AU2009326196B2 - Dihydroetorphines and Their Preparation - Google Patents

Dihydroetorphines and Their Preparation Download PDF

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Publication number
AU2009326196B2
AU2009326196B2 AU2009326196A AU2009326196A AU2009326196B2 AU 2009326196 B2 AU2009326196 B2 AU 2009326196B2 AU 2009326196 A AU2009326196 A AU 2009326196A AU 2009326196 A AU2009326196 A AU 2009326196A AU 2009326196 B2 AU2009326196 B2 AU 2009326196B2
Authority
AU
Australia
Prior art keywords
compound
formula
dose
test
dhe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2009326196A
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English (en)
Other versions
AU2009326196A2 (en
AU2009326196A1 (en
Inventor
Deborah Phyllis Harding
Carl David Turner
Steve Whitelock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42046251&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2009326196(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0822342A external-priority patent/GB0822342D0/en
Priority claimed from GB0920699A external-priority patent/GB0920699D0/en
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Publication of AU2009326196A1 publication Critical patent/AU2009326196A1/en
Assigned to EURO-CELTIQUE S.A. reassignment EURO-CELTIQUE S.A. Amend patent request/document other than specification (104) Assignors: EURO-CELTIQUE S.A.
Publication of AU2009326196A2 publication Critical patent/AU2009326196A2/en
Application granted granted Critical
Publication of AU2009326196B2 publication Critical patent/AU2009326196B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2009326196A 2008-12-08 2009-12-04 Dihydroetorphines and Their Preparation Ceased AU2009326196B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0822342A GB0822342D0 (en) 2008-12-08 2008-12-08 Dihydroetorphine
GB0822342.2 2008-12-08
GB0920699A GB0920699D0 (en) 2009-11-26 2009-11-26 Dihydroetorphine
GB0920699.6 2009-11-26
PCT/GB2009/051655 WO2010067101A1 (en) 2008-12-08 2009-12-04 Dihydroetorphines and their preparation

Publications (3)

Publication Number Publication Date
AU2009326196A1 AU2009326196A1 (en) 2011-06-23
AU2009326196A2 AU2009326196A2 (en) 2012-08-30
AU2009326196B2 true AU2009326196B2 (en) 2016-08-11

Family

ID=42046251

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009326196A Ceased AU2009326196B2 (en) 2008-12-08 2009-12-04 Dihydroetorphines and Their Preparation

Country Status (31)

Country Link
US (4) US20120010231A1 (enExample)
EP (2) EP2370443B1 (enExample)
JP (2) JP5787764B2 (enExample)
KR (2) KR20170082665A (enExample)
CN (2) CN104119349B (enExample)
AR (1) AR074545A1 (enExample)
AU (1) AU2009326196B2 (enExample)
CA (1) CA2745537C (enExample)
CL (1) CL2011001363A1 (enExample)
CY (1) CY1116875T1 (enExample)
DK (1) DK2370443T3 (enExample)
EA (1) EA022210B1 (enExample)
ES (1) ES2548881T3 (enExample)
HR (1) HRP20151138T1 (enExample)
HU (1) HUE025913T2 (enExample)
IL (1) IL213207B (enExample)
ME (1) ME02262B (enExample)
MX (2) MX359363B (enExample)
MY (1) MY159913A (enExample)
NZ (1) NZ593102A (enExample)
PA (1) PA8852801A1 (enExample)
PL (1) PL2370443T3 (enExample)
PT (1) PT2370443E (enExample)
RS (1) RS54309B1 (enExample)
SG (1) SG171456A1 (enExample)
SI (1) SI2370443T1 (enExample)
SM (1) SMT201500273B (enExample)
TW (2) TWI630208B (enExample)
UY (1) UY32295A (enExample)
WO (1) WO2010067101A1 (enExample)
ZA (1) ZA201104161B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI630208B (zh) 2008-12-08 2018-07-21 歐陸斯迪公司 二氫羥戊甲嗎啡
EP2941433B1 (en) 2012-12-31 2019-08-07 Rhodes Technologies Process for preparing 7 -substituted 6 ,14 -ethenomorphinans and 7 -substituted 6 ,14 -ethanomorphinans
GB201309654D0 (en) 2013-05-30 2013-07-17 Euro Celtique Sa Method
EP3023427A1 (en) * 2014-11-19 2016-05-25 Siegfried AG Improved method of manufacturing buprenorphine and analogues thereof from oripavine
EP3067357A1 (en) * 2015-03-11 2016-09-14 Siegfried AG Method of manufacturing stereoisomers of buprenorphine and analogues thereof
GB201513441D0 (en) * 2015-07-30 2015-09-16 Euro Celtique Sa Transdermal delivery system
GB201513442D0 (en) * 2015-07-30 2015-09-16 Euro Celtique Sa Transdermal patch
CN114105875B (zh) * 2021-12-06 2023-11-03 四川大学 一种吗啡衍生物二氢埃托啡的合成方法
EP4613751A1 (en) 2024-03-07 2025-09-10 Siegfried AG Method of making chemical compounds useful for the synthesis of buprenorphine

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Publication number Publication date
JP6151307B2 (ja) 2017-06-21
AU2009326196A2 (en) 2012-08-30
KR20170082665A (ko) 2017-07-14
NZ593102A (en) 2013-10-25
PL2370443T3 (pl) 2016-01-29
US9481681B2 (en) 2016-11-01
DK2370443T3 (en) 2015-11-09
US20170267687A1 (en) 2017-09-21
MY159913A (en) 2017-02-15
HK1161720A1 (en) 2012-08-03
MX2011006095A (es) 2011-09-22
EA201170781A1 (ru) 2012-01-30
EP3018133A1 (en) 2016-05-11
RS54309B1 (sr) 2016-02-29
TWI630208B (zh) 2018-07-21
EP2370443A1 (en) 2011-10-05
MX359363B (es) 2018-09-26
SI2370443T1 (sl) 2015-12-31
CN104119349B (zh) 2017-04-12
EA022210B1 (ru) 2015-11-30
JP2012510985A (ja) 2012-05-17
KR101992272B1 (ko) 2019-06-24
CN102307877A (zh) 2012-01-04
IL213207B (en) 2018-01-31
CN104119349A (zh) 2014-10-29
AR074545A1 (es) 2011-01-26
KR20110098801A (ko) 2011-09-01
JP2015157864A (ja) 2015-09-03
CA2745537C (en) 2017-01-17
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PA8852801A1 (es) 2010-04-21
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UY32295A (es) 2010-06-30
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WO2010067101A1 (en) 2010-06-17
US10745406B2 (en) 2020-08-18
PT2370443E (pt) 2015-10-23
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TW201531476A (zh) 2015-08-16
AU2009326196A1 (en) 2011-06-23
ZA201104161B (en) 2016-05-25
EP2370443B1 (en) 2015-08-05
SMT201500273B (it) 2016-01-08
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US9206190B2 (en) 2015-12-08

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