AU2008269989B2 - Production and purification of esters of polyunsaturated fatty acids - Google Patents

Production and purification of esters of polyunsaturated fatty acids Download PDF

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Publication number
AU2008269989B2
AU2008269989B2 AU2008269989A AU2008269989A AU2008269989B2 AU 2008269989 B2 AU2008269989 B2 AU 2008269989B2 AU 2008269989 A AU2008269989 A AU 2008269989A AU 2008269989 A AU2008269989 A AU 2008269989A AU 2008269989 B2 AU2008269989 B2 AU 2008269989B2
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AU
Australia
Prior art keywords
composition
ester
fatty acid
acid
polyunsaturated fatty
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008269989A
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English (en)
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AU2008269989A1 (en
Inventor
Jung Lee
Neil Leininger
Chris Luigart
Krishna Raman
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DSM IP Assets BV
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DSM IP Assets BV
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Publication of AU2008269989A1 publication Critical patent/AU2008269989A1/en
Assigned to DSM IP ASSETS B.V. reassignment DSM IP ASSETS B.V. Request for Assignment Assignors: MARTEK BIOSCIENCES CORPORATION
Application granted granted Critical
Publication of AU2008269989B2 publication Critical patent/AU2008269989B2/en
Priority to AU2014202880A priority Critical patent/AU2014202880B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/587—Monocarboxylic acid esters having at least two carbon-to-carbon double bonds
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT OF FLOUR OR DOUGH FOR BAKING, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS
    • A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
    • A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
    • A21D2/14—Organic oxygen compounds
    • A21D2/16—Fatty acid esters
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/60—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/003—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with alcohols

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2008269989A 2007-06-29 2008-06-27 Production and purification of esters of polyunsaturated fatty acids Ceased AU2008269989B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2014202880A AU2014202880B2 (en) 2007-06-29 2014-05-27 Production and purification of esters of polyunsaturated fatty acids

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94728407P 2007-06-29 2007-06-29
US60/947,284 2007-06-29
PCT/US2008/068613 WO2009006317A1 (en) 2007-06-29 2008-06-27 Production and purification of esters of polyunsaturated fatty acids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2014202880A Division AU2014202880B2 (en) 2007-06-29 2014-05-27 Production and purification of esters of polyunsaturated fatty acids

Publications (2)

Publication Number Publication Date
AU2008269989A1 AU2008269989A1 (en) 2009-01-08
AU2008269989B2 true AU2008269989B2 (en) 2014-02-27

Family

ID=40226489

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2008269989A Ceased AU2008269989B2 (en) 2007-06-29 2008-06-27 Production and purification of esters of polyunsaturated fatty acids
AU2014202880A Ceased AU2014202880B2 (en) 2007-06-29 2014-05-27 Production and purification of esters of polyunsaturated fatty acids

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2014202880A Ceased AU2014202880B2 (en) 2007-06-29 2014-05-27 Production and purification of esters of polyunsaturated fatty acids

Country Status (8)

Country Link
US (3) US20090023808A1 (enExample)
EP (1) EP2173699A4 (enExample)
JP (1) JP2010532418A (enExample)
CN (1) CN101796014A (enExample)
AU (2) AU2008269989B2 (enExample)
CA (1) CA2692355C (enExample)
MX (2) MX2010000263A (enExample)
WO (1) WO2009006317A1 (enExample)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130101596A (ko) * 2005-07-08 2013-09-13 마텍 바이오싸이언스스 코포레이션 치매 및 치매-전단계와 관련된 용태의 치료를 위한 다중불포화 지방산
US20090023808A1 (en) * 2007-06-29 2009-01-22 Martek Biosciences Corporation Production and Purification of Esters of Polyunsaturated Fatty Acids
US20090071064A1 (en) * 2007-07-27 2009-03-19 Machacek Mark T Continuous algal biodiesel production facility
CN104042600A (zh) 2009-02-02 2014-09-17 帝斯曼知识产权资产有限公司 改善认知功能和降低心率的方法
US20110177061A1 (en) 2009-07-10 2011-07-21 Martek Biosciences Corporation Methods of treating and preventing neurological disorders using docosahexaenoic acid
DE102009038354B4 (de) * 2009-08-21 2018-09-20 Auto-Kabel Management Gmbh Batteriepolklemme
US20110082205A1 (en) * 2009-10-01 2011-04-07 Panker Cynthia A Docosahexaenoic Acid Gel Caps
AU2010306870B2 (en) * 2009-10-13 2016-08-18 Dsm Ip Assets B.V. Reducing the risk of pathological effects of traumatic brain injury
US9247547B2 (en) * 2009-10-15 2016-01-26 Qualcomm Incorporated Downlink and uplink resource element mapping for carrier extension
US9321715B2 (en) 2009-12-30 2016-04-26 Basf Pharma (Callanish) Limited Simulated moving bed chromatographic separation process
WO2011097273A1 (en) * 2010-02-02 2011-08-11 Martek Biosciences Corporation Methods and compositions for treating non-alcoholic fatty liver disease with docosahexaenoic acid and n-acetyl lcystenine
US8372465B2 (en) * 2010-02-17 2013-02-12 Bunge Oils, Inc. Oil compositions of stearidonic acid
US9585837B2 (en) 2010-04-09 2017-03-07 Dsm Ip Assets B.V. Thermally stable oil-in-water emulsions containing an oil that contains polyunsaturated fatty acids
SG185578A1 (en) 2010-06-14 2013-01-30 Io Mega Holding Corp Methods for the production of algae derived oils
US9051260B2 (en) * 2010-09-03 2015-06-09 Stepan Speciality Products, Llc Elimination of organohalo and oxirane species in carboxylic acid ester streams
GB201111594D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New improved process
GB201111591D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Further new process
GB201111595D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Improved process
GB201111589D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New modified process
GB201111601D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New process
EP2734626B1 (en) * 2011-07-21 2020-12-16 DSM IP Assets B.V. Microbial oils enriched in polyunsaturated fatty acids
WO2013024174A1 (en) 2011-08-18 2013-02-21 Dsm Ip Assets B.V. Dha triglyceride, dha free fatty acid, and dha ethyl ester emulsions, and methods of treating spinal cord injury
ES2845556T3 (es) 2011-11-01 2021-07-27 Dsm Ip Assets Bv Aceite que contiene ácidos grasos poliinsaturados estable oxidativamente
AU2013259503B2 (en) 2012-05-10 2017-03-16 Solutex Na Llc Oils with anti-inflammatory activity containing natural specialized proresolving mediators and their precursors
FR2991337B1 (fr) * 2012-05-29 2016-09-02 Roquette Freres Procede continu d'enrichissement en esters ethyliques de dha d'une huile produite par des microalgues
GB201300354D0 (en) 2013-01-09 2013-02-20 Basf Pharma Callanish Ltd Multi-step separation process
PE20151724A1 (es) * 2013-03-13 2015-12-11 Dsm Nutritional Products Ag Recuperacion de urea y aceite a partir de un complejo urea/aceite
WO2014152283A1 (en) 2013-03-15 2014-09-25 Heliae Development, Llc Direct transesterification of algal biomass for synthesis of fatty acid ethyl esters (faee)
