AU2013308826B2 - Diagnosis and treatment of autism spectrum disorder - Google Patents

Diagnosis and treatment of autism spectrum disorder Download PDF

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Publication number
AU2013308826B2
AU2013308826B2 AU2013308826A AU2013308826A AU2013308826B2 AU 2013308826 B2 AU2013308826 B2 AU 2013308826B2 AU 2013308826 A AU2013308826 A AU 2013308826A AU 2013308826 A AU2013308826 A AU 2013308826A AU 2013308826 B2 AU2013308826 B2 AU 2013308826B2
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asd
level
fragilis
metabolite
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AU2013308826A
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AU2013308826A1 (en
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Elaine Hsiao
Sarkis K. Mazmanian
Sara Mcbride
Paul H. Patterson
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California Institute of Technology
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California Institute of Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7057—(Intracellular) signaling and trafficking pathways
    • G01N2800/7066—Metabolic pathways
    • G01N2800/7076—Amino acid metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7057—(Intracellular) signaling and trafficking pathways
    • G01N2800/7066—Metabolic pathways
    • G01N2800/7085—Lipogenesis or lipolysis, e.g. fatty acid metabolism

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
AU2013308826A 2012-08-29 2013-08-28 Diagnosis and treatment of autism spectrum disorder Ceased AU2013308826B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2019206081A AU2019206081B2 (en) 2012-08-29 2019-07-18 Diagnosis And Treatment Of Autism Spectrum Disorder

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261694679P 2012-08-29 2012-08-29
US61/694,679 2012-08-29
PCT/US2013/057148 WO2014036182A2 (en) 2012-08-29 2013-08-28 Diagnosis and treatment of autism spectrum disorder

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2019206081A Division AU2019206081B2 (en) 2012-08-29 2019-07-18 Diagnosis And Treatment Of Autism Spectrum Disorder

Publications (2)

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AU2013308826A1 AU2013308826A1 (en) 2015-02-26
AU2013308826B2 true AU2013308826B2 (en) 2019-04-18

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AU2013308826A Ceased AU2013308826B2 (en) 2012-08-29 2013-08-28 Diagnosis and treatment of autism spectrum disorder
AU2019206081A Ceased AU2019206081B2 (en) 2012-08-29 2019-07-18 Diagnosis And Treatment Of Autism Spectrum Disorder

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US (2) US10220089B2 (cg-RX-API-DMAC7.html)
EP (1) EP2890808A4 (cg-RX-API-DMAC7.html)
JP (2) JP6679309B2 (cg-RX-API-DMAC7.html)
CN (2) CN114949001A (cg-RX-API-DMAC7.html)
AU (2) AU2013308826B2 (cg-RX-API-DMAC7.html)
CA (1) CA2881656C (cg-RX-API-DMAC7.html)
WO (1) WO2014036182A2 (cg-RX-API-DMAC7.html)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
EP3424515A3 (en) 2010-08-04 2019-06-19 Thomas Julius Borody Stool collection devices and methods for using them
US9968638B2 (en) 2011-03-09 2018-05-15 Regents Of The University Of Minnesota Compositions and methods for transplantation of colon microbiota
GB201112091D0 (en) 2011-07-14 2011-08-31 Gt Biolog Ltd Bacterial strains isolated from pigs
GB201117313D0 (en) 2011-10-07 2011-11-16 Gt Biolog Ltd Bacterium for use in medicine
WO2013139861A1 (en) 2012-03-20 2013-09-26 Luc Montagnier Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders
US9719144B2 (en) 2012-05-25 2017-08-01 Arizona Board Of Regents Microbiome markers and therapies for autism spectrum disorders
WO2014036182A2 (en) 2012-08-29 2014-03-06 California Institute Of Technology Diagnosis and treatment of autism spectrum disorder
GB201306536D0 (en) 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
MX2016000293A (es) 2013-07-09 2016-06-21 Stemina Biomarker Discovery Inc Biomarcadores del trastrono del espectro autista.
US9176113B1 (en) * 2014-04-11 2015-11-03 Synapdx Corporation Methods and systems for determining autism spectrum disorder risk
US20150294081A1 (en) 2014-04-11 2015-10-15 Synapdx Corporation Methods and systems for determining autism spectrum disorder risk
WO2016065075A1 (en) 2014-10-21 2016-04-28 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics
US10265009B2 (en) 2014-10-21 2019-04-23 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with microbiome taxonomic features
US9758839B2 (en) 2014-10-21 2017-09-12 uBiome, Inc. Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with microbiome functional features
WO2016069801A1 (en) 2014-10-30 2016-05-06 California Institute Of Technology Compositions and methods comprising bacteria for improving behavior in neurodecelopmental disorders
KR20170086027A (ko) * 2014-10-30 2017-07-25 캘리포니아 인스티튜트 오브 테크놀로지 신경발달 장애에서의 행동을 개선시키기 위한 박테리아를 포함하는 조성물 및 방법
CA2966360C (en) * 2014-10-30 2023-09-05 California Institute Of Technology Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders
EP3400953A1 (en) 2014-12-23 2018-11-14 4D Pharma Research Limited Pirin polypeptide and immune modulation
AR103260A1 (es) 2014-12-23 2017-04-26 4D Pharma Res Ltd Modulación inmunitaria
JP6611156B2 (ja) * 2015-01-30 2019-11-27 史郎 栃谷 妊娠期母体腸内細菌攪乱による行動異常モデル動物の作製方法とその用途
US10525020B2 (en) 2015-02-11 2020-01-07 Laboratory Corporation Of America Holdings Metabolic markers of attention deficit hyperactivity disorder
CN107848984B (zh) 2015-03-13 2021-08-24 米洛诺瓦创新有限责任公司 用于制备麦角硫因化合物的Nα,Nα,Nα-三烷基组氨酸衍生物
AU2016248050A1 (en) * 2015-04-13 2017-11-09 Psomagen, Inc. Method and system for microbiome-derived diagnostics and therapeutics for neurological health issues
CN107708716B (zh) * 2015-04-13 2022-12-06 普梭梅根公司 用于微生物组分类学特征相关的状况的微生物组来源的诊断和治疗的方法及系统
EP3283086A4 (en) * 2015-04-13 2019-04-24 Ubiome Inc. METHOD AND SYSTEM FOR MICROBIOMY-DERIVED DIAGNOSTICS AND THERAPEUTIC FOR DISEASES RELATED TO MICROBIOMIC FUNCTIONAL PROPERTIES
BR112017024264B1 (pt) 2015-05-14 2022-07-12 Crestovo Holdings Llc Composições para transplante de flora fecal e métodos de preparação e utilização das mesmas, e dispositivos para sua administração
KR102534545B1 (ko) * 2015-05-22 2023-05-18 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 자폐 스펙트럼 장애 및 관련된 증상을 치료하는 방법
NZ737752A (en) 2015-06-15 2022-02-25 4D Pharma Res Ltd Compositions comprising bacterial strains
MA41010B1 (fr) 2015-06-15 2020-01-31 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
WO2016203221A1 (en) 2015-06-15 2016-12-22 4D Pharma Research Limited Compositions comprising bacterial strains
MA41060B1 (fr) 2015-06-15 2019-11-29 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
SMT201900588T1 (it) 2015-06-15 2019-11-13 4D Pharma Res Limited Blautia stercoris e wexlerae per uso nel trattamento di malattie infiammatorie ed autoimmuni
CN105213433A (zh) * 2015-11-06 2016-01-06 王益超 一种用于治疗孤独症、复发性流产和不孕症的组合物
CN108513545B (zh) 2015-11-20 2020-11-03 4D制药研究有限公司 包含细菌菌株的组合物
GB201520497D0 (en) 2015-11-20 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201520638D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201520631D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
CN105543369B (zh) * 2016-01-13 2020-07-14 金锋 精神障碍的生物标志物及其应用
ME03487B (me) 2016-03-04 2020-01-20 4D Pharma Plc Kompozicije koje sadrže blautia bakterijske sojeve za liječenje visceralne hipersenzitivnosti
GB201612191D0 (en) 2016-07-13 2016-08-24 4D Pharma Plc Compositions comprising bacterial strains
WO2017197252A1 (en) * 2016-05-13 2017-11-16 Stemina Biomarker Discovery, Inc. Autism subsets
CN121534089A (zh) 2016-05-23 2026-02-17 加州理工学院 调节肠微生物群来治疗神经退行性病症
US20170360848A1 (en) 2016-06-15 2017-12-21 Arizona Board Of Regents On Behalf Of Arizona State University Methods for treating autism spectrum disorder and associated symptoms
US10849936B2 (en) 2016-07-01 2020-12-01 Regents Of The University Of Minnesota Compositions and methods for C. difficile treatment
TWI802545B (zh) 2016-07-13 2023-05-21 英商４Ｄ製藥有限公司 包含細菌菌株之組合物
US20180036352A1 (en) 2016-08-03 2018-02-08 Crestovo Holdings Llc Methods for treating ulcerative colitis
US11340237B2 (en) 2016-09-16 2022-05-24 Takeda Pharmaceutical Company Limited Metabolite biomarkers for diseases associated with the contact activation system
WO2018071536A1 (en) 2016-10-11 2018-04-19 Crestovo Holdings Llc Compositions and methods for treating primary sclerosing cholangitis and related disorders
WO2018071537A1 (en) 2016-10-11 2018-04-19 Crestovo Holdings Llc Compositions and methods for treating multiple sclerosis and related disorders
US10092601B2 (en) 2016-10-11 2018-10-09 Crestovo Holdings Llc Compositions and methods for treating multiple sclerosis and related disorders
WO2018089794A1 (en) * 2016-11-11 2018-05-17 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for changing metabolite levels in a subject
GB201621123D0 (en) 2016-12-12 2017-01-25 4D Pharma Plc Compositions comprising bacterial strains
MX2018015344A (es) * 2016-12-15 2019-04-29 Nestec Sa Composiciones y metodos que modulan las bacterias en un animal de compañía.
JP2020506968A (ja) * 2017-02-07 2020-03-05 カリフォルニア インスティチュート オブ テクノロジー ハンチントン病およびレット症候群における腸内微生物叢の調節
CA3053245A1 (en) * 2017-02-09 2018-08-16 Cognoa, Inc. Platform and system for digital personalized medicine
US11224624B2 (en) 2017-02-14 2022-01-18 California Institute Of Technology Modulation of microbial synthesis of 4-etylphenol and 4-ethylphenyl sulfate in behavior and disease
BR112019020289A2 (pt) * 2017-03-31 2020-09-01 Axial Biotherapeutics, Inc. agentes sequestrantes seletivos do intestino para o tratamento ou prevenção de autismo e distúrbios relacionados
EP3606541A1 (en) 2017-04-05 2020-02-12 Crestovo Holdings LLC Compositions and methods for treating parkinson's disease (pd) and related disorders
US11040073B2 (en) 2017-04-05 2021-06-22 Finch Therapeutics Holdings Llc Compositions and methods for treating diverticulitis and related disorders
WO2018213204A1 (en) 2017-05-15 2018-11-22 Axial Biotherapeutics, Inc. Inhibitors of microbially induced amyloid
DK3630136T3 (da) 2017-05-22 2021-05-25 4D Pharma Res Ltd Sammensætninger, der omfatter bakteriestammer
EP3630942B1 (en) 2017-05-24 2022-11-30 4D Pharma Research Limited Compositions comprising bacterial strain
JP2020521760A (ja) 2017-05-26 2020-07-27 クレストヴォ・ホールディングス・エルエルシー 糞便微生物ベースの治療剤を含む凍結乾燥組成物ならびにそれを製造および使用する方法
WO2018216912A1 (ko) * 2017-05-26 2018-11-29 주식회사 엠디헬스케어 세균 메타게놈 분석을 통한 자폐증 진단방법
CA3066189A1 (en) 2017-06-14 2018-12-20 4D Pharma Research Limited Compositions comprising bacterial strains
SMT202000555T1 (it) 2017-06-14 2020-11-10 4D Pharma Res Limited Composizioni comprendenti un ceppo batterico del genere megaspaera e loro usi
SMT202000695T1 (it) 2017-06-14 2021-01-05 4D Pharma Res Limited Composizioni comprendenti ceppi batterici
US11883155B2 (en) 2017-07-05 2024-01-30 Yusuf Ozgur Cakmak System for monitoring auditory startle response
US11141089B2 (en) * 2017-07-05 2021-10-12 Yusuf Ozgur Cakmak System for monitoring auditory startle response
US10939862B2 (en) * 2017-07-05 2021-03-09 Yusuf Ozgur Cakmak System for monitoring auditory startle response
WO2019014714A1 (en) 2017-07-17 2019-01-24 smartDNA Pty Ltd DIAGNOSTIC METHOD OF DYSBIOSIS
JP2020530494A (ja) 2017-08-07 2020-10-22 フィンチ セラピューティクス、インコーポレイテッド． 健康な腸バリアを維持及び回復するための組成物及び方法
WO2019136214A1 (en) * 2018-01-05 2019-07-11 California Institute Of Technology Probiotics, metabolites, and uses thereof
MX2020009810A (es) 2018-03-22 2021-02-18 Adare Pharmaceuticals Sas Nuevo uso de las composiciones microbiológicas.
US20210269860A1 (en) * 2018-07-08 2021-09-02 Yeda Research And Development Co. Ltd. Person-specific assessment of probiotics responsiveness
US11166990B2 (en) 2018-07-13 2021-11-09 Finch Therapeutics Holdings Llc Methods and compositions for treating ulcerative colitis
CN109142744A (zh) * 2018-07-26 2019-01-04 珠海中科先进技术研究院有限公司 一种自闭症谱系障碍诊断试剂盒
EP3856212A1 (en) 2018-09-27 2021-08-04 Finch Therapeutics Holdings LLC Compositions and methods for treating epilepsy and related disorders
US12474327B2 (en) 2018-11-06 2025-11-18 Stalicla Sa Metabolic profiling for the diagnosis of a subset of idiopathic autism spectrum disorder patients, ADS Phenotype 1
US11676719B2 (en) * 2018-12-20 2023-06-13 Oregon Health & Science University Subtyping heterogeneous disorders using functional random forest models
CN109706235A (zh) * 2019-01-29 2019-05-03 广州康昕瑞基因健康科技有限公司 一种肠道微生物菌群的检测和分析方法及其系统
