AU2009246870B2 - Controlled release corticosteroid compositions and methods for the treatment of otic disorders - Google Patents
Controlled release corticosteroid compositions and methods for the treatment of otic disorders Download PDFInfo
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- AU2009246870B2 AU2009246870B2 AU2009246870A AU2009246870A AU2009246870B2 AU 2009246870 B2 AU2009246870 B2 AU 2009246870B2 AU 2009246870 A AU2009246870 A AU 2009246870A AU 2009246870 A AU2009246870 A AU 2009246870A AU 2009246870 B2 AU2009246870 B2 AU 2009246870B2
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- dexamethasone
- auris
- formulations
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 229940029614 triethanolamine stearate Drugs 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
- 229960001082 trimethoprim Drugs 0.000 description 1
- 239000003656 tris buffered saline Substances 0.000 description 1
- 229960004418 trolamine Drugs 0.000 description 1
- 229960005041 troleandomycin Drugs 0.000 description 1
- LQCLVBQBTUVCEQ-QTFUVMRISA-N troleandomycin Chemical compound O1[C@@H](C)[C@H](OC(C)=O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)OC(C)=O)[C@H]1C LQCLVBQBTUVCEQ-QTFUVMRISA-N 0.000 description 1
- 229920001664 tyloxapol Polymers 0.000 description 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 description 1
- 229960004224 tyloxapol Drugs 0.000 description 1
- 229950008396 ulobetasol propionate Drugs 0.000 description 1
- BDSYKGHYMJNPAB-LICBFIPMSA-N ulobetasol propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H](C)[C@@](C(=O)CCl)(OC(=O)CC)[C@@]2(C)C[C@@H]1O BDSYKGHYMJNPAB-LICBFIPMSA-N 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- 238000000214 vapour pressure osmometry Methods 0.000 description 1
- 230000003639 vasoconstrictive effect Effects 0.000 description 1
- 239000003038 vasopressin antagonist Substances 0.000 description 1
- 210000003273 vestibular nerve Anatomy 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- GXFAIFRPOKBQRV-GHXCTMGLSA-N viomycin Chemical compound N1C(=O)\C(=C\NC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)C[C@@H](N)CCCN)CNC(=O)[C@@H]1[C@@H]1NC(=N)N[C@@H](O)C1 GXFAIFRPOKBQRV-GHXCTMGLSA-N 0.000 description 1
- 229950001272 viomycin Drugs 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12771308P | 2008-05-14 | 2008-05-14 | |
| US61/127,713 | 2008-05-14 | ||
| US6042508P | 2008-06-10 | 2008-06-10 | |
| US61/060,425 | 2008-06-10 | ||
| US7458308P | 2008-06-20 | 2008-06-20 | |
| US61/074,583 | 2008-06-20 | ||
| US8245008P | 2008-07-21 | 2008-07-21 | |
| US61/082,450 | 2008-07-21 | ||
| US8794008P | 2008-08-11 | 2008-08-11 | |
| US61/087,940 | 2008-08-11 | ||
| US9438408P | 2008-09-04 | 2008-09-04 | |
| US61/094,384 | 2008-09-04 | ||
| US9524808P | 2008-09-08 | 2008-09-08 | |
| US61/095,248 | 2008-09-08 | ||
| US10111208P | 2008-09-29 | 2008-09-29 | |
| US61/101,112 | 2008-09-29 | ||
| US14003308P | 2008-12-22 | 2008-12-22 | |
| US61/140,033 | 2008-12-22 | ||
| GB0823378.5 | 2008-12-22 | ||
| GB0823378A GB2459910B (en) | 2008-04-21 | 2008-12-22 | Controlled Release Corticosteroid Compositions and Methods for the Treatment of Otic Disorders |
| PCT/US2009/003066 WO2009139924A2 (en) | 2008-05-14 | 2009-05-14 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
Publications (2)
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| AU2009246870A1 AU2009246870A1 (en) | 2009-11-19 |
| AU2009246870B2 true AU2009246870B2 (en) | 2013-08-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009246870A Ceased AU2009246870B2 (en) | 2008-05-14 | 2009-05-14 | Controlled release corticosteroid compositions and methods for the treatment of otic disorders |
Country Status (14)
| Country | Link |
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| US (9) | US8030297B2 (enExample) |
| EP (1) | EP2303227B1 (enExample) |
| JP (3) | JP5551685B2 (enExample) |
| KR (2) | KR101477329B1 (enExample) |
| CN (2) | CN102026623B (enExample) |
| AU (1) | AU2009246870B2 (enExample) |
| BR (1) | BRPI0912482A2 (enExample) |
| CA (1) | CA2723458C (enExample) |
| IL (2) | IL208806A (enExample) |
| MX (1) | MX2010012397A (enExample) |
| MY (1) | MY161021A (enExample) |
| RU (2) | RU2469726C2 (enExample) |
| WO (1) | WO2009139924A2 (enExample) |
| ZA (1) | ZA201007482B (enExample) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130079749A1 (en) * | 2007-08-29 | 2013-03-28 | Advanced Bionics, Llc | Modular Drug Delivery System for Minimizing Trauma During and After Insertion of a Cochlear Lead |
| CA2716390C (en) | 2008-02-25 | 2016-08-23 | Eyegate Pharma S.A.S. | Enhanced delivery of a therapeutic to ocular tissues through iontophoresis |
| MX2010011545A (es) | 2008-04-21 | 2011-04-11 | Otonomy Inc | Formulaciones para tratar enfermedades y afecciones del oido. |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| JP5551685B2 (ja) | 2008-05-14 | 2014-07-16 | オトノミ―，インク． | 制御放出型コルチコステロイド組成物、および耳の疾患を処置する方法 |
| US8648119B2 (en) * | 2008-05-23 | 2014-02-11 | Otonomy, Inc. | Controlled release immunomodulator compositions and methods for the treatment of otic disorders |
| US8846770B2 (en) * | 2008-06-18 | 2014-09-30 | Otonomy, Inc. | Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders |
| WO2010011466A2 (en) | 2008-06-27 | 2010-01-28 | Otonomy, Inc. | Controlled-release cns modulating compositions and methods for the treatment of otic disorders |
| US8349353B2 (en) * | 2008-06-27 | 2013-01-08 | Otonomy, Inc. | Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders |
| JP5491502B2 (ja) * | 2008-07-14 | 2014-05-14 | オトノミ―，インク． | 制御放出アポトーシス調節化合物および耳の障害の処置のための方法 |
| US8318817B2 (en) | 2008-07-21 | 2012-11-27 | Otonomy, Inc. | Controlled release antimicrobial compositions and methods for the treatment of otic disorders |
| US8784870B2 (en) * | 2008-07-21 | 2014-07-22 | Otonomy, Inc. | Controlled release compositions for modulating free-radical induced damage and methods of use thereof |
| US20100016450A1 (en) * | 2008-07-21 | 2010-01-21 | Otonomy, Inc. | Controlled release delivery devices for the treatment of otic disorders |
| US8399018B2 (en) * | 2008-07-21 | 2013-03-19 | Otonomy, Inc. | Controlled release ion channel modulator compositions and methods for the treatment of otic disorders |
| EP2306975A4 (en) * | 2008-07-21 | 2012-10-31 | Otonomy Inc | COMPOSITIONS WITH A TAXED RELEASE FOR MODULATING THE EARM STRUCTURE AND THE BORN IMMUNE SYSTEM, AND METHODS OF TREATING EAR OR DISEASE |
| US8496957B2 (en) | 2008-07-21 | 2013-07-30 | Otonomy, Inc | Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders |
| AU2009307825A1 (en) | 2008-10-22 | 2010-04-29 | Rick FRIEDMAN | Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor |
| CN106344495A (zh) * | 2008-12-22 | 2017-01-25 | 奥德纳米有限公司 | 用于治疗耳部病症的控制释放耳感觉细胞调节剂组合物 |
| US20140076336A1 (en) * | 2009-09-17 | 2014-03-20 | Ascentia Health, Inc. | Ear insert for relief of tmj discomfort and headaches |
| AU2010302350B2 (en) | 2009-10-02 | 2015-06-18 | Journey Medical Corporation | Surfactant-free water-free foamable compositions, breakable foams and gels and their uses |
| US20120277199A1 (en) * | 2009-10-21 | 2012-11-01 | Otonomy, Inc. | Modulation of Gel Temperature of Poloxamer-Containing Formulations |
| WO2012112810A1 (en) * | 2011-02-18 | 2012-08-23 | Otonomy, Inc. | Prevention of and recovery from drug-induced ototoxicity |
| US20140142191A1 (en) * | 2011-07-20 | 2014-05-22 | Theracoat Ltd. | Production of thermoreversible hydrogels for therapeutic applications |
| DK2773325T3 (en) * | 2011-11-04 | 2019-01-14 | Enceladus Pharmaceuticals B V | LIPOSOMAL CORTICOSTEROIDS FOR TREATMENT OF INFLAMMATORY DISORDERS BY HUMANS |
| CA2862406C (en) | 2012-01-10 | 2024-06-18 | Entrx LLC | Otic formulations, methods and devices |
| CA2883896C (en) | 2012-09-07 | 2023-03-07 | Massachusetts Eye & Ear Infirmary | Treating hearing loss |
| WO2014056097A1 (en) | 2012-10-12 | 2014-04-17 | Litens Automotive Partnership | Isolator for use with engine that is assisted or started by an mgu or a motor through an endless drive member |
| US9849126B2 (en) | 2013-01-03 | 2017-12-26 | Entrx LLC | Sterile otic formulations |
| AU2014209346B2 (en) | 2013-01-23 | 2018-11-15 | Semnur Pharmaceuticals, Inc. | Pharmaceutical formulation comprising an insoluble corticosteroid and a soluble corticosteroid |
| US9468620B2 (en) | 2013-02-28 | 2016-10-18 | Andida Pharma, Inc. | Methods of treating ototoxicity |
| ES2727714T3 (es) * | 2013-04-25 | 2019-10-18 | Seachaid Pharmaceuticals Inc | Composiciones de cefepima orales y uso de las mismas |
| KR102373982B1 (ko) | 2013-08-21 | 2022-03-14 | 센세오닉스, 인코포레이티드 | 생-감지 분석물의 생체 내 보호를 위한 약물 용출 |
| EA201690323A1 (ru) | 2013-08-27 | 2016-07-29 | Отономи, Инк. | Способы лечения заболеваний уха у детей |
| CN103751779A (zh) * | 2014-02-25 | 2014-04-30 | 中国农业科学院上海兽医研究所 | O型口蹄疫多肽的泊洛沙姆凝胶佐剂 |
| CN104644545A (zh) * | 2015-02-27 | 2015-05-27 | 苏州丝美特生物技术有限公司 | 一种治疗内耳疾病的控释缓释丝素蛋白凝胶制剂 |
| KR101628707B1 (ko) * | 2014-05-29 | 2016-06-10 | 한남대학교 산학협력단 | 난청 치료용 약물 전달 시스템 및 이의 제조방법 |
| JP2017522360A (ja) * | 2014-07-29 | 2017-08-10 | オトノミー，インク． | 耳垢症の処置のための耳科用製剤 |
| FR3024361B1 (fr) * | 2014-07-30 | 2017-11-24 | Affichem | Utilisation de derives de sterols pour traitement de la perte auditive neurosensorielle et composition correspondante |
| TWI674899B (zh) | 2015-01-21 | 2019-10-21 | 美商桑紐爾製藥公司 | 醫藥配方 |
| US9155775B1 (en) | 2015-01-28 | 2015-10-13 | Teva Pharmaceutical Industries, Ltd. | Process for manufacturing glatiramer acetate product |
| US9687526B2 (en) | 2015-01-30 | 2017-06-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9744209B2 (en) | 2015-01-30 | 2017-08-29 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9750785B2 (en) | 2015-01-30 | 2017-09-05 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9937223B2 (en) | 2015-01-30 | 2018-04-10 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9925233B2 (en) | 2015-01-30 | 2018-03-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9744239B2 (en) | 2015-01-30 | 2017-08-29 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| TWI773641B (zh) | 2015-05-08 | 2022-08-11 | 日商活效製藥股份有限公司 | 含有糖皮質類固醇（ｇｌｕｃｏｃｏｒｔｉｃｏｉｄｓ）之奈米微粒子之水性懸浮液劑 |
| KR20180037994A (ko) * | 2015-07-28 | 2018-04-13 | 오토노미, 인코포레이티드 | TrkB 또는 TrkC 아고니스트 조성물 및 귀 병태의 치료 방법 |
| US11185536B2 (en) | 2015-12-04 | 2021-11-30 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss by inhibition of casein kinase 1 |
| US20170196802A1 (en) * | 2016-01-08 | 2017-07-13 | Abon Pharmaceuticals, Llc | Long Acting Injectable Formulations |
| WO2018193423A1 (en) * | 2017-04-21 | 2018-10-25 | Ferring B.V. | Oral pharmaceutical compositions of corticosteroids |
| PH12019550291B1 (en) * | 2017-06-23 | 2023-05-17 | Salvat Lab Sa | An oil-in-water nanoemulsion composition of clobetasol |
| WO2019066505A1 (ko) * | 2017-09-29 | 2019-04-04 | 주식회사 엘지화학 | 히알루론산 기반 하이드로겔 약제학적 안정화 조성물 및 그 제조방법 |
| KR20190038368A (ko) * | 2017-09-29 | 2019-04-08 | 주식회사 엘지화학 | 히알루론산 기반 하이드로겔 약제학적 안정화 조성물 및 그 제조방법 |
| CN107823636A (zh) * | 2017-12-14 | 2018-03-23 | 阜阳市平衡医疗保健器械有限公司 | 一种治疗耳鸣的药物 |
| CN108403628B (zh) * | 2018-05-21 | 2021-01-08 | 北京和舆医药科技有限公司 | 一种地塞米松磷酸钠注射剂 |
| WO2020084530A1 (en) * | 2018-10-24 | 2020-04-30 | Ferring B.V. | Mucoadhesive pharmaceutical compositions of corticosteroids |
| WO2020092897A1 (en) | 2018-11-02 | 2020-05-07 | Senseonics, Incorporated | Drug eluting matrix on analyte indicator |
| EP3897673A4 (en) * | 2018-12-21 | 2022-07-13 | Qmark Medical Inc. | HYDROGEL COMPOSITION FOR MUCOUS LIFTING IN ANATOMIC LUMEN STRUCTURES |
| US10561736B1 (en) | 2019-01-09 | 2020-02-18 | Spiral Therapeutics, Inc. | Apoptosis inhibitor formulations for prevention of hearing loss |
| US20200214976A1 (en) * | 2019-01-09 | 2020-07-09 | Spiral Therapeutics, Inc. | Self-gelling solutions for administration of therapeutics to the inner ear |
| CA3130138A1 (en) * | 2019-02-27 | 2020-09-03 | Oticara, Inc. | Method for treating nasal, sinonasal, and nasopharyngeal tissue infection and/or inflammation |
| WO2020243478A1 (en) | 2019-05-29 | 2020-12-03 | Massachusetts Eye And Ear Infirmary | Fibroblast growth factor 2 (fgf2) for treatment of human sensorineural hearing loss |
| KR102425971B1 (ko) * | 2020-06-02 | 2022-07-28 | 충남대학교산학협력단 | 덱사메타손 및 소듐 카프르산을 포함하는 내이 전달용 조성물 |
| CA3188400A1 (en) * | 2020-08-03 | 2022-02-10 | Daniel S. Kohane | Thermo-sensitive permeation enhancing formulations for drug delivery |
| WO2022065404A1 (ja) * | 2020-09-25 | 2022-03-31 | アステラス製薬株式会社 | 耳内投与用の医薬組成物 |
| EP4279061A1 (en) * | 2022-05-18 | 2023-11-22 | Acousia Therapeutics GmbH | Aqueous gel composition |
| KR20240086291A (ko) * | 2022-12-09 | 2024-06-18 | 가톨릭대학교 산학협력단 | 약물 전달용 조성물 및 이의 용도 |
| WO2025072841A1 (en) * | 2023-09-28 | 2025-04-03 | Syntis Bio, Inc. | Synergistic permeation enhancers for gastrointestinal synthetic epithelial linings |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060046970A1 (en) * | 2004-08-31 | 2006-03-02 | Insite Vision Incorporated | Topical otic compositions and methods of topical treatment of prevention of otic infections |
| US20070178051A1 (en) * | 2006-01-27 | 2007-08-02 | Elan Pharma International, Ltd. | Sterilized nanoparticulate glucocorticosteroid formulations |
Family Cites Families (103)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4188373A (en) * | 1976-02-26 | 1980-02-12 | Cooper Laboratories, Inc. | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes |
| US4478822A (en) | 1983-05-16 | 1984-10-23 | Merck & Co., Inc. | Drug delivery system utilizing thermosetting gels |
| US4968507A (en) | 1984-06-20 | 1990-11-06 | Merck & Co., Inc. | Controlled porosity osmotic pump |
| US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
| US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
| US5702716A (en) | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| US5292516A (en) * | 1990-05-01 | 1994-03-08 | Mediventures, Inc. | Body cavity drug delivery with thermoreversible gels containing polyoxyalkylene copolymers |
| IT1251151B (it) | 1991-08-05 | 1995-05-04 | Fidia Spa | Materiale spugnoso essenzialmente costituito da acido ialuronico,o suoi derivati |
| EP0551626A1 (en) * | 1991-12-19 | 1993-07-21 | LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. | Thermoreversible gel as a liquid pharmaceutical carrier for a galenic formulation |
| US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
| ES2141775T3 (es) * | 1993-04-16 | 2000-04-01 | Wakamoto Pharma Co Ltd | Composicion medicinal a base de agua termicamente gelificante reversible. |
| US5421818A (en) | 1993-10-18 | 1995-06-06 | Inner Ear Medical Delivery Systems, Inc. | Multi-functional inner ear treatment and diagnostic system |
| WO1995015152A1 (en) | 1993-11-30 | 1995-06-08 | Zenichi Ogita | External preparation |
| JP3696265B2 (ja) | 1994-02-04 | 2005-09-14 | 日本オルガノン株式会社 | 点鼻液剤 |
| DK1125577T3 (da) | 1994-04-08 | 2006-06-19 | Qlt Usa Inc | Væskeformige medikamentindföringspræparater |
| CA2228118A1 (en) | 1995-07-28 | 1997-02-13 | Focal, Inc. | Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatments agents |
| FR2742357B1 (fr) | 1995-12-19 | 1998-01-09 | Rhone Poulenc Rorer Sa | Nanoparticules stabilisees et filtrables dans des conditions steriles |
| WO1997038698A1 (en) | 1996-04-18 | 1997-10-23 | University Technology Corporation | Methods for treating middle and inner ear disorders |
| US5861174A (en) | 1996-07-12 | 1999-01-19 | University Technology Corporation | Temperature sensitive gel for sustained delivery of protein drugs |
| NL1004214C2 (nl) * | 1996-10-07 | 1998-04-10 | Avebe Coop Verkoop Prod | Toepassing van gemodificeerd zetmeel als middel voor het vormen van een thermoreversibele gel. |
| US6117949A (en) | 1998-10-01 | 2000-09-12 | Macromed, Inc. | Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| US6004573A (en) | 1997-10-03 | 1999-12-21 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| US6201072B1 (en) | 1997-10-03 | 2001-03-13 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| KR100883149B1 (ko) | 1997-10-22 | 2009-02-10 | 젠스 포니카우 | 진균류에 의한 점막염을 국소 치료하기 위한 항진균제의용도 |
| DE19748763A1 (de) | 1997-11-05 | 1999-05-06 | Hans Peter Zenner | Verwendung von Vasopressin-Antagonisten |
| SE9704186D0 (sv) | 1997-11-14 | 1997-11-14 | Astra Ab | New composition of matter |
| US6177434B1 (en) | 1997-12-16 | 2001-01-23 | The United States Of America As Represented By The Secretary Of The Navy | Prevention or reversal of sensorineural hearing loss (SNHL) through biologic mechanisms |
| US6649621B2 (en) | 1997-12-16 | 2003-11-18 | The United States Of America As Represented By The Secretary Of The Navy | Prevention or reversal of sensorineural hearing loss (SNHL) through biologic mechanisms |
| CA2316248A1 (en) | 1997-12-23 | 1999-07-01 | Alliance Pharmaceutical Corp. | Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions |
| EP1109563A4 (en) | 1998-08-04 | 2009-07-22 | Madash Llp | HEAT-SENSITIVE HYDROGELS WITH MODIFIED TERMINATION |
| US6509327B1 (en) | 1998-09-30 | 2003-01-21 | Alcon Manufacturing, Ltd. | Compositions and methods for treating otic, ophthalmic and nasal infections |
