AU2008318196B2 - Medium-chain length fatty acids and glycerides as nephroprotection agents - Google Patents
Medium-chain length fatty acids and glycerides as nephroprotection agents Download PDFInfo
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- AU2008318196B2 AU2008318196B2 AU2008318196A AU2008318196A AU2008318196B2 AU 2008318196 B2 AU2008318196 B2 AU 2008318196B2 AU 2008318196 A AU2008318196 A AU 2008318196A AU 2008318196 A AU2008318196 A AU 2008318196A AU 2008318196 B2 AU2008318196 B2 AU 2008318196B2
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- 235000014113 dietary fatty acids Nutrition 0.000 title claims abstract description 12
- 239000000194 fatty acid Substances 0.000 title claims abstract description 12
- 229930195729 fatty acid Natural products 0.000 title claims abstract description 12
- 239000003795 chemical substances by application Substances 0.000 title abstract description 13
- 150000004665 fatty acids Chemical class 0.000 title abstract description 11
- 125000005456 glyceride group Chemical group 0.000 title 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims abstract description 34
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims abstract description 24
- 150000003626 triacylglycerols Chemical class 0.000 claims abstract description 21
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims abstract description 20
- 208000017169 kidney disease Diseases 0.000 claims abstract description 16
- 229960002446 octanoic acid Drugs 0.000 claims abstract description 15
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims abstract description 14
- 208000020832 chronic kidney disease Diseases 0.000 claims abstract description 14
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims abstract description 11
- 238000013059 nephrectomy Methods 0.000 claims abstract description 10
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 208000037999 tubulointerstitial fibrosis Diseases 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US98509407P | 2007-11-02 | 2007-11-02 | |
| US60/985.094 | 2007-11-02 | ||
| PCT/CA2008/001930 WO2009055933A1 (en) | 2007-11-02 | 2008-11-03 | Medium-chain length fatty acids and glycerides as nephroprotection agents |
Publications (2)
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| AU2008318196A1 AU2008318196A1 (en) | 2009-05-07 |
| AU2008318196B2 true AU2008318196B2 (en) | 2014-04-10 |
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| AU2008318196A Ceased AU2008318196B2 (en) | 2007-11-02 | 2008-11-03 | Medium-chain length fatty acids and glycerides as nephroprotection agents |
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| PT (1) | PT2299998T (enExample) |
| RU (1) | RU2519215C2 (enExample) |
| WO (1) | WO2009055933A1 (enExample) |
| ZA (1) | ZA201003030B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2010127440A1 (en) | 2009-05-04 | 2010-11-11 | Prometic Biosciences Inc. | Substituted aromatic compounds and pharmaceutical uses thereof |
| JP5706142B2 (ja) * | 2010-04-28 | 2015-04-22 | 株式会社ファンケル | フユボダイジュ花のエタノール抽出物を有効成分とする血中グルコース低下剤、内臓脂肪蓄積抑制剤、ｔｇ低下剤、糞中脂肪排泄促進剤 |
| DK3443957T3 (da) | 2010-10-27 | 2020-12-21 | Liminal Biosciences Ltd | Forbindelser og sammensætninger til behandling af cancer |
| JP5810166B2 (ja) | 2011-08-26 | 2015-11-11 | 国立大学法人大阪大学 | 糖尿病性心血管合併症の予防・治療剤 |
| KR20130023583A (ko) * | 2011-08-29 | 2013-03-08 | 아주대학교산학협력단 | 파골세포 형성 억제 효과가 있는 카프르산 및 이를 포함하는 약학적 조성물 |
| EP3065731B1 (en) | 2013-11-05 | 2018-10-24 | Hill's Pet Nutrition, Inc. | Methods and compositions for improving kidney function |
| WO2017074266A1 (en) * | 2015-10-30 | 2017-05-04 | National University Of Singapore | Androgen biosynthesis inhibitor |
| CN105559071A (zh) * | 2016-01-12 | 2016-05-11 | 刘保惠 | 一种适用于肾病的特殊医学用途配方食品及其制备方法 |
| JP2017214342A (ja) * | 2016-06-02 | 2017-12-07 | 日清オイリオグループ株式会社 | 排尿障害の予防用又は改善用組成物 |
| TWI749016B (zh) | 2016-06-08 | 2021-12-11 | 董宇紅 | 具有奇數碳的脂類化合物及其作為醫藥組合物或者營養補充劑的用途 |
| TW201825110A (zh) * | 2016-12-21 | 2018-07-16 | 英商波麥堤克藥學Ｓｍｔ有限公司 | 用於預防或最小化上皮─間葉轉變之方法及組成物 |
| JP7055429B2 (ja) * | 2017-10-27 | 2022-04-18 | 学校法人北里研究所 | 慢性腎臓病の予防又は治療剤 |
| WO2019155336A1 (en) * | 2018-02-08 | 2019-08-15 | Societe Des Produits Nestle S.A. | Mct-based nutrition blend for providing health benefits in companion animals |
| CA3112073A1 (en) | 2018-10-11 | 2020-04-16 | Basf As | Aromatic compounds and pharmaceutical uses thereof |
| CN109602012A (zh) * | 2018-12-11 | 2019-04-12 | 李卫平 | 一种功能性低蛋白能量米及其制备方法 |
| CN111184728B (zh) * | 2020-02-20 | 2023-04-04 | 上海市儿童医院 | 海藻糖在肾病综合征中的应用 |
| US20230404957A1 (en) * | 2022-06-15 | 2023-12-21 | Hill's Pet Nutrition, Inc. | Pet Food Compositions |
| CN118592613B (zh) * | 2024-08-05 | 2025-01-07 | 杭州康源食品科技有限公司 | 中链脂肪酸混合结构脂在改善膳食诱导的糖脂代谢紊乱中的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002083120A2 (en) * | 2001-04-18 | 2002-10-24 | Prometic Biosciences Inc. | Medium-chain length fatty acids, glycerides and analogues as neutrophil survival and activation factors |
| WO2004069237A1 (en) * | 2003-02-07 | 2004-08-19 | Prometic Biosciences Inc. | Medium-chain length fatty acids, glycerides and analogues as stimulators of erythropoiesis |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4602040A (en) | 1983-04-18 | 1986-07-22 | Warner-Lambert Company | Meclofenamic acid topical pharmaceutical composition |
| US4737384A (en) * | 1985-11-01 | 1988-04-12 | Allied Corporation | Deposition of thin films using supercritical fluids |
| EP0583480A4 (en) | 1992-02-07 | 1994-03-18 | Tsumura & Co | SIDE EFFECTS MITIGATION AGENT. |
| US6689700B1 (en) * | 1999-11-02 | 2004-02-10 | University Of Massachusetts | Chemical fluid deposition method for the formation of metal and metal alloy films on patterned and unpatterned substrates |
| CN100348183C (zh) | 2000-06-20 | 2007-11-14 | 营养科学公司 | 可用作抗微生物剂的中链脂肪酸 |
| IL142535A0 (en) * | 2001-04-11 | 2002-03-10 | Yeda Res & Dev | Pharmaceutical compositions for the treatment of inflammation |
| CN1827766B (zh) | 2001-06-28 | 2010-08-25 | 徐荣祥 | 体外细胞的培养方法 |
| RU2213570C2 (ru) * | 2001-08-22 | 2003-10-10 | Санкт-Петербургская Государственная Химико-Фармацевтическая Академия | ЛЕЧЕБНО-ПРОФИЛАКТИЧЕСКОЕ СРЕДСТВО ИЗ ЛИСТЬЕВ ЛИПЫ Folia Tilia И СПОСОБ ПОЛУЧЕНИЯ ЭКСТРАКТИВНЫХ ВЕЩЕСТВ |
| US7030168B2 (en) * | 2001-12-31 | 2006-04-18 | Advanced Technology Materials, Inc. | Supercritical fluid-assisted deposition of materials on semiconductor substrates |
| US20040052836A1 (en) * | 2002-09-13 | 2004-03-18 | Li Luk Chiu | Pharmaceutical compositions containing at least one stable liposphere having an improved shelf life |
| DE602004006137T3 (de) | 2003-07-25 | 2012-01-19 | Prometic Biosciences Inc. | Herstellung von metallsalzen von fettsäuren mit mittlerer kettenlänge |
| EP1940379A4 (en) | 2005-09-30 | 2009-05-13 | Jackson H M Found Military Med | METHOD FOR THE TREATMENT OF HEMORRHAGIC SHOCKS AND ASSOCIATED DISEASES |
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2008
- 2008-11-03 PT PT88451224T patent/PT2299998T/pt unknown
- 2008-11-03 EP EP08845122.4A patent/EP2299998B1/en not_active Not-in-force
- 2008-11-03 ES ES08845122.4T patent/ES2664594T3/es active Active
- 2008-11-03 MY MYPI2010001861A patent/MY151439A/en unknown
- 2008-11-03 DK DK08845122.4T patent/DK2299998T3/en active
- 2008-11-03 BR BRPI0818310A patent/BRPI0818310A8/pt not_active IP Right Cessation
- 2008-11-03 NO NO08845122A patent/NO2299998T3/no unknown
- 2008-11-03 US US12/740,700 patent/US9532962B2/en not_active Expired - Fee Related
- 2008-11-03 JP JP2010532389A patent/JP5575655B2/ja not_active Expired - Fee Related
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- 2008-11-03 MX MX2010004856A patent/MX338513B/es active IP Right Grant
- 2008-11-03 WO PCT/CA2008/001930 patent/WO2009055933A1/en not_active Ceased
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- 2008-11-03 RU RU2010122302/15A patent/RU2519215C2/ru active
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- 2008-11-03 NZ NZ584981A patent/NZ584981A/en not_active IP Right Cessation
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2010
- 2010-04-26 IL IL205362A patent/IL205362A/en active IP Right Grant
- 2010-04-30 ZA ZA2010/03030A patent/ZA201003030B/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002083120A2 (en) * | 2001-04-18 | 2002-10-24 | Prometic Biosciences Inc. | Medium-chain length fatty acids, glycerides and analogues as neutrophil survival and activation factors |
| WO2004069237A1 (en) * | 2003-02-07 | 2004-08-19 | Prometic Biosciences Inc. | Medium-chain length fatty acids, glycerides and analogues as stimulators of erythropoiesis |
Non-Patent Citations (1)
| Title |
|---|
| Research in Experimental Medicine, Vol. 199, No. 4, February 2000, pages 195-206 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100106958A (ko) | 2010-10-04 |
| CA2704286C (en) | 2016-08-23 |
| MX338513B (es) | 2016-04-20 |
| RU2519215C2 (ru) | 2014-06-10 |
| KR101601987B1 (ko) | 2016-03-09 |
| EP2299998A4 (en) | 2011-03-30 |
| EP2299998A1 (en) | 2011-03-30 |
| RU2010122302A (ru) | 2011-12-10 |
| AU2008318196A1 (en) | 2009-05-07 |
| IL205362A0 (en) | 2010-12-30 |
| NO2299998T3 (enExample) | 2018-06-02 |
| ES2664594T3 (es) | 2018-04-20 |
| BRPI0818310A2 (pt) | 2017-10-10 |
| EP2299998B1 (en) | 2018-01-03 |
| CN101878028A (zh) | 2010-11-03 |
| IL205362A (en) | 2015-01-29 |
| ZA201003030B (en) | 2011-02-23 |
| DK2299998T3 (en) | 2018-03-26 |
| CA2704286A1 (en) | 2009-05-07 |
| US20100286269A1 (en) | 2010-11-11 |
| MY151439A (en) | 2014-05-30 |
| BRPI0818310A8 (pt) | 2017-12-26 |
| NZ584981A (en) | 2012-05-25 |
| JP5575655B2 (ja) | 2014-08-20 |
| MX2010004856A (es) | 2010-06-30 |
| JP2011502174A (ja) | 2011-01-20 |
| US9532962B2 (en) | 2017-01-03 |
| PT2299998T (pt) | 2018-04-02 |
| WO2009055933A1 (en) | 2009-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| PC | Assignment registered |
Owner name: PROMETIC PHARMA SMT LIMITED Free format text: FORMER OWNER WAS: PROMETIC BIOSCIENCES INC. |
|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |