KR101992272B1 - 디히드로에토르핀 및 그의 제조 - Google Patents

디히드로에토르핀 및 그의 제조 Download PDF

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Publication number
KR101992272B1
KR101992272B1 KR1020117015829A KR20117015829A KR101992272B1 KR 101992272 B1 KR101992272 B1 KR 101992272B1 KR 1020117015829 A KR1020117015829 A KR 1020117015829A KR 20117015829 A KR20117015829 A KR 20117015829A KR 101992272 B1 KR101992272 B1 KR 101992272B1
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South Korea
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compound
formula
administration
test
reaction
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Expired - Fee Related
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KR1020117015829A
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English (en)
Korean (ko)
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KR20110098801A (ko
Inventor
스티브 화이트락
데보라 필리스 하딩
칼 데이비드 터너
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유로-셀띠끄 소시에떼 아노님
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42046251&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR101992272(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0822342A external-priority patent/GB0822342D0/en
Priority claimed from GB0920699A external-priority patent/GB0920699D0/en
Application filed by 유로-셀띠끄 소시에떼 아노님 filed Critical 유로-셀띠끄 소시에떼 아노님
Publication of KR20110098801A publication Critical patent/KR20110098801A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020117015829A 2008-12-08 2009-12-04 디히드로에토르핀 및 그의 제조 Expired - Fee Related KR101992272B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0822342.2 2008-12-08
GB0822342A GB0822342D0 (en) 2008-12-08 2008-12-08 Dihydroetorphine
GB0920699.6 2009-11-26
GB0920699A GB0920699D0 (en) 2009-11-26 2009-11-26 Dihydroetorphine
PCT/GB2009/051655 WO2010067101A1 (en) 2008-12-08 2009-12-04 Dihydroetorphines and their preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020177018820A Division KR20170082665A (ko) 2008-12-08 2009-12-04 디히드로에토르핀 및 그의 제조

Publications (2)

Publication Number Publication Date
KR20110098801A KR20110098801A (ko) 2011-09-01
KR101992272B1 true KR101992272B1 (ko) 2019-06-24

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ID=42046251

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020177018820A Ceased KR20170082665A (ko) 2008-12-08 2009-12-04 디히드로에토르핀 및 그의 제조
KR1020117015829A Expired - Fee Related KR101992272B1 (ko) 2008-12-08 2009-12-04 디히드로에토르핀 및 그의 제조

Family Applications Before (1)

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KR1020177018820A Ceased KR20170082665A (ko) 2008-12-08 2009-12-04 디히드로에토르핀 및 그의 제조

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US (4) US20120010231A1 (enExample)
EP (2) EP2370443B1 (enExample)
JP (2) JP5787764B2 (enExample)
KR (2) KR20170082665A (enExample)
CN (2) CN104119349B (enExample)
AR (1) AR074545A1 (enExample)
AU (1) AU2009326196B2 (enExample)
CA (1) CA2745537C (enExample)
CL (1) CL2011001363A1 (enExample)
CY (1) CY1116875T1 (enExample)
DK (1) DK2370443T3 (enExample)
EA (1) EA022210B1 (enExample)
ES (1) ES2548881T3 (enExample)
HR (1) HRP20151138T1 (enExample)
HU (1) HUE025913T2 (enExample)
IL (1) IL213207B (enExample)
ME (1) ME02262B (enExample)
MX (2) MX2011006095A (enExample)
MY (1) MY159913A (enExample)
NZ (1) NZ593102A (enExample)
PA (1) PA8852801A1 (enExample)
PL (1) PL2370443T3 (enExample)
PT (1) PT2370443E (enExample)
RS (1) RS54309B1 (enExample)
SG (1) SG171456A1 (enExample)
SI (1) SI2370443T1 (enExample)
SM (1) SMT201500273B (enExample)
TW (2) TWI541246B (enExample)
UY (1) UY32295A (enExample)
WO (1) WO2010067101A1 (enExample)
ZA (1) ZA201104161B (enExample)

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TWI541246B (zh) 2008-12-08 2016-07-11 歐陸斯迪公司 二氫羥戊甲嗎啡
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CN114105875B (zh) * 2021-12-06 2023-11-03 四川大学 一种吗啡衍生物二氢埃托啡的合成方法
EP4613751A1 (en) 2024-03-07 2025-09-10 Siegfried AG Method of making chemical compounds useful for the synthesis of buprenorphine

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Also Published As

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AU2009326196B2 (en) 2016-08-11
CN104119349B (zh) 2017-04-12
PL2370443T3 (pl) 2016-01-29
EA201170781A1 (ru) 2012-01-30
TW201022274A (en) 2010-06-16
PT2370443E (pt) 2015-10-23
US20170267687A1 (en) 2017-09-21
ME02262B (me) 2016-02-29
SG171456A1 (en) 2011-07-28
JP5787764B2 (ja) 2015-09-30
KR20110098801A (ko) 2011-09-01
HK1161720A1 (en) 2012-08-03
AR074545A1 (es) 2011-01-26
SI2370443T1 (sl) 2015-12-31
AU2009326196A2 (en) 2012-08-30
JP6151307B2 (ja) 2017-06-21
WO2010067101A1 (en) 2010-06-17
HRP20151138T1 (hr) 2015-11-20
ES2548881T3 (es) 2015-10-21
US20120010231A1 (en) 2012-01-12
US9481681B2 (en) 2016-11-01
JP2012510985A (ja) 2012-05-17
MX359363B (es) 2018-09-26
MX2011006095A (es) 2011-09-22
AU2009326196A1 (en) 2011-06-23
CY1116875T1 (el) 2017-04-05
UY32295A (es) 2010-06-30
CA2745537A1 (en) 2010-06-17
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