AU2012290129B2 - Microfluidic drug delivery devices - Google Patents
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- AU2012290129B2 AU2012290129B2 AU2012290129A AU2012290129A AU2012290129B2 AU 2012290129 B2 AU2012290129 B2 AU 2012290129B2 AU 2012290129 A AU2012290129 A AU 2012290129A AU 2012290129 A AU2012290129 A AU 2012290129A AU 2012290129 B2 AU2012290129 B2 AU 2012290129B2
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Classifications
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- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
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- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
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- A—HUMAN NECESSITIES
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- A61M25/00—Catheters; Hollow probes
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Materials For Medical Uses (AREA)
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Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3125150A1 (en) | 2011-08-01 | 2013-02-07 | Alcyone Lifesciences, Inc. | Microfluidic drug delivery devices |
| US9919129B2 (en) | 2012-12-18 | 2018-03-20 | Alcyone Lifesciences, Inc. | Systems and methods for reducing or preventing backflow in a delivery system |
| WO2014204954A1 (en) | 2013-06-17 | 2014-12-24 | Alcyone Lifesciences, Inc. | Methods and devices for protecting catheter tips and stereotactic fixtures for microcatheters |
| ES2738298T3 (es) * | 2013-07-31 | 2020-01-21 | Alcyone Lifesciences Inc | Sistemas y métodos de suministro de fármacos, tratamiento y monitoreo |
| KR101562865B1 (ko) * | 2014-01-24 | 2015-10-26 | 한국과학기술연구원 | 신경 영양인자를 감지하기 위한 초소형 센서 시스템 |
| US10213564B2 (en) | 2014-05-19 | 2019-02-26 | Frank J. Cain | Biomedical aural delivery systems and methods |
| WO2016014464A1 (en) | 2014-07-21 | 2016-01-28 | The Cleveland Clinic Foundation | Convection enhanced delivery device and system |
| US9968765B2 (en) | 2014-07-21 | 2018-05-15 | The Cleveland Clinic Foundation | Convection enhanced delivery device and system |
| MX2017009336A (es) | 2015-01-16 | 2017-11-15 | Voyager Therapeutics Inc | Polinucleótidos dirigidos al sistema nervioso central. |
| US10806396B2 (en) | 2015-01-26 | 2020-10-20 | Alcyone Lifesciences, Inc. | Drug delivery methods with tracer |
| US10130740B2 (en) * | 2015-03-17 | 2018-11-20 | Wells Johnson Company | Pressure control during processing of adipose tissue |
| US10143811B2 (en) * | 2015-03-17 | 2018-12-04 | Wells Johnson Company | Fluid management of adipose tissue |
| WO2016183123A1 (en) | 2015-05-11 | 2016-11-17 | Alcyone Lifesciences, Inc. | Drug delivery systems and methods |
| US10286128B2 (en) * | 2015-05-22 | 2019-05-14 | Wells Johnson Company | Pressure control during processing of adipose tissue |
| KR102483951B1 (ko) | 2015-06-22 | 2023-01-03 | 삼성디스플레이 주식회사 | 액정 표시 장치 및 액정 표시 장치의 제조 방법 |
| US10315016B2 (en) * | 2016-01-04 | 2019-06-11 | Corflow Therapeutics Ag | System and methods for treating MVO |
| JP2019502473A (ja) | 2016-01-04 | 2019-01-31 | アルキオーネ・ライフサイエンシズ・インコーポレイテッドAlcyone Lifesciences, Inc. | 脳卒中を治療するための方法および装置 |
| JP6729026B2 (ja) * | 2016-06-15 | 2020-07-22 | ウシオ電機株式会社 | マイクロ流路チップおよび検体濃度測定装置 |
| US10406336B2 (en) | 2016-08-03 | 2019-09-10 | Neil S. Davey | Adjustable rate drug delivery implantable device |
| CN114887153A (zh) | 2016-12-21 | 2022-08-12 | 亚克安娜治疗学有限公司 | 药物递送系统和方法 |
| KR20190098215A (ko) | 2016-12-21 | 2019-08-21 | 멤젠 엘엘씨 | 무장된 복제-가능 종양 분해 아데노바이러스 |
| WO2018169955A1 (en) * | 2017-03-14 | 2018-09-20 | Massachusetts Institute Of Technology | Systems and methods for neural drug delivery and modulation of brain activity |
| EP3662060A2 (en) | 2017-08-03 | 2020-06-10 | Voyager Therapeutics, Inc. | Compositions and methods for delivery of aav |
| CA3076035A1 (en) | 2017-09-19 | 2019-03-28 | Corflow Therapeutics Ag | Intracoronary characterization of microvascular obstruction (mvo) and myocardial infarction |
| US10675438B2 (en) * | 2017-11-15 | 2020-06-09 | Alcyone Lifesciences, Inc. | Therapy specific, pre-programmed auto injection device |
| EP3761892B1 (en) | 2018-03-09 | 2024-07-24 | Corflow Therapeutics AG | System for diagnosing and treating microvascular obstructions |
| US20190314574A1 (en) | 2018-04-13 | 2019-10-17 | Alcyone Lifesciences, Inc. | Devices and methods for percutaneous lung intratumoral therapy delivery |
| TW202015742A (zh) | 2018-05-15 | 2020-05-01 | 美商航海家醫療公司 | 投遞腺相關病毒(aav)之組成物和方法 |
| MX2020012077A (es) | 2018-05-15 | 2021-03-09 | Voyager Therapeutics Inc | Composiciones y metodos para el tratamiento de la enfermedad de parkinson. |
| WO2019222444A2 (en) | 2018-05-16 | 2019-11-21 | Voyager Therapeutics, Inc. | Directed evolution |
| EP3793686A1 (en) | 2018-05-16 | 2021-03-24 | Voyager Therapeutics, Inc. | Aav serotypes for brain specific payload delivery |
| US12100516B2 (en) | 2018-05-31 | 2024-09-24 | Corflow Therapeutics Ag | Microfluidic coronary circulatory model |
| WO2020023612A1 (en) | 2018-07-24 | 2020-01-30 | Voyager Therapeutics, Inc. | Systems and methods for producing gene therapy formulations |
| US10940290B2 (en) * | 2018-08-27 | 2021-03-09 | Alcyone Lifesciences, Inc. | Fluid delivery systems and methods |
| AU2019327386A1 (en) * | 2018-08-27 | 2021-03-18 | Alcyone Therapeutics, Inc. | Fluid delivery systems and methods |
| AU2019333136B2 (en) * | 2018-08-29 | 2022-11-17 | W. L. Gore & Associates, Inc. | Drug therapy delivery systems and methods |
| US20200078509A1 (en) * | 2018-09-12 | 2020-03-12 | Xinova, LLC | Micro-dispenser based ear treatment |
| EP3852653B1 (en) | 2018-09-21 | 2023-11-08 | CorFlow Therapeutics AG | Apparatus for assessment of microvascular dysfunction |
| WO2020077165A1 (en) | 2018-10-12 | 2020-04-16 | Voyager Therapeutics, Inc. | Compositions and methods for delivery of aav |
| US11857326B2 (en) * | 2019-03-08 | 2024-01-02 | Neuroone Medical Technologies Corporation | Agent-delivering neural probe devices and related systems and methods |
| US20200305742A1 (en) * | 2019-03-27 | 2020-10-01 | Kamran Ghodsian | System and method for child-birth monitoring and assistance |
| US12172037B2 (en) * | 2019-08-15 | 2024-12-24 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for mechanogenetic functional ultrasound imaging |
| WO2021035190A1 (en) | 2019-08-21 | 2021-02-25 | Corflow Therapeutics Ag | Controlled-flow infusion catheter and method |
| WO2021046155A1 (en) | 2019-09-03 | 2021-03-11 | Voyager Therapeutics, Inc. | Vectorized editing of nucleic acids to correct overt mutations |
| WO2021176672A1 (ja) * | 2020-03-05 | 2021-09-10 | 日本ライフライン株式会社 | デリバリシャフトおよびデリバリシステム |
| US12435407B2 (en) | 2020-08-03 | 2025-10-07 | Neuroone Medical Technologies Corporation | Methods for making probe devices and related devices |
| US11744939B2 (en) | 2020-10-29 | 2023-09-05 | Medtronic, Inc. | Cyclic intrathecal drug delivery system and biomarker monitoring |
| JPWO2022181126A1 (enExample) * | 2021-02-26 | 2022-09-01 | ||
| WO2022241099A2 (en) * | 2021-05-12 | 2022-11-17 | Arizona Board Of Regents On Behalf Of The University Of Arizona | In situ soil gas probes and sampling sytems |
| ES3031889T3 (en) * | 2021-08-18 | 2025-07-11 | Dixi Neurolab Inc | Injectrode with multiple electrical sensors |
| WO2023091939A1 (en) * | 2021-11-16 | 2023-05-25 | Massachusetts Institute Of Technology | Multifunctional microelectronics fibers as implantable bioelectronic interfaces |
| CN115869492A (zh) * | 2022-05-26 | 2023-03-31 | 杭州堃博生物科技有限公司 | 介入系统、控制方法、计算机设备、程序产品以及存储介质 |
| CN116999412A (zh) * | 2023-08-03 | 2023-11-07 | 四川迈可隆生物科技有限公司 | 一种含有倍他米松药物的缓释微球制剂及其制备方法 |
| WO2025184653A1 (en) * | 2024-03-01 | 2025-09-04 | Massachusetts Institute Of Technology | Micro-invasive neural system for delivering therapeutic agents for the treatment of neurological disorders |
| CN117982146B (zh) * | 2024-04-07 | 2024-07-12 | 华中科技大学 | 用于颅内肿瘤切除手术监测与治疗的水凝胶混合电子系统 |
| CN119385986A (zh) * | 2024-09-19 | 2025-02-07 | 江苏知原药业股份有限公司 | 一种特比萘芬成膜组合物的文丘里效应制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090124976A1 (en) * | 2007-11-14 | 2009-05-14 | Stephan Mittermeyer | Drug supply system for ced (convection-enhanced delivery) catheter infusions |
| US20100098767A1 (en) * | 2007-02-13 | 2010-04-22 | Olbricht William L | Convection enhanced delivery apparatus, method, and application |
| WO2010081072A2 (en) * | 2009-01-12 | 2010-07-15 | Becton, Dickinson And Company | Optimized intracranial catheters for convection-enhanced delivery of therapeutics |
Family Cites Families (186)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2830587A (en) | 1954-02-01 | 1958-04-15 | Everett Samuel James | Hypodermic needles |
| US3460537A (en) | 1966-09-26 | 1969-08-12 | Donald C Zeis | Stereotactic guide for use in the creation of destructive brain lesions |
| US3886948A (en) | 1972-08-14 | 1975-06-03 | Hakim Co Ltd | Ventricular shunt having a variable pressure valve |
| US4146029A (en) | 1974-04-23 | 1979-03-27 | Ellinwood Jr Everett H | Self-powered implanted programmable medication system and method |
| US4692146A (en) | 1985-10-24 | 1987-09-08 | Cormed, Inc. | Multiple vascular access port |
| US4917686A (en) | 1985-12-16 | 1990-04-17 | Colorado Biomedical, Inc. | Antimicrobial device and method |
| EP0343237B1 (en) | 1987-12-05 | 1992-06-17 | Renishaw plc | Apparatus for changing a sensing device |
| US4885945A (en) | 1988-02-23 | 1989-12-12 | Activational Systems, Inc. | Micropipettes and fabrication thereof |
| US5088208A (en) | 1988-10-11 | 1992-02-18 | Renishaw Plc | Measurement probe for position determining apparatus |
| US5407431A (en) | 1989-07-11 | 1995-04-18 | Med-Design Inc. | Intravenous catheter insertion device with retractable needle |
| US5695518A (en) | 1990-12-28 | 1997-12-09 | Laerum; Frode | Filtering device for preventing embolism and/or distension of blood vessel walls |
| US5868711A (en) | 1991-04-29 | 1999-02-09 | Board Of Regents, The University Of Texas System | Implantable intraosseous device for rapid vascular access |
| US5190046A (en) | 1992-05-01 | 1993-03-02 | Shturman Cardiology Systems, Inc. | Ultrasound imaging balloon catheter |
| US5620479A (en) | 1992-11-13 | 1997-04-15 | The Regents Of The University Of California | Method and apparatus for thermal therapy of tumors |
| US5415648A (en) | 1993-07-08 | 1995-05-16 | Malay; Manuel R. | Multiple purpose syringe |
| US5954651A (en) | 1993-08-18 | 1999-09-21 | Scimed Life Systems, Inc. | Catheter having a high tensile strength braid wire constraint |
| AU7676894A (en) | 1993-08-27 | 1995-03-21 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Convection-enhanced drug delivery |
| US5509910A (en) | 1994-05-02 | 1996-04-23 | Medtronic, Inc. | Method of soft tip attachment for thin walled catheters |
| US5604976A (en) | 1994-10-18 | 1997-02-25 | Pi Medical Corporation | Method of making percutaneous connector for multi-conductor electrical cables |
| US6176842B1 (en) | 1995-03-08 | 2001-01-23 | Ekos Corporation | Ultrasound assembly for use with light activated drugs |
| US5954687A (en) | 1995-04-28 | 1999-09-21 | Medtronic, Inc. | Burr hole ring with catheter for use as an injection port |
| US6454945B1 (en) | 1995-06-16 | 2002-09-24 | University Of Washington | Microfabricated devices and methods |
| WO1997000442A1 (en) | 1995-06-16 | 1997-01-03 | The University Of Washington | Microfabricated differential extraction device and method |
| US5624396A (en) | 1995-10-30 | 1997-04-29 | Micro Therapeutics, Inc. | Longitudinally extendable infusion device |
| US5590657A (en) | 1995-11-06 | 1997-01-07 | The Regents Of The University Of Michigan | Phased array ultrasound system and method for cardiac ablation |
| US5979453A (en) | 1995-11-09 | 1999-11-09 | Femrx, Inc. | Needle myolysis system for uterine fibriods |
| US5735814A (en) | 1996-04-30 | 1998-04-07 | Medtronic, Inc. | Techniques of treating neurodegenerative disorders by brain infusion |
| BR9601849A (pt) | 1996-06-18 | 1998-09-01 | Newton Paes | Aperfeiçoamento em cateter de dupla via para lavagem drenagem monitoração e controle de pressão intracraniana |
| US6193963B1 (en) | 1996-10-17 | 2001-02-27 | The Regents Of The University Of California | Method of treating tumor-bearing patients with human plasma hyaluronidase |
| JP2001525703A (ja) | 1997-05-15 | 2001-12-11 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 磁気共鳴画像化を使用する患者への標的投薬のための方法および装置 |
| US7048716B1 (en) | 1997-05-15 | 2006-05-23 | Stanford University | MR-compatible devices |
| US6061587A (en) | 1997-05-15 | 2000-05-09 | Regents Of The University Of Minnesota | Method and apparatus for use with MR imaging |
| US6610235B1 (en) * | 1997-06-30 | 2003-08-26 | The Regents Of The University Of California | Method of fabricating epidermal abrasion device |
| AU8681098A (en) | 1997-08-01 | 1999-03-08 | Massachusetts Institute Of Technology | Three-dimensional polymer matrices |
| US5963367A (en) * | 1997-09-23 | 1999-10-05 | Lucent Technologies, Inc. | Micromechanical xyz stage for use with optical elements |
| US5843150A (en) | 1997-10-08 | 1998-12-01 | Medtronic, Inc. | System and method for providing electrical and/or fluid treatment within a patient's brain |
| EP1024832A1 (en) | 1997-10-24 | 2000-08-09 | Children's Medical Center Corporation | METHODS FOR PROMOTING CELL TRANSFECTION $i(IN VIVO) |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| US20020055702A1 (en) | 1998-02-10 | 2002-05-09 | Anthony Atala | Ultrasound-mediated drug delivery |
| US5957912A (en) | 1998-04-16 | 1999-09-28 | Camino Neurocare, Inc. | Catheter having distal stylet opening and connector |
| ES2326893T3 (es) | 1998-05-27 | 2009-10-21 | Genzyme Corporation | Vectores aav para la fabricacion de medicamentos para administracion potenciada por conveccion. |
| US6547779B2 (en) * | 1998-07-22 | 2003-04-15 | Endovasix, Inc. | Flexible flow apparatus and method for the disruption of occlusions |
| US20030009153A1 (en) | 1998-07-29 | 2003-01-09 | Pharmasonics, Inc. | Ultrasonic enhancement of drug injection |
| ATE308353T1 (de) | 1999-03-03 | 2005-11-15 | Uab Research Foundation | Für das zentrale nervensystem bestimmer katheter mit temperaturkontrollsystem |
| US6464687B1 (en) * | 1999-03-09 | 2002-10-15 | Ball Semiconductor, Inc. | Implantable drug delivery system |
| US6224566B1 (en) | 1999-05-04 | 2001-05-01 | Cardiodyne, Inc. | Method and devices for creating a trap for confining therapeutic drugs and/or genes in the myocardium |
| US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| US6599274B1 (en) * | 2000-01-20 | 2003-07-29 | John Kucharczyk | Cell delivery catheter and method |
| DE10008825C2 (de) | 2000-02-25 | 2002-11-21 | Disetronic Licensing Ag | Mikroperfusionsvorrichtung |
| US6626902B1 (en) * | 2000-04-12 | 2003-09-30 | University Of Virginia Patent Foundation | Multi-probe system |
| US7473244B2 (en) | 2000-06-02 | 2009-01-06 | The University Of Utah Research Foundation | Active needle devices with integrated functionality |
| EP1573416A4 (en) | 2000-07-07 | 2010-01-27 | Fenwal Inc | MEDICAL SYSTEM, METHOD AND DEVICE USING MEMS |
| US6464662B1 (en) | 2000-07-26 | 2002-10-15 | Image-Guided Neurologics, Inc. | Drug delivery and catheter systems, apparatus and processes |
| GB0019200D0 (en) | 2000-08-05 | 2000-09-27 | Renishaw Plc | Bearing arrangement |
| US6902564B2 (en) | 2001-08-15 | 2005-06-07 | Roy E. Morgan | Methods and devices for electrosurgery |
| US7445619B2 (en) | 2000-08-18 | 2008-11-04 | Map Technologies Llc | Devices for electrosurgery |
| WO2002068036A1 (en) | 2000-12-27 | 2002-09-06 | The General Hospital Corporation | Dual balloon catheter with sensor for continuosu transvenous measurmentof intracranial pressure |
| US7914470B2 (en) | 2001-01-12 | 2011-03-29 | Celleration, Inc. | Ultrasonic method and device for wound treatment |
| US20020099356A1 (en) | 2001-01-19 | 2002-07-25 | Unger Evan C. | Transmembrane transport apparatus and method |
| US7029697B2 (en) | 2001-02-14 | 2006-04-18 | Northwestern University | Controlled surface-associated delivery of genes and oligonucleotides |
| US6623444B2 (en) * | 2001-03-21 | 2003-09-23 | Advanced Medical Applications, Inc. | Ultrasonic catheter drug delivery method and device |
| WO2002085431A2 (en) | 2001-04-24 | 2002-10-31 | Neuron Therapeutics, Inc. | Method of delivering liquid through cerebral spinal pathway |
| US6740058B2 (en) * | 2001-06-08 | 2004-05-25 | Wisconsin Alumni Research Foundation | Surgical tool with integrated pressure and flow sensors |
| US20030138403A1 (en) * | 2001-06-29 | 2003-07-24 | Maxygen Aps | Interferon formulations |
| US7150737B2 (en) | 2001-07-13 | 2006-12-19 | Sci/Med Life Systems, Inc. | Methods and apparatuses for navigating the subarachnoid space |
| US6803568B2 (en) * | 2001-09-19 | 2004-10-12 | Predicant Biosciences, Inc. | Multi-channel microfluidic chip for electrospray ionization |
| US20030148539A1 (en) | 2001-11-05 | 2003-08-07 | California Institute Of Technology | Micro fabricated fountain pen apparatus and method for ultra high density biological arrays |
| US6971999B2 (en) | 2001-11-14 | 2005-12-06 | Medical Instill Technologies, Inc. | Intradermal delivery device and method |
| AU2002367296A1 (en) | 2001-12-28 | 2003-07-24 | Ekos Corporation | Multi-resonant ultrasonic catheter |
| US20070005017A1 (en) | 2002-02-04 | 2007-01-04 | Becton, Dickinson And Company | Intradermal delivery device with crenellated skin engaging surface geometry |
| JP2005517180A (ja) | 2002-02-05 | 2005-06-09 | ザ ユニヴァーシティー コート オブ ザ ユニヴァーシティー オブ グラスゴー | 細胞検定を実施するための装置 |
| GB0205773D0 (en) | 2002-03-12 | 2002-04-24 | Gill Steven S | Clamp |
| GB0205772D0 (en) | 2002-03-12 | 2002-04-24 | Gill Steven S | Catheter |
| GB0208627D0 (en) | 2002-04-16 | 2002-05-22 | Imprint Pharm Ltd | Needle |
| US20030199831A1 (en) | 2002-04-23 | 2003-10-23 | Morris Mary M. | Catheter anchor system and method |
| GB2389791B (en) | 2002-04-30 | 2006-12-13 | Steven Gill | Implantable drug delivery pump |
| US6784600B2 (en) * | 2002-05-01 | 2004-08-31 | Koninklijke Philips Electronics N.V. | Ultrasonic membrane transducer for an ultrasonic diagnostic probe |
| US7771387B2 (en) | 2002-05-17 | 2010-08-10 | Boston Scientific Scimed, Inc. | Liquid embolic composition delivery devices and methods |
| US7316676B2 (en) | 2002-08-20 | 2008-01-08 | Gholam A. Peyman | Treatment of retinal detachment |
| EP1590034B1 (en) | 2002-10-07 | 2014-05-14 | Biovalve Technologies, Inc. | Microneedle array patch |
| US7034854B2 (en) | 2002-11-12 | 2006-04-25 | Nanoink, Inc. | Methods and apparatus for ink delivery to nanolithographic probe systems |
| EP1581285B1 (en) | 2002-12-23 | 2009-02-25 | Medtronic, Inc. | Drug solution density adjustment systems and methods |
| US8946151B2 (en) | 2003-02-24 | 2015-02-03 | Northern Bristol N.H.S. Trust Frenchay Hospital | Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen |
| EP1462141B1 (en) * | 2003-03-26 | 2006-09-20 | Terumo Kabushiki Kaisha | Catheter with puncture sensor |
| US7963956B2 (en) | 2003-04-22 | 2011-06-21 | Antisense Pharma Gmbh | Portable equipment for administration of fluids into tissues and tumors by convection enhanced delivery technique |
| US8886273B2 (en) * | 2003-08-01 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
| EP1684861B1 (en) * | 2003-10-21 | 2014-12-03 | The Regents Of The University Of Michigan | Intracranial neural interface system |
| GB0324519D0 (en) | 2003-10-21 | 2003-11-26 | Renishaw Plc | Metrology instruments |
| US20050149049A1 (en) | 2003-10-23 | 2005-07-07 | Assell Robert L. | Exchange system for soft tissue access pathway |
| WO2005083390A1 (en) * | 2004-02-20 | 2005-09-09 | Research Foundation Of The State University Of New York | Method and device for manipulating liquids in microfluidic systems |
| US7775087B2 (en) * | 2004-03-16 | 2010-08-17 | Northwestern University | Microchannel forming method and nanotipped dispensing device having a microchannel |
| US20050236566A1 (en) * | 2004-04-26 | 2005-10-27 | Chang Liu | Scanning probe microscope probe with integrated capillary channel |
| CA2564876C (en) * | 2004-04-30 | 2013-04-16 | Bioforce Nanosciences, Inc. | Method and apparatus for depositing material onto a surface |
| US8992454B2 (en) | 2004-06-09 | 2015-03-31 | Bard Access Systems, Inc. | Splitable tip catheter with bioresorbable adhesive |
| US7727225B2 (en) * | 2004-07-28 | 2010-06-01 | University Of Virginia Patent Foundation | Coaxial catheter systems for transference of medium |
| CN101123919A (zh) * | 2004-10-05 | 2008-02-13 | 建新公司 | 台阶式插管 |
| CA2581714C (en) | 2004-10-05 | 2017-09-12 | Avigen, Inc. | Stepped cannula |
| US7729780B2 (en) | 2004-10-21 | 2010-06-01 | Vardiman Arnold B | Various apparatus and methods for deep brain stimulating electrodes |
| AU2006200951B2 (en) | 2005-03-13 | 2012-01-19 | Integra LifeSciences Switzerland Sarl | Pressure sensing devices |
| US7510533B2 (en) | 2005-03-15 | 2009-03-31 | Codman & Shurtleff, Inc. | Pressure sensing valve |
| US10362947B2 (en) | 2005-03-15 | 2019-07-30 | Integra LifeSciences Switzerland Sarl | Pressure sensing devices |
| US20060211945A1 (en) | 2005-03-15 | 2006-09-21 | Codman & Shurtleff, Inc. | Pressure sensing methods |
| GB0512078D0 (en) | 2005-06-14 | 2005-07-20 | Gill Steven S | RF Coil structure |
| US7717853B2 (en) | 2005-06-24 | 2010-05-18 | Henry Nita | Methods and apparatus for intracranial ultrasound delivery |
| US7615050B2 (en) | 2005-06-27 | 2009-11-10 | Boston Scientific Scimed, Inc. | Systems and methods for creating a lesion using transjugular approach |
| US20070128083A1 (en) | 2005-07-18 | 2007-06-07 | U.S. Genomics, Inc. | Microfluidic methods and apparatuses for sample preparation and analysis |
| WO2007024841A2 (en) | 2005-08-23 | 2007-03-01 | The Regents Of The University Of California | Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery |
| US7967763B2 (en) | 2005-09-07 | 2011-06-28 | Cabochon Aesthetics, Inc. | Method for treating subcutaneous tissues |
| US8182444B2 (en) * | 2005-11-04 | 2012-05-22 | Medrad, Inc. | Delivery of agents such as cells to tissue |
| US20070191767A1 (en) * | 2005-12-16 | 2007-08-16 | Medtronic Vascular, Inc. | Bifurcated Catheter Joints |
| US8206334B2 (en) * | 2006-01-31 | 2012-06-26 | Kralick Francis A | Implantable micro-system for treatment of hydrocephalus |
| GB0603037D0 (en) | 2006-02-15 | 2006-03-29 | Renishaw Plc | Implantable fluid distribution device and a method of drug delivery |
| GB0604952D0 (en) | 2006-03-13 | 2006-04-19 | Renishaw Plc | A fluid connector for fluid delivery apparatus |
| GB0604929D0 (en) | 2006-03-13 | 2006-04-19 | Renishaw Plc | Method and apparatus for fluid delivery |
| US8795270B2 (en) | 2006-04-24 | 2014-08-05 | Covidien Ag | System and method for ablating tissue |
| WO2007133545A2 (en) | 2006-05-11 | 2007-11-22 | Ceramoptec Industries, Inc. | Device and method for improved vascular laser treatment |
| US20100030102A1 (en) | 2006-05-15 | 2010-02-04 | David Poston | Active Delivery and Flow Redirections: Novel Devices and Method of Delivery of Materials to Patients |
| US7998128B2 (en) | 2006-05-15 | 2011-08-16 | Therataxis, LLC. | Active delivery and flow redirection: novel devices and method of delivery of materials to patients |
| GB0612980D0 (en) | 2006-06-30 | 2006-08-09 | Renishaw Plc | Gas bearings |
| GB0612979D0 (en) | 2006-06-30 | 2006-08-09 | Renishaw Plc | Gas bearing fabrication method |
| WO2008005440A2 (en) | 2006-06-30 | 2008-01-10 | University Of Illinois | Monitoring and controlling hydrocephalus |
| GB0616411D0 (en) | 2006-08-18 | 2006-09-27 | Renishaw Plc | Neurosurgical instruments |
| US8403858B2 (en) * | 2006-10-12 | 2013-03-26 | Perceptive Navigation Llc | Image guided catheters and methods of use |
| KR20130014619A (ko) * | 2006-11-03 | 2013-02-07 | 리써치 트라이앵글 인스티튜트 | 굴곡 모드 압전 트랜스듀서를 사용하는 보강된 초음파 촬영 프로브 |
| US7842006B2 (en) * | 2006-11-17 | 2010-11-30 | Cfd Research Corporation | Thrombectomy microcatheter |
| GB0623395D0 (en) | 2006-11-23 | 2007-01-03 | Renishaw Plc | Port |
| WO2008106357A1 (en) * | 2007-02-27 | 2008-09-04 | Regents Of The University Of Minnesota | Thermochemical ablation of bodily tissue |
| US20080275466A1 (en) | 2007-05-01 | 2008-11-06 | James Grant Skakoon | Dual cannula system and method for using same |
| US7870616B2 (en) * | 2007-05-11 | 2011-01-11 | Csem Centre Suisse D'electronique Et De Microtechnique Sa | Probe arrangement |
| WO2008144585A1 (en) | 2007-05-17 | 2008-11-27 | Medgenesis Therapeutix Inc. | Convection-enhanced delivery catheter with removable stiffening member and method for using same |
| US20100121307A1 (en) * | 2007-08-24 | 2010-05-13 | Microfabrica Inc. | Microneedles, Microneedle Arrays, Methods for Making, and Transdermal and/or Intradermal Applications |
| US8147480B2 (en) | 2007-09-28 | 2012-04-03 | Codman & Shurtleff, Inc. | Catheter for reduced reflux in targeted tissue delivery of a therapeutic agent |
| US7766875B2 (en) | 2007-09-28 | 2010-08-03 | Codman & Shurtleff, Inc. | Catheter for reduced reflux in targeted tissue delivery of a therapeutic agent |
| WO2009045343A1 (en) | 2007-09-29 | 2009-04-09 | El Spectra, Llc | Instrumented pipette tip |
| CA2701132A1 (en) | 2007-10-08 | 2009-04-16 | Renishaw (Ireland) Limited | Apparatus for stereotactic neurosurgery |
| WO2009047490A2 (en) | 2007-10-08 | 2009-04-16 | Renishaw Plc | Catheter |
| GB0802634D0 (en) | 2008-02-13 | 2008-03-19 | Renishaw Plc | Catheter |
| GB0719608D0 (en) | 2007-10-08 | 2007-11-14 | Renishaw Plc | Medical Apparatus |
| US20090112278A1 (en) | 2007-10-30 | 2009-04-30 | Neuropace, Inc. | Systems, Methods and Devices for a Skull/Brain Interface |
| US8480626B2 (en) * | 2007-11-30 | 2013-07-09 | Medtronic, Inc. | Infusion catheter assembly with reduced backflow |
| WO2009086624A1 (en) | 2008-01-04 | 2009-07-16 | The Royal Institution For The Advancement Of Learning/Mcgill University | Microfluidic microarray system and method for the multiplexed analysis of biomolecules |
| ES2596360T3 (es) | 2008-01-16 | 2017-01-09 | Neurodyn Life Sciences Inc. | Progranulina para su uso en el tratamiento de enfermedad de Parkinson o enfermedad de Alzheimer |
| WO2010005479A1 (en) | 2008-06-16 | 2010-01-14 | Wayne State University | Method of making 3-dimensional neural probes having electrical and chemical interfaces |
| US9138559B2 (en) | 2008-06-16 | 2015-09-22 | Twin Star Medical, Inc | Flexible catheter |
| WO2010006293A2 (en) | 2008-07-10 | 2010-01-14 | Cornell University | Ultrasound wave generating apparatus |
| NL2003364A (en) | 2008-09-26 | 2010-03-29 | Asml Netherlands Bv | Lithographic apparatus and method. |
| US8539905B2 (en) * | 2008-11-07 | 2013-09-24 | The Research Foundation For The State University Of New York | Polymeric micro-cantilevers for ultra-low volume fluid and living cell deposition |
| US8540667B2 (en) | 2008-11-12 | 2013-09-24 | Sanovas, Inc. | Multi-balloon catheter for extravasated drug delivery |
| GB0820839D0 (en) | 2008-11-13 | 2008-12-24 | Renishaw Plc | Assessing and/or correcting tomogram errors |
| US8784360B2 (en) | 2009-01-21 | 2014-07-22 | Medtronic, Inc. | Catheter systems having flow restrictors |
| US20100185179A1 (en) * | 2009-01-21 | 2010-07-22 | Abbott Cardiovascular Systems Inc. | Needled cannula with filter device |
| TWI449551B (zh) | 2009-01-30 | 2014-08-21 | Terumo Corp | 注射針組合體以及藥劑注射裝置 |
| JP5838093B2 (ja) | 2009-02-24 | 2015-12-24 | クライン,ジョージ | 固定カテーテルシース |
| EP3827858A1 (en) | 2009-03-03 | 2021-06-02 | Becton, Dickinson and Company | Pen needle assembly for delivering drug solutions |
| US8602644B2 (en) | 2009-05-08 | 2013-12-10 | University Of North Texas | Multifunctional micropipette biological sensor |
| GB0908787D0 (en) | 2009-05-21 | 2009-07-01 | Renishaw Plc | Head clamp for imaging and neurosurgery |
| GB0908784D0 (en) | 2009-05-21 | 2009-07-01 | Renishaw Plc | Apparatus for imaging a body part |
| US20110003330A1 (en) | 2009-07-06 | 2011-01-06 | Durack Gary P | Microfluidic device |
| CA2771175C (en) * | 2009-08-25 | 2017-12-05 | The Regents Of The Univeristy Of California | Optimized placement of cannula for delivery of therapeutics to the brain |
| US9936884B2 (en) | 2009-10-28 | 2018-04-10 | Megan Mikhail | Method and system for treating hypotension |
| US9498271B2 (en) * | 2009-10-29 | 2016-11-22 | Cook Medical Technologies Llc | Coaxial needle cannula with distal spiral mixer and side ports for fluid injection |
| US8814853B2 (en) | 2009-10-29 | 2014-08-26 | Cook Medical Technologies Llc | Thermochemical ablation needle |
| US20110301235A1 (en) | 2009-12-02 | 2011-12-08 | Alquest Therapeutics, Inc. | Organoselenium compounds and uses thereof |
| GB201002370D0 (en) | 2010-02-12 | 2010-03-31 | Renishaw Ireland Ltd | Percutaneous drug delivery apparatus |
| US10537725B2 (en) * | 2010-03-05 | 2020-01-21 | Cornell University | Ultrasound-assisted convection enhanced delivery of compounds in vivo with a transducer cannula assembly |
| CN102844064A (zh) | 2010-03-31 | 2012-12-26 | 泰尔茂株式会社 | 预灌封注射器 |
| JP2013540981A (ja) | 2010-04-30 | 2013-11-07 | レニショウ パブリック リミテッド カンパニー | 計測装置 |
| US20120019270A1 (en) | 2010-07-21 | 2012-01-26 | Amodei Dario G | Microfabricated pipette and method of manufacture |
| US9498248B2 (en) | 2010-10-05 | 2016-11-22 | Medtronic, Inc. | Retainer for immobilizing an implanted catheter during stylet retraction, and stylet holder for use with same |
| WO2012068283A1 (en) | 2010-11-16 | 2012-05-24 | C2C Development, Llc | Seal tip catheter devices or methods |
| EP2672903A4 (en) | 2011-02-10 | 2017-07-12 | Actuated Medical, Inc. | Medical tool with electromechanical control and feedback |
| WO2012145652A1 (en) | 2011-04-20 | 2012-10-26 | Trustees Of Tufts College | Dynamic silk coatings for implantable devices |
| US9138343B2 (en) | 2011-05-31 | 2015-09-22 | Bayer Healthcare Llc | Tip protector sleeve |
| CA3125150A1 (en) | 2011-08-01 | 2013-02-07 | Alcyone Lifesciences, Inc. | Microfluidic drug delivery devices |
| US20130079596A1 (en) | 2011-09-23 | 2013-03-28 | Todd Edward Smith | Dynamic surgical fluid sensing |
| US8753344B2 (en) * | 2011-09-23 | 2014-06-17 | Smith & Nephew, Inc. | Dynamic orthoscopic sensing |
| US9539389B2 (en) | 2012-02-08 | 2017-01-10 | Stmicroelectronics, Inc. | Wireless flow sensor using present flow rate data |
| US9255245B2 (en) * | 2012-07-03 | 2016-02-09 | Agilent Technologies, Inc. | Sample probes and methods for sampling intracellular material |
| US10751513B2 (en) | 2012-07-24 | 2020-08-25 | Renishaw Plc | Neurosurgical apparatus and methods |
| US10188396B2 (en) | 2012-08-06 | 2019-01-29 | Covidien Lp | Apparatus and method for delivering an embolic composition |
| US9919129B2 (en) | 2012-12-18 | 2018-03-20 | Alcyone Lifesciences, Inc. | Systems and methods for reducing or preventing backflow in a delivery system |
| US9539382B2 (en) | 2013-03-12 | 2017-01-10 | Medtronic, Inc. | Stepped catheters with flow restrictors and infusion systems using the same |
| WO2014204954A1 (en) | 2013-06-17 | 2014-12-24 | Alcyone Lifesciences, Inc. | Methods and devices for protecting catheter tips and stereotactic fixtures for microcatheters |
| ES2738298T3 (es) | 2013-07-31 | 2020-01-21 | Alcyone Lifesciences Inc | Sistemas y métodos de suministro de fármacos, tratamiento y monitoreo |
| US10806396B2 (en) | 2015-01-26 | 2020-10-20 | Alcyone Lifesciences, Inc. | Drug delivery methods with tracer |
| WO2016183123A1 (en) * | 2015-05-11 | 2016-11-17 | Alcyone Lifesciences, Inc. | Drug delivery systems and methods |
-
2012
- 2012-08-01 CA CA3125150A patent/CA3125150A1/en active Pending
- 2012-08-01 US US13/563,786 patent/US10137244B2/en active Active
- 2012-08-01 CA CA3050475A patent/CA3050475C/en active Active
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- 2018-11-13 US US16/188,402 patent/US20190117886A1/en not_active Abandoned
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- 2021-03-02 AU AU2021201360A patent/AU2021201360A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100098767A1 (en) * | 2007-02-13 | 2010-04-22 | Olbricht William L | Convection enhanced delivery apparatus, method, and application |
| US20090124976A1 (en) * | 2007-11-14 | 2009-05-14 | Stephan Mittermeyer | Drug supply system for ced (convection-enhanced delivery) catheter infusions |
| WO2010081072A2 (en) * | 2009-01-12 | 2010-07-15 | Becton, Dickinson And Company | Optimized intracranial catheters for convection-enhanced delivery of therapeutics |
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