AU2014262546B2 - ACC inhibitors and uses thereof - Google Patents
ACC inhibitors and uses thereof Download PDFInfo
- Publication number
- AU2014262546B2 AU2014262546B2 AU2014262546A AU2014262546A AU2014262546B2 AU 2014262546 B2 AU2014262546 B2 AU 2014262546B2 AU 2014262546 A AU2014262546 A AU 2014262546A AU 2014262546 A AU2014262546 A AU 2014262546A AU 2014262546 B2 AU2014262546 B2 AU 2014262546B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- patient
- nitrogen
- compounds
- sulfur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 C*C(C(C)SC1C(CC(*)=*)NN2C(*)(*)*)C1C2=O Chemical compound C*C(C(C)SC1C(CC(*)=*)NN2C(*)(*)*)C1C2=O 0.000 description 5
- KEQGZUUPPQEDPF-UHFFFAOYSA-N CC(C)(C(N(C1=O)Cl)=O)N1Cl Chemical compound CC(C)(C(N(C1=O)Cl)=O)N1Cl KEQGZUUPPQEDPF-UHFFFAOYSA-N 0.000 description 1
- NQRNUSCBMBTZLZ-UHFFFAOYSA-N CC(C)(C(O)=O)N(C(Nc1c2c(C)c(-c3ncc[o]3)[s]1)=O)S2(=O)=O Chemical compound CC(C)(C(O)=O)N(C(Nc1c2c(C)c(-c3ncc[o]3)[s]1)=O)S2(=O)=O NQRNUSCBMBTZLZ-UHFFFAOYSA-N 0.000 description 1
- QROONWVALKNMRS-UHFFFAOYSA-N CC(C)(C)OC(C(C)(C)N(C(N(C(c1ccccc1)c1ccccc1)c1c2c(C)c(-c3ncc[o]3)[s]1)=O)S2(=O)=O)=O Chemical compound CC(C)(C)OC(C(C)(C)N(C(N(C(c1ccccc1)c1ccccc1)c1c2c(C)c(-c3ncc[o]3)[s]1)=O)S2(=O)=O)=O QROONWVALKNMRS-UHFFFAOYSA-N 0.000 description 1
- YSHIIFKHXHXHRL-UHFFFAOYSA-N CC(C)(C)OC(C(C)(C)N(C(N(C(c1ccccc1)c1ccccc1)c1c2c(C)c(C)[s]1)=O)S2(=O)=O)=O Chemical compound CC(C)(C)OC(C(C)(C)N(C(N(C(c1ccccc1)c1ccccc1)c1c2c(C)c(C)[s]1)=O)S2(=O)=O)=O YSHIIFKHXHXHRL-UHFFFAOYSA-N 0.000 description 1
- CTJSWZWDPLVWHD-ONEGZZNKSA-N CCO/C(/Br)=C(/S)\Br Chemical compound CCO/C(/Br)=C(/S)\Br CTJSWZWDPLVWHD-ONEGZZNKSA-N 0.000 description 1
- ILYCZKOBLRJJSW-UHFFFAOYSA-N CCOC(c1c(N)[s]cc1C)=O Chemical compound CCOC(c1c(N)[s]cc1C)=O ILYCZKOBLRJJSW-UHFFFAOYSA-N 0.000 description 1
- ZNSIHGXAXBRNSW-UHFFFAOYSA-N CCOC(c1c[s]cc1C)=O Chemical compound CCOC(c1c[s]cc1C)=O ZNSIHGXAXBRNSW-UHFFFAOYSA-N 0.000 description 1
- UXTDCJJEJZCEBF-BQYQJAHWSA-N CCOc1ccccc1/C=C/C(O)=O Chemical compound CCOc1ccccc1/C=C/C(O)=O UXTDCJJEJZCEBF-BQYQJAHWSA-N 0.000 description 1
- PKZJLOCLABXVMC-UHFFFAOYSA-N COc1ccccc1C=O Chemical compound COc1ccccc1C=O PKZJLOCLABXVMC-UHFFFAOYSA-N 0.000 description 1
- XSZSNLOPIWWFHS-UHFFFAOYSA-N COc1ccccc1CCC(O)=O Chemical compound COc1ccccc1CCC(O)=O XSZSNLOPIWWFHS-UHFFFAOYSA-N 0.000 description 1
- JPRPCUDDTUNMTL-UHFFFAOYSA-N Cc1c[s]c([N+]([O-])=O)c1S(Cl)(=O)=O Chemical compound Cc1c[s]c([N+]([O-])=O)c1S(Cl)(=O)=O JPRPCUDDTUNMTL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361821829P | 2013-05-10 | 2013-05-10 | |
| US61/821,829 | 2013-05-10 | ||
| PCT/US2014/037368 WO2014182950A1 (en) | 2013-05-10 | 2014-05-08 | Acc inhibitors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014262546A1 AU2014262546A1 (en) | 2015-11-26 |
| AU2014262546B2 true AU2014262546B2 (en) | 2018-11-08 |
Family
ID=51867754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014262546A Ceased AU2014262546B2 (en) | 2013-05-10 | 2014-05-08 | ACC inhibitors and uses thereof |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9765089B2 (enExample) |
| EP (1) | EP2994128B1 (enExample) |
| JP (1) | JP6417402B2 (enExample) |
| KR (1) | KR20160005364A (enExample) |
| CN (1) | CN105358143B (enExample) |
| AR (1) | AR096243A1 (enExample) |
| AU (1) | AU2014262546B2 (enExample) |
| BR (1) | BR112015028173A2 (enExample) |
| CA (1) | CA2911818A1 (enExample) |
| CL (1) | CL2015003316A1 (enExample) |
| EA (1) | EA030958B1 (enExample) |
| HK (2) | HK1221419A1 (enExample) |
| MX (1) | MX2015015421A (enExample) |
| WO (1) | WO2014182950A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014262636A1 (en) * | 2013-05-10 | 2015-11-26 | Gilead Apollo, Llc | ACC inhibitors and uses thereof |
| AU2014262638A1 (en) | 2013-05-10 | 2015-11-26 | Gilead Apollo, Llc | ACC inhibitors and uses thereof |
| EA201591962A1 (ru) | 2013-05-10 | 2016-06-30 | Нимбус Аполло, Инк. | Ингибиторы акк и их применение |
| EP3670496A3 (en) | 2013-10-17 | 2020-09-30 | Shionogi&Co., Ltd. | Acc2 inhibitors |
| US10202361B2 (en) | 2014-08-29 | 2019-02-12 | Fmc Corporation | Pyridazinones as herbicides |
| MX2017008844A (es) | 2015-01-09 | 2018-03-14 | Gilead Apollo Llc | Terapia de combinacion con inhibidor de acetil-coa carboxilasa (acc) para el tratamiento de enfermedad de higado graso no alcoholico. |
| UY36586A (es) | 2015-03-26 | 2016-10-31 | Bayer Pharma AG | Heterociclilmetiltienouracilos y uso de los mismos |
| GB201512286D0 (en) * | 2015-07-14 | 2015-08-19 | F2G Ltd | Chemical compounds |
| AR106472A1 (es) * | 2015-10-26 | 2018-01-17 | Gilead Apollo Llc | Inhibidores de acc y usos de los mismos |
| CN108347939B (zh) | 2015-11-25 | 2021-09-28 | 吉利德阿波罗公司 | 含有2,4-二氧代-1,4-二氢噻吩并[2,3-d]嘧啶的衍生物的杀真菌组合物 |
| US20170166582A1 (en) * | 2015-11-25 | 2017-06-15 | Gilead Apollo, Llc | Pyrazole acc inhibitors and uses thereof |
| EP3380478B1 (en) * | 2015-11-25 | 2020-12-23 | Gilead Apollo, LLC | Ester acc inhibitors and uses thereof |
| PL3380479T3 (pl) * | 2015-11-25 | 2023-05-08 | Gilead Apollo, Llc | Triazolowe inhibitory acc i ich zastosowania |
| WO2017100703A1 (en) * | 2015-12-10 | 2017-06-15 | Colin Combs | Ems analogues of lyn/src-tyrosine kinase inhibitors |
| CA3155220C (en) | 2016-03-02 | 2024-01-16 | Gilead Apollo, Llc | Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof |
| WO2018041771A1 (de) | 2016-09-02 | 2018-03-08 | Bayer Pharma Aktiengesellschaft | (1-methylcyclopropyl)methyl-substituierte thienouracile und ihre verwendung |
| SG11201902588PA (en) | 2016-09-23 | 2019-05-30 | Bayer Ag | N3-Cyclically Substituted Thienouracils And Use Thereof |
| AU2018209006B2 (en) | 2017-01-22 | 2021-04-22 | Sunshine Lake Pharma Co., Ltd. | Thienopyrimidine derivative and use thereof in medicine |
| WO2018171698A1 (zh) * | 2017-03-24 | 2018-09-27 | 浙江海正药业股份有限公司 | 杂芳基并嘧啶酮类衍生物及其制备方法和用途 |
| CN110431144B (zh) * | 2017-03-24 | 2022-08-05 | 浙江海正药业股份有限公司 | 氰基取代的杂芳基并嘧啶酮类衍生物及其制备方法和用途 |
| ES2982801T3 (es) | 2017-03-28 | 2024-10-17 | Gilead Sciences Inc | Combinaciones terapéuticas para el tratamiento de las enfermedades hepáticas |
| BR112020002804A2 (pt) | 2017-08-24 | 2020-07-28 | Novo Nordisk A/S | composição farmacêutica líquida, e, kit |
| KR20190036705A (ko) | 2017-09-28 | 2019-04-05 | 한미약품 주식회사 | (2r)-2-(2-메톡시페닐)-2-(옥산-4-일옥시)에탄-1-올 화합물의 신규 제조방법 및 이에 사용되는 중간체 |
| CN112218871B (zh) | 2018-06-05 | 2022-10-18 | 南京明德新药研发有限公司 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类衍生物及其应用 |
| CN113924303B (zh) | 2019-07-02 | 2023-10-20 | 广东东阳光药业股份有限公司 | 具有立体构型的噻吩并嘧啶衍生物及其在药物中的应用 |
| AR119594A1 (es) | 2019-08-09 | 2021-12-29 | Gilead Sciences Inc | Derivados de tienopirimidina como inhibidores acc y usos de los mismos |
| CN114787166B (zh) * | 2019-12-05 | 2023-09-19 | 漳州片仔癀药业股份有限公司 | 噻吩并[2,3-c]哒嗪-4(1H)-酮类化合物的晶型及其制备方法和应用 |
| WO2021112213A1 (ja) * | 2019-12-05 | 2021-06-10 | 日本曹達株式会社 | ２，４－ジオキソ－１，４－ジヒドロチエノピリミジン化合物、及びそれを含有する農園芸用殺菌剤又は医療用・動物用抗真菌剤 |
| IL294521A (en) | 2020-02-18 | 2022-09-01 | Novo Nordisk As | glp-1 compounds and their uses |
| US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
| WO2023007360A1 (en) * | 2021-07-26 | 2023-02-02 | Rao Dr Boggarapu Prakash | Molecules as anticancer agents for targeted treatment of breast and prostate cancer |
| WO2024089216A1 (en) | 2022-10-27 | 2024-05-02 | Syngenta Crop Protection Ag | Novel sulfur-containing heteroaryl carboxamide compounds |
| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
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| FR1453897A (fr) * | 1965-06-16 | 1966-07-22 | Dérivés du thiophène et de thiéno pyridazines | |
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2014
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- 2014-05-08 CN CN201480036138.5A patent/CN105358143B/zh not_active Expired - Fee Related
- 2014-05-08 JP JP2016513085A patent/JP6417402B2/ja not_active Expired - Fee Related
- 2014-05-08 HK HK16109661.1A patent/HK1221419A1/zh unknown
- 2014-05-08 CA CA2911818A patent/CA2911818A1/en not_active Abandoned
- 2014-05-08 EA EA201591961A patent/EA030958B1/ru not_active IP Right Cessation
- 2014-05-08 BR BR112015028173A patent/BR112015028173A2/pt not_active Application Discontinuation
- 2014-05-08 AU AU2014262546A patent/AU2014262546B2/en not_active Ceased
- 2014-05-08 KR KR1020157035035A patent/KR20160005364A/ko not_active Withdrawn
- 2014-05-08 HK HK16109918.2A patent/HK1221660A1/zh unknown
- 2014-05-08 US US14/890,344 patent/US9765089B2/en not_active Expired - Fee Related
- 2014-05-08 WO PCT/US2014/037368 patent/WO2014182950A1/en not_active Ceased
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2015
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Also Published As
| Publication number | Publication date |
|---|---|
| HK1221660A1 (zh) | 2017-06-09 |
| EA201591961A1 (ru) | 2016-06-30 |
| EP2994128B1 (en) | 2019-01-30 |
| AU2014262546A1 (en) | 2015-11-26 |
| JP6417402B2 (ja) | 2018-11-07 |
| KR20160005364A (ko) | 2016-01-14 |
| MX2015015421A (es) | 2016-06-21 |
| HK1221419A1 (zh) | 2017-06-02 |
| CN105358143A (zh) | 2016-02-24 |
| WO2014182950A1 (en) | 2014-11-13 |
| AR096243A1 (es) | 2015-12-16 |
| US9765089B2 (en) | 2017-09-19 |
| BR112015028173A2 (pt) | 2017-07-25 |
| CN105358143B (zh) | 2019-01-22 |
| US20160185799A1 (en) | 2016-06-30 |
| EA030958B1 (ru) | 2018-10-31 |
| EP2994128A1 (en) | 2016-03-16 |
| EP2994128A4 (en) | 2016-11-23 |
| JP2016520064A (ja) | 2016-07-11 |
| CL2015003316A1 (es) | 2016-07-29 |
| CA2911818A1 (en) | 2014-11-13 |
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