AU2007340944B2 - 2-aza-bicyclo[3.1.0]hexane derivatives as orexin receptor antagonists - Google Patents

2-aza-bicyclo[3.1.0]hexane derivatives as orexin receptor antagonists Download PDF

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Publication number
AU2007340944B2
AU2007340944B2 AU2007340944A AU2007340944A AU2007340944B2 AU 2007340944 B2 AU2007340944 B2 AU 2007340944B2 AU 2007340944 A AU2007340944 A AU 2007340944A AU 2007340944 A AU2007340944 A AU 2007340944A AU 2007340944 B2 AU2007340944 B2 AU 2007340944B2
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Prior art keywords
aza
bicyclo
thiazole
carboxylic acid
hex
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Expired - Fee Related
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AU2007340944A1 (en
Inventor
Hamed Aissaoui
Christoph Boss
Markus Gude
Ralf Koberstein
Thierry Sifferlen
Daniel Trachsel
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Actelion Pharmaceuticals Ltd
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Actelion Pharmaceuticals Ltd
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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AU2007340944A 2006-12-28 2007-12-28 2-aza-bicyclo[3.1.0]hexane derivatives as orexin receptor antagonists Expired - Fee Related AU2007340944B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IBPCT/IB2006/055042 2006-12-28
IB2006055042 2006-12-28
PCT/IB2007/055326 WO2008081399A2 (en) 2006-12-28 2007-12-28 2-aza-bicyclo[3.1.0]hexane derivatives as orexin receptor antagonists

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AU2007340944A1 AU2007340944A1 (en) 2008-07-10
AU2007340944B2 true AU2007340944B2 (en) 2013-04-18

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US (1) US8288435B2 (Direct)
EP (1) EP2094690B1 (Direct)
JP (1) JP2010514751A (Direct)
KR (1) KR20090094168A (Direct)
CN (1) CN101568536B (Direct)
AR (1) AR064561A1 (Direct)
AT (1) ATE505467T1 (Direct)
AU (1) AU2007340944B2 (Direct)
BR (1) BRPI0720876A2 (Direct)
CA (1) CA2669821A1 (Direct)
CL (1) CL2007003827A1 (Direct)
CY (1) CY1111705T1 (Direct)
DE (1) DE602007013937D1 (Direct)
DK (1) DK2094690T3 (Direct)
ES (1) ES2364297T3 (Direct)
HR (1) HRP20110509T1 (Direct)
MA (1) MA31000B1 (Direct)
MX (1) MX2009006860A (Direct)
MY (1) MY157344A (Direct)
NO (1) NO20092762L (Direct)
NZ (1) NZ578642A (Direct)
PL (1) PL2094690T3 (Direct)
PT (1) PT2094690E (Direct)
RU (1) RU2460732C2 (Direct)
SI (1) SI2094690T1 (Direct)
TW (1) TW200833328A (Direct)
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AU2008260647A1 (en) 2007-05-23 2008-12-11 Merck Sharp & Dohme Corp. Cyclopropyl pyrrolidine orexin receptor antagonists
CN101874030B (zh) * 2007-09-24 2012-11-14 埃科特莱茵药品有限公司 用作食欲素受体拮抗剂的吡咯烷和哌啶
CA2713184A1 (en) * 2008-02-21 2009-08-27 Actelion Pharmaceuticals Ltd 2-aza-bicyclo[2.2.1]heptane derivatives
CN102015645B (zh) * 2008-04-30 2012-11-14 埃科特莱茵药品有限公司 哌啶和吡咯烷化合物
CA2739344A1 (en) * 2008-10-14 2010-04-22 Actelion Pharmaceuticals Ltd Phenethylamide derivatives and their heterocyclic analogues
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CA2785957C (en) 2009-12-29 2015-06-16 Suven Life Sciences Limited .alpha.4.beta.2 neuronal nicotinic acetylcholine receptor ligands
PE20131162A1 (es) * 2010-09-22 2013-10-19 Eisai Randd Man Co Ltd Compuestos de ciclopropano como antagonistas del receptor de orexina
US9012489B2 (en) * 2011-08-03 2015-04-21 Boehringer Ingelheim International Gmbh Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament
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ITMI20112329A1 (it) * 2011-12-21 2013-06-22 Rottapharm Spa Nuovi derivati spiro amminici
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
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