AU2008300185B2 - Adherent cells from adipose or placenta tissues and use thereof in therapy - Google Patents

Adherent cells from adipose or placenta tissues and use thereof in therapy Download PDF

Info

Publication number
AU2008300185B2
AU2008300185B2 AU2008300185A AU2008300185A AU2008300185B2 AU 2008300185 B2 AU2008300185 B2 AU 2008300185B2 AU 2008300185 A AU2008300185 A AU 2008300185A AU 2008300185 A AU2008300185 A AU 2008300185A AU 2008300185 B2 AU2008300185 B2 AU 2008300185B2
Authority
AU
Australia
Prior art keywords
cells
cell
plx
adherent
adherent cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008300185A
Other languages
English (en)
Other versions
AU2008300185A1 (en
Inventor
Zami Aberman
Nirit Drori-Carmi
Moran Meiron
Rachel Ofir
Amir Toren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pluri Biotech Ltd
Original Assignee
Pluristem Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40118825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2008300185(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pluristem Ltd filed Critical Pluristem Ltd
Publication of AU2008300185A1 publication Critical patent/AU2008300185A1/en
Application granted granted Critical
Publication of AU2008300185B2 publication Critical patent/AU2008300185B2/en
Priority to AU2013267050A priority Critical patent/AU2013267050B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/50Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2008300185A 2007-09-19 2008-09-02 Adherent cells from adipose or placenta tissues and use thereof in therapy Ceased AU2008300185B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013267050A AU2013267050B2 (en) 2007-09-19 2013-12-05 Adherent cells from adipose or placenta tissues and use thereof in therapy

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96018407P 2007-09-19 2007-09-19
US60/960,184 2007-09-19
PCT/IL2008/001185 WO2009037690A1 (en) 2007-09-19 2008-09-02 Adherent cells from adipose or placenta tissues and use thereof in therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013267050A Division AU2013267050B2 (en) 2007-09-19 2013-12-05 Adherent cells from adipose or placenta tissues and use thereof in therapy

Publications (2)

Publication Number Publication Date
AU2008300185A1 AU2008300185A1 (en) 2009-03-26
AU2008300185B2 true AU2008300185B2 (en) 2013-09-05

Family

ID=40118825

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008300185A Ceased AU2008300185B2 (en) 2007-09-19 2008-09-02 Adherent cells from adipose or placenta tissues and use thereof in therapy

Country Status (18)

Country Link
US (4) US8529888B2 (OSRAM)
EP (3) EP3103463B1 (OSRAM)
JP (5) JP2010539228A (OSRAM)
KR (4) KR20140107677A (OSRAM)
CN (2) CN107028981B (OSRAM)
AU (1) AU2008300185B2 (OSRAM)
BR (1) BRPI0815946B8 (OSRAM)
CA (1) CA2699664C (OSRAM)
ES (1) ES2392729T5 (OSRAM)
HR (1) HRP20120887T4 (OSRAM)
IL (4) IL204566A (OSRAM)
MX (1) MX2010003019A (OSRAM)
PL (1) PL2200622T5 (OSRAM)
PT (1) PT2200622E (OSRAM)
RU (2) RU2709780C2 (OSRAM)
SI (1) SI2200622T2 (OSRAM)
WO (1) WO2009037690A1 (OSRAM)
ZA (1) ZA201001929B (OSRAM)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
DK1926813T4 (da) 2005-09-23 2019-08-19 Tigenix S A U Cellepopulationer med immunregulatorisk aktivitet, fremgangsmåde til isolering og anvendelser
JP5505760B2 (ja) 2005-09-27 2014-05-28 ティッシュテク・インコーポレーテッド 羊膜調製物及び精製組成物及びその使用方法
WO2011132087A1 (en) 2010-04-23 2011-10-27 Pluristem Ltd. Adherent stromal cells derived from plancentas of multiple donors and uses thereof
CN106886688B (zh) 2007-07-23 2020-07-10 香港中文大学 用于分析癌症相关的遗传变异的系统
US12180549B2 (en) 2007-07-23 2024-12-31 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using genomic sequencing
EP3103463B1 (en) 2007-09-19 2020-01-01 Pluristem Ltd. Adherent cells from adipose or placenta tissues and use thereof in therapy
EP2205719A1 (en) * 2007-09-26 2010-07-14 Celgene Cellular Therapeutics Angiogenic cells from human placental perfusate
CA2725637A1 (en) * 2008-05-27 2009-12-03 Pluristem Ltd. Methods of treating inflammatory colon diseases
EP3172963B1 (en) 2008-08-20 2019-02-06 Celularity, Inc. Improved cell composition and methods of making the same
SG190659A1 (en) * 2008-09-02 2013-06-28 Pluristem Ltd Adherent cells from placenta tissue and use thereof in therapy
RU2562154C2 (ru) 2008-11-19 2015-09-10 Антродженезис Корпорейшн Амниотические адгезивные клетки
EP2507362A2 (en) 2009-11-30 2012-10-10 Pluristem Ltd. Adherent cells from placenta and use of same in disease treatment
PT2556145T (pt) * 2010-04-07 2016-10-25 Anthrogenesis Corp Angiogénese usando células estaminais placentárias
AU2013203479B2 (en) * 2010-04-07 2016-05-19 Celularity Inc. Angiogenesis using placental stem cells
ES2572211T3 (es) 2010-05-27 2016-05-30 Pluristem Ltd Regeneración de músculo esquelético utilizando células madre mesenquimales
US9677042B2 (en) 2010-10-08 2017-06-13 Terumo Bct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
KR101903339B1 (ko) 2011-03-22 2018-10-01 플루리스템 리미티드 방사선 또는 화학적 손상을 치료하는 방법
SG10201601537QA (en) * 2011-04-15 2016-04-28 Pluristem Ltd Methods and systems for harvesting cells
WO2012149486A1 (en) 2011-04-28 2012-11-01 Tissuetech, Inc. Methods of modulating bone remodeling
US9040035B2 (en) 2011-06-01 2015-05-26 Anthrogenesis Corporation Treatment of pain using placental stem cells
SG10201914092XA (en) 2011-06-06 2020-03-30 ReGenesys BVBA Expansion of stem cells in hollow fiber bioreactors
WO2013012698A1 (en) * 2011-07-15 2013-01-24 Anthrogenesis Corporation Treatment of radiation injury using amnion derived adherent cells
HK1202251A1 (en) 2011-11-07 2015-09-25 Hina W. Chaudhry Methods of cardiac repair
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
KR101921787B1 (ko) 2012-09-04 2018-11-23 플루리스템 리미티드 자간전증의 예방 및 치료 방법
ES2529501T3 (es) 2012-09-06 2015-02-20 Pluristem Ltd. Dispositivos y métodos para el cultivo de células
US9662355B2 (en) 2013-01-18 2017-05-30 Mimedx Group, Inc. Methods for treating cardiac conditions
JP6581908B2 (ja) * 2013-02-12 2019-09-25 レプリセル ライフ サイエンシーズ インコーポレイテッド 腱の治療及び修復用組成物及び方法
US10351910B2 (en) 2013-02-20 2019-07-16 Pluristem Ltd Gene and protein expression properties of adherent stromal cells cultured in 3D
WO2014141111A1 (en) 2013-03-14 2014-09-18 Pluristem Ltd. Methods for prevention and treatment of graft-versus-host disease
SG11201508199QA (en) * 2013-04-05 2015-11-27 Claudia Zylberberg Matrix metalloproteinases and uses thereof
WO2015004609A2 (en) 2013-07-09 2015-01-15 Pluristem Ltd. Adherent cells from placenta and use thereof in treatment of injured tendons
EP3068867B1 (en) 2013-11-16 2018-04-18 Terumo BCT, Inc. Expanding cells in a bioreactor
AU2015206236B2 (en) 2014-01-17 2020-02-20 Mimedx Group, Inc. Method for inducing angiogenesis
EP3114206B1 (en) 2014-03-04 2020-07-29 Pluristem Ltd. Systems and methods for growing and harvesting cells
CN106232800B (zh) 2014-03-25 2020-07-03 泰尔茂比司特公司 介质的被动替代
EP3198006B1 (en) 2014-09-26 2021-03-24 Terumo BCT, Inc. Scheduled feed
EP3214171A4 (en) * 2014-10-29 2018-07-11 Sungkwang Medical Foundation Placenta-derived cells excreting c3 or c1r complement and composition containing same
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
CN107864627A (zh) 2015-03-23 2018-03-30 普拉里斯坦有限公司 包含粘附基质细胞的方法和组合物
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
WO2017039251A1 (ko) * 2015-08-28 2017-03-09 주식회사 차바이오텍 향상된 산후 부착형 세포 및 그의 용도
IL261146B (en) * 2016-02-18 2022-07-01 Pluristem Ltd Methods and compositions for treating cancers and neoplasms
GB201604304D0 (en) 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
CN109415696A (zh) 2016-05-25 2019-03-01 泰尔茂比司特公司 细胞扩增
US10851347B2 (en) 2016-06-06 2020-12-01 Pluristem Ltd. Altered adherent stromal cells and methods of producing and using same
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
CA3032160C (en) 2016-08-24 2024-05-28 Arthrex, Inc. Tissue hybrid for use in repairing, reconstructing or regenerating musculoskeletal degenerative processes or injuries
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
WO2018184028A2 (en) 2017-03-31 2018-10-04 Terumo Bct, Inc. Cell expansion
CN106932571A (zh) * 2017-04-12 2017-07-07 广东国盛医学科技有限公司 基于rcn2标志物检测的心血管病检测方法及试剂盒
IL270114B2 (en) 2017-04-24 2024-01-01 Pluri Biotech Ltd Methods and compounds for the treatment of neurological diseases
CA3061508A1 (en) * 2017-04-25 2018-11-01 Abraham J And Phyllis Katz Cord Blood Foundation Enriched cellular compositions and therapeutic use
EP3733838A4 (en) * 2017-12-28 2021-11-03 Kaneka Corporation CELL POPULATION WITH ADHESIVE STEM CELLS, METHOD FOR MANUFACTURING SUCH CELL POPULATION AND PHARMACEUTICAL COMPOSITION
CN109810992A (zh) * 2019-02-01 2019-05-28 天津师范大学 一种编码牙鲆胞外ATP水解酶CD39的cDNA全长序列及其应用
KR102143840B1 (ko) * 2019-02-22 2020-08-12 송미연 손상된 성상교세포 치료방법
US11511017B2 (en) 2019-03-12 2022-11-29 Arthrex, Inc. Ligament reconstruction
US20220160787A1 (en) * 2019-03-15 2022-05-26 Celularity Inc. Placenta derived adherent cells for improved xenoplantation
CA3125311A1 (en) * 2019-03-27 2020-10-01 Pluristem Ltd. Methods and compositions for aesthetic and cosmetic treatment and stimulating hair growth
US20200392448A1 (en) * 2019-06-14 2020-12-17 Ge Healthcare Uk Limited Monitoring of Cell Expansion
KR20200000415A (ko) * 2019-12-24 2020-01-02 (주)안트로젠 면역 질환 또는 염증성 질환의 예방 또는 치료용 중간엽줄기세포 배양액 및 이의 제조방법
JP7705950B2 (ja) 2021-03-23 2025-07-10 テルモ ビーシーティー、インコーポレーテッド 細胞を増殖する方法
WO2023037358A1 (en) * 2021-09-09 2023-03-16 Pluri Biotech Ltd. Placental cell treatment for critical limb ischemia patient subpopulations
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001082991A2 (en) * 2000-05-03 2001-11-08 Fidia Advanced Biopolymers Srl Biomaterials comprised of preadipocyte cells for soft tissue repair
WO2003105908A2 (en) * 2002-03-15 2003-12-24 Department Of Veterans Affairs, Rehabilitation R & D Service Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
US20050054098A1 (en) * 2003-06-27 2005-03-10 Sanjay Mistry Postpartum cells derived from umbilical cord tissue, and methods of making and using the same

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US4846835A (en) * 1987-06-15 1989-07-11 Grande Daniel A Technique for healing lesions in cartilage
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5108989A (en) * 1990-04-04 1992-04-28 Genentech, Inc. Method of predisposing mammals to accelerated tissue repair
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US5877295A (en) * 1992-09-30 1999-03-02 The Center For Blood Research Antibodies which bind a subpopulation of Mac-1 (CD11b/CD18) molecules which mediate neutrophil adhesion to ICAM-1 and fibrinogen
US5629186A (en) 1994-04-28 1997-05-13 Lockheed Martin Corporation Porous matrix and method of its production
US5474687A (en) * 1994-08-31 1995-12-12 Activated Cell Therapy, Inc. Methods for enriching CD34+ human hematopoietic progenitor cells
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US6132463A (en) 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
ATE288480T1 (de) 1995-11-16 2005-02-15 Univ Case Western Reserve Chondrogene in vitro induktion von menschlichen mensenchymalen stammzellen
WO1999047922A2 (en) 1998-03-18 1999-09-23 Massachusetts Institute Of Technology Vascularized perfused microtissue/micro-organ arrays
FR2784284B1 (fr) * 1998-10-13 2000-12-15 Natural Implant Sa Procede de preparation d'un implant dentaire par immersion dans une culture de cellules mesenchymateuses, dispositif de culture de cellules pour la preparation dudit implant et implant obtenu
US6153432A (en) 1999-01-29 2000-11-28 Zen-Bio, Inc Methods for the differentiation of human preadipocytes into adipocytes
KR20020013496A (ko) 1999-02-04 2002-02-20 추후제출 조혈 간세포 및(또는) 전구세포의 유지 및 증대 방법 및장치
EP1165830B1 (en) * 1999-03-10 2017-07-12 University of Pittsburgh of the Commonwealth System of Higher Education Adipose-derived stem cells and lattices
US7582292B2 (en) 2000-02-26 2009-09-01 Artecel, Inc. Adipose tissue derived stromal cells for the treatment of neurological disorders
ES2300320T3 (es) 2000-02-26 2008-06-16 Artecel, Inc. Celulas madre pluripotentes generadas a partir de celulas del estroma derivadas de tejido adiposo y sus usos.
EP2305795B1 (en) * 2000-12-06 2019-07-03 Celularity, Inc. Method of collecting placental stem cells
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
WO2002064755A2 (en) * 2001-02-14 2002-08-22 Anthrogenesis Corporation Post-partum mammalian placenta, its use and placental stem cells therefrom
AU2002243980B2 (en) * 2001-02-14 2007-08-23 Robert J. Hariri Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells
AU2002330077A1 (en) * 2001-09-21 2003-04-01 University Of Rochester Circadian control of stem/progenitor cell self-renewal and differentiation and of clock controlled gene expression
US9597395B2 (en) * 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US7504099B2 (en) 2001-12-27 2009-03-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods of inducing or enhancing connective tissue repair
KR20110036114A (ko) 2002-02-13 2011-04-06 안트로제네시스 코포레이션 산후 포유류 태반으로부터 유래한 배아-유사 줄기 세포와 그 세포를 사용한 용도 및 치료방법
EP1483371B1 (en) * 2002-02-19 2007-06-27 Medipost, Co., Ltd. Isolation and culture-expansion methods of mesenchymal stem/progenitor cells from umbilical cord blood, and differentiation method of umbilical cord blood-derived mesenchymal stem/progenitor cells into various mesenchymal tissues
JP4554940B2 (ja) 2002-04-03 2010-09-29 直秀 山下 ヒト胎盤由来の間葉系細胞を含む医薬及び該細胞を用いたvegfの製造方法
US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
WO2003089619A2 (en) * 2002-04-19 2003-10-30 University Of Pittsburgh Of The Commonwealth System Of Higher Education Placental derived stem cells and uses thereof
US20040161419A1 (en) 2002-04-19 2004-08-19 Strom Stephen C. Placental stem cells and uses thereof
CN1234429C (zh) * 2002-05-09 2006-01-04 中国人民解放军军事医学科学院野战输血研究所 一种人工皮肤及其制备方法与应用
WO2003102151A2 (en) * 2002-05-30 2003-12-11 Celgene Corporation Modulating cell differentiation and treating myeloprolifertive disorders with jnk/mkk inhibitors
ATE438857T1 (de) * 2002-06-13 2009-08-15 Merck Patent Gmbh Verfahren für die identifizierung von allo- antigenen und ihren verwendung für krebs therapie und transplantation
US8455458B2 (en) * 2002-10-16 2013-06-04 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
PL376714A1 (pl) * 2002-11-01 2006-01-09 Boys Town National Research Hospital Indukowalny ligand Ó1ß1 integryny i zastosowania
EP1599575B9 (en) * 2003-02-20 2012-03-14 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
CN1901802B (zh) 2003-02-20 2010-12-29 马克罗珀尔生物外科公司 用脂肪组织来源的细胞治疗心血管疾病的方法
JP2004254674A (ja) * 2003-02-25 2004-09-16 Mutsumi Takagi 動物細胞の分化誘導培養方法
US20060172304A1 (en) 2003-02-27 2006-08-03 Elaine Fuchs Method for modulating epithelial stem cell lineage
CN1548529A (zh) * 2003-05-09 2004-11-24 中国人民解放军军事医学科学院基础医 一种人胎盘间充质干细胞的分离方法
WO2005007799A2 (en) * 2003-07-17 2005-01-27 Gamida-Cell Ltd. Methods for ex-vivo expanding stem/progenitor cells
EP1651756B1 (en) 2003-08-01 2010-11-24 Two Cells Co., Ltd Scaffold-free self-organized 3d synthetic tissue
FR2859381B1 (fr) 2003-09-05 2008-07-25 Centre Nat Rech Scient Utilisaton de cellules issues du tissu adipeux pour induire la formation d'un reseau vasculaire fonctionnel
MXPA06003088A (es) 2003-09-17 2006-06-20 Macropore Biosurgery Inc Metodos para usar celulas regenerativas en el tratamiento de enfermedades vasculares perifericas y trastornos relacionados.
TWI338714B (en) 2003-12-02 2011-03-11 Cathay General Hospital Method of isolation and enrichment of mesenchymal stem cells from amniotic fluid
US7534606B2 (en) 2004-01-12 2009-05-19 National Health Research Institutes Placental stem cell and methods thereof
RU2006129469A (ru) * 2004-01-16 2008-02-27 Новартис АГ (CH) 2, 4-диаминопиримидины и их применение для индукции кардиомиогенеза
JP4445765B2 (ja) * 2004-02-05 2010-04-07 グンゼ株式会社 細胞培養装置
EP2298863B1 (en) 2004-03-22 2015-07-22 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
WO2005113751A1 (en) * 2004-05-14 2005-12-01 Becton, Dickinson And Company Cell culture environments for the serum-free expansion of mesenchymal stem cells
CN1746295A (zh) * 2004-09-09 2006-03-15 中国人民解放军军事医学科学院基础医学研究所 一种基于胎盘来源间充质干细胞的组织工程化软骨及其制造方法
CN1746296A (zh) * 2004-09-09 2006-03-15 中国人民解放军军事医学科学院基础医学研究所 一种基于胎盘来源间充质干细胞的组织工程化骨及其制造方法
CN100336567C (zh) * 2004-10-19 2007-09-12 北京科宇联合干细胞生物技术有限公司 医用角膜贴片
JP5425400B2 (ja) 2004-12-23 2014-02-26 エシコン・インコーポレイテッド 産褥由来細胞を用いた脳卒中および他の急性神経変性障害の治療
WO2006074075A2 (en) 2004-12-30 2006-07-13 Primegen Biotech, Llc Adipose-derived stem cells for tissue regeneration and wound healing
US20070059288A1 (en) * 2005-03-31 2007-03-15 Dinsmore Jonathan H Treatment for heart disease
ES2387402T3 (es) 2005-03-31 2012-09-21 Stemnion, Inc. Composiciones celulares derivadas del amnios, procedimientos de fabricación y usos de las mismas
WO2006112390A1 (ja) 2005-04-14 2006-10-26 Japan As Represented By General Director Of Agency Of National Cardiovascular Center 脂肪由来前駆細胞およびその利用
WO2006138552A2 (en) 2005-06-15 2006-12-28 Government Of The Usa, As Represented By The Secretary, Dept. Of Health & Human Services Tissue engineered cartilage, method of making same, therapeutic and cosmetic surgical applications using same
CA2624916A1 (en) 2005-10-13 2007-04-26 Anthrogenesis Corporation Production of oligodendrocytes from placenta-derived stem cells
EP1957633B1 (en) * 2005-10-13 2013-12-18 Anthrogenesis Corporation Immunomodulation using placental stem cells
CN101330935B (zh) 2005-10-21 2013-11-13 细胞研究私人有限公司 自脐带羊膜分离和培养干/祖细胞及其分化的细胞的应用
SG170789A1 (en) * 2005-12-28 2011-05-30 Ethicon Inc Treatment of peripheral vascular disease using postpartum-derived cells
EP2471903B1 (en) 2005-12-29 2018-02-14 Anthrogenesis Corporation Placental stem cell populations
GB0600972D0 (en) * 2006-01-18 2006-03-01 Univ Leeds Enrichment of cells
US20100233130A1 (en) * 2006-02-06 2010-09-16 Pluristem Ltd. Method and Apparatus for Maintenance and Expansion of Hematopoietic Stem Cells From Mononuclear Cells
MX2008012085A (es) * 2006-03-23 2009-01-22 Pluristem Ltd Metodos para expansion de celulas y usos de celulas y medios acondicionados producidos de esta manera para terapia.
US20110171182A1 (en) 2006-03-23 2011-07-14 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
US20110293583A1 (en) 2006-03-23 2011-12-01 Pluristem Ltd. Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
WO2011132087A1 (en) 2010-04-23 2011-10-27 Pluristem Ltd. Adherent stromal cells derived from plancentas of multiple donors and uses thereof
EP1845154A1 (en) 2006-04-12 2007-10-17 RNL Bio Co., Ltd. Multipotent stem cells derived from placenta tissue and cellular therapeutic agents comprising the same
DE102006043625B4 (de) * 2006-09-12 2012-02-23 Eberhard-Karls-Universität Tübingen Universitätsklinikum Verfahren zur Isolierung und/oder Identifizierung von mesenchymalen Stammzellen (MSC)
US20080138415A1 (en) * 2006-09-26 2008-06-12 Mehboob Hussain Composition and method for producing composition for constructing tissue, and tissue construct
KR20090076989A (ko) * 2006-10-23 2009-07-13 안트로제네시스 코포레이션 태반 줄기세포군으로 뼈의 결함을 치료하기 위한 방법과 조성물
PL2120977T3 (pl) 2007-02-12 2013-12-31 Anthrogenesis Corp Leczenie chorób zapalnych z zastosowaniem łożyskowych komórek macierzystych
WO2009023566A2 (en) * 2007-08-09 2009-02-19 Genzyme Corporation Method of treating autoimmune disease with mesenchymal stem cells
EP3103463B1 (en) 2007-09-19 2020-01-01 Pluristem Ltd. Adherent cells from adipose or placenta tissues and use thereof in therapy
CA2725637A1 (en) 2008-05-27 2009-12-03 Pluristem Ltd. Methods of treating inflammatory colon diseases
EP2334310B1 (en) 2008-09-02 2016-06-29 Pluristem Ltd. Adherent cells from placenta tissue and use thereof in therapy
SG190659A1 (en) 2008-09-02 2013-06-28 Pluristem Ltd Adherent cells from placenta tissue and use thereof in therapy
WO2010026573A1 (en) 2008-09-02 2010-03-11 Pluristem Ltd. Methods of selection of cells for transplantation
EP2507362A2 (en) 2009-11-30 2012-10-10 Pluristem Ltd. Adherent cells from placenta and use of same in disease treatment
ES2572211T3 (es) 2010-05-27 2016-05-30 Pluristem Ltd Regeneración de músculo esquelético utilizando células madre mesenquimales
US20140017209A1 (en) 2011-03-22 2014-01-16 Pluristem Ltd. Methods for treating radiation or chemical injury
SG10201601537QA (en) 2011-04-15 2016-04-28 Pluristem Ltd Methods and systems for harvesting cells
KR101921787B1 (ko) 2012-09-04 2018-11-23 플루리스템 리미티드 자간전증의 예방 및 치료 방법
ES2529501T3 (es) 2012-09-06 2015-02-20 Pluristem Ltd. Dispositivos y métodos para el cultivo de células
BR112015009137A2 (pt) 2012-10-31 2017-07-04 Pluristem Ltd método para descongelamento de material biológico congelado, e, sistema para o aquecimento de um material biológico em um recipiente

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001082991A2 (en) * 2000-05-03 2001-11-08 Fidia Advanced Biopolymers Srl Biomaterials comprised of preadipocyte cells for soft tissue repair
WO2003105908A2 (en) * 2002-03-15 2003-12-24 Department Of Veterans Affairs, Rehabilitation R & D Service Methods and compositions using cellular asialodeterminants and glycoconjugates for targeting cells to tissues and organs
US20050054098A1 (en) * 2003-06-27 2005-03-10 Sanjay Mistry Postpartum cells derived from umbilical cord tissue, and methods of making and using the same

Also Published As

Publication number Publication date
KR101738285B1 (ko) 2017-05-29
IL204566A0 (en) 2010-11-30
CA2699664C (en) 2016-10-18
WO2009037690A1 (en) 2009-03-26
BRPI0815946B8 (pt) 2021-05-25
EP3103463A1 (en) 2016-12-14
IL248955B (en) 2020-03-31
CN107028981A (zh) 2017-08-11
CN107050057B (zh) 2021-04-20
JP6294517B2 (ja) 2018-03-14
ES2392729T5 (es) 2015-08-28
IL248956B (en) 2019-07-31
EP2591789B1 (en) 2016-06-22
CN107028981B (zh) 2021-04-20
SI2200622T2 (sl) 2015-09-30
EP2591789A2 (en) 2013-05-15
IL272587B2 (en) 2023-02-01
HK1145800A1 (en) 2011-05-06
IL272587B (en) 2022-10-01
US9517248B2 (en) 2016-12-13
CA2699664A1 (en) 2009-03-26
KR20100075924A (ko) 2010-07-05
HRP20120887T4 (hr) 2015-12-04
JP2014208682A (ja) 2014-11-06
KR20160081994A (ko) 2016-07-08
US20100209403A1 (en) 2010-08-19
EP2200622B1 (en) 2012-08-08
IL248956A0 (en) 2017-01-31
SI2200622T1 (sl) 2013-01-31
JP2016094464A (ja) 2016-05-26
PL2200622T5 (pl) 2016-08-31
ES2392729T3 (es) 2012-12-13
US8529888B2 (en) 2013-09-10
BRPI0815946B1 (pt) 2020-12-01
EP2591789A3 (en) 2014-01-01
US20130323213A1 (en) 2013-12-05
JP2018109031A (ja) 2018-07-12
IL272587A (en) 2020-03-31
IL204566A (en) 2016-11-30
RU2015141314A3 (OSRAM) 2019-03-14
IL248955A0 (en) 2017-01-31
PT2200622E (pt) 2012-11-06
ZA201001929B (en) 2011-02-23
AU2008300185A1 (en) 2009-03-26
RU2010109698A (ru) 2011-09-27
CN101861156A (zh) 2010-10-13
KR20140107677A (ko) 2014-09-04
US20180256648A9 (en) 2018-09-13
US20220378847A1 (en) 2022-12-01
JP2017095516A (ja) 2017-06-01
EP2591789B2 (en) 2022-07-20
EP2200622A1 (en) 2010-06-30
RU2709780C2 (ru) 2019-12-20
CN107050057A (zh) 2017-08-18
HRP20120887T1 (en) 2012-12-31
BRPI0815946A2 (pt) 2018-06-26
JP2010539228A (ja) 2010-12-16
JP5931132B2 (ja) 2016-06-08
EP2200622B2 (en) 2015-07-29
US20140242039A1 (en) 2014-08-28
EP3103463B1 (en) 2020-01-01
MX2010003019A (es) 2010-04-30
HK1180241A1 (en) 2013-10-18
PL2200622T3 (pl) 2013-01-31
KR101738323B1 (ko) 2017-05-19
JP6560381B2 (ja) 2019-08-14
KR20150100959A (ko) 2015-09-02
RU2015141314A (ru) 2018-12-26

Similar Documents

Publication Publication Date Title
US20220378847A1 (en) Adherent cells from adipose or placenta tissues and use thereof in therapy
AU2013267050B2 (en) Adherent cells from adipose or placenta tissues and use thereof in therapy
CN101861156B (zh) 来自脂肪或胎盘组织的粘附细胞及其在治疗中的用途
HK1234986A1 (en) Adherent cells from adipose or placenta tissues and use thereof in therapy
HK1234986A (en) Adherent cells from adipose or placenta tissues and use thereof in therapy
HK1145800B (en) Adherent cells from adipose or placenta tissues and use thereof in therapy
HK1180241B (en) Adherent cells from adipose or placenta tissues and use thereof in therapy

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired