AU2007237901B2 - Pyridone sulfonamides and pyridone sulfamides as MEK inhibitors - Google Patents

Pyridone sulfonamides and pyridone sulfamides as MEK inhibitors Download PDF

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Publication number
AU2007237901B2
AU2007237901B2 AU2007237901A AU2007237901A AU2007237901B2 AU 2007237901 B2 AU2007237901 B2 AU 2007237901B2 AU 2007237901 A AU2007237901 A AU 2007237901A AU 2007237901 A AU2007237901 A AU 2007237901A AU 2007237901 B2 AU2007237901 B2 AU 2007237901B2
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formula
cancer
compound
alkyl
additional embodiments
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AU2007237901A1 (en
Inventor
Suetying Chow
Zhi Hong
Yung-Hyo Koh
Jean-Michel Vernier
Shungi Yan
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Ardea Biociences Inc
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Ardea Biociences Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
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  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
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  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
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  • Endocrinology (AREA)
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  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
AU2007237901A 2006-04-18 2007-04-18 Pyridone sulfonamides and pyridone sulfamides as MEK inhibitors Ceased AU2007237901B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79312906P 2006-04-18 2006-04-18
US60/793,129 2006-04-18
PCT/US2007/066894 WO2007121481A2 (en) 2006-04-18 2007-04-18 Pyridone sulfonamides and pyridone sulfamides as mek inhibitors

Publications (2)

Publication Number Publication Date
AU2007237901A1 AU2007237901A1 (en) 2007-10-25
AU2007237901B2 true AU2007237901B2 (en) 2012-07-05

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AU2007237901A Ceased AU2007237901B2 (en) 2006-04-18 2007-04-18 Pyridone sulfonamides and pyridone sulfamides as MEK inhibitors

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US (2) US7897624B2 (OSRAM)
EP (1) EP2012786B1 (OSRAM)
JP (1) JP5269762B2 (OSRAM)
KR (1) KR101391461B1 (OSRAM)
CN (1) CN101454004B (OSRAM)
AT (1) ATE483463T1 (OSRAM)
AU (1) AU2007237901B2 (OSRAM)
BR (1) BRPI0710817A2 (OSRAM)
CA (1) CA2649122C (OSRAM)
DE (1) DE602007009663D1 (OSRAM)
EA (1) EA016674B1 (OSRAM)
ES (1) ES2354182T3 (OSRAM)
IL (1) IL194595A (OSRAM)
MX (1) MX2008013097A (OSRAM)
WO (1) WO2007121481A2 (OSRAM)

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