US8802880B1 (en) 2013-05-07 2014-08-12 Group Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US9428711B2 (en) 2013-05-07 2016-08-30 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
JP6302310B2 (ja) * 2013-08-30 2018-03-28 備前化成株式会社 高純度オメガ３系脂肪酸エチルエステルの生産方法
ES2872449T3 (es) * 2013-12-04 2021-11-02 Nippon Suisan Kaisha Ltd Aceite microbiano, procedimiento para fabricar aceite microbiano, aceite microbiano concentrado y procedimiento para fabricar aceite microbiano concentrado
EP2883860B1 (fr) 2013-12-11 2016-08-24 Novasep Process Procédé chromatographique de production d'acides gras polyinsaturés
FR3014436B1 (fr) * 2013-12-11 2016-10-21 Novasep Process Procede de purification chromatographique d'un acide gras
JP6303017B2 (ja) 2014-01-07 2018-03-28 ノヴァセプ プロセスＮｏｖａｓｅｐ Ｐｒｏｃｅｓｓ 芳香族アミノ酸を精製する方法
CN105779123B (zh) * 2014-08-06 2020-03-10 石家庄搏澳增塑材料科技有限公司 氯化胆碱法解包尿素-饱和脂肪酸甲酯包合物的清洁工艺
CN105566103B (zh) * 2014-10-13 2019-02-19 浙江医药股份有限公司新昌制药厂 一种甘油酯型多不饱和脂肪酸的制备方法
US10501704B2 (en) * 2015-05-13 2019-12-10 Epax Norway As Very long chain polyunsaturated fatty acids from natural oils
US11672258B2 (en) * 2015-08-25 2023-06-13 Dsm Ip Assets B.V. Refined oil compositions and methods for making
WO2017041094A1 (en) 2015-09-03 2017-03-09 Solutex Na Llc Compositions comprising omega-3 fatty acids, 17-hdha and 18- hepe and methods of using same
HK1258568A1 (zh) 2015-10-05 2019-11-15 Dsm Ip Assets B.V. 油组合物和制备方法
KR101815110B1 (ko) 2015-10-16 2018-01-10 에이케이 앤 엠엔 바이오팜 주식회사 오메가-7계 불포화 지방산의 정제공정
KR102405390B1 (ko) 2016-07-13 2022-06-03 에보닉 오퍼레이션스 게엠베하 용해된 지질을 함유하는 바이오매스로부터 지질을 분리하는 방법
ES2872009T3 (es) 2016-12-27 2021-11-02 Evonik Degussa Gmbh Método de aislamiento de lípidos a partir de una biomasa que contiene lípidos
KR20200039704A (ko) * 2017-08-07 2020-04-16 디에스엠 아이피 어셋츠 비.브이. 농축된 다중-불포화 지방산의 제조 방법
EP3470502A1 (en) 2017-10-13 2019-04-17 Evonik Degussa GmbH Method of separating lipids from a lysed lipids containing biomass
EP3527664A1 (en) 2018-02-15 2019-08-21 Evonik Degussa GmbH Method of isolating lipids from a lipids containing biomass
WO2019219396A1 (en) 2018-05-15 2019-11-21 Evonik Operations Gmbh Method of isolating lipids from a lysed lipids containing biomass by emulsion inversion
WO2019219443A1 (en) 2018-05-15 2019-11-21 Evonik Operations Gmbh Method of isolating lipids from a lipids containing biomass with aid of hydrophobic silica
EP3586640A1 (en) * 2018-06-21 2020-01-01 Nuseed Pty Ltd Dha enriched polyunsaturated fatty acid compositions
EP3586642A1 (en) * 2018-06-21 2020-01-01 Nuseed Pty Ltd Ala enriched polyunsaturated fatty acid compositions
EP3586643A1 (en) * 2018-06-21 2020-01-01 Nuseed Pty Ltd Dha enriched polyunsaturated fatty acid compositions
EP3586641A1 (en) * 2018-06-21 2020-01-01 Nuseed Pty Ltd Dha enriched polyunsaturated fatty acid compositions
CN109061000A (zh) * 2018-09-13 2018-12-21 中国科学院海洋研究所 一种衍生化处理植物油脂的混合液及其衍生化方法和应用
CN109337939B (zh) * 2018-09-30 2021-07-27 河北康睿达脂质有限公司 一种多不饱和脂肪酸结构脂质的制备方法
NO20181574A1 (en) * 2018-12-06 2020-06-08 Epax Norway As Very long chain fatty acids
EP3666082B1 (en) * 2018-12-12 2022-05-04 Nippon Suisan Kaisha, Ltd. A composition containing highly unsaturated fatty acid or alkyl ester thereof and a method for producing the same
RU2709620C1 (ru) * 2019-07-01 2019-12-19 Федеральное государственное автономное образовательное учреждение высшего образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет, НГУ) Водная эмульсия на основе диметоксинитробензиловых эфиров арахидоновой кислоты
FR3108622B1 (fr) 2020-03-27 2024-08-23 Polaris Procédé de fractionnement d’acides gras à deux carbones de différence par distillation moléculaire
LU102019B1 (de) * 2020-08-26 2022-02-28 K D Pharma Bexbach Gmbh Verfahren zur Herstellung von Öl aus einem Mikroalgenerzeugnis
WO2025114579A2 (en) 2023-12-01 2025-06-05 Tate & Lyle Solutions Usa Llc Methods of processing an oil composition

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019144A1 (en) * 1992-03-18 1993-09-30 F. Hoffmann-La Roche Ag Fatty acid esters
WO2002010322A1 (en) * 2000-08-02 2002-02-07 Dsm N.V. Purifying crude pufa oils
US20050129831A1 (en) * 2001-10-19 2005-06-16 Dirk Fabritius Mixtures of triglycerides of natural polyunsaturated fatty acids with high polyunsaturated fatty acid content, method for producing same and use thereof

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3082228A (en) * 1959-12-18 1963-03-19 Escambia Chem Corp Method for producing monoesters of polyunsaturated fatty acids
NL8300698A (nl) * 1983-02-24 1984-09-17 Univ Leiden Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten.
IT1205043B (it) * 1987-05-28 1989-03-10 Innova Di Ridolfi Flora & C S Procedimento per l'estrazione di esteri di acidi grassi poliinsaturi da olii di pesce e composizioni farmaceutiche e dietetiche contenenti detti esteri
GB2218984B (en) * 1988-05-27 1992-09-23 Renafield Limited Process for preparing high-concentration mixtures of polyunsaturated fatty acids & their esters and their prophylactic or therapeutic uses
GB8819110D0 (en) * 1988-08-11 1988-09-14 Norsk Hydro As Antihypertensive drug & method for production
US5340594A (en) * 1988-09-07 1994-08-23 Omegatech Inc. Food product having high concentrations of omega-3 highly unsaturated fatty acids
US5340742A (en) * 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US5130242A (en) * 1988-09-07 1992-07-14 Phycotech, Inc. Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids
US5407957A (en) * 1990-02-13 1995-04-18 Martek Corporation Production of docosahexaenoic acid by dinoflagellates
US5658767A (en) * 1991-01-24 1997-08-19 Martek Corporation Arachidonic acid and methods for the production and use thereof
EP0567653A4 (en) * 1991-11-14 1994-06-01 Sagami Chem Res Drug for hepatic diseases
ES2135756T3 (es) * 1994-08-16 1999-11-01 Frische Gmbh Procedimiento para la obtencion de productos nativos no solubles en agua a partir de mezclas de sustancias con ayuda de la fuerza centrifuga.
BR9710394A (pt) * 1996-07-23 2000-01-11 Nagase Biochemicals Ltda Processo para preparação de ácido docosahexaenóico e ácido docosapentaenóico;processo de preparação a partir de lipidio;microorganismo produtor de lipìdios;alimentos e congenêres abtidos através do processo
CA2283422A1 (en) * 1997-06-04 1998-12-10 Calgene, Llc Production of polyunsaturated fatty acids by expression of polyketide-like synthesis genes in plants
US6566583B1 (en) * 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
CN1204638A (zh) * 1997-07-02 1999-01-13 湖南天海林实业股份有限公司 二十二碳六烯酸的制备和酯化工艺
US6677145B2 (en) * 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
US7217856B2 (en) * 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7211418B2 (en) * 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7271315B2 (en) * 1999-01-14 2007-09-18 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7247461B2 (en) * 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
DE60012934T2 (de) * 1999-02-26 2005-08-25 Martek Biosciences Corp. Verfahren zum Abtrennen von einem Docosahexaensäure enthaltenden Triglycerid aus einem Triglyceridgemisch
CA2273570A1 (en) 1999-05-31 2000-11-30 Jfs Envirohealth Ltd. Concentration and purification of polyunsaturated fatty acid esters by distillation-enzymatic transesterification coupling
CA2311974A1 (en) * 1999-06-28 2000-12-28 Nisshin Flour Milling Co., Ltd. Processes of selectively separating and purifying eicosapentaenoic and docosahexaenoic acids or their esters
US6712867B1 (en) * 1999-08-18 2004-03-30 Biox Corporation Process for production of fatty acid methyl esters from fatty acid triglycerides
US6395778B1 (en) * 2000-01-11 2002-05-28 Omegatech, Inc. Process for making an enriched mixture of polyunsaturated fatty acid esters
KR101591834B1 (ko) * 2000-01-19 2016-02-18 마텍 바이오싸이언스스 코포레이션 무용매 추출 방법
EP1707055A3 (en) * 2000-01-28 2009-01-14 Martek Biosciences Corporation Enhanced production of lipids containing polyenoic fatty acids by very high density cultures of eukaryotic microbes in fermentors
TWI377253B (en) * 2001-04-16 2012-11-21 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
DE10224937A1 (de) * 2001-06-05 2002-12-12 Celanese Ventures Gmbh Festphasen-Extraktionsverfahren zur Gewinnung hochreiner ungesättigter Verbindungen bzw. Derivate dieser Verbindungen
US20030032826A1 (en) * 2001-07-20 2003-02-13 The Board Of Regents Of The University Of Nebraska Transesterification process for production of biodiesel
JP2003048831A (ja) * 2001-08-02 2003-02-21 Suntory Ltd 脳機能の低下に起因する症状あるいは疾患の予防又は改善作用を有する組成物
KR100556337B1 (ko) * 2002-02-05 2006-03-03 주식회사 가야에너지 단일단계 연속공정을 통한 고순도 지방산 알킬에스테르의제조방법
US9101151B2 (en) * 2002-05-03 2015-08-11 Dsm Ip Assets B.V. High-quality lipids produced by enzymatic liberation from biomass
US20060165735A1 (en) * 2002-06-18 2006-07-27 Abril Jesus R Stable emulsions of oils in aqueous solutions and methods for producing same
KR101195574B1 (ko) * 2002-09-24 2012-10-30 산토리 홀딩스 가부시키가이샤 아라키돈산을 단독으로 또는 도코사헥사엔산과의 조합으로함유하는 인지 능력 향상용 조성물
US20040106584A1 (en) * 2002-09-27 2004-06-03 Linda Arterburn Prophylactic docosahexaenoic acid therapy for patients with subclinical inflammation
US20040172682A1 (en) * 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
US7507846B2 (en) * 2003-03-20 2009-03-24 Pelly Michael F Method and apparatus for refining biodiesel
CN1208308C (zh) * 2003-05-08 2005-06-29 南京大学 从卤虾粉提取、制备、纯化二十二碳六烯酸乙酯的方法
US7208590B2 (en) * 2003-07-15 2007-04-24 Abbott Laboratories Genes involved in polyketide synthase pathways and uses thereof
EP1670880A4 (en) * 2003-10-02 2007-04-04 Univ Mississippi METHOD FOR PRODUCING BIODIESEL AND OTHER VALUABLE CHEMICALS FROM SLUDGE FROM WASTEWATER TREATMENT PLANTS
US7169946B1 (en) * 2004-03-05 2007-01-30 Twin Rivers Technologies, L.P. Alternatives to distilled oleo chemicals in derivatives and production thereof
WO2006017692A2 (en) * 2004-08-06 2006-02-16 Transform Pharmaceuticals, Inc. Novel fenofibrate formulations and related methods of treatment
US7666234B2 (en) * 2004-10-20 2010-02-23 Council Of Scientific And Industrial Research Process for the preparation of fatty acid methyl ester from triglyceride oil by transesterification
DE102005003624A1 (de) * 2005-01-26 2006-07-27 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Herstellung und Anwendung eines antioxidativ wirksamen Extraktes aus Crypthecodinium sp.
EP1907520A1 (en) * 2005-06-09 2008-04-09 Biosphere Environmental Energy LLC Systems and methods for esterification and transesterification of fats and oils
US20090023808A1 (en) * 2007-06-29 2009-01-22 Martek Biosciences Corporation Production and Purification of Esters of Polyunsaturated Fatty Acids

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019144A1 (en) * 1992-03-18 1993-09-30 F. Hoffmann-La Roche Ag Fatty acid esters
WO2002010322A1 (en) * 2000-08-02 2002-02-07 Dsm N.V. Purifying crude pufa oils
US20050129831A1 (en) * 2001-10-19 2005-06-16 Dirk Fabritius Mixtures of triglycerides of natural polyunsaturated fatty acids with high polyunsaturated fatty acid content, method for producing same and use thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GREEN et al. "Dietary Docosahexaenoic Acid and Docosapentaenoic Acid Ameliorate Amyloid-beta and Tau Pathology via a Mechanism Involving Presenilin 1 Levels, April 18, 2007, The Journal of Neuroscience, vol 27, pp 4385-4395. *
HARRIS Omega-3 long chain PUFA and triglyceride lowering: minimum effective intakes, 2001, 110 European Heart J Supplements (Supplement D), vol 3, pp D59-D61, *
LIANG et al Fractionation of Squid Visceral Oil Ethyl Esters by Short-Path Distillation, 2000, J. Am. Oil Chern. Soc., vol 77, pp 773-777, *
MANSOUR et al. Lipid and fatty acid yield of nine stationary-phase microalgae: Applications and unusual C24-C28 polyunsaturated fatty acids, 2005, J. Applied Phycology, vol 17, p 287-300 *
NAPIER J. A. "Plumbing the depths of PUFA biosynthesis: a novel polyketide synthase-like pathway from marine organisms", 2002, TRENDS in Plant Science, vol 7, pp 51-54, *

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CA2692355A1 (en) 2009-01-08
US20110098356A1 (en) 2011-04-28
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WO2009006317A1 (en) 2009-01-08
US9796658B2 (en) 2017-10-24
AU2014202880B2 (en) 2017-08-31
US20090023808A1 (en) 2009-01-22
CN101796014A (zh) 2010-08-04
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