US20220214358A1 (en) 2019-04-05 2022-07-07 Arizona Board Of Regents On Behalf Of Arizona State University Diagnostic for childhood risk of autism spectrum disorder
EP3948277A4 (en) * 2019-04-05 2023-05-24 Arizona Board of Regents on behalf of Arizona State University METABOLITES AS DIAGNOSTICS OF AUTISTIC SPECTRUM DISEASE IN CHILDREN WITH GASTROINTESTINAL SYMPTOMS
US20220373563A1 (en) * 2019-04-23 2022-11-24 Peking Union Medical College Hospital Machine learning-based autism spectrum disorder diagnosis method and device using metabolite as marker
EP3965820A4 (en) * 2019-05-07 2023-02-08 The Regents of the University of California COMPOSITIONS AND METHODS TO PROMOTE HEALTHY NEURAL DEVELOPMENT IN AN UNBORN BABY
CN110178787B (zh) * 2019-05-08 2022-03-22 河南中医药大学 一种运用粪菌移植法建立自闭症大鼠模型的方法
PH12021553137A1 (en) 2019-07-19 2022-07-25 Finch Therapeutics Holdings Llc Methods and products for treatment of gastrointestinal disorders
CA3157694A1 (en) * 2019-10-11 2021-04-15 Stemina Biomarker Discovery, Inc. Diagnosis and treatment of autism spectrum disorders using altered ratios of metabolite concentrations
JPWO2021079869A1 (cg-RX-API-DMAC7.html) 2019-10-21 2021-04-29
US20230026402A1 (en) * 2019-10-22 2023-01-26 Cornell University Microbiota based therapies to promote mental health
CA3164484A1 (en) * 2019-12-19 2021-06-24 Hill's Pet Nutrition, Inc. Compositions and methods of treating and reducing risk of conditions associated with elevated 4-ethylphenyl sulfate in canines using tomato pomace and methods of identifying canines at risk of such conditions
US20230145281A1 (en) * 2020-03-06 2023-05-11 University Of Virginia Patent Foundation System and method for predicting risk of diagnosis for autism spectrum disorder using neonatal analytics
CN111455076B (zh) * 2020-04-17 2022-10-21 济南市儿童医院 用于儿童孤独症评估的口腔菌群微生物
KR20230074216A (ko) * 2020-09-21 2023-05-26 몰레큘러 유 코포레이션 자폐 스펙트럼 장애의 진단 및 치료 방법
CN116547520A (zh) * 2020-09-21 2023-08-04 分子优公司 孤独症谱系障碍的诊断与治疗方法
CN117083062A (zh) * 2020-10-19 2023-11-17 第二基因组公司 用于治疗孤独症谱系障碍的方法
CN114544826B (zh) * 2020-11-24 2023-12-08 重庆医科大学 检测血浆中组氨酸的试剂在制备抑郁症检测试剂盒中的用途
EP4012414A1 (en) 2020-12-11 2022-06-15 Stalicla S.A. Diagnosis of autism spectrum disorder phenotype 1
CN113069469B (zh) * 2021-04-07 2022-12-13 上海市精神卫生中心（上海市心理咨询培训中心） 调节性t细胞在制备治疗孤独症药物或细胞疗法中的应用
CN114699423B (zh) * 2022-02-16 2023-06-23 广州知易生物科技有限公司 脆弱拟杆菌的荚膜多糖提取物在制备防治精神分裂症的药物中的应用
CN114699424B (zh) * 2022-02-16 2023-07-18 广州知易生物科技有限公司 脆弱拟杆菌两性离子荚膜多糖或/和改性的两性离子荚膜多糖的新应用
CN114457153A (zh) * 2022-03-15 2022-05-10 西安交通大学 一种孤独症血清神经元来源外泌体标志物chrm1的应用
CN117598247B (zh) * 2022-03-25 2026-02-10 天津中医药大学 咪唑丙酸在制备用于诱导溃疡性结肠炎动物模型的造模剂中的应用
CN114622026B (zh) * 2022-04-02 2024-10-01 中南大学湘雅三医院 拟杆菌作为预测自闭症疗效的客观指标
CN116990395A (zh) * 2022-04-26 2023-11-03 中国科学院深圳先进技术研究院 一种基于粪便的阿尔兹海默症生物标志物及其应用
CN115482924A (zh) * 2022-09-06 2022-12-16 浙江大学医学院附属儿童医院 孤独症谱系障碍儿童智力障碍诊断模型的建立方法及装置
CN115368300B (zh) * 2022-10-27 2023-03-24 北京拓领博泰生物科技有限公司 用于tlr8抑制剂的化合物及其制备方法、应用
CN115616227B (zh) * 2022-11-18 2023-05-16 四川大学华西医院 吲哚-3-丙烯酰甘氨酸检测试剂的用途、诊断或辅助诊断慢性阻塞性肺病的试剂盒及系统
US12005044B1 (en) 2022-11-29 2024-06-11 Autism Therapeutics Inc. Treatment of autism spectrum disorders with ergothioneine, selenoneine, or combinations thereof
WO2025007066A1 (en) * 2023-06-30 2025-01-02 University Of Massachusetts Biomarkers and methods related to fragile x syndrome

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120087895A1 (en) * 2010-10-07 2012-04-12 Mazmanian Sarkis K Probiotic Therapies for Autism
US20120190055A1 (en) * 2010-04-29 2012-07-26 Stemina Biomarker Discovery, Inc. Molecule biomarkers of autism
US20120207726A1 (en) * 2009-06-16 2012-08-16 The Trustees Of Columbia University In The City Of New York Autism-associated biomarkers and uses thereof

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443826A (en) 1988-08-02 1995-08-22 Borody; Thomas J. Treatment of gastro-intestinal disorders with a fecal composition or a composition of bacteroides and E. Coli
AUPM864894A0 (en) 1994-10-07 1994-11-03 Borody, Thomas Julius Treatment of bowel-dependent neurological disorders
US5951977A (en) 1997-10-14 1999-09-14 The United States Of America, As Represented By The Secretary Of Agriculture Competitive exclusion culture for swine
US20020013270A1 (en) 2000-06-05 2002-01-31 Bolte Ellen R. Method for treating a mental disorder
US20040170617A1 (en) 2000-06-05 2004-09-02 Finegold Sydney M. Method of treating diseases associated with abnormal gastrointestinal flora
AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
US20040005304A1 (en) 2002-07-08 2004-01-08 Mak Wood, Inc. Novel compositions and methods for treating neurological disorders and associated gastrointestinal conditions
US20060177424A1 (en) 2003-08-29 2006-08-10 Cobb Mark L Treatment of disease states and adverse physiological conditions utilizing anti-fungal compositions
US8192733B2 (en) 2003-08-29 2012-06-05 Cobb & Associates Probiotic composition useful for dietary augmentation and/or combating disease states and adverse physiological conditions
US7749509B2 (en) 2003-08-29 2010-07-06 Cobb And Company, Llp Treatment of autism using probiotic composition
US7731976B2 (en) 2003-08-29 2010-06-08 Cobb And Company, Llp Treatment of irritable bowel syndrome using probiotic composition
CN101103018A (zh) 2004-11-16 2008-01-09 神经化学（国际）有限公司 治疗cns和淀粉样蛋白-相关疾病的化合物
GB0504096D0 (en) * 2005-02-28 2005-04-06 Tipogen As Method
US20100233312A9 (en) 2005-04-11 2010-09-16 The Procter & Gamble Company Compositions comprising probiotic and sweetener components
EP2211879B1 (en) 2007-10-26 2014-05-07 Brenda E. Moore Probiotic compositions and methods for inducing and supporting weight loss
EA038941B1 (ru) 2007-11-06 2021-11-12 ПиТиСи ТЕРАПЬЮТИКС, ИНК. ПРОИЗВОДНЫЕ 4-(п-ХИНОНИЛ)-2-ГИДРОКСИБУТАНАМИДА ДЛЯ ЛЕЧЕНИЯ МИТОХОНДРИАЛЬНЫХ ЗАБОЛЕВАНИЙ
US20110118135A1 (en) 2008-01-09 2011-05-19 State Matthew W Mutations in Contaction Associated Protein 2 (CNTNAP2) are Associated with Increased Risk for Ideopathic Autism
US20110294794A1 (en) 2008-11-13 2011-12-01 Link Medicine Corporation Treatment of proteinopathies using a farnesyl transferase inhibitor
WO2010111516A2 (en) 2009-03-25 2010-09-30 Whitehead Institute For Biomedical Research Compositions and methods for inhibiting biofilms
US20110081320A1 (en) 2009-10-06 2011-04-07 Nubiome, Inc. Treatment/Cure of Autoimmune Disease
JP2013507394A (ja) 2009-10-09 2013-03-04 プロセラ インコーポレイテッド 自閉症スペクトル障害と診断されたヒトにおいて自閉症スペクトル障害に関連する少なくとも一つの症状を低減するための、ペディオコッカス属を含む組成物及び方法
US9707207B2 (en) 2010-05-26 2017-07-18 The United States Of America As Represented By The Department Of Veterans Affairs Method for diagnosing, preventing, and treating neurological diseases
WO2011153226A2 (en) 2010-06-01 2011-12-08 Moore Research Enterprises Llc Cellular constituents from bacteroides, compositions thereof, and therapeutic methods employing bacteroides or cellular constituents thereof
WO2012003554A2 (en) 2010-07-08 2012-01-12 Katholieke Universiteit Leuven Compositions and methods for removal or destruction of amyloid fibril or amyloid adhesin comprising aggregates
US20120237482A1 (en) 2011-03-18 2012-09-20 Juan Rodriguez Methods for treatment of neurological disorders by modulation of microglial activation
ES2993669T3 (en) 2011-12-01 2025-01-03 Univ Tokyo Human-derived bacteria that induce proliferation or accumulation of regulatory t cells
CN104507483A (zh) 2012-04-13 2015-04-08 波士顿学院理事会 益生元组合物及使用方法
WO2014036182A2 (en) 2012-08-29 2014-03-06 California Institute Of Technology Diagnosis and treatment of autism spectrum disorder
JP2016509003A (ja) 2013-02-04 2016-03-24 セレス セラピューティクス インコーポレイテッド 組成物および方法
US10973861B2 (en) 2013-02-04 2021-04-13 Seres Therapeutics, Inc. Compositions and methods
US9511100B2 (en) 2013-06-05 2016-12-06 Rebiotix, Inc. Microbiota restoration therapy (MRT), compositions and methods of manufacture
FI127671B (en) 2014-05-28 2018-11-30 Filip Scheperjans Method for diagnostics of Parkinson’s disease
CN104546932A (zh) 2014-09-30 2015-04-29 深圳华大基因科技有限公司 卵形拟杆菌在治疗或预防类风湿性关节炎或其相关疾病中的应用
KR20170086027A (ko) 2014-10-30 2017-07-25 캘리포니아 인스티튜트 오브 테크놀로지 신경발달 장애에서의 행동을 개선시키기 위한 박테리아를 포함하는 조성물 및 방법
WO2016069801A1 (en) 2014-10-30 2016-05-06 California Institute Of Technology Compositions and methods comprising bacteria for improving behavior in neurodecelopmental disorders
CA2966360C (en) 2014-10-30 2023-09-05 California Institute Of Technology Compositions and methods comprising bacteria for improving behavior in neurodevelopmental disorders
EP3242673A1 (en) 2015-01-07 2017-11-15 Ecole Polytechnique Fédérale de Lausanne (EPFL) Gastro-intestinal biomarkers for diagnosis and therapies of proteinopathies
KR102534545B1 (ko) 2015-05-22 2023-05-18 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 자폐 스펙트럼 장애 및 관련된 증상을 치료하는 방법
CN121534089A (zh) 2016-05-23 2026-02-17 加州理工学院 调节肠微生物群来治疗神经退行性病症
MX390386B (es) 2016-06-22 2025-03-20 Microbial Res Management Health Nv Carotenoides microbianos que afectan la composicion de la microbiota intestinal

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120207726A1 (en) * 2009-06-16 2012-08-16 The Trustees Of Columbia University In The City Of New York Autism-associated biomarkers and uses thereof
US20120190055A1 (en) * 2010-04-29 2012-07-26 Stemina Biomarker Discovery, Inc. Molecule biomarkers of autism
US20120087895A1 (en) * 2010-10-07 2012-04-12 Mazmanian Sarkis K Probiotic Therapies for Autism

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CRITCHFIELD J WILLIAM ET AL, "The potential role of probiotics in the management of childhood autism spectrum disorders.", GASTROENTEROLOGY RESEARCH AND PRACTICE, (2011), vol. 2011, ISSN 1687-630X, pages 1 - 8 *

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