AU2014268529C1 - TMPRSS6 iRNA compositions and methods of use thereof - Google Patents

TMPRSS6 iRNA compositions and methods of use thereof Download PDF

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Publication number
AU2014268529C1
AU2014268529C1 AU2014268529A AU2014268529A AU2014268529C1 AU 2014268529 C1 AU2014268529 C1 AU 2014268529C1 AU 2014268529 A AU2014268529 A AU 2014268529A AU 2014268529 A AU2014268529 A AU 2014268529A AU 2014268529 C1 AU2014268529 C1 AU 2014268529C1
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Australia
Prior art keywords
nucleotides
nucleotide
rnai agent
strand
tmprss6
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AU2014268529A
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AU2014268529A1 (en
AU2014268529B2 (en
Inventor
Brian Bettencourt
James Butler
Klaus CHARISSE
Martin Maier
Kallanthottathil G. Rajeev
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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Publication of AU2014268529B2 publication Critical patent/AU2014268529B2/en
Priority to AU2020207874A priority Critical patent/AU2020207874B2/en
Publication of AU2014268529C1 publication Critical patent/AU2014268529C1/en
Priority to AU2023201014A priority patent/AU2023201014B2/en
Priority to AU2026201214A priority patent/AU2026201214A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/34—Spatial arrangement of the modifications
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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AU2014268529A 2013-05-22 2014-05-22 TMPRSS6 iRNA compositions and methods of use thereof Ceased AU2014268529C1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2020207874A AU2020207874B2 (en) 2013-05-22 2020-07-24 TMPRSS6 iRNA compositions and methods of use thereof
AU2023201014A AU2023201014B2 (en) 2013-05-22 2023-02-21 TMPRSS6 iRNA compositions and methods of use thereof
AU2026201214A AU2026201214A1 (en) 2013-05-22 2026-02-18 TMPRSS6 iRNA compositions and methods of use thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361826178P 2013-05-22 2013-05-22
US61/826,178 2013-05-22
US201361912988P 2013-12-06 2013-12-06
US61/912,988 2013-12-06
PCT/US2014/039149 WO2014190157A1 (en) 2013-05-22 2014-05-22 Tmprss6 compositions and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020207874A Division AU2020207874B2 (en) 2013-05-22 2020-07-24 TMPRSS6 iRNA compositions and methods of use thereof

Publications (3)

Publication Number Publication Date
AU2014268529A1 AU2014268529A1 (en) 2015-12-17
AU2014268529B2 AU2014268529B2 (en) 2020-04-30
AU2014268529C1 true AU2014268529C1 (en) 2020-10-01

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AU2014268529A Ceased AU2014268529C1 (en) 2013-05-22 2014-05-22 TMPRSS6 iRNA compositions and methods of use thereof
AU2020207874A Active AU2020207874B2 (en) 2013-05-22 2020-07-24 TMPRSS6 iRNA compositions and methods of use thereof
AU2023201014A Active AU2023201014B2 (en) 2013-05-22 2023-02-21 TMPRSS6 iRNA compositions and methods of use thereof
AU2026201214A Pending AU2026201214A1 (en) 2013-05-22 2026-02-18 TMPRSS6 iRNA compositions and methods of use thereof

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Application Number Title Priority Date Filing Date
AU2020207874A Active AU2020207874B2 (en) 2013-05-22 2020-07-24 TMPRSS6 iRNA compositions and methods of use thereof
AU2023201014A Active AU2023201014B2 (en) 2013-05-22 2023-02-21 TMPRSS6 iRNA compositions and methods of use thereof
AU2026201214A Pending AU2026201214A1 (en) 2013-05-22 2026-02-18 TMPRSS6 iRNA compositions and methods of use thereof

Country Status (20)

Country Link
US (6) US9783806B2 (https=)
EP (3) EP2999786A1 (https=)
JP (5) JP2016520593A (https=)
KR (3) KR102486617B1 (https=)
CN (2) CN105452463B (https=)
AP (1) AP2015008862A0 (https=)
AU (4) AU2014268529C1 (https=)
BR (1) BR112015029276B1 (https=)
CA (3) CA3178370A1 (https=)
CL (2) CL2015003440A1 (https=)
EA (1) EA201592225A1 (https=)
HK (1) HK1221978A1 (https=)
IL (6) IL324706A (https=)
MY (1) MY181888A (https=)
RU (1) RU2015154738A (https=)
SG (2) SG11201510565TA (https=)
TW (3) TW202342750A (https=)
UY (1) UY35583A (https=)
WO (1) WO2014190157A1 (https=)
ZA (1) ZA202110854B (https=)

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ES2667066T3 (es) 2010-05-24 2018-05-09 The Trustees Of Columbia University In The City Of New York Proteínas NGAL mutantes y usos de las mismas
KR102365961B1 (ko) 2011-03-29 2022-02-23 알닐람 파마슈티칼스 인코포레이티드 Tmprss6 유전자의 발현을 억제하기 위한 조성물 및 방법
EP2780454A2 (en) * 2011-11-18 2014-09-24 Alnylam Pharmaceuticals, Inc. Modified rnai agents
EP2925337B1 (en) 2012-11-21 2019-07-03 The Trustees of Columbia University in the City of New York Mutant ngal proteins and uses thereof
KR102486617B1 (ko) 2013-05-22 2023-01-12 알닐람 파마슈티칼스 인코포레이티드 Ｔｍｐｒｓｓ6 조성물 및 이의 사용 방법
CN105899663B (zh) 2013-12-26 2019-07-26 学校法人东京医科大学 用于基因表达控制的人工模拟miRNA及其用途
SG10201913570XA (en) 2013-12-27 2020-03-30 Bonac Corp Artificial match-type mirna for controlling gene expression and use therefor
IL316808A (en) 2014-08-20 2025-01-01 Alnylam Pharmaceuticals Inc Modified double-stranded RNA materials and their uses
WO2016085852A1 (en) 2014-11-24 2016-06-02 Alnylam Pharmaceuticals, Inc. Tmprss6 irna compositions and methods of use thereof
SG11201705223XA (en) 2014-12-27 2017-07-28 Bonac Corp NATURALLY OCCURING miRNA FOR CONTROLLING GENE EXPRESSION, AND USE OF SAME
JP6602847B2 (ja) * 2015-03-27 2019-11-06 株式会社ボナック デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子
EP3277811B1 (en) 2015-04-03 2020-12-23 University of Massachusetts Fully stabilized asymmetric sirna
MX2017012426A (es) * 2015-04-03 2018-01-26 Ionis Pharmaceuticals Inc Composiciones y metodos para modular la expresion de tmprss6.
KR102827366B1 (ko) * 2015-05-06 2025-07-03 알닐람 파마슈티칼스 인코포레이티드 인자 ＸＩＩ(하게만 인자)(Ｆ12), 칼리크레인 Ｂ, 혈장(플레처 인자) 1(ＫＬＫＢ1) 및 키니노겐 1(ＫＮＧ1) ｉＲＮＡ 조성물 및 그의 이용 방법
US10633653B2 (en) 2015-08-14 2020-04-28 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
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