AU2008316830B2 - Process for the preparation of macrolide antibacterial agents - Google Patents

Process for the preparation of macrolide antibacterial agents Download PDF

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Publication number
AU2008316830B2
AU2008316830B2 AU2008316830A AU2008316830A AU2008316830B2 AU 2008316830 B2 AU2008316830 B2 AU 2008316830B2 AU 2008316830 A AU2008316830 A AU 2008316830A AU 2008316830 A AU2008316830 A AU 2008316830A AU 2008316830 B2 AU2008316830 B2 AU 2008316830B2
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Australia
Prior art keywords
compound
formula
ome
hydrogen
group
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Ceased
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AU2008316830A
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AU2008316830A1 (en
Inventor
Keshav Deo
Manish Kanchanbhai Patel
David E. Pereira
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Cempra Pharmaceuticals Inc
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Cempra Pharmaceuticals Inc
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Publication of AU2008316830B2 publication Critical patent/AU2008316830B2/en
Priority to AU2016203649A priority Critical patent/AU2016203649A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2008316830A 2007-10-25 2008-10-23 Process for the preparation of macrolide antibacterial agents Ceased AU2008316830B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2016203649A AU2016203649A1 (en) 2007-10-25 2016-06-01 Process for the preparation of macrolide antibacterial agents

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98244607P 2007-10-25 2007-10-25
US60/982,446 2007-10-25
PCT/US2008/080936 WO2009055557A1 (en) 2007-10-25 2008-10-23 Process for the preparation of macrolide antibacterial agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016203649A Division AU2016203649A1 (en) 2007-10-25 2016-06-01 Process for the preparation of macrolide antibacterial agents

Publications (2)

Publication Number Publication Date
AU2008316830A1 AU2008316830A1 (en) 2009-04-30
AU2008316830B2 true AU2008316830B2 (en) 2016-03-17

Family

ID=40580003

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2008316830A Ceased AU2008316830B2 (en) 2007-10-25 2008-10-23 Process for the preparation of macrolide antibacterial agents
AU2016203649A Abandoned AU2016203649A1 (en) 2007-10-25 2016-06-01 Process for the preparation of macrolide antibacterial agents

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2016203649A Abandoned AU2016203649A1 (en) 2007-10-25 2016-06-01 Process for the preparation of macrolide antibacterial agents

Country Status (9)

Country Link
US (3) US9453042B2 (enExample)
EP (1) EP2214484A4 (enExample)
JP (4) JP5698979B2 (enExample)
CN (2) CN105732745A (enExample)
AU (2) AU2008316830B2 (enExample)
CA (1) CA2703475A1 (enExample)
HK (1) HK1226411A1 (enExample)
IL (1) IL205254A (enExample)
WO (1) WO2009055557A1 (enExample)

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EP2772254A3 (en) 2003-03-10 2015-03-11 Optimer Pharmaceuticals, Inc. Novel Antibacterial Agents
CA2703475A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
AU2009308182B2 (en) 2008-10-24 2016-05-19 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
WO2011032052A1 (en) 2009-09-10 2011-03-17 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
WO2011119604A1 (en) 2010-03-22 2011-09-29 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
DK2571506T3 (en) * 2010-05-20 2017-08-28 Cempra Pharmaceuticals Inc PROCEDURES FOR THE MANUFACTURE OF MACROLIDES AND KETOLIDES AND INTERMEDIATES
KR20130120458A (ko) * 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
US10188674B2 (en) 2012-03-27 2019-01-29 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
AU2014239959A1 (en) 2013-03-14 2015-10-01 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
KR20160020403A (ko) * 2013-03-15 2016-02-23 셈프라 파마슈티컬스, 인크. 매크로라이드 항세균제들을 제조하기 위한 수렴 프로세스들
WO2014165792A2 (en) 2013-04-04 2014-10-09 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
CN104151382B (zh) * 2014-08-08 2016-09-14 广东东阳光药业有限公司 一种固态大环内酯的晶型
CN104311611B (zh) * 2014-08-13 2017-01-18 广东东阳光药业有限公司 一种制备固态大环内酯的方法
HK1242920A1 (zh) 2014-10-08 2018-07-06 哈佛大学的校长及成员们 14-元酮内酯及其制备和使用方法
US20180016226A1 (en) * 2015-02-06 2018-01-18 Cempra Pharmaceuticals, Inc. 4-azidobutylamines and processes for preparing
CN107405355A (zh) * 2015-03-06 2017-11-28 森普拉制药公司 用于制备氟酮内酯的方法
CN107530365A (zh) 2015-03-25 2018-01-02 哈佛大学的校长及成员们 具有修饰的脱氧糖胺糖的大环内酯及其用途
CN106518939B (zh) * 2015-09-14 2019-12-31 江苏奥赛康药业有限公司 一种制备Solithromycin化合物的方法
CN106554381A (zh) * 2015-09-25 2017-04-05 苏州鹏旭医药科技有限公司 酮内酯类抗生素中间体及其制备方法和应用
CN105503976B (zh) * 2015-12-04 2018-02-06 浙江京新药业股份有限公司 一种索利霉素中间体
CN105348341B (zh) * 2015-12-04 2018-01-09 浙江京新药业股份有限公司 一种制备索利霉素的方法
EP3190122A1 (en) 2016-01-08 2017-07-12 LEK Pharmaceuticals d.d. A novel synthetic pathway towards solithromycin and purification thereof
WO2018045294A1 (en) * 2016-09-02 2018-03-08 Cempra Pharmaceuticals, Inc. Processes for preparing fluoroketolides

Citations (1)

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