| US6740664B2 (en) | 1998-09-30 | 2004-05-25 | Alcon, Inc. | Methods for treating otic and ophthalmic infections |
| WO2000050005A1 (en) | 1999-02-24 | 2000-08-31 | Dong Wha Pharm. Ind. Co., Ltd | Liquid suppository composition of diclofenac sodium |
| US6239113B1 (en) | 1999-03-31 | 2001-05-29 | Insite Vision, Incorporated | Topical treatment or prevention of ocular infections |
| US6287588B1 (en) | 1999-04-29 | 2001-09-11 | Macromed, Inc. | Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof |
| MXPA02003130A (es) | 1999-09-24 | 2004-04-21 | Alcon Inc | Formulaciones topicas en suspension que contienen ciprofloxacino y dexametasona. |
| US20040082509A1 (en) | 1999-10-12 | 2004-04-29 | Christophe Bonny | Cell-permeable peptide inhibitors of the JNK signal transduction pathway |
| CA2402652C (en) | 2000-03-14 | 2008-11-18 | Alcon, Inc. | Viscoelastics for use in middle ear surgery |
| AU2001251011A1 (en) | 2000-03-27 | 2001-10-08 | The General Hospital Corporation | Treatments for immune-mediated ear disorders |
| US6998137B2 (en) | 2000-04-07 | 2006-02-14 | Macromed, Inc. | Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix |
| US7758888B2 (en) | 2000-04-21 | 2010-07-20 | Sol-Gel Technologies Ltd. | Composition exhibiting enhanced formulation stability and delivery of topical active ingredients |
| US6589549B2 (en) | 2000-04-27 | 2003-07-08 | Macromed, Incorporated | Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles |
| DE10346940B3 (de) | 2003-10-06 | 2005-06-16 | Schering Ag | Substituierte Pentanole, ihre Verwendung zur Herstellung von Arzneimitteln speziell Entzündungshemmer sowie diese enthaltende pharmazeutische Präparate |
| AR031135A1 (es) | 2000-10-10 | 2003-09-10 | Upjohn Co | Composiciones de antibiotico topico para el tratamiento de infecciones oculares |
| SE0100158D0 (sv) | 2001-01-19 | 2001-01-19 | Synphora Ab | Novel method and composition for local treatment of Meniere´s disease and tinnitus |
| US20060269602A1 (en) | 2001-04-13 | 2006-11-30 | Dasch James R | Method of modifying the release profile of sustained release compositions |
| TWI324925B (en) | 2001-08-23 | 2010-05-21 | Novartis Ag | Ophthalmic composition |
| US6488952B1 (en) | 2001-08-28 | 2002-12-03 | John P. Kennedy | Semisolid therapeutic delivery system and combination semisolid, multiparticulate, therapeutic delivery system |
| EP1429780B1 (en) * | 2001-09-21 | 2005-12-21 | Alcon, Inc. | Method of treating middle ear infections |
| US7001615B1 (en) | 2001-12-07 | 2006-02-21 | Alcon, Inc. | Sustained release ophthalmic, otic and nasal suspension |
| DE10162593A1 (de) | 2001-12-19 | 2003-07-03 | Menarini Ricerche Spa | Stabilisierte topische Brivudin-Formulierungen |
| WO2003071986A2 (en) * | 2002-02-22 | 2003-09-04 | Control Delivery Systems, Inc. | Method for treating otic disorders |
| WO2004039328A2 (en) | 2002-10-29 | 2004-05-13 | Oregon Health & Science University | Fludrocortisone treatment for hearing loss |
| US20040101506A1 (en) | 2002-11-25 | 2004-05-27 | Fust Charles A. | Composition for the prevention and treatment of inflammation of the ear |
| US7220431B2 (en) | 2002-11-27 | 2007-05-22 | Regents Of The University Of Minnesota | Methods and compositions for applying pharmacologic agents to the ear |
| US20040204471A1 (en) | 2003-03-20 | 2004-10-14 | Pharmacia Corporation | Treatment and prevention of otic disorders with Cox-2 inhibitors alone or in combination with otic agents |
| US7700086B2 (en) | 2003-11-06 | 2010-04-20 | Pluromed, Inc. | Internal clamp for surgical procedures |
| US20050191270A1 (en) * | 2004-02-27 | 2005-09-01 | Hydromer, Inc. | Anti-infectious hydrogel compositions |
| US8268866B2 (en) | 2004-03-29 | 2012-09-18 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| US20060063802A1 (en) | 2004-03-29 | 2006-03-23 | Matthieu Guitton | Methods for the treatment of tinnitus induced by cochlear excitotoxicity |
| WO2005115527A2 (en) | 2004-05-24 | 2005-12-08 | Auris Medical, Llc. | Combined otic aspirator and medication dispenser |
| US7858115B2 (en) * | 2004-06-24 | 2010-12-28 | Idexx Laboratories | Phospholipid gel compositions for drug delivery and methods of treating conditions using same |
| US20080124385A1 (en) | 2004-09-03 | 2008-05-29 | Piedmont Pharmaceuticals,Llc. | Methods for Transmembrane Treatment and Prevention of Otitis Media |
| JP2006111585A (ja) | 2004-10-15 | 2006-04-27 | Mebiol Kk | 徐放性組成物およびその徐放方法 |
| CA2594963A1 (en) | 2005-01-24 | 2006-07-27 | Neurosystec Corporation | Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues |
| JP2008533048A (ja) | 2005-03-10 | 2008-08-21 | スリーエム イノベイティブ プロパティズ カンパニー | 耳の感染症の治療方法 |
| CN101175480A (zh) * | 2005-03-16 | 2008-05-07 | 伊兰制药国际有限公司 | 纳米微粒白三烯受体拮抗剂/皮质类固醇制剂 |
| EP1863453A2 (en) * | 2005-03-29 | 2007-12-12 | Evonik Röhm GmbH | Multiparticulate pharmaceutical form comprising pellets with a substance having a modular effect in relation to active ingredient release |
| WO2006122183A2 (en) | 2005-05-10 | 2006-11-16 | Cytophil, Inc. | Injectable hydrogels and methods of making and using same |
| KR101041843B1 (ko) | 2005-07-30 | 2011-06-17 | 삼성엘이디 주식회사 | 질화물계 화합물 반도체 발광소자 및 그 제조방법 |
| US20070048338A1 (en) | 2005-08-26 | 2007-03-01 | Ladd Byron S | Compositions and methods for surface treatment in medical and surgical procedures |
| WO2007031098A1 (en) | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
| CN101272807A (zh) | 2005-09-26 | 2008-09-24 | 皮埃蒙特医药品有限公司 | 使用非离子表面活性剂促进跨膜药物输送到中耳治疗和预防中耳炎的方法 |
| WO2007037874A2 (en) | 2005-09-26 | 2007-04-05 | Piedmont Pharmaceuticals Llc | Methods for treatment and prevention of otitis media using chemical penetration enhancers to facilitate transmembrane drug delivery into the middle ear |
| BRPI0520588B8 (pt) | 2005-09-28 | 2021-05-25 | Auris Medical Ag | uso de composições farmacêuticas para o tratamento de doenças do ouvido interno |
| US20070110788A1 (en) | 2005-11-14 | 2007-05-17 | Hissong James B | Injectable formulation capable of forming a drug-releasing device |
| FR2894585B1 (fr) | 2005-12-14 | 2012-04-27 | Rhodia Recherches Et Tech | Copolymere comprenant des unites zwitterioniques et d'autres unites, composition comprenant le copolymere, et utilisation |
| CA2655596C (en) | 2006-06-27 | 2011-10-25 | Biovail Laboratories International Srl | Multiparticulate osmotic delivery system |
| WO2008049196A1 (en) | 2006-10-27 | 2008-05-02 | Iomedix Development International Srl | Composition for improving blood cholesterol levels |
| AU2007334260A1 (en) | 2006-11-15 | 2008-06-26 | Massachusetts Eye & Ear Infirmary | Generation of inner ear cells |
| CN105251035A (zh) | 2006-12-11 | 2016-01-20 | 健赞公司 | 灌注器官止血法 |
| US20100197800A1 (en) | 2007-04-23 | 2010-08-05 | Richard Friedman | Treatment and/or Prevention of Presbycusis by Modulation of Metabotropic Glutamate Receptor 7 |
| US7795231B2 (en) | 2007-10-04 | 2010-09-14 | Insite Vision Incorporated | Concentrated aqueous azalide formulations |
| MX2010011545A (es) | 2008-04-21 | 2011-04-11 | Otonomy Inc | Formulaciones para tratar enfermedades y afecciones del oido. |
| JP5551685B2 (ja) | 2008-05-14 | 2014-07-16 | オトノミ―，インク． | 制御放出型コルチコステロイド組成物、および耳の疾患を処置する方法 |
| US8822410B2 (en) | 2008-05-19 | 2014-09-02 | Children's Medical Center Corporation | Tympanic membrane permeating ear drops and uses thereof |
| US8648119B2 (en) | 2008-05-23 | 2014-02-11 | Otonomy, Inc. | Controlled release immunomodulator compositions and methods for the treatment of otic disorders |
| US8846770B2 (en) | 2008-06-18 | 2014-09-30 | Otonomy, Inc. | Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders |
| US8349353B2 (en) | 2008-06-27 | 2013-01-08 | Otonomy, Inc. | Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders |
| WO2010011466A2 (en) | 2008-06-27 | 2010-01-28 | Otonomy, Inc. | Controlled-release cns modulating compositions and methods for the treatment of otic disorders |
| JP5491502B2 (ja) | 2008-07-14 | 2014-05-14 | オトノミ―，インク． | 制御放出アポトーシス調節化合物および耳の障害の処置のための方法 |
| US20100016450A1 (en) | 2008-07-21 | 2010-01-21 | Otonomy, Inc. | Controlled release delivery devices for the treatment of otic disorders |
| US8318817B2 (en) | 2008-07-21 | 2012-11-27 | Otonomy, Inc. | Controlled release antimicrobial compositions and methods for the treatment of otic disorders |
| EP2306975A4 (en) | 2008-07-21 | 2012-10-31 | Otonomy Inc | COMPOSITIONS WITH A TAXED RELEASE FOR MODULATING THE EARM STRUCTURE AND THE BORN IMMUNE SYSTEM, AND METHODS OF TREATING EAR OR DISEASE |
| US8784870B2 (en) | 2008-07-21 | 2014-07-22 | Otonomy, Inc. | Controlled release compositions for modulating free-radical induced damage and methods of use thereof |
| KR101367479B1 (ko) | 2008-07-21 | 2014-03-14 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 귀 질병 치료를 위한 제어 방출형 항미생물성 조성물 및 방법 |
| US8399018B2 (en) | 2008-07-21 | 2013-03-19 | Otonomy, Inc. | Controlled release ion channel modulator compositions and methods for the treatment of otic disorders |
| US8496957B2 (en) | 2008-07-21 | 2013-07-30 | Otonomy, Inc | Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders |
| CN101664381A (zh) | 2009-08-21 | 2010-03-10 | 天津生机集团股份有限公司 | 治疗奶牛乳房炎的原位凝胶缓释制剂的制备方法 |
| US20120277199A1 (en) | 2009-10-21 | 2012-11-01 | Otonomy, Inc. | Modulation of Gel Temperature of Poloxamer-Containing Formulations |
| ES2369101B2 (es) | 2010-05-07 | 2012-08-02 | Universidade De Santiago De Compostela | Sistema farmacéutico acuoso para la administración de fármacos en las uñas. |
-
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- 2009-05-14 JP JP2011509498A patent/JP5551685B2/ja not_active Expired - Fee Related
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- 2009-05-14 EP EP09747010.8A patent/EP2303227B1/en active Active
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- 2017-06-02 US US15/612,701 patent/US20180110727A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060046970A1 (en) * | 2004-08-31 | 2006-03-02 | Insite Vision Incorporated | Topical otic compositions and methods of topical treatment of prevention of otic infections |
| US20070178051A1 (en) * | 2006-01-27 | 2007-08-02 | Elan Pharma International, Ltd. | Sterilized nanoparticulate glucocorticosteroid formulations |
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