ES2671998T3 - Derivados de indol-3-carbinol - Google Patents

Derivados de indol-3-carbinol Download PDF

Info

Publication number
ES2671998T3
ES2671998T3 ES14759311.5T ES14759311T ES2671998T3 ES 2671998 T3 ES2671998 T3 ES 2671998T3 ES 14759311 T ES14759311 T ES 14759311T ES 2671998 T3 ES2671998 T3 ES 2671998T3
Authority
ES
Spain
Prior art keywords
indole
carboxylic acid
cpl
inflammation
butyl ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14759311.5T
Other languages
English (en)
Spanish (es)
Inventor
Rajiv Indravadan Modi
Chandan Hardhan Singh
Niravkumar Sureshbhai SAGAR
Sunilkumar Ramsuratbhai TIVARI
Bipin Dhanajibhai GADHIYA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cadila Pharmaceuticals Ltd
Original Assignee
Cadila Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Pharmaceuticals Ltd filed Critical Cadila Pharmaceuticals Ltd
Application granted granted Critical
Publication of ES2671998T3 publication Critical patent/ES2671998T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
ES14759311.5T 2013-07-16 2014-07-11 Derivados de indol-3-carbinol Active ES2671998T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
INMM23702013 2013-07-16
IN2370MU2013 IN2013MU02370A (enExample) 2013-07-16 2014-07-11
PCT/IB2014/063031 WO2015008202A1 (en) 2013-07-16 2014-07-11 Indole-3-carbinol derivatives

Publications (1)

Publication Number Publication Date
ES2671998T3 true ES2671998T3 (es) 2018-06-12

Family

ID=52345790

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14759311.5T Active ES2671998T3 (es) 2013-07-16 2014-07-11 Derivados de indol-3-carbinol

Country Status (9)

Country Link
US (1) US9708258B2 (enExample)
EP (1) EP3022177B1 (enExample)
JP (1) JP6293271B2 (enExample)
AU (1) AU2014291683B2 (enExample)
CA (1) CA2918277C (enExample)
EA (1) EA030692B1 (enExample)
ES (1) ES2671998T3 (enExample)
IN (1) IN2013MU02370A (enExample)
WO (1) WO2015008202A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104906086A (zh) * 2015-06-24 2015-09-16 安徽四正医药科技有限公司 吲哚-3-甲醇、二吲哚甲烷及其衍生物用于治疗肾小球肾炎药物的应用
WO2020014465A1 (en) 2018-07-11 2020-01-16 Arrys Therapeutics, Inc. Polymorphic compounds and uses thereof
CN113260363A (zh) * 2018-09-27 2021-08-13 阿瑞斯医疗有限公司 格拉普兰特(grapiprant)单位剂型

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002060382A (ja) * 2000-08-22 2002-02-26 Ajinomoto Co Inc モナティンの立体異性体及びその使用、並びにモナティン類の製造方法及びそのための中間体
GB0614068D0 (en) * 2006-07-14 2006-08-23 Glaxo Group Ltd Compounds
WO2008144263A1 (en) * 2007-05-18 2008-11-27 The Ohio State University Research Foundation Potent indole-3-carbinol-derived antitumor agents
US8153680B2 (en) 2009-08-25 2012-04-10 The Ohio State University Research Foundation Alkyl indole-3-carbinol-derived antitumor agents

Also Published As

Publication number Publication date
JP2016527226A (ja) 2016-09-08
US20160159740A1 (en) 2016-06-09
US9708258B2 (en) 2017-07-18
EP3022177B1 (en) 2018-03-28
EA030692B1 (ru) 2018-09-28
AU2014291683A1 (en) 2016-02-18
CA2918277A1 (en) 2015-01-22
EP3022177A1 (en) 2016-05-25
IN2013MU02370A (enExample) 2015-06-19
JP6293271B2 (ja) 2018-03-14
CA2918277C (en) 2021-02-16
WO2015008202A1 (en) 2015-01-22
AU2014291683B2 (en) 2017-11-02
EA201690236A1 (ru) 2016-07-29

Similar Documents

Publication Publication Date Title
CN106660974B (zh) 含氨磺酰基的1,2,5-噁二唑类衍生物、其制备方法及其在医药上的应用
CN102532144B (zh) 一种新型吲哚胺-2,3-双加氧酶抑制剂及其制备方法和用途
ES2428873T3 (es) Derivados novedosos de pirona-indol y proceso para su preparación
CN1294579A (zh) 含有磺酰胺的吲哚化合物
BRPI0619963A2 (pt) compostos derivados pirrólicos fundidos, composições farmacêuticas compreendendo os mesmos, bem como seus usos
CN102149384A (zh) 作为ep4受体拮抗剂的杂环酰胺衍生物
WO2021017880A1 (zh) 一类靶向stat3双功能磷酸化位点的三芳香环类化合物及其应用
AU2016200541A1 (en) Functionalised and substituted indoles as anti-cancer agents
TW200301110A (en) Indole compounds
AU2014353893A1 (en) Functionalised and substituted indoles as anti-cancer agents
ES2671998T3 (es) Derivados de indol-3-carbinol
EA015689B1 (ru) Производные 2-арилиндола в качестве ингибиторов npges-1
BRPI0615158A2 (pt) composto de 3-aminocarbazol, composição farmacêutica, uso de um composto de 3-aminocarbazol, e, método para preparar um composto
ES2900362T3 (es) Compuestos "multidiana" con actividad inhibidora de las histona-desacetilasas y de la polimerización de la tubulina para su utilización en el tratamiento del cáncer
CN110526854B (zh) 一种ɑ,β-不饱和酮衍生物、制备方法及作为药物的用途
JPH08502037A (ja) ４環性化合物、これらを調整するための方法及び中間体並びに抗腫瘍剤としてのこれらの使用
CN113248524B (zh) 一种双吲哚生物碱化合物及其合成方法和用途
CN116635373A (zh) 酰胺衍生物及其应用
CN103945696B (zh) 新颖吲哚啉酮蛋白激酶抑制剂
CN117177969A (zh) 具有苄氧基芳基醚结构的化合物及其制备方法和用途
WO2015127878A1 (zh) 稠合吖啶衍生物及其药物组合物、制备方法及应用
CN108727341A (zh) 一种吡咯取代吲哚酮类衍生物或其药学上可接受的盐、及它们的制备方法和用途
CN103274988B (zh) 3-(氰基-p-硝基苯甲撑基)-2-吲哚酮衍生物及其合成方法和用途
RU2336269C2 (ru) Кристаллическое индолсульфонамидное соединение и способ его получения
CN105481751A (zh) 一类2-吲哚酮衍生物及其制备和应用