05 The Ohio State University Research Foundation Potent indole-3-carbinol-derived antitumor agents
US8153680B2 (en) 2009-08-25 2012-04-10 The Ohio State University Research Foundation Alkyl indole-3-carbinol-derived antitumor agents

Also Published As

Publication number Publication date
WO2015008202A1 (en) 2015-01-22
IN2013MU02370A (enExample) 2015-06-19
EA030692B1 (ru) 2018-09-28
EA201690236A1 (ru) 2016-07-29
JP2016527226A (ja) 2016-09-08
US20160159740A1 (en) 2016-06-09
AU2014291683A1 (en) 2016-02-18
EP3022177A1 (en) 2016-05-25
JP6293271B2 (ja) 2018-03-14
CA2918277A1 (en) 2015-01-22
CA2918277C (en) 2021-02-16
ES2671998T3 (es) 2018-06-12
EP3022177B1 (en) 2018-03-28
US9708258B2 (en) 2017-07-18

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired