JP5478261B2 - 抗kir抗体、製剤、およびその使用 - Google Patents
抗kir抗体、製剤、およびその使用 Download PDFInfo
- Publication number
- JP5478261B2 JP5478261B2 JP2009545192A JP2009545192A JP5478261B2 JP 5478261 B2 JP5478261 B2 JP 5478261B2 JP 2009545192 A JP2009545192 A JP 2009545192A JP 2009545192 A JP2009545192 A JP 2009545192A JP 5478261 B2 JP5478261 B2 JP 5478261B2
- Authority
- JP
- Japan
- Prior art keywords
- kir
- antibody
- seq
- dose
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87996407P | 2007-01-11 | 2007-01-11 | |
| US60/879,964 | 2007-01-11 | ||
| US91152707P | 2007-04-13 | 2007-04-13 | |
| US60/911,527 | 2007-04-13 | ||
| PCT/EP2008/050306 WO2008084106A1 (en) | 2007-01-11 | 2008-01-11 | Anti-kir antibodies, formulations, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013213757A Division JP6223771B2 (ja) | 2007-01-11 | 2013-10-11 | 抗kir抗体、製剤、およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010515709A JP2010515709A (ja) | 2010-05-13 |
| JP2010515709A5 JP2010515709A5 (cg-RX-API-DMAC7.html) | 2011-03-03 |
| JP5478261B2 true JP5478261B2 (ja) | 2014-04-23 |
Family
ID=39144327
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009545192A Expired - Fee Related JP5478261B2 (ja) | 2007-01-11 | 2008-01-11 | 抗kir抗体、製剤、およびその使用 |
| JP2013213757A Expired - Fee Related JP6223771B2 (ja) | 2007-01-11 | 2013-10-11 | 抗kir抗体、製剤、およびその使用 |
| JP2015227492A Pending JP2016104728A (ja) | 2007-01-11 | 2015-11-20 | 抗kir抗体、製剤、およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013213757A Expired - Fee Related JP6223771B2 (ja) | 2007-01-11 | 2013-10-11 | 抗kir抗体、製剤、およびその使用 |
| JP2015227492A Pending JP2016104728A (ja) | 2007-01-11 | 2015-11-20 | 抗kir抗体、製剤、およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20100189723A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2604278B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP5478261B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN105037549B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008204433B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2675291C (cg-RX-API-DMAC7.html) |
| ES (2) | ES2579768T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008084106A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004253770C1 (en) | 2003-07-02 | 2010-04-15 | Innate Pharma | PAN-KIR2DL NK-receptor antibodies and their use in diagnostik and therapy |
| US20090191213A9 (en) * | 2003-07-02 | 2009-07-30 | Novo Nordisk A/S | Compositions and methods for regulating NK cell activity |
| ES2732623T3 (es) * | 2005-01-06 | 2019-11-25 | Innate Pharma Sa | Tratamientos y métodos de combinación anti-KIR |
| WO2010065939A1 (en) | 2008-12-05 | 2010-06-10 | Indiana University Research & Technology Corporation | Combination therapy to enhace nk cell mediated cytotoxicty |
| WO2010117729A1 (en) | 2009-03-30 | 2010-10-14 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same |
| EP2453910B1 (en) * | 2009-07-15 | 2016-08-31 | Portola Pharmaceuticals, Inc. | Unit dose formulation of antidote for factor xa inhibitors for use in preventing bleeding |
| EP3514170A1 (en) * | 2010-10-22 | 2019-07-24 | Dana-Farber Cancer Institute, Inc. | Discovery of regulatory t cells programmed to suppress an immune response |
| EA035033B1 (ru) * | 2010-11-22 | 2020-04-20 | Иннейт Фарма Са | Способ лечения гематологического предракового или гематологического ракового заболеваний |
| KR20120093002A (ko) * | 2011-02-14 | 2012-08-22 | (주)에이티젠 | Nk 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트 |
| JP6342325B2 (ja) | 2011-05-25 | 2018-06-13 | イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. | 炎症性障害の治療のための抗kir抗体 |
| EP2904011B1 (en) * | 2012-10-02 | 2017-08-23 | Bristol-Myers Squibb Company | Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer |
| CN105025925A (zh) * | 2013-03-15 | 2015-11-04 | 拜尔健康护理有限责任公司 | 抗-催乳素受体抗体制剂 |
| US10494433B2 (en) | 2013-11-06 | 2019-12-03 | Bristol-Myers Squibb Company | Combination of anti-KIR and anti-CS1 antibodies to treat multiple myeloma |
| US11639384B2 (en) | 2014-10-28 | 2023-05-02 | University Children's Hospital Tübingen | Treatment of pediatric BCP-ALL patients with an anti-KIR antibody |
| DK3283107T3 (da) | 2015-04-17 | 2020-08-31 | Bristol Myers Squibb Co | Sammensætninger omfattende en kombination af ipilimumab og nivolumab |
| EP3907285A1 (en) | 2015-05-06 | 2021-11-10 | Snipr Technologies Limited | Altering microbial populations & modifying microbiota |
| SG10202002131PA (en) | 2015-05-21 | 2020-05-28 | Harpoon Therapeutics Inc | Trispecific binding proteins and methods of use |
| CN107921087A (zh) | 2015-07-16 | 2018-04-17 | 百欧肯治疗有限公司 | 治疗癌症的组合物及方法 |
| US20190038713A1 (en) | 2015-11-07 | 2019-02-07 | Multivir Inc. | Compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer |
| JP2018536404A (ja) | 2015-11-09 | 2018-12-13 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Cho細胞において産生したポリペプチドの品質特性を操作する方法 |
| JP2019506438A (ja) * | 2016-02-24 | 2019-03-07 | チルドレンズ ホスピタル オブ イースタン オンタリオ リサーチ インスティチュート インコーポレイテッド | がんの処置のためのsmc組合せ療法 |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| JP7169195B2 (ja) | 2016-05-20 | 2022-11-10 | バイオヘイブン・ファーマシューティカル・ホールディング・カンパニー・リミテッド | 癌を処置するためのリルゾール、リルゾールプロドラッグまたはリルゾール類似体と免疫療法との併用 |
| GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
| JP7542946B2 (ja) | 2016-09-27 | 2024-09-02 | ボード オブ リージェンツ, ザ ユニヴァーシティー オブ テキサス システム | マイクロバイオームをモジュレートすることにより、免疫チェックポイント遮断療法を増強するための方法 |
| MX386249B (es) | 2016-10-12 | 2025-03-18 | Univ Texas | Terapia tusc2 para usarse en el tratamiento de cáncer. |
| WO2018111902A1 (en) | 2016-12-12 | 2018-06-21 | Multivir Inc. | Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases |
| WO2018183928A1 (en) | 2017-03-31 | 2018-10-04 | Bristol-Myers Squibb Company | Methods of treating tumor |
| CN121159691A (zh) | 2017-05-12 | 2025-12-19 | 哈普恩治疗公司 | 间皮素结合蛋白质 |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| EA202090817A1 (ru) | 2017-10-13 | 2020-09-08 | Харпун Терапьютикс, Инк. | Триспецифические белки и способы их применения |
| KR20200064132A (ko) | 2017-10-15 | 2020-06-05 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하는 방법 |
| CN112020510B (zh) | 2018-03-19 | 2024-10-11 | 茂体外尔公司 | 包含用于治疗癌症的肿瘤抑制基因疗法和cd122/cd132激动剂的方法及组合物 |
| TW202003565A (zh) | 2018-03-23 | 2020-01-16 | 美商必治妥美雅史谷比公司 | 抗mica及/或micb抗體及其用途 |
| GB2587521B (en) | 2018-03-25 | 2023-06-21 | Snipr Biome Aps | Treating & preventing microbial infections |
| US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
| US20210032344A1 (en) | 2018-03-30 | 2021-02-04 | Bristol-Myers Squibb Company | Methods of treating tumor |
| JP2021528393A (ja) | 2018-06-15 | 2021-10-21 | フラグシップ パイオニアリング イノベーションズ ブイ,インコーポレーテッド | 後細胞シグナル伝達因子の調節による免疫活性の上昇 |
| WO2020061482A1 (en) | 2018-09-21 | 2020-03-26 | Harpoon Therapeutics, Inc. | Egfr binding proteins and methods of use |
| AU2019346466A1 (en) | 2018-09-25 | 2021-05-20 | Harpoon Therapeutics, Inc. | DLL3 binding proteins and methods of use |
| US20220054524A1 (en) | 2018-12-21 | 2022-02-24 | Onxeo | New conjugated nucleic acid molecules and their uses |
| MA55033A (fr) | 2019-02-18 | 2021-12-29 | Lilly Co Eli | Formulation d'anticorps thérapeutique |
| WO2020227159A2 (en) | 2019-05-03 | 2020-11-12 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity |
| US20220233691A1 (en) | 2019-05-30 | 2022-07-28 | Bristol-Myers Squibb Company | Cell localization signature and combination therapy |
| JP2022534967A (ja) | 2019-05-30 | 2022-08-04 | ブリストル-マイヤーズ スクイブ カンパニー | 多腫瘍遺伝子シグネチャーおよびその使用 |
| CN114127315A (zh) | 2019-05-30 | 2022-03-01 | 百时美施贵宝公司 | 鉴定适合于免疫肿瘤学(i-o)疗法的受试者的方法 |
| WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
| US20230114107A1 (en) | 2019-12-17 | 2023-04-13 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| TW202214857A (zh) | 2020-06-19 | 2022-04-16 | 法商昂席歐公司 | 新型結合核酸分子及其用途 |
| CA3184366A1 (en) | 2020-06-29 | 2022-01-06 | Darby Rye Schmidt | Viruses engineered to promote thanotransmission and their use in treating cancer |
| AU2021306613A1 (en) | 2020-07-07 | 2023-02-02 | BioNTech SE | Therapeutic RNA for HPV-positive cancer |
| BR112023003553A2 (pt) | 2020-08-31 | 2023-04-04 | Bristol Myers Squibb Co | Assinatura de localização celular e imunoterapia |
| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
| WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
| TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性rna |
| WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
| JP2024501029A (ja) | 2020-12-28 | 2024-01-10 | ブリストル-マイヤーズ スクイブ カンパニー | Pd1/pd-l1抗体の皮下投与 |
| EP4566674A3 (en) | 2020-12-28 | 2025-08-06 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| CA3209479A1 (en) | 2021-02-03 | 2022-08-11 | Mozart Therapeutics, Inc. | Binding agents and methods of using the same |
| CA3214085A1 (en) | 2021-03-31 | 2022-10-06 | Darby Rye Schmidt | Thanotransmission polypeptides and their use in treating cancer |
| WO2022212876A1 (en) | 2021-04-02 | 2022-10-06 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
| CA3224374A1 (en) | 2021-06-29 | 2023-01-05 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
| JP2024525758A (ja) | 2021-07-13 | 2024-07-12 | ビオンテック・ソシエタス・エウロパエア | がんのための併用療法におけるcd40およびcd137に対する多重特異性結合剤 |
| TW202333802A (zh) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | 用於肺癌之治療性rna(二) |
| CA3240558A1 (en) | 2021-12-16 | 2023-06-22 | Valerio Therapeutics | New conjugated nucleic acid molecules and their uses |
| JP2025509749A (ja) | 2022-03-18 | 2025-04-11 | ブリストル-マイヤーズ スクイブ カンパニー | ポリペプチドの単離方法 |
| US20250332252A1 (en) | 2022-06-02 | 2025-10-30 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
| WO2024077191A1 (en) | 2022-10-05 | 2024-04-11 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer |
| KR20250120305A (ko) | 2022-12-14 | 2025-08-08 | 아스텔라스 파마 유럽 비.브이. | Cldn18.2 및 cd3에 결합하는 2중 특이성 결합제와 면역 체크포인트 저해제를 수반한 조합 요법 |
| US20240269251A1 (en) | 2023-01-09 | 2024-08-15 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
| WO2025038763A1 (en) | 2023-08-15 | 2025-02-20 | Bristol-Myers Squibb Company | Ceramic hydroxyapatite chromatography flow through method |
| WO2025120866A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| WO2025121445A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| WO2025120867A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies |
| US20250215087A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg depleting agent |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2186455A1 (en) | 1994-03-29 | 1995-10-05 | Raymond John Owens | Antibodies against e-selectin |
| US6824780B1 (en) * | 1999-10-29 | 2004-11-30 | Genentech, Inc. | Anti-tumor antibody compositions and methods of use |
| US20010046496A1 (en) * | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
| AR035119A1 (es) * | 2001-08-16 | 2004-04-14 | Lilly Co Eli | Anticuerpos humanos antagonistas anti-htnfsf13b |
| EP1465720A4 (en) | 2001-12-19 | 2010-05-12 | Biogen Idec Inc | METHODS FOR DETECTING HALF ANTIBODIES BY IMPLEMENTING GEL ELECTROPHORESIS ON INTEGRATED CIRCUITS |
| AU2003208946A1 (en) | 2002-02-28 | 2003-09-16 | Eli Lilly And Company | Anti-interleukin-1 beta analogs |
| US20040152632A1 (en) * | 2002-11-06 | 2004-08-05 | Wyeth | Combination therapy for the treatment of acute leukemia and myelodysplastic syndrome |
| ES2358078T3 (es) * | 2003-07-02 | 2011-05-05 | Novo Nordisk A/S | Métodos para la producción y evaluación de la citotoxicidad de anticuerpos del receptor kir2dl de células nk. |
| AU2004253770C1 (en) * | 2003-07-02 | 2010-04-15 | Innate Pharma | PAN-KIR2DL NK-receptor antibodies and their use in diagnostik and therapy |
| US20090191213A9 (en) * | 2003-07-02 | 2009-07-30 | Novo Nordisk A/S | Compositions and methods for regulating NK cell activity |
| BRPI0506726B8 (pt) | 2004-01-07 | 2021-05-25 | Chiron Corp | anticorpo monoclonal específico para m-csf e usos deste |
| EP1718310A4 (en) * | 2004-02-06 | 2009-05-06 | Elan Pharm Inc | METHODS AND COMPOSITIONS FOR TREATING TUMORS AND METASTATIC DISEASE |
| SI2287195T1 (sl) * | 2004-07-01 | 2019-08-30 | Novo Nordisk A/S | Pan-kir2dl nk-receptor protitelesa in njihova uporaba pri diagnostiki in terapiji |
| AU2005302539B2 (en) * | 2004-10-29 | 2011-03-03 | Assa Abloy Ab | Credential production using a secured consumable supply |
| WO2006072626A1 (en) * | 2005-01-06 | 2006-07-13 | Novo Nordisk A/S | Kir-binding agents and methods of use thereof |
| BRPI0612972A2 (pt) * | 2005-04-22 | 2010-12-14 | Genentech Inc | mÉtodo para tratar doenÇa de alzheimer, mÉtodo para tratar demÊncia, artigo de fabricaÇço e usos de um anticorpo cd20 |
| WO2010065939A1 (en) * | 2008-12-05 | 2010-06-10 | Indiana University Research & Technology Corporation | Combination therapy to enhace nk cell mediated cytotoxicty |
| JP6342325B2 (ja) * | 2011-05-25 | 2018-06-13 | イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. | 炎症性障害の治療のための抗kir抗体 |
-
2008
- 2008-01-11 US US12/521,105 patent/US20100189723A1/en not_active Abandoned
- 2008-01-11 WO PCT/EP2008/050306 patent/WO2008084106A1/en not_active Ceased
- 2008-01-11 AU AU2008204433A patent/AU2008204433B2/en not_active Ceased
- 2008-01-11 ES ES08707869.7T patent/ES2579768T3/es active Active
- 2008-01-11 JP JP2009545192A patent/JP5478261B2/ja not_active Expired - Fee Related
- 2008-01-11 CN CN201510142726.3A patent/CN105037549B/zh not_active Expired - Fee Related
- 2008-01-11 CN CN200880002001.2A patent/CN101578113B/zh not_active Expired - Fee Related
- 2008-01-11 EP EP13159380.8A patent/EP2604278B1/en active Active
- 2008-01-11 EP EP08707869.7A patent/EP2109460B1/en active Active
- 2008-01-11 ES ES13159380.8T patent/ES2627923T3/es active Active
- 2008-01-11 CA CA2675291A patent/CA2675291C/en active Active
-
2013
- 2013-10-11 JP JP2013213757A patent/JP6223771B2/ja not_active Expired - Fee Related
-
2015
- 2015-01-27 US US14/606,814 patent/US9879082B2/en active Active
- 2015-11-20 JP JP2015227492A patent/JP2016104728A/ja active Pending
-
2017
- 2017-12-20 US US15/849,128 patent/US10815299B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010515709A (ja) | 2010-05-13 |
| JP2014050393A (ja) | 2014-03-20 |
| EP2604278B1 (en) | 2017-04-12 |
| US9879082B2 (en) | 2018-01-30 |
| WO2008084106A9 (en) | 2009-09-17 |
| ES2579768T3 (es) | 2016-08-16 |
| WO2008084106A1 (en) | 2008-07-17 |
| CN101578113B (zh) | 2015-04-22 |
| JP6223771B2 (ja) | 2017-11-01 |
| AU2008204433A1 (en) | 2008-07-17 |
| US20100189723A1 (en) | 2010-07-29 |
| US20180208652A1 (en) | 2018-07-26 |
| CN101578113A (zh) | 2009-11-11 |
| CA2675291C (en) | 2017-05-23 |
| EP2604278A1 (en) | 2013-06-19 |
| US10815299B2 (en) | 2020-10-27 |
| CN105037549A (zh) | 2015-11-11 |
| EP2109460A1 (en) | 2009-10-21 |
| ES2627923T3 (es) | 2017-08-01 |
| US20150197569A1 (en) | 2015-07-16 |
| JP2016104728A (ja) | 2016-06-09 |
| AU2008204433B2 (en) | 2014-03-13 |
| CA2675291A1 (en) | 2008-07-17 |
| EP2109460B1 (en) | 2016-05-18 |
| CN105037549B (zh) | 2018-09-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5478261B2 (ja) | 抗kir抗体、製剤、およびその使用 | |
| ES3039441T3 (en) | Ilt-binding agents and methods of use thereof | |
| TWI731861B (zh) | FcRH5之人源化及親和力成熟抗體及使用方法 | |
| JP6552621B2 (ja) | 抗pd−1抗体およびその使用方法 | |
| TWI713480B (zh) | 抗CD79b抗體及其使用方法 | |
| JP2025016349A (ja) | 抗cd112r組成物及び方法 | |
| KR102679554B1 (ko) | Pd-l1에 대한 단일클론 항체 | |
| KR20220092584A (ko) | 항tigit 항체 및 이의 용도 | |
| AU2013237638B2 (en) | Anti-kir antibodies, formulations, and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110111 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20110111 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20120309 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20121030 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130130 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20130611 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131011 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20131126 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20140114 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140210 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5478261 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |