AU2013289555B2 - Methods for synthesizing amatoxin building block and amatoxins - Google Patents
Methods for synthesizing amatoxin building block and amatoxins Download PDFInfo
- Publication number
- AU2013289555B2 AU2013289555B2 AU2013289555A AU2013289555A AU2013289555B2 AU 2013289555 B2 AU2013289555 B2 AU 2013289555B2 AU 2013289555 A AU2013289555 A AU 2013289555A AU 2013289555 A AU2013289555 A AU 2013289555A AU 2013289555 B2 AU2013289555 B2 AU 2013289555B2
- Authority
- AU
- Australia
- Prior art keywords
- compound
- fmoc
- compounds
- create
- resin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/065—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for hydroxy functions, not being part of carboxy functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12005173.5 | 2012-07-13 | ||
| EP12005173.5A EP2684865A1 (fr) | 2012-07-13 | 2012-07-13 | Procédés de synthèse de bloc de construction dýamatoxine et amatoxine |
| PCT/EP2013/002084 WO2014009025A1 (fr) | 2012-07-13 | 2013-07-12 | Procédés permettant de synthétiser un élément constitutif d'amatoxine et des amatoxines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2013289555A1 AU2013289555A1 (en) | 2015-01-22 |
| AU2013289555B2 true AU2013289555B2 (en) | 2017-10-05 |
Family
ID=48793164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013289555A Active AU2013289555B2 (en) | 2012-07-13 | 2013-07-12 | Methods for synthesizing amatoxin building block and amatoxins |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US9676702B2 (fr) |
| EP (2) | EP2684865A1 (fr) |
| JP (2) | JP2015528799A (fr) |
| KR (1) | KR102122575B1 (fr) |
| CN (1) | CN104470891B (fr) |
| AU (1) | AU2013289555B2 (fr) |
| BR (1) | BR112015000232B1 (fr) |
| CA (1) | CA2878081C (fr) |
| CY (1) | CY1117950T1 (fr) |
| DK (1) | DK2872479T3 (fr) |
| ES (1) | ES2589306T3 (fr) |
| HK (1) | HK1209723A1 (fr) |
| HR (1) | HRP20160984T1 (fr) |
| HU (1) | HUE029538T2 (fr) |
| IL (1) | IL236129A (fr) |
| MX (1) | MX361116B (fr) |
| NZ (1) | NZ702752A (fr) |
| PL (1) | PL2872479T3 (fr) |
| PT (1) | PT2872479T (fr) |
| RU (1) | RU2637924C2 (fr) |
| SG (1) | SG11201500225WA (fr) |
| SI (1) | SI2872479T1 (fr) |
| UA (1) | UA116991C2 (fr) |
| WO (1) | WO2014009025A1 (fr) |
| ZA (1) | ZA201409384B (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9938323B2 (en) | 2014-11-06 | 2018-04-10 | Novartis Ag | Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase |
| US10723766B2 (en) | 2015-11-27 | 2020-07-28 | Heidelberg Pharma Research Gmbh | Derivatives of gamma-amanitin |
| EP3222292A1 (fr) | 2016-03-03 | 2017-09-27 | Heidelberg Pharma GmbH | Conjugués d'amanitine |
| US10464969B2 (en) | 2016-05-05 | 2019-11-05 | Novartis Ag | Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase |
| MX2018015684A (es) * | 2016-06-17 | 2019-08-29 | Magenta Therapeutics Inc | Composiciones y metodos para el agotamiento de celulas cd117. |
| BR112018076263A2 (pt) | 2016-06-17 | 2019-03-26 | Magenta Therapeutics, Inc. | composições e métodos para a depleção de células |
| KR102455175B1 (ko) * | 2016-12-23 | 2022-10-17 | 하이델베르크 파마 리서치 게엠베하 | 아마니틴 접합체 |
| EP3571230A4 (fr) | 2017-01-20 | 2020-12-16 | Magenta Therapeutics, Inc. | Compositions et procédés pour la déplétion des cellules cd137+ |
| EP3661938A1 (fr) | 2017-08-07 | 2020-06-10 | Heidelberg Pharma Research GmbH | Nouveau procédé de synthèse d'amanitines |
| AU2018314668B2 (en) | 2017-08-07 | 2022-06-02 | Heidelberg Pharma Research Gmbh | Novel method for synthesizing amanitins |
| EP3738608A4 (fr) * | 2017-08-18 | 2021-12-08 | Sichuan Baili Pharm Co. Ltd | Conjugué d'anticorps de type amatoxine non-naturelle |
| WO2019047941A1 (fr) * | 2017-09-08 | 2019-03-14 | 四川百利药业有限责任公司 | Conjugué d'anticorps à base d'amanitine |
| KR20190043031A (ko) * | 2017-10-17 | 2019-04-25 | 한국화학연구원 | 아마톡신 유도체 및 이의 제조방법 |
| AU2018354189A1 (en) | 2017-10-24 | 2020-04-23 | Crispr Therapeutics Ag | Compositions and methods for the depletion of CD117+ cells |
| EP3546447A1 (fr) | 2018-03-29 | 2019-10-02 | Heidelberg Pharma GmbH | Synthèse de (2s,3r,4r)-4,5-dihydroxyisoleucine et de ses dérivés |
| CA3107383A1 (fr) | 2018-07-23 | 2020-01-30 | Magenta Therapeutics, Inc. | Utilisation d'un conjugue anticorps anti-cd5 -medicament (adc) dans une therapie cellulaire allogenique |
| SG11202110287QA (en) | 2019-04-24 | 2021-10-28 | Heidelberg Pharma Res Gmbh | Amatoxin antibody-drug conjugates and uses thereof |
| WO2021004973A1 (fr) * | 2019-07-05 | 2021-01-14 | Pure Bioorganics Sia | Synthèse d'alpha-amanitine et de ses dérivés |
| EP3792250A1 (fr) * | 2019-09-13 | 2021-03-17 | Pure Bioorganics SIA | Synthèse d'alpha-amanitine et de ses dérivés |
| KR102092817B1 (ko) * | 2019-08-22 | 2020-03-24 | 한국화학연구원 | 아마톡신 유도체 및 이의 제조방법 |
| CN112552196B (zh) * | 2020-11-23 | 2024-02-02 | 蚌埠丰原医药科技发展有限公司 | 一种制备赖氨匹林的方法 |
| WO2024121632A1 (fr) | 2022-12-09 | 2024-06-13 | Crispr Therapeutics Ag | Utilisation d'un conjugué anticorps-médicament (adc) anti-cd117 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1585076A (en) | 1976-07-13 | 1981-02-25 | Roche Products Ltd | Peptides of phosphonic and phosphinic acids |
| DE4104024A1 (de) | 1991-02-09 | 1992-08-13 | Merck Patent Gmbh | Aminosaeurederivate |
| JPH0959228A (ja) * | 1995-08-17 | 1997-03-04 | Hokuriku Seiyaku Co Ltd | 光学活性なアミノアルコール及びその製造方法 |
| TW374758B (en) * | 1996-09-13 | 1999-11-21 | Nippon Kayakk Kk | The process for preparing an optical active erythro-3-amino-2-hydroxyl butyrate |
| JPH11137291A (ja) * | 1997-11-12 | 1999-05-25 | Mori Sangyo Kk | アマニチン類の製造法 |
| WO1999061466A1 (fr) | 1998-05-22 | 1999-12-02 | Abbott Laboratories | Medicament anti-angiogenique pour le traitement du cancer, de l'arthrite et de la retinopathie |
| PL360678A1 (en) | 2000-03-17 | 2004-09-20 | Bristol-Myers Squibb Pharma Company | Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha |
| US7169919B2 (en) | 2000-04-18 | 2007-01-30 | Eli Lilly And Company | Process for preparing lipid II |
| ES2371085T3 (es) | 2006-05-27 | 2011-12-27 | Faulstich, Heinz, Dr. | Utilización de conjugados de amatoxinas o falotoxinas con macromoléculas para la terapia tumoral y de la inflamación. |
| WO2010115630A1 (fr) | 2009-04-08 | 2010-10-14 | Deutsches Krebsforschungszentrum | Fractions contenant de l'amatoxine de liaison a une cible pour le traitement du cancer |
| EP3192529B1 (fr) | 2009-04-08 | 2020-03-25 | Faulstich, Heinz, Dr. | Constituants thérapeutiques contenant de l'amatoxine de liaison à la surface cellulaire destinés à la thérapie des tumeurs |
-
2012
- 2012-07-13 EP EP12005173.5A patent/EP2684865A1/fr not_active Withdrawn
-
2013
- 2013-07-12 SG SG11201500225WA patent/SG11201500225WA/en unknown
- 2013-07-12 BR BR112015000232-3A patent/BR112015000232B1/pt active IP Right Grant
- 2013-07-12 DK DK13737145.6T patent/DK2872479T3/en active
- 2013-07-12 CA CA2878081A patent/CA2878081C/fr active Active
- 2013-07-12 RU RU2015104802A patent/RU2637924C2/ru active
- 2013-07-12 KR KR1020157003282A patent/KR102122575B1/ko active IP Right Grant
- 2013-07-12 EP EP13737145.6A patent/EP2872479B1/fr active Active
- 2013-07-12 CN CN201380037459.2A patent/CN104470891B/zh active Active
- 2013-07-12 MX MX2015000479A patent/MX361116B/es active IP Right Grant
- 2013-07-12 JP JP2015520852A patent/JP2015528799A/ja active Pending
- 2013-07-12 US US14/414,143 patent/US9676702B2/en active Active
- 2013-07-12 AU AU2013289555A patent/AU2013289555B2/en active Active
- 2013-07-12 WO PCT/EP2013/002084 patent/WO2014009025A1/fr active Application Filing
- 2013-07-12 UA UAA201501155A patent/UA116991C2/uk unknown
- 2013-07-12 NZ NZ702752A patent/NZ702752A/en unknown
- 2013-07-12 ES ES13737145.6T patent/ES2589306T3/es active Active
- 2013-07-12 SI SI201330268A patent/SI2872479T1/sl unknown
- 2013-07-12 HU HUE13737145A patent/HUE029538T2/en unknown
- 2013-07-12 PL PL13737145.6T patent/PL2872479T3/pl unknown
- 2013-07-12 PT PT137371456T patent/PT2872479T/pt unknown
-
2014
- 2014-12-08 IL IL236129A patent/IL236129A/en active IP Right Grant
- 2014-12-19 ZA ZA2014/09384A patent/ZA201409384B/en unknown
-
2015
- 2015-10-22 HK HK15110372.0A patent/HK1209723A1/xx unknown
-
2016
- 2016-08-02 HR HRP20160984TT patent/HRP20160984T1/hr unknown
- 2016-08-22 CY CY20161100827T patent/CY1117950T1/el unknown
-
2018
- 2018-02-16 JP JP2018025844A patent/JP6560382B2/ja active Active
Non-Patent Citations (1)
| Title |
|---|
| Giancarlo Zanotti ET AL, In!. J. Peptide Protein Res., (1987-01-01), pages 450 - 459 * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2013289555B2 (en) | Methods for synthesizing amatoxin building block and amatoxins | |
| CA3131774A1 (fr) | Procede de production d'un compose peptidique, reactif formant un groupe protecteur et compose heterocyclique aromatique | |
| US9175053B2 (en) | Chemical preparation of ubiquitin thioesters and modifications thereof | |
| CA3131772A1 (fr) | Procede de production d'un compose peptidique, reactif formant un groupe protecteur et compose hydrocarbone aromatique polycyclique fusionne | |
| EP3802554A1 (fr) | Procédé de synthèse peptidique en phase solution et stratégies de protection associées | |
| JP7301965B2 (ja) | ペプチド化合物の製造方法、保護基形成用試薬、及び、縮合多環化合物 | |
| US8076299B2 (en) | Method for producing peptide thioester | |
| RU2810786C2 (ru) | Синтез (s)-6-гидрокситриптофана и его производных | |
| US8981049B2 (en) | Aziridine mediated native chemical ligation | |
| US20070260041A1 (en) | Allylic disulfide rearrangement and desulfurization method for the preparation of allylic sulfides | |
| US20220024870A1 (en) | Synthesis of (S)-6-Hydroxytryptophan and Derivatives Thereof | |
| Vernall | Cross Metathesis and Ring-Closing Metathesis Reactions of Modified Amino Acids and Peptides. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |