AU2013330603B2 - Monohydrate crystal of fimasartan potassium salt, method for preparing same, and pharmacological composition comprising same - Google Patents
Monohydrate crystal of fimasartan potassium salt, method for preparing same, and pharmacological composition comprising same Download PDFInfo
- Publication number
- AU2013330603B2 AU2013330603B2 AU2013330603A AU2013330603A AU2013330603B2 AU 2013330603 B2 AU2013330603 B2 AU 2013330603B2 AU 2013330603 A AU2013330603 A AU 2013330603A AU 2013330603 A AU2013330603 A AU 2013330603A AU 2013330603 B2 AU2013330603 B2 AU 2013330603B2
- Authority
- AU
- Australia
- Prior art keywords
- potassium salt
- fimasartan
- fimasartan potassium
- salt monohydrate
- monohydrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- AMEROGPZOLAFBN-UHFFFAOYSA-N fimasartan Chemical class CCCCC1=NC(C)=C(CC(=S)N(C)C)C(=O)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 AMEROGPZOLAFBN-UHFFFAOYSA-N 0.000 title claims abstract description 175
- 239000013078 crystal Substances 0.000 title claims abstract description 34
- 238000000034 method Methods 0.000 title claims description 67
- 150000004682 monohydrates Chemical class 0.000 title abstract description 13
- 239000008196 pharmacological composition Substances 0.000 title description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 54
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 45
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 36
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 36
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 33
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- 239000000203 mixture Substances 0.000 claims description 28
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 26
- 229960003489 fimasartan Drugs 0.000 claims description 26
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- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 21
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2012-0113848 | 2012-10-12 | ||
| KR20120113848A KR101490329B1 (ko) | 2012-10-12 | 2012-10-12 | 피마살탄 포타슘염의 일수화물 결정, 그 제조방법, 및 그를 포함하는 약제학적 조성물 |
| PCT/KR2013/009097 WO2014058268A1 (ko) | 2012-10-12 | 2013-10-11 | 피마살탄 포타슘염의 일수화물 결정, 그 제조방법, 및 그를 포함하는 약제학적 조성물 |
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| AU2013330603A1 AU2013330603A1 (en) | 2015-05-28 |
| AU2013330603B2 true AU2013330603B2 (en) | 2016-03-31 |
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| AU2013330603A Ceased AU2013330603B2 (en) | 2012-10-12 | 2013-10-11 | Monohydrate crystal of fimasartan potassium salt, method for preparing same, and pharmacological composition comprising same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101545268B1 (ko) * | 2015-02-05 | 2015-08-20 | 보령제약 주식회사 | 정제 및 이의 제조방법 |
| CN105784867B (zh) * | 2016-03-28 | 2019-01-01 | 北京睿创康泰医药研究院有限公司 | 用于分析非马沙坦有关物质的hplc方法及这些杂质作参比标准的用途 |
| KR102247408B1 (ko) | 2017-09-18 | 2021-05-03 | 보령제약 주식회사 | 피마살탄 프로드러그 |
| KR102402501B1 (ko) * | 2018-04-24 | 2022-05-26 | (주)국전약품 | 피마살탄 트로메타민염 및 이를 포함하는 약제학적 조성물 |
| KR102221856B1 (ko) | 2020-10-12 | 2021-03-02 | 유니셀랩 주식회사 | 신규한 피마살탄 결정형의 다형체 |
| KR20230062916A (ko) | 2021-11-01 | 2023-05-09 | 그린케미칼 주식회사 | 피마살탄 무수물 a형 결정다형 및 그 제조방법 |
| KR20230062917A (ko) | 2021-11-01 | 2023-05-09 | 그린케미칼 주식회사 | 피마살탄 일수화물 b형 결정다형 및 그 제조방법 |
| KR20240146734A (ko) | 2023-03-30 | 2024-10-08 | (주) 에프엔지리서치 | 피마살탄의 신규 염 및 이의 제조방법 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040032639A (ko) * | 2002-10-10 | 2004-04-17 | 보령제약 주식회사 | 피리미디논 화합물 및 이의 염의 삼수화물의 제조 방법 |
| WO2012141385A1 (en) * | 2011-04-12 | 2012-10-18 | Boryung Pharmaceutical Co., Ltd. | Antihypertensive pharmaceutical composition |
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| KR100300566B1 (ko) * | 1994-09-17 | 2001-11-22 | 조생현 | 피리미디논유도체와그의제조방법및용도 |
| KR19990081093A (ko) * | 1998-04-25 | 1999-11-15 | 조생현 | 피리미디논 화합물, 이를 함유하는 약제학적 조성물 및 이의제조방법 |
| KR100617953B1 (ko) | 2000-03-23 | 2006-08-30 | 보령제약 주식회사 | 피리미디논 화합물 및 이의 염의 제조방법 |
| MXPA04002653A (es) * | 2001-09-21 | 2004-07-08 | Boryung Pharm | Metodo para preparar compuestos de pirimidinona y sales farmaceuticamente aceptables del mismo. |
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2012
- 2012-10-12 KR KR20120113848A patent/KR101490329B1/ko active Active
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2013
- 2013-10-11 IN IN3975DEN2015 patent/IN2015DN03975A/en unknown
- 2013-10-11 CA CA2887056A patent/CA2887056C/en not_active Expired - Fee Related
- 2013-10-11 WO PCT/KR2013/009097 patent/WO2014058268A1/ko active Application Filing
- 2013-10-11 BR BR112015008170A patent/BR112015008170A2/pt not_active Application Discontinuation
- 2013-10-11 AU AU2013330603A patent/AU2013330603B2/en not_active Ceased
- 2013-10-11 EP EP13845572.0A patent/EP2927226A4/en not_active Withdrawn
- 2013-10-11 RU RU2015117524A patent/RU2613555C2/ru active
- 2013-10-11 CN CN201380063465.5A patent/CN104854099B/zh not_active Expired - Fee Related
- 2013-10-11 MX MX2015004573A patent/MX353635B/es active IP Right Grant
- 2013-10-11 MY MYPI2015000875A patent/MY169064A/en unknown
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2015
- 2015-04-10 PH PH12015500794A patent/PH12015500794A1/en unknown
- 2015-04-12 SA SA515360275A patent/SA515360275B1/ar unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040032639A (ko) * | 2002-10-10 | 2004-04-17 | 보령제약 주식회사 | 피리미디논 화합물 및 이의 염의 삼수화물의 제조 방법 |
| WO2012141385A1 (en) * | 2011-04-12 | 2012-10-18 | Boryung Pharmaceutical Co., Ltd. | Antihypertensive pharmaceutical composition |
Non-Patent Citations (1)
| Title |
|---|
| SOHN, Y. T: J. Thermal Analysis & Calorimetry, 2007, 89(3), 799-802 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MY169064A (en) | 2019-02-12 |
| BR112015008170A2 (pt) | 2017-07-04 |
| RU2015117524A (ru) | 2016-12-10 |
| IN2015DN03975A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-10-02 |
| MX353635B (es) | 2018-01-22 |
| CN104854099A (zh) | 2015-08-19 |
| AU2013330603A1 (en) | 2015-05-28 |
| EP2927226A1 (en) | 2015-10-07 |
| RU2613555C2 (ru) | 2017-03-17 |
| CA2887056A1 (en) | 2014-04-17 |
| CN104854099B (zh) | 2016-11-16 |
| WO2014058268A1 (ko) | 2014-04-17 |
| MX2015004573A (es) | 2015-07-21 |
| SA515360275B1 (ar) | 2017-07-11 |
| KR101490329B1 (ko) | 2015-02-04 |
| CA2887056C (en) | 2017-09-05 |
| KR20140047483A (ko) | 2014-04-22 |
| EP2927226A4 (en) | 2016-07-13 |
| PH12015500794A1 (en) | 2015-06-15 |
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