AU2008269989B2 - Production and purification of esters of polyunsaturated fatty acids - Google Patents
Production and purification of esters of polyunsaturated fatty acids Download PDFInfo
- Publication number
- AU2008269989B2 AU2008269989B2 AU2008269989A AU2008269989A AU2008269989B2 AU 2008269989 B2 AU2008269989 B2 AU 2008269989B2 AU 2008269989 A AU2008269989 A AU 2008269989A AU 2008269989 A AU2008269989 A AU 2008269989A AU 2008269989 B2 AU2008269989 B2 AU 2008269989B2
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- AU
- Australia
- Prior art keywords
- composition
- ester
- fatty acid
- acid
- polyunsaturated fatty
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 235000020777 polyunsaturated fatty acids Nutrition 0.000 title claims abstract description 212
- 150000002148 esters Chemical class 0.000 title claims abstract description 180
- 238000004519 manufacturing process Methods 0.000 title claims description 18
- 238000000746 purification Methods 0.000 title description 7
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- 238000000034 method Methods 0.000 claims abstract description 100
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 97
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- 150000004665 fatty acids Chemical group 0.000 claims abstract description 41
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 128
- 125000004494 ethyl ester group Chemical group 0.000 claims description 72
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 70
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 claims description 69
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- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/587—Monocarboxylic acid esters having at least two carbon-to-carbon double bonds
-
- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT OF FLOUR OR DOUGH FOR BAKING, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS
- A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
- A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
- A21D2/14—Organic oxygen compounds
- A21D2/16—Fatty acid esters
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/60—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
- C11C3/003—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with alcohols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Fats And Perfumes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2014202880A AU2014202880B2 (en) | 2007-06-29 | 2014-05-27 | Production and purification of esters of polyunsaturated fatty acids |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94728407P | 2007-06-29 | 2007-06-29 | |
| US60/947,284 | 2007-06-29 | ||
| PCT/US2008/068613 WO2009006317A1 (en) | 2007-06-29 | 2008-06-27 | Production and purification of esters of polyunsaturated fatty acids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014202880A Division AU2014202880B2 (en) | 2007-06-29 | 2014-05-27 | Production and purification of esters of polyunsaturated fatty acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2008269989A1 AU2008269989A1 (en) | 2009-01-08 |
| AU2008269989B2 true AU2008269989B2 (en) | 2014-02-27 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| AU2008269989A Ceased AU2008269989B2 (en) | 2007-06-29 | 2008-06-27 | Production and purification of esters of polyunsaturated fatty acids |
| AU2014202880A Ceased AU2014202880B2 (en) | 2007-06-29 | 2014-05-27 | Production and purification of esters of polyunsaturated fatty acids |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014202880A Ceased AU2014202880B2 (en) | 2007-06-29 | 2014-05-27 | Production and purification of esters of polyunsaturated fatty acids |
Country Status (8)
| Country | Link |
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| US (3) | US20090023808A1 (enExample) |
| EP (1) | EP2173699A4 (enExample) |
| JP (1) | JP2010532418A (enExample) |
| CN (1) | CN101796014A (enExample) |
| AU (2) | AU2008269989B2 (enExample) |
| CA (1) | CA2692355C (enExample) |
| MX (2) | MX374545B (enExample) |
| WO (1) | WO2009006317A1 (enExample) |
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| MX336435B (es) * | 2005-07-08 | 2016-01-19 | Dsm Ip Assets Bv | Acidos grasos poliinsaturados para el tratamiento de demencia y condiciones relacionadas con pre-demencia. |
| AU2008269989B2 (en) * | 2007-06-29 | 2014-02-27 | Dsm Ip Assets B.V. | Production and purification of esters of polyunsaturated fatty acids |
| US20090071064A1 (en) * | 2007-07-27 | 2009-03-19 | Machacek Mark T | Continuous algal biodiesel production facility |
| WO2010088700A1 (en) | 2009-02-02 | 2010-08-05 | Martek Biosciences Corporation | Methods for improving cognitive function and decreasing heart rate |
| US20110177061A1 (en) | 2009-07-10 | 2011-07-21 | Martek Biosciences Corporation | Methods of treating and preventing neurological disorders using docosahexaenoic acid |
| DE102009038354B4 (de) * | 2009-08-21 | 2018-09-20 | Auto-Kabel Management Gmbh | Batteriepolklemme |
| WO2011041710A2 (en) | 2009-10-01 | 2011-04-07 | Martek Biosciences Corporation | Docosahexaenoic acid gel caps |
| CA2777367A1 (en) * | 2009-10-13 | 2011-04-21 | Martek Biosciences Corporation | Reducing the risk of pathological effects of traumatic brain injury |
| US9247547B2 (en) * | 2009-10-15 | 2016-01-26 | Qualcomm Incorporated | Downlink and uplink resource element mapping for carrier extension |
| PE20130491A1 (es) | 2009-12-30 | 2013-05-02 | Basf Pharma Callanish Ltd | Proceso simulado de separacion cromatografica de lecho movil para la purificacion de acidos grasos poliinsaturados |
| WO2011097273A1 (en) * | 2010-02-02 | 2011-08-11 | Martek Biosciences Corporation | Methods and compositions for treating non-alcoholic fatty liver disease with docosahexaenoic acid and n-acetyl lcystenine |
| US8372465B2 (en) | 2010-02-17 | 2013-02-12 | Bunge Oils, Inc. | Oil compositions of stearidonic acid |
| US9585837B2 (en) | 2010-04-09 | 2017-03-07 | Dsm Ip Assets B.V. | Thermally stable oil-in-water emulsions containing an oil that contains polyunsaturated fatty acids |
| SG185578A1 (en) | 2010-06-14 | 2013-01-30 | Io Mega Holding Corp | Methods for the production of algae derived oils |
| EP2611767B1 (en) * | 2010-09-03 | 2017-10-25 | Stepan Specialty Products, LLC | Elimination of organohalo and oxirane species in carboxylic acid ester streams |
| GB201111595D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | Improved process |
| GB201111589D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New modified process |
| GB201111594D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New improved process |
| GB201111591D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | Further new process |
| GB201111601D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New process |
| ES2857173T3 (es) * | 2011-07-21 | 2021-09-28 | Dsm Ip Assets Bv | Aceites microbianos enriquecidos en ácidos grasos poliinsaturados |
| WO2013024174A1 (en) | 2011-08-18 | 2013-02-21 | Dsm Ip Assets B.V. | Dha triglyceride, dha free fatty acid, and dha ethyl ester emulsions, and methods of treating spinal cord injury |
| RU2619755C2 (ru) | 2011-11-01 | 2017-05-18 | ДСМ АйПи АССЕТС Б.В. | Масла, содержащие полиненасыщенные жирные кислоты, устойчивые к окислению |
| CN110478342A (zh) | 2012-05-10 | 2019-11-22 | 索卢泰克斯Na有限责任公司 | 含有天然专门促消退介质及其前体的具有抗炎活性的油 |
| FR2991337B1 (fr) * | 2012-05-29 | 2016-09-02 | Roquette Freres | Procede continu d'enrichissement en esters ethyliques de dha d'une huile produite par des microalgues |
| GB201300354D0 (en) | 2013-01-09 | 2013-02-20 | Basf Pharma Callanish Ltd | Multi-step separation process |
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| US9428711B2 (en) | 2013-05-07 | 2016-08-30 | Groupe Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
| US8802880B1 (en) | 2013-05-07 | 2014-08-12 | Group Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
| JP6302310B2 (ja) * | 2013-08-30 | 2018-03-28 | 備前化成株式会社 | 高純度オメガ３系脂肪酸エチルエステルの生産方法 |
| JP6824038B2 (ja) | 2013-12-04 | 2021-02-03 | 日本水産株式会社 | ジホモ−γ−リノレン酸含有微生物油及びジホモ−γ−リノレン酸含有微生物菌体 |
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| EP3118186B1 (fr) | 2013-12-11 | 2022-02-09 | Novasep Process | Installation chromatographique de production d acides gras polyinsatures |
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- 2008-06-27 CA CA2692355A patent/CA2692355C/en active Active
- 2008-06-27 MX MX2015006380A patent/MX374545B/es unknown
- 2008-06-27 US US12/163,555 patent/US20090023808A1/en not_active Abandoned
- 2008-06-27 JP JP2010515186A patent/JP2010532418A/ja active Pending
- 2008-06-27 WO PCT/US2008/068613 patent/WO2009006317A1/en not_active Ceased
- 2008-06-27 CN CN200880104965A patent/CN101796014A/zh active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2692355A1 (en) | 2009-01-08 |
| MX2010000263A (es) | 2010-03-11 |
| JP2010532418A (ja) | 2010-10-07 |
| MX374545B (es) | 2025-03-06 |
| US9796658B2 (en) | 2017-10-24 |
| WO2009006317A1 (en) | 2009-01-08 |
| AU2014202880B2 (en) | 2017-08-31 |
| AU2014202880A1 (en) | 2014-06-19 |
| EP2173699A4 (en) | 2014-04-16 |
| CA2692355C (en) | 2018-09-11 |
| US20140128465A1 (en) | 2014-05-08 |
| AU2008269989A1 (en) | 2009-01-08 |
| US20090023808A1 (en) | 2009-01-22 |
| EP2173699A1 (en) | 2010-04-14 |
| US20110098356A1 (en) | 2011-04-28 |
| CN101796014A (zh) | 2010-08-04 |
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