AU2006304811C1 - Camptothecin derivatives as chemoradiosensitizing agents - Google Patents

Camptothecin derivatives as chemoradiosensitizing agents Download PDF

Info

Publication number
AU2006304811C1
AU2006304811C1 AU2006304811A AU2006304811A AU2006304811C1 AU 2006304811 C1 AU2006304811 C1 AU 2006304811C1 AU 2006304811 A AU2006304811 A AU 2006304811A AU 2006304811 A AU2006304811 A AU 2006304811A AU 2006304811 C1 AU2006304811 C1 AU 2006304811C1
Authority
AU
Australia
Prior art keywords
cpt
hydrogen
lower alkyl
hydroxy
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006304811A
Other languages
English (en)
Other versions
AU2006304811B2 (en
AU2006304811A1 (en
Inventor
Li-Xi Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Catholic Healthcare West
Sutter West Bay Hospitals
Original Assignee
Catholic Healthcare West
Sutter West Bay Hospitals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Catholic Healthcare West, Sutter West Bay Hospitals filed Critical Catholic Healthcare West
Publication of AU2006304811A1 publication Critical patent/AU2006304811A1/en
Assigned to CATHOLIC HEALTHCARE WEST, DOING BUSINESS AS ST. MARY'S MEDICAL CENTER, SUTTER WEST BAY HOSPITALS reassignment CATHOLIC HEALTHCARE WEST, DOING BUSINESS AS ST. MARY'S MEDICAL CENTER Alteration of Name(s) of Applicant(s) under S113 Assignors: CALIFORNIA PACIFIC MEDICAL CENTER, CATHOLIC HEALTHCARE WEST, DOING BUSINESS AS ST. MARY'S MEDICAL CENTER
Publication of AU2006304811B2 publication Critical patent/AU2006304811B2/en
Application granted granted Critical
Publication of AU2006304811C1 publication Critical patent/AU2006304811C1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2006304811A 2005-10-21 2006-10-19 Camptothecin derivatives as chemoradiosensitizing agents Ceased AU2006304811C1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72892405P 2005-10-21 2005-10-21
US60/728,924 2005-10-21
US11/444,150 2006-05-30
US11/444,150 US7875602B2 (en) 2005-10-21 2006-05-30 Camptothecin derivatives as chemoradiosensitizing agents
PCT/US2006/041175 WO2007048002A2 (en) 2005-10-21 2006-10-19 Camptothecin derivatives as chemoradiosensitizing agents

Publications (3)

Publication Number Publication Date
AU2006304811A1 AU2006304811A1 (en) 2007-04-26
AU2006304811B2 AU2006304811B2 (en) 2012-03-22
AU2006304811C1 true AU2006304811C1 (en) 2012-11-01

Family

ID=37963356

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006304811A Ceased AU2006304811C1 (en) 2005-10-21 2006-10-19 Camptothecin derivatives as chemoradiosensitizing agents

Country Status (11)

Country Link
US (3) US7875602B2 (https=)
EP (1) EP1951231B1 (https=)
JP (1) JP5328357B2 (https=)
KR (1) KR101320160B1 (https=)
CN (1) CN101300009B (https=)
AU (1) AU2006304811C1 (https=)
CA (1) CA2626032C (https=)
ES (1) ES2428088T3 (https=)
NZ (2) NZ567454A (https=)
TW (1) TWI402270B (https=)
WO (1) WO2007048002A2 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101402640B (zh) * 2008-09-02 2011-06-15 暨南大学 双酯化喜树碱衍生物及其制备方法和应用
DE102009004204A1 (de) * 2009-01-09 2010-07-15 Christian-Albrechts-Universität Zu Kiel Verfahren zur verbesserten Bioaktivierung von Arzneistoffen
US8168648B2 (en) * 2009-03-06 2012-05-01 Taiwan Liposome Co., Ltd. Camptothecin derivatives and uses thereof
WO2010148138A2 (en) * 2009-06-17 2010-12-23 Threshold Pharmaceuticals, Inc. Camptothecin derivatives
US10980798B2 (en) 2011-11-03 2021-04-20 Taiwan Liposome Company, Ltd. Pharmaceutical compositions of hydrophobic camptothecin derivatives
TWI549679B (zh) * 2011-11-03 2016-09-21 台灣微脂體股份有限公司 疏水性喜樹鹼衍生物之醫藥組合物
US20140135357A1 (en) * 2012-11-12 2014-05-15 Taiwan Liposome Company, Ltd. Dose regime for camptothecin derivatives
JP6669499B2 (ja) 2013-02-15 2020-03-18 カラ ファーマシューティカルズ インコーポレイテッド 治療用化合物
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
JP2016510000A (ja) 2013-02-20 2016-04-04 カラ ファーマシューティカルズ インコーポレイテッド 治療用化合物およびその使用
NZ719185A (en) 2013-11-01 2017-11-24 Kala Pharmaceuticals Inc Crystalline forms of therapeutic compounds and uses thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
JP6654899B2 (ja) 2013-12-26 2020-02-26 東亞合成株式会社 カルレティキュリンの発現促進方法および該方法に用いられる合成ペプチド
JP6872713B2 (ja) 2015-05-29 2021-05-19 東亞合成株式会社 腫瘍細胞の放射線感受性を増大させる合成ペプチド及びその利用
JP6550538B2 (ja) * 2015-10-27 2019-07-24 カリフォルニア パシフィック メディカル センター ポドフィロトキシン誘導体およびそれらの使用
US10087194B2 (en) 2015-10-27 2018-10-02 California Pacific Medical Center Podophyllotoxin derivatives and their use
AU2017324713B2 (en) 2016-09-08 2020-08-13 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
KR20190051010A (ko) 2016-09-08 2019-05-14 칼라 파마슈티컬스, 인크. 치료 화합물의 결정형 및 그의 용도
EP3509423A4 (en) 2016-09-08 2020-05-13 Kala Pharmaceuticals, Inc. CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
MX2022000474A (es) 2019-07-11 2022-03-11 Sun Pharma Advanced Res Co Ltd Derivados de camptotecina con un resto disulfuro y un resto piperazina.
JP2023512214A (ja) 2020-01-28 2023-03-24 リフレクション メディカル， インコーポレイテッド 放射性核種および外部ビーム放射線療法の共同最適化

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026950A1 (en) * 1995-03-01 1996-09-06 Pharmacia S.P.A. Increased bioavailability of biologically active compounds by linking to polypyrrolecarboxamidonaphthalene derivatives
US20030138432A1 (en) * 1999-11-15 2003-07-24 Drug Innovation & Design, Inc. Selective cellular targeting: multifunctional delivery vehicles, multifunctional prodrugs, use as antineoplastic drugs

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US554990A (en) * 1896-02-18 Target-throwing trap
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
JPS6019790A (ja) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
US5196413A (en) * 1984-12-10 1993-03-23 Johnson Matthey, Inc. Platinum complexes and the like
US4663161A (en) * 1985-04-22 1987-05-05 Mannino Raphael J Liposome methods and compositions
US5032617A (en) * 1985-05-03 1991-07-16 Sri International Substituted benzamide radiosensitizers
US5041653A (en) * 1985-05-03 1991-08-20 Sri International Substituted benzamide radiosensitizers
US5175278A (en) * 1985-06-28 1992-12-29 Merck & Co., Inc. Heteropolysaccharide S-657
US4727068A (en) * 1985-10-23 1988-02-23 Johnson Matthey, Inc. Radiosensitization by cobalt and Fe(III) complexes
US5175287A (en) * 1986-09-25 1992-12-29 S R I International Process for preparing 1,2,4-benzotriazine oxides
US4921963A (en) * 1987-04-13 1990-05-01 British Columbia Cancer Foundation Platinum complexes with one radiosensitizing ligand
US5026694A (en) * 1987-04-13 1991-06-25 The British Columbia Cancer Foundation Platinum complexes with one radiosensitizing ligand
CA1329206C (en) 1987-06-10 1994-05-03 Tsutomu Kagiya Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same
US5304654A (en) * 1987-06-10 1994-04-19 Yasunori Nishijima Fluorine-containing nitroimidazole compounds
US4797397A (en) * 1987-07-31 1989-01-10 Warner-Lambert Company 2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
JPH0819111B2 (ja) * 1987-10-22 1996-02-28 ポーラ化成工業株式会社 ２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
US5036096A (en) * 1988-11-25 1991-07-30 Warner-Lambert Company Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives
US4954515A (en) * 1988-11-25 1990-09-04 Warner-Lambert Company Haloalkylaminomethyl-2-nitro-1H-imidazoles
US5043165A (en) 1988-12-14 1991-08-27 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs
IL92597A0 (en) * 1988-12-14 1990-08-31 Yasunori Nishijima President K Novel fluorine-containing 2-nitroimidazole derivatives and radiosensitizer comprising the same
US5549910A (en) * 1989-03-31 1996-08-27 The Regents Of The University Of California Preparation of liposome and lipid complex compositions
US5077057A (en) * 1989-04-05 1991-12-31 The Regents Of The University Of California Preparation of liposome and lipid complex compositions
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5294715A (en) * 1991-02-01 1994-03-15 University Of Pittsburgh Acridine-intercalator based hypoxia selective cytotoxins
CA2097163C (en) * 1992-06-01 2002-07-30 Marianna Foldvari Topical patch for liposomal drug delivery system
MX9304399A (es) * 1992-07-31 1994-02-28 Warner Lambert Co Proceso novedoso para preparar [[2-bromoetil)-amino]metil]-2-nitro-1h-imidazol-1-etanol quiral y compuestos relacionados.
US5552156A (en) * 1992-10-23 1996-09-03 Ohio State University Liposomal and micellular stabilization of camptothecin drugs
US5631237A (en) * 1992-12-22 1997-05-20 Dzau; Victor J. Method for producing in vivo delivery of therapeutic agents via liposomes
GB9320781D0 (en) 1993-10-08 1993-12-01 Erba Carlo Spa Polymer-bound camptothecin derivatives
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5919455A (en) * 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5646159A (en) * 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
US5736156A (en) * 1995-03-22 1998-04-07 The Ohio State University Liposomal anf micellular stabilization of camptothecin drugs
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
JPH08333370A (ja) 1995-06-08 1996-12-17 Kyorin Pharmaceut Co Ltd 水に可溶な新規フルオロエチルカンプトテシン誘導体、及びその製造方法
GB9512670D0 (en) * 1995-06-21 1995-08-23 Sod Conseils Rech Applic Camptothecin analogues
US6339091B1 (en) * 1995-06-21 2002-01-15 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Comptothecin analogues, preparation methods therefor, use thereof as drugs, and pharmaceutical compositions containing said analogues
CN1211919A (zh) * 1995-09-13 1999-03-24 佛罗里达州立大学 放射增敏性紫杉烷及其药物制剂
AU7732996A (en) 1995-11-22 1997-06-11 Research Triangle Institute Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US5731316A (en) * 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US5874105A (en) * 1996-01-31 1999-02-23 Collaborative Laboratories, Inc. Lipid vesicles formed with alkylammonium fatty acid salts
IL127800A (en) * 1996-08-19 2005-11-20 Bionumerik Pharmaceuticals Inc Highly lipophilic 7-substituted camptothecin derivatives and pharmaceutical compositions containing them
WO1998011877A1 (en) * 1996-09-18 1998-03-26 Dragoco, Inc. Liposome encapsulated active agent dry powder composition
EP0961619A4 (en) 1996-09-27 2001-09-26 Bristol Myers Squibb Co HYDROLYSABLE DRUGS FOR THE RELEASE OF ANTI-CANCER DRUGS IN METASTATIC CELLS
ATE210673T1 (de) * 1996-09-30 2001-12-15 Bayer Ag Glycokonjugate von modifizierten camptothecin- derivaten (20-o-verknüpfung)
KR100219562B1 (ko) * 1996-10-28 1999-09-01 윤종용 반도체장치의 다층 배선 형성방법
TW464652B (en) * 1996-10-30 2001-11-21 Tanabe Seiyaku Co S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
US5827533A (en) * 1997-02-06 1998-10-27 Duke University Liposomes containing active agents aggregated with lipid surfactants
ATE329903T1 (de) 1997-02-14 2006-07-15 Bionumerik Pharmaceuticals Inc Hochgradig lipophile camptothecin-derivate
JP3209509B2 (ja) * 1997-03-28 2001-09-17 インターナショナル・ビジネス・マシーンズ・コーポレーション ディスク状記録装置及びディスクドライブ装置
ID23424A (id) * 1997-05-14 2000-04-20 Bayer Ag Glikokonjugat dari 20(s)-kamptotesin
GB9721070D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Bioactive derivatives of camptothecin
US5935949A (en) * 1998-03-20 1999-08-10 Trustees Of Dartmouth College Use of androgen therapy in fibromyalgia and chronic fatigue syndrome
US6153655A (en) * 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6057303A (en) * 1998-10-20 2000-05-02 Bionumerik Pharmaceuticals, Inc. Highly lipophilic Camptothecin derivatives
US6207832B1 (en) * 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
US6281223B1 (en) * 1999-04-13 2001-08-28 Supergen, Inc. Radioenhanced camptothecin derivative cancer treatments
WO2000066127A1 (en) 1999-05-04 2000-11-09 Bionumerik Pharmaceuticals, Inc. Novel highly lipophilic camptothecin analogs
US6765019B1 (en) 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
US6228855B1 (en) * 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6423707B1 (en) * 2000-08-28 2002-07-23 California Pacific Medical Center Nitroimidazole ester analogues and therapeutic applications
US6350756B1 (en) * 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6403604B1 (en) * 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6855720B2 (en) * 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
GB0119578D0 (en) 2001-08-10 2001-10-03 Pharmacia & Upjohn Spa Fluoro linkers
US6933302B2 (en) * 2002-06-03 2005-08-23 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026950A1 (en) * 1995-03-01 1996-09-06 Pharmacia S.P.A. Increased bioavailability of biologically active compounds by linking to polypyrrolecarboxamidonaphthalene derivatives
US20030138432A1 (en) * 1999-11-15 2003-07-24 Drug Innovation & Design, Inc. Selective cellular targeting: multifunctional delivery vehicles, multifunctional prodrugs, use as antineoplastic drugs

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
de Groot et al. (2002) Bioorganic & Medicinal Chemistry Letters 12: 2371-2376 *

Also Published As

Publication number Publication date
ES2428088T3 (es) 2013-11-05
CA2626032A1 (en) 2007-04-26
EP1951231A4 (en) 2010-09-22
WO2007048002A3 (en) 2007-09-13
US8563537B2 (en) 2013-10-22
US8779138B2 (en) 2014-07-15
CN101300009A (zh) 2008-11-05
CN101300009B (zh) 2013-04-03
KR20080086436A (ko) 2008-09-25
NZ593706A (en) 2012-11-30
EP1951231B1 (en) 2013-07-31
TWI402270B (zh) 2013-07-21
AU2006304811B2 (en) 2012-03-22
US20080318873A1 (en) 2008-12-25
EP1951231A2 (en) 2008-08-06
WO2007048002A2 (en) 2007-04-26
JP5328357B2 (ja) 2013-10-30
AU2006304811A1 (en) 2007-04-26
US7875602B2 (en) 2011-01-25
KR101320160B1 (ko) 2013-10-23
US20110184009A1 (en) 2011-07-28
TW200730532A (en) 2007-08-16
NZ567454A (en) 2011-07-29
US20070093432A1 (en) 2007-04-26
HK1115321A1 (en) 2008-11-28
CA2626032C (en) 2011-12-06
JP2009512714A (ja) 2009-03-26

Similar Documents

Publication Publication Date Title
US8779138B2 (en) Camptothecin derivatives as chemoradiosensitizing agents
KR101688898B1 (ko) 소수성 캄프토테신 유도체의 약제 조성물
CN100406013C (zh) 喜树碱衍生物
EP1643987B1 (en) Podophyllotoxin derivatives
JP2009512714A5 (https=)
CN101328159B (zh) 紫杉烷前体抗癌药及其药物组合物和用途
HK1115321B (en) Camptothecin derivatives as chemoradiosensitizing agents
CN112759603A (zh) 鬼臼毒素衍生物及其应用
EP2699580B1 (en) Diazonamide analogs
CN101402640B (zh) 双酯化喜树碱衍生物及其制备方法和应用
WO2010127363A1 (en) Toposiomerase inhibitors
US20040034050A1 (en) Homo-camptothecin derivatives
NZ620933B2 (en) Pharmaceutical compositions of hydrophobic camptothecin derivatives
HK1196556A (en) Pharmaceutical compositions of hydrophobic camptothecin derivatives
HK1196556B (zh) 疏水性喜樹鹼衍生物的藥物組合物
PT2044078E (pt) Derivados da camptotecina com actividade antitumoral

Legal Events

Date Code Title Description
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 15 JUN 2012 .

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 15 JUN 2012

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired