AU2012310157B2 - Solid forms of a transthyretin dissociation inhibitor - Google Patents

Solid forms of a transthyretin dissociation inhibitor Download PDF

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Publication number
AU2012310157B2
AU2012310157B2 AU2012310157A AU2012310157A AU2012310157B2 AU 2012310157 B2 AU2012310157 B2 AU 2012310157B2 AU 2012310157 A AU2012310157 A AU 2012310157A AU 2012310157 A AU2012310157 A AU 2012310157A AU 2012310157 B2 AU2012310157 B2 AU 2012310157B2
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crystalline form
compound
solid
peaks
raman
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AU2012310157A1 (en
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Richard Frederic Labaudiniere
Michael Henry O'NEILL
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Pfizer Inc
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Pfizer Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AU2012310157A 2011-09-16 2012-09-12 Solid forms of a transthyretin dissociation inhibitor Active AU2012310157B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161535551P 2011-09-16 2011-09-16
US61/535,551 2011-09-16
PCT/IB2012/054748 WO2013038351A1 (en) 2011-09-16 2012-09-12 Solid forms of a transthyretin dissociation inhibitor

Publications (2)

Publication Number Publication Date
AU2012310157A1 AU2012310157A1 (en) 2014-04-03
AU2012310157B2 true AU2012310157B2 (en) 2015-11-12

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AU2012310157A Active AU2012310157B2 (en) 2011-09-16 2012-09-12 Solid forms of a transthyretin dissociation inhibitor

Country Status (16)

Country Link
US (2) US9249112B2 (https=)
EP (1) EP2755961A1 (https=)
JP (2) JP5869677B2 (https=)
KR (1) KR20140054231A (https=)
CN (1) CN103781770B (https=)
AR (1) AR088755A1 (https=)
AU (1) AU2012310157B2 (https=)
BR (1) BR112014005810A2 (https=)
CA (1) CA2847293C (https=)
IL (1) IL231472A0 (https=)
MX (1) MX2014003043A (https=)
RU (1) RU2586330C2 (https=)
SG (1) SG2014013270A (https=)
TW (2) TWI476185B (https=)
WO (1) WO2013038351A1 (https=)
ZA (1) ZA201401202B (https=)

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RU2586330C2 (ru) * 2011-09-16 2016-06-10 Пфайзер Инк. Твердые формы ингибитора диссоциации транстиретина
EP2764866A1 (en) 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
SI3977993T1 (sl) 2014-09-08 2024-05-31 Pfizer Inc. Kristalne trdne oblike 6-karboksi-2-(3,5-diklorofenil)-benzoksazola za uporabo kot zdravilo
CN107344927A (zh) * 2016-05-05 2017-11-14 苏州晶云药物科技有限公司 Tafamidis葡甲胺盐的晶型E及其制备方法和用途
GB2571950A (en) * 2018-03-13 2019-09-18 Azad Pharma Ag New polymorph and new path to synthesize tafamidis
WO2020128816A2 (en) 2018-12-20 2020-06-25 Pfizer Inc. Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent
ES2991081T3 (es) * 2019-04-11 2024-12-02 Inke Sa Procedimiento para preparar 2-(3,5-diclorofenil)-6-benzoxazolcarboxilato de 1-desoxi-1-metilamino-D-glucitol
EP3969443B1 (en) 2019-05-16 2024-11-20 Teva Pharmaceuticals International GmbH Solid state forms of tafamidis and salts thereof
EP3976017A4 (en) * 2019-05-31 2023-06-14 Plex Pharmaceuticals, Inc. PHARMACOLOGICAL SUBSTANCES FOR THE TREATMENT OF PROTEIN AGGREGATION DISEASES OF THE EYE
WO2021019448A1 (en) * 2019-08-01 2021-02-04 Honour (R&D) Process for the preparation of transthyretin dissociation inhibitor
JP2023503833A (ja) * 2019-11-15 2023-02-01 ▲蘇▼州科睿思制▲葯▼有限公司 タファミジスの結晶形及びその調製方法及びその使用
MX2022007787A (es) * 2019-12-20 2022-07-19 Pfizer Ireland Pharmaceuticals Proceso eficiente para elaborar derivados de 6-carboxi-benzoxazol.
WO2021232619A1 (zh) * 2020-05-19 2021-11-25 苏州科睿思制药有限公司 一种他发米帝司游离酸的晶型及其制备方法和用途
WO2022009221A1 (en) * 2020-07-04 2022-01-13 Nuray Chemicals Private Limited Solid state forms of 6-carboxy-2-(3, 5-dichlorophenyl)-benzoxazole of formula-i and pharmaceutically acceptable salts thereof
FR3114230B1 (fr) 2020-09-23 2022-12-23 Pierre Berger Dispositif de connexion entre une toile et un rail
WO2022084790A1 (en) * 2020-10-19 2022-04-28 Glenmark Life Sciences Limited Process for preparation of tafamidis and salts thereof
WO2022112919A1 (en) 2020-11-25 2022-06-02 Pfizer Inc. (aza)benzothiazolyl substituted pyrazole compounds
EP4083027A1 (en) 2021-04-26 2022-11-02 Química Sintética, S.A. A solid state form of tafamidis and a process for its preparation
WO2023020762A1 (en) 2021-08-16 2023-02-23 Synthon B.V. Crystalline forms of tafamidis nicotinamide adduct
US20250042864A1 (en) 2021-11-17 2025-02-06 Teva Pharmaceuticals International Gmbh Solid state form of tafamidis

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Also Published As

Publication number Publication date
TW201315720A (zh) 2013-04-16
US20160185739A1 (en) 2016-06-30
JP2014526498A (ja) 2014-10-06
CA2847293A1 (en) 2013-03-21
US9249112B2 (en) 2016-02-02
MX2014003043A (es) 2015-02-05
IL231472A0 (en) 2014-04-30
KR20140054231A (ko) 2014-05-08
TW201516039A (zh) 2015-05-01
RU2014109676A (ru) 2015-10-27
RU2586330C2 (ru) 2016-06-10
ZA201401202B (en) 2016-01-27
BR112014005810A2 (pt) 2017-03-28
JP5869677B2 (ja) 2016-02-24
NZ621194A (en) 2016-02-26
TWI538909B (zh) 2016-06-21
AR088755A1 (es) 2014-07-02
WO2013038351A1 (en) 2013-03-21
AU2012310157A1 (en) 2014-04-03
HK1197239A1 (zh) 2015-01-09
CA2847293C (en) 2017-03-28
US20150031735A1 (en) 2015-01-29
EP2755961A1 (en) 2014-07-23
TWI476185B (zh) 2015-03-11
CN103781770A (zh) 2014-05-07
SG2014013270A (en) 2014-05-29
JP2016128444A (ja) 2016-07-14
CN103781770B (zh) 2016-04-13

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