AU2011367230B2 - Peptide oligonucleotide conjugates - Google Patents
Peptide oligonucleotide conjugates Download PDFInfo
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- AU2011367230B2 AU2011367230B2 AU2011367230A AU2011367230A AU2011367230B2 AU 2011367230 B2 AU2011367230 B2 AU 2011367230B2 AU 2011367230 A AU2011367230 A AU 2011367230A AU 2011367230 A AU2011367230 A AU 2011367230A AU 2011367230 B2 AU2011367230 B2 AU 2011367230B2
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- Australia
- Prior art keywords
- conjugate
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- carrier peptide
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
- A61K47/6455—Polycationic oligopeptides, polypeptides or polyamino acids, e.g. for complexing nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2017206179A AU2017206179A1 (en) | 2011-05-05 | 2017-07-18 | Peptide oligonucleotide conjugates |
AU2019204913A AU2019204913A1 (en) | 2011-05-05 | 2019-07-09 | Peptide oligonucleotide conjugates |
AU2021202224A AU2021202224A1 (en) | 2011-05-05 | 2021-04-13 | Peptide oligonucleotide conjugates |
AU2023203112A AU2023203112A1 (en) | 2011-05-05 | 2023-05-18 | Peptide oligonucleotide conjugates |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/101,942 | 2011-05-05 | ||
US13/101,942 US20110269665A1 (en) | 2009-06-26 | 2011-05-05 | Compound and method for treating myotonic dystrophy |
US13/107,528 | 2011-05-13 | ||
US13/107,528 US9238042B2 (en) | 2010-05-13 | 2011-05-13 | Antisense modulation of interleukins 17 and 23 signaling |
PCT/US2011/061282 WO2012150960A1 (en) | 2011-05-05 | 2011-11-17 | Peptide oligonucleotide conjugates |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2017206179A Division AU2017206179A1 (en) | 2011-05-05 | 2017-07-18 | Peptide oligonucleotide conjugates |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2011367230A1 AU2011367230A1 (en) | 2013-12-05 |
AU2011367230B2 true AU2011367230B2 (en) | 2017-08-10 |
Family
ID=45218873
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2011367230A Active AU2011367230B2 (en) | 2011-05-05 | 2011-11-17 | Peptide oligonucleotide conjugates |
AU2017206179A Abandoned AU2017206179A1 (en) | 2011-05-05 | 2017-07-18 | Peptide oligonucleotide conjugates |
AU2019204913A Abandoned AU2019204913A1 (en) | 2011-05-05 | 2019-07-09 | Peptide oligonucleotide conjugates |
AU2021202224A Abandoned AU2021202224A1 (en) | 2011-05-05 | 2021-04-13 | Peptide oligonucleotide conjugates |
AU2023203112A Pending AU2023203112A1 (en) | 2011-05-05 | 2023-05-18 | Peptide oligonucleotide conjugates |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2017206179A Abandoned AU2017206179A1 (en) | 2011-05-05 | 2017-07-18 | Peptide oligonucleotide conjugates |
AU2019204913A Abandoned AU2019204913A1 (en) | 2011-05-05 | 2019-07-09 | Peptide oligonucleotide conjugates |
AU2021202224A Abandoned AU2021202224A1 (en) | 2011-05-05 | 2021-04-13 | Peptide oligonucleotide conjugates |
AU2023203112A Pending AU2023203112A1 (en) | 2011-05-05 | 2023-05-18 | Peptide oligonucleotide conjugates |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP2704749A1 (hr) |
JP (6) | JP6478632B2 (hr) |
KR (3) | KR102229650B1 (hr) |
CN (2) | CN107693797B (hr) |
AU (5) | AU2011367230B2 (hr) |
CA (2) | CA3092114A1 (hr) |
IL (2) | IL273838B (hr) |
WO (1) | WO2012150960A1 (hr) |
Families Citing this family (87)
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PT1766010E (pt) | 2004-06-28 | 2011-05-25 | Univ Western Australia | Oligonucle?tidos antisense para a indu??o de skipping de ex?es e seus m?todos de utiliza??o |
AU2006213686A1 (en) | 2005-02-09 | 2006-08-17 | Avi Bio Pharma, Inc. | Antisense composition and method for treating muscle atrophy |
CA2660523C (en) | 2006-08-11 | 2019-03-19 | Prosensa Technologies B.V. | Methods and means for treating dna repeat instability associated genetic disorders |
US20100016215A1 (en) | 2007-06-29 | 2010-01-21 | Avi Biopharma, Inc. | Compound and method for treating myotonic dystrophy |
CN105641700B (zh) | 2007-10-26 | 2021-01-01 | 莱顿教学医院 | 对抗肌肉病症的方式和方法 |
EP2119783A1 (en) | 2008-05-14 | 2009-11-18 | Prosensa Technologies B.V. | Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means |
BRPI0920276B1 (pt) | 2008-10-24 | 2021-06-08 | Sarepta Therapeutics, Inc | oligonucleotídeo antissenso, composição que compreende o mesmo e uso do dito oligonucleotídeo para tratar distrofia muscular |
RS58079B1 (sr) | 2009-11-12 | 2019-02-28 | Univ Western Australia | Antisens molekuli i postupci za tretman patologija |
TWI541024B (zh) | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
US20130085139A1 (en) | 2011-10-04 | 2013-04-04 | Royal Holloway And Bedford New College | Oligomers |
CN111808135A (zh) * | 2011-11-18 | 2020-10-23 | 萨勒普塔医疗公司 | 功能改性的寡核苷酸及其亚单元 |
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CN104203289B (zh) | 2012-01-27 | 2020-11-03 | 比奥马林技术公司 | 用于治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸 |
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CN118109469A (zh) | 2019-12-26 | 2024-05-31 | 日本新药株式会社 | 诱导外显子50的跳读的反义核酸 |
JPWO2021167107A1 (hr) | 2020-02-22 | 2021-08-26 | ||
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JP2018135396A (ja) | 2018-08-30 |
KR102339196B1 (ko) | 2021-12-15 |
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JP2024032974A (ja) | 2024-03-12 |
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AU2019204913A1 (en) | 2019-07-25 |
CN103619356B (zh) | 2017-09-12 |
KR102183273B1 (ko) | 2020-11-27 |
JP6884250B2 (ja) | 2021-06-09 |
AU2017206179A1 (en) | 2017-08-03 |
IL273838A (en) | 2020-05-31 |
JP2021113232A (ja) | 2021-08-05 |
JP2016185991A (ja) | 2016-10-27 |
CN107693797B (zh) | 2021-05-11 |
AU2011367230A1 (en) | 2013-12-05 |
WO2012150960A1 (en) | 2012-11-08 |
CA2834128A1 (en) | 2012-11-08 |
JP2020111607A (ja) | 2020-07-27 |
CA3092114A1 (en) | 2012-11-08 |
KR20210032545A (ko) | 2021-03-24 |
CN103619356A (zh) | 2014-03-05 |
JP6478632B2 (ja) | 2019-03-06 |
IL229227A0 (en) | 2014-01-30 |
IL229227B (en) | 2020-07-30 |
KR102229650B1 (ko) | 2021-03-19 |
JP2014515762A (ja) | 2014-07-03 |
CN107693797A (zh) | 2018-02-16 |
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