AU2014290298B2 - Piperidinyl indole derivatives and their use as complement factor B inhibitors - Google Patents

Piperidinyl indole derivatives and their use as complement factor B inhibitors Download PDF

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Publication number
AU2014290298B2
AU2014290298B2 AU2014290298A AU2014290298A AU2014290298B2 AU 2014290298 B2 AU2014290298 B2 AU 2014290298B2 AU 2014290298 A AU2014290298 A AU 2014290298A AU 2014290298 A AU2014290298 A AU 2014290298A AU 2014290298 B2 AU2014290298 B2 AU 2014290298B2
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Prior art keywords
methyl
indol
methoxy
piperidin
dimethyl
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AU2014290298A1 (en
Inventor
Christopher Adams
Michael Paul Capparelli
Takeru Ehara
Rajeshri Ganesh Karki
Chun Zhang
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Novartis AG
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Novartis AG
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
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  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
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AU2014290298A 2013-07-15 2014-07-14 Piperidinyl indole derivatives and their use as complement factor B inhibitors Active 2039-07-14 AU2014290298B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361846355P 2013-07-15 2013-07-15
US61/846,355 2013-07-15
US201461977028P 2014-04-08 2014-04-08
US61/977,028 2014-04-08
PCT/US2014/046515 WO2015009616A1 (en) 2013-07-15 2014-07-14 Piperidinyl indole derivatives and their use as complement factor b inhibitors

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AU2014290298A1 AU2014290298A1 (en) 2016-02-11
AU2014290298B2 true AU2014290298B2 (en) 2017-06-15

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AU2014290298A Active 2039-07-14 AU2014290298B2 (en) 2013-07-15 2014-07-14 Piperidinyl indole derivatives and their use as complement factor B inhibitors

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US (2) US9682968B2 (enExample)
EP (2) EP3299365A1 (enExample)
JP (1) JP6378761B2 (enExample)
KR (1) KR102242742B1 (enExample)
CN (1) CN105579444B (enExample)
AP (1) AP2016008992A0 (enExample)
AU (1) AU2014290298B2 (enExample)
BR (1) BR112016000909B1 (enExample)
CA (1) CA2917839C (enExample)
CL (1) CL2016000060A1 (enExample)
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