AU2008204433B2 - Anti-KIR antibodies, formulations, and uses thereof - Google Patents

Anti-KIR antibodies, formulations, and uses thereof Download PDF

Info

Publication number
AU2008204433B2
AU2008204433B2 AU2008204433A AU2008204433A AU2008204433B2 AU 2008204433 B2 AU2008204433 B2 AU 2008204433B2 AU 2008204433 A AU2008204433 A AU 2008204433A AU 2008204433 A AU2008204433 A AU 2008204433A AU 2008204433 B2 AU2008204433 B2 AU 2008204433B2
Authority
AU
Australia
Prior art keywords
kir
antibody
formulation
patient
dose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008204433A
Other languages
English (en)
Other versions
AU2008204433A1 (en
Inventor
Lene Hjorth Alifrangis
Rune Viig Overgaard
Ivan Svendsen
Rozana Svensson
Peter Andreas Nicolai Reumert Wagtmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of AU2008204433A1 publication Critical patent/AU2008204433A1/en
Priority to AU2013237638A priority Critical patent/AU2013237638B2/en
Application granted granted Critical
Publication of AU2008204433B2 publication Critical patent/AU2008204433B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
AU2008204433A 2007-01-11 2008-01-11 Anti-KIR antibodies, formulations, and uses thereof Ceased AU2008204433B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013237638A AU2013237638B2 (en) 2007-01-11 2013-10-01 Anti-kir antibodies, formulations, and uses thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87996407P 2007-01-11 2007-01-11
US60/879,964 2007-01-11
US91152707P 2007-04-13 2007-04-13
US60/911,527 2007-04-13
PCT/EP2008/050306 WO2008084106A1 (en) 2007-01-11 2008-01-11 Anti-kir antibodies, formulations, and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2013237638A Division AU2013237638B2 (en) 2007-01-11 2013-10-01 Anti-kir antibodies, formulations, and uses thereof

Publications (2)

Publication Number Publication Date
AU2008204433A1 AU2008204433A1 (en) 2008-07-17
AU2008204433B2 true AU2008204433B2 (en) 2014-03-13

Family

ID=39144327

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008204433A Ceased AU2008204433B2 (en) 2007-01-11 2008-01-11 Anti-KIR antibodies, formulations, and uses thereof

Country Status (8)

Country Link
US (3) US20100189723A1 (cg-RX-API-DMAC7.html)
EP (2) EP2604278B1 (cg-RX-API-DMAC7.html)
JP (3) JP5478261B2 (cg-RX-API-DMAC7.html)
CN (2) CN105037549B (cg-RX-API-DMAC7.html)
AU (1) AU2008204433B2 (cg-RX-API-DMAC7.html)
CA (1) CA2675291C (cg-RX-API-DMAC7.html)
ES (2) ES2579768T3 (cg-RX-API-DMAC7.html)
WO (1) WO2008084106A1 (cg-RX-API-DMAC7.html)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004253770C1 (en) 2003-07-02 2010-04-15 Innate Pharma PAN-KIR2DL NK-receptor antibodies and their use in diagnostik and therapy
US20090191213A9 (en) * 2003-07-02 2009-07-30 Novo Nordisk A/S Compositions and methods for regulating NK cell activity
ES2732623T3 (es) * 2005-01-06 2019-11-25 Innate Pharma Sa Tratamientos y métodos de combinación anti-KIR
WO2010065939A1 (en) 2008-12-05 2010-06-10 Indiana University Research & Technology Corporation Combination therapy to enhace nk cell mediated cytotoxicty
WO2010117729A1 (en) 2009-03-30 2010-10-14 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same
EP2453910B1 (en) * 2009-07-15 2016-08-31 Portola Pharmaceuticals, Inc. Unit dose formulation of antidote for factor xa inhibitors for use in preventing bleeding
EP3514170A1 (en) * 2010-10-22 2019-07-24 Dana-Farber Cancer Institute, Inc. Discovery of regulatory t cells programmed to suppress an immune response
EA035033B1 (ru) * 2010-11-22 2020-04-20 Иннейт Фарма Са Способ лечения гематологического предракового или гематологического ракового заболеваний
KR20120093002A (ko) * 2011-02-14 2012-08-22 (주)에이티젠 Nk 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트
JP6342325B2 (ja) 2011-05-25 2018-06-13 イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. 炎症性障害の治療のための抗kir抗体
EP2904011B1 (en) * 2012-10-02 2017-08-23 Bristol-Myers Squibb Company Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer
CN105025925A (zh) * 2013-03-15 2015-11-04 拜尔健康护理有限责任公司 抗-催乳素受体抗体制剂
US10494433B2 (en) 2013-11-06 2019-12-03 Bristol-Myers Squibb Company Combination of anti-KIR and anti-CS1 antibodies to treat multiple myeloma
US11639384B2 (en) 2014-10-28 2023-05-02 University Children's Hospital Tübingen Treatment of pediatric BCP-ALL patients with an anti-KIR antibody
DK3283107T3 (da) 2015-04-17 2020-08-31 Bristol Myers Squibb Co Sammensætninger omfattende en kombination af ipilimumab og nivolumab
EP3907285A1 (en) 2015-05-06 2021-11-10 Snipr Technologies Limited Altering microbial populations & modifying microbiota
SG10202002131PA (en) 2015-05-21 2020-05-28 Harpoon Therapeutics Inc Trispecific binding proteins and methods of use
CN107921087A (zh) 2015-07-16 2018-04-17 百欧肯治疗有限公司 治疗癌症的组合物及方法
US20190038713A1 (en) 2015-11-07 2019-02-07 Multivir Inc. Compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer
JP2018536404A (ja) 2015-11-09 2018-12-13 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Cho細胞において産生したポリペプチドの品質特性を操作する方法
JP2019506438A (ja) * 2016-02-24 2019-03-07 チルドレンズ ホスピタル オブ イースタン オンタリオ リサーチ インスティチュート インコーポレイテッド がんの処置のためのsmc組合せ療法
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
JP7169195B2 (ja) 2016-05-20 2022-11-10 バイオヘイブン・ファーマシューティカル・ホールディング・カンパニー・リミテッド 癌を処置するためのリルゾール、リルゾールプロドラッグまたはリルゾール類似体と免疫療法との併用
GB201609811D0 (en) 2016-06-05 2016-07-20 Snipr Technologies Ltd Methods, cells, systems, arrays, RNA and kits
JP7542946B2 (ja) 2016-09-27 2024-09-02 ボード オブ リージェンツ, ザ ユニヴァーシティー オブ テキサス システム マイクロバイオームをモジュレートすることにより、免疫チェックポイント遮断療法を増強するための方法
MX386249B (es) 2016-10-12 2025-03-18 Univ Texas Terapia tusc2 para usarse en el tratamiento de cáncer.
WO2018111902A1 (en) 2016-12-12 2018-06-21 Multivir Inc. Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases
WO2018183928A1 (en) 2017-03-31 2018-10-04 Bristol-Myers Squibb Company Methods of treating tumor
CN121159691A (zh) 2017-05-12 2025-12-19 哈普恩治疗公司 间皮素结合蛋白质
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
EA202090817A1 (ru) 2017-10-13 2020-09-08 Харпун Терапьютикс, Инк. Триспецифические белки и способы их применения
KR20200064132A (ko) 2017-10-15 2020-06-05 브리스톨-마이어스 스큅 컴퍼니 종양을 치료하는 방법
CN112020510B (zh) 2018-03-19 2024-10-11 茂体外尔公司 包含用于治疗癌症的肿瘤抑制基因疗法和cd122/cd132激动剂的方法及组合物
TW202003565A (zh) 2018-03-23 2020-01-16 美商必治妥美雅史谷比公司 抗mica及/或micb抗體及其用途
GB2587521B (en) 2018-03-25 2023-06-21 Snipr Biome Aps Treating & preventing microbial infections
US10760075B2 (en) 2018-04-30 2020-09-01 Snipr Biome Aps Treating and preventing microbial infections
US20210032344A1 (en) 2018-03-30 2021-02-04 Bristol-Myers Squibb Company Methods of treating tumor
JP2021528393A (ja) 2018-06-15 2021-10-21 フラグシップ パイオニアリング イノベーションズ ブイ,インコーポレーテッド 後細胞シグナル伝達因子の調節による免疫活性の上昇
WO2020061482A1 (en) 2018-09-21 2020-03-26 Harpoon Therapeutics, Inc. Egfr binding proteins and methods of use
AU2019346466A1 (en) 2018-09-25 2021-05-20 Harpoon Therapeutics, Inc. DLL3 binding proteins and methods of use
US20220054524A1 (en) 2018-12-21 2022-02-24 Onxeo New conjugated nucleic acid molecules and their uses
MA55033A (fr) 2019-02-18 2021-12-29 Lilly Co Eli Formulation d'anticorps thérapeutique
WO2020227159A2 (en) 2019-05-03 2020-11-12 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity
US20220233691A1 (en) 2019-05-30 2022-07-28 Bristol-Myers Squibb Company Cell localization signature and combination therapy
JP2022534967A (ja) 2019-05-30 2022-08-04 ブリストル-マイヤーズ スクイブ カンパニー 多腫瘍遺伝子シグネチャーおよびその使用
CN114127315A (zh) 2019-05-30 2022-03-01 百时美施贵宝公司 鉴定适合于免疫肿瘤学(i-o)疗法的受试者的方法
WO2021024020A1 (en) 2019-08-06 2021-02-11 Astellas Pharma Inc. Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
WO2021113644A1 (en) 2019-12-05 2021-06-10 Multivir Inc. Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer
US20230114107A1 (en) 2019-12-17 2023-04-13 Flagship Pioneering Innovations V, Inc. Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
TW202214857A (zh) 2020-06-19 2022-04-16 法商昂席歐公司 新型結合核酸分子及其用途
CA3184366A1 (en) 2020-06-29 2022-01-06 Darby Rye Schmidt Viruses engineered to promote thanotransmission and their use in treating cancer
AU2021306613A1 (en) 2020-07-07 2023-02-02 BioNTech SE Therapeutic RNA for HPV-positive cancer
BR112023003553A2 (pt) 2020-08-31 2023-04-04 Bristol Myers Squibb Co Assinatura de localização celular e imunoterapia
WO2022120179A1 (en) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Multi-tumor gene signatures and uses thereof
WO2022135667A1 (en) 2020-12-21 2022-06-30 BioNTech SE Therapeutic rna for treating cancer
TW202245808A (zh) 2020-12-21 2022-12-01 德商拜恩迪克公司 用於治療癌症之治療性rna
WO2022135666A1 (en) 2020-12-21 2022-06-30 BioNTech SE Treatment schedule for cytokine proteins
JP2024501029A (ja) 2020-12-28 2024-01-10 ブリストル-マイヤーズ スクイブ カンパニー Pd1/pd-l1抗体の皮下投与
EP4566674A3 (en) 2020-12-28 2025-08-06 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
CA3209479A1 (en) 2021-02-03 2022-08-11 Mozart Therapeutics, Inc. Binding agents and methods of using the same
CA3214085A1 (en) 2021-03-31 2022-10-06 Darby Rye Schmidt Thanotransmission polypeptides and their use in treating cancer
WO2022212876A1 (en) 2021-04-02 2022-10-06 The Regents Of The University Of California Antibodies against cleaved cdcp1 and uses thereof
CA3224374A1 (en) 2021-06-29 2023-01-05 Flagship Pioneering Innovations V, Inc. Immune cells engineered to promote thanotransmission and uses thereof
JP2024525758A (ja) 2021-07-13 2024-07-12 ビオンテック・ソシエタス・エウロパエア がんのための併用療法におけるcd40およびcd137に対する多重特異性結合剤
TW202333802A (zh) 2021-10-11 2023-09-01 德商拜恩迪克公司 用於肺癌之治療性rna(二)
CA3240558A1 (en) 2021-12-16 2023-06-22 Valerio Therapeutics New conjugated nucleic acid molecules and their uses
JP2025509749A (ja) 2022-03-18 2025-04-11 ブリストル-マイヤーズ スクイブ カンパニー ポリペプチドの単離方法
US20250332252A1 (en) 2022-06-02 2025-10-30 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
GB202209518D0 (en) 2022-06-29 2022-08-10 Snipr Biome Aps Treating & preventing E coli infections
WO2024077191A1 (en) 2022-10-05 2024-04-11 Flagship Pioneering Innovations V, Inc. Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer
KR20250120305A (ko) 2022-12-14 2025-08-08 아스텔라스 파마 유럽 비.브이. Cldn18.2 및 cd3에 결합하는 2중 특이성 결합제와 면역 체크포인트 저해제를 수반한 조합 요법
US20240269251A1 (en) 2023-01-09 2024-08-15 Flagship Pioneering Innovations V, Inc. Genetic switches and their use in treating cancer
WO2025038763A1 (en) 2023-08-15 2025-02-20 Bristol-Myers Squibb Company Ceramic hydroxyapatite chromatography flow through method
WO2025120866A1 (en) 2023-12-08 2025-06-12 Astellas Pharma Inc. Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2
WO2025121445A1 (en) 2023-12-08 2025-06-12 Astellas Pharma Inc. Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2
WO2025120867A1 (en) 2023-12-08 2025-06-12 Astellas Pharma Inc. Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies
US20250215087A1 (en) 2023-12-29 2025-07-03 Bristol-Myers Squibb Company Combination therapy of kras inhibitor and treg depleting agent

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005003172A2 (en) * 2003-07-02 2005-01-13 Innate Pharma Pan-kir2dl nk-receptor antibodies and their use in diagnostik and therapy
WO2006003179A2 (en) * 2004-07-01 2006-01-12 Novo Nordisk A/S Antibodies binding to receptors kir2dl1, -2, 3 but not kir2ds4 and their therapeutic use
US20060280740A1 (en) * 2003-07-02 2006-12-14 Novo Nordisk A/S Compositions and methods for regulating NK cell activity

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2186455A1 (en) 1994-03-29 1995-10-05 Raymond John Owens Antibodies against e-selectin
US6824780B1 (en) * 1999-10-29 2004-11-30 Genentech, Inc. Anti-tumor antibody compositions and methods of use
US20010046496A1 (en) * 2000-04-14 2001-11-29 Brettman Lee R. Method of administering an antibody
AR035119A1 (es) * 2001-08-16 2004-04-14 Lilly Co Eli Anticuerpos humanos antagonistas anti-htnfsf13b
EP1465720A4 (en) 2001-12-19 2010-05-12 Biogen Idec Inc METHODS FOR DETECTING HALF ANTIBODIES BY IMPLEMENTING GEL ELECTROPHORESIS ON INTEGRATED CIRCUITS
AU2003208946A1 (en) 2002-02-28 2003-09-16 Eli Lilly And Company Anti-interleukin-1 beta analogs
US20040152632A1 (en) * 2002-11-06 2004-08-05 Wyeth Combination therapy for the treatment of acute leukemia and myelodysplastic syndrome
ES2358078T3 (es) * 2003-07-02 2011-05-05 Novo Nordisk A/S Métodos para la producción y evaluación de la citotoxicidad de anticuerpos del receptor kir2dl de células nk.
BRPI0506726B8 (pt) 2004-01-07 2021-05-25 Chiron Corp anticorpo monoclonal específico para m-csf e usos deste
EP1718310A4 (en) * 2004-02-06 2009-05-06 Elan Pharm Inc METHODS AND COMPOSITIONS FOR TREATING TUMORS AND METASTATIC DISEASE
AU2005302539B2 (en) * 2004-10-29 2011-03-03 Assa Abloy Ab Credential production using a secured consumable supply
WO2006072626A1 (en) * 2005-01-06 2006-07-13 Novo Nordisk A/S Kir-binding agents and methods of use thereof
BRPI0612972A2 (pt) * 2005-04-22 2010-12-14 Genentech Inc mÉtodo para tratar doenÇa de alzheimer, mÉtodo para tratar demÊncia, artigo de fabricaÇço e usos de um anticorpo cd20
WO2010065939A1 (en) * 2008-12-05 2010-06-10 Indiana University Research & Technology Corporation Combination therapy to enhace nk cell mediated cytotoxicty
JP6342325B2 (ja) * 2011-05-25 2018-06-13 イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. 炎症性障害の治療のための抗kir抗体

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005003172A2 (en) * 2003-07-02 2005-01-13 Innate Pharma Pan-kir2dl nk-receptor antibodies and their use in diagnostik and therapy
US20060280740A1 (en) * 2003-07-02 2006-12-14 Novo Nordisk A/S Compositions and methods for regulating NK cell activity
WO2006003179A2 (en) * 2004-07-01 2006-01-12 Novo Nordisk A/S Antibodies binding to receptors kir2dl1, -2, 3 but not kir2ds4 and their therapeutic use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Angal, S et al. 1993 Molecular Immunology. vol. 30, no. 1, pp. 105-108 *

Also Published As

Publication number Publication date
JP2010515709A (ja) 2010-05-13
JP2014050393A (ja) 2014-03-20
EP2604278B1 (en) 2017-04-12
US9879082B2 (en) 2018-01-30
WO2008084106A9 (en) 2009-09-17
ES2579768T3 (es) 2016-08-16
WO2008084106A1 (en) 2008-07-17
CN101578113B (zh) 2015-04-22
JP6223771B2 (ja) 2017-11-01
AU2008204433A1 (en) 2008-07-17
US20100189723A1 (en) 2010-07-29
US20180208652A1 (en) 2018-07-26
CN101578113A (zh) 2009-11-11
CA2675291C (en) 2017-05-23
EP2604278A1 (en) 2013-06-19
US10815299B2 (en) 2020-10-27
CN105037549A (zh) 2015-11-11
EP2109460A1 (en) 2009-10-21
ES2627923T3 (es) 2017-08-01
US20150197569A1 (en) 2015-07-16
JP5478261B2 (ja) 2014-04-23
JP2016104728A (ja) 2016-06-09
CA2675291A1 (en) 2008-07-17
EP2109460B1 (en) 2016-05-18
CN105037549B (zh) 2018-09-28

Similar Documents

Publication Publication Date Title
AU2008204433B2 (en) Anti-KIR antibodies, formulations, and uses thereof
JP7600285B2 (ja) 抗pd-l1モノクローナル抗体
BR112021012299A2 (pt) Anticorpo anti-pd1 humanizado e uso do mesmo
US20230382991A1 (en) Anti-lilrb antibodies and uses thereof
WO2023046113A1 (zh) 一种抗人pd-l1人源化抗体或其抗原结合片段及其应用
AU2013237638B2 (en) Anti-kir antibodies, formulations, and uses thereof
CN118165116A (zh) 新型多特异性抗体
CN116761627A (zh) 艾萨妥昔单抗用于治疗多发性骨髓瘤的用途
EA041915B1 (ru) Моноклональное антитело к pd-l1

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired