AU2006256860B2 - Controlled release of a drug through skin on the basis of a topical composition comprising a drug, a film-forming silicone and at least one volatile solvent - Google Patents
Controlled release of a drug through skin on the basis of a topical composition comprising a drug, a film-forming silicone and at least one volatile solvent Download PDFInfo
- Publication number
- AU2006256860B2 AU2006256860B2 AU2006256860A AU2006256860A AU2006256860B2 AU 2006256860 B2 AU2006256860 B2 AU 2006256860B2 AU 2006256860 A AU2006256860 A AU 2006256860A AU 2006256860 A AU2006256860 A AU 2006256860A AU 2006256860 B2 AU2006256860 B2 AU 2006256860B2
- Authority
- AU
- Australia
- Prior art keywords
- composition
- drug
- silicone
- vitamin
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 239000003814 drug Substances 0.000 title claims abstract description 42
- 229940079593 drug Drugs 0.000 title claims abstract description 40
- 229920001296 polysiloxane Polymers 0.000 title claims abstract description 40
- 239000002904 solvent Substances 0.000 title claims abstract description 24
- 238000013270 controlled release Methods 0.000 title claims abstract description 11
- 230000000699 topical effect Effects 0.000 title claims description 9
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- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 24
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- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 22
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- 210000000245 forearm Anatomy 0.000 description 1
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- GEAWFZNTIFJMHR-UHFFFAOYSA-N hepta-1,6-diene Chemical compound C=CCCCC=C GEAWFZNTIFJMHR-UHFFFAOYSA-N 0.000 description 1
- PYGSKMBEVAICCR-UHFFFAOYSA-N hexa-1,5-diene Chemical compound C=CCCC=C PYGSKMBEVAICCR-UHFFFAOYSA-N 0.000 description 1
- NFVSFLUJRHRSJG-UHFFFAOYSA-N hexadecamethylheptasiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C NFVSFLUJRHRSJG-UHFFFAOYSA-N 0.000 description 1
- HTDJPCNNEPUOOQ-UHFFFAOYSA-N hexamethylcyclotrisiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O1 HTDJPCNNEPUOOQ-UHFFFAOYSA-N 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000000121 hypercalcemic effect Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- VKPSKYDESGTTFR-UHFFFAOYSA-N isododecane Natural products CC(C)(C)CC(C)CC(C)(C)C VKPSKYDESGTTFR-UHFFFAOYSA-N 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- XMYQHJDBLRZMLW-UHFFFAOYSA-N methanolamine Chemical compound NCO XMYQHJDBLRZMLW-UHFFFAOYSA-N 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- DIOQZVSQGTUSAI-UHFFFAOYSA-N n-butylhexane Natural products CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- QYZLKGVUSQXAMU-UHFFFAOYSA-N penta-1,4-diene Chemical compound C=CCC=C QYZLKGVUSQXAMU-UHFFFAOYSA-N 0.000 description 1
- AERBNCYCJBRYDG-KSZLIROESA-N phytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO AERBNCYCJBRYDG-KSZLIROESA-N 0.000 description 1
- 229940033329 phytosphingosine Drugs 0.000 description 1
- 229920001921 poly-methyl-phenyl-siloxane Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- SCPYDCQAZCOKTP-UHFFFAOYSA-N silanol Chemical compound [SiH3]O SCPYDCQAZCOKTP-UHFFFAOYSA-N 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000000498 stratum granulosum Anatomy 0.000 description 1
- 210000000439 stratum lucidum Anatomy 0.000 description 1
- 210000000437 stratum spinosum Anatomy 0.000 description 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- XMRSTLBCBDIKFI-UHFFFAOYSA-N tetradeca-1,13-diene Chemical compound C=CCCCCCCCCCCC=C XMRSTLBCBDIKFI-UHFFFAOYSA-N 0.000 description 1
- 229940008424 tetradecamethylhexasiloxane Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- SCRSFLUHMDMRFP-UHFFFAOYSA-N trimethyl-(methyl-octyl-trimethylsilyloxysilyl)oxysilane Chemical compound CCCCCCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C SCRSFLUHMDMRFP-UHFFFAOYSA-N 0.000 description 1
- OTOIBUHBRMYFLY-UHFFFAOYSA-N trimethyl-[(2,4,4,6,6-pentamethyl-1,3,5,2,4,6-trioxatrisilinan-2-yl)oxy]silane Chemical compound C[Si](C)(C)O[Si]1(C)O[Si](C)(C)O[Si](C)(C)O1 OTOIBUHBRMYFLY-UHFFFAOYSA-N 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- ZQTYRTSKQFQYPQ-UHFFFAOYSA-N trisiloxane Chemical compound [SiH3]O[SiH2]O[SiH3] ZQTYRTSKQFQYPQ-UHFFFAOYSA-N 0.000 description 1
- 229940040064 ubiquinol Drugs 0.000 description 1
- QNTNKSLOFHEFPK-UPTCCGCDSA-N ubiquinol-10 Chemical compound COC1=C(O)C(C)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(O)=C1OC QNTNKSLOFHEFPK-UPTCCGCDSA-N 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 description 1
- 102000009310 vitamin D receptors Human genes 0.000 description 1
- 108050000156 vitamin D receptors Proteins 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68928205P | 2005-06-10 | 2005-06-10 | |
| US60/689,282 | 2005-06-10 | ||
| PCT/EP2006/005831 WO2006131401A2 (en) | 2005-06-10 | 2006-05-22 | Controlled release of a drug through skin on the basis of a topical composition comprising a drug, a film-forming silicone and at least one volatile solvent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2006256860A1 AU2006256860A1 (en) | 2006-12-14 |
| AU2006256860B2 true AU2006256860B2 (en) | 2012-04-19 |
Family
ID=37137556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2006256860A Expired - Fee Related AU2006256860B2 (en) | 2005-06-10 | 2006-05-22 | Controlled release of a drug through skin on the basis of a topical composition comprising a drug, a film-forming silicone and at least one volatile solvent |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1901709A2 (pt) |
| JP (1) | JP2008542423A (pt) |
| KR (1) | KR20080016612A (pt) |
| CN (1) | CN101247787B (pt) |
| AR (1) | AR054381A1 (pt) |
| AU (1) | AU2006256860B2 (pt) |
| BR (1) | BRPI0613230A2 (pt) |
| CA (1) | CA2610755A1 (pt) |
| MX (1) | MX2007015672A (pt) |
| RU (1) | RU2008100037A (pt) |
| WO (1) | WO2006131401A2 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2909284B1 (fr) * | 2006-11-30 | 2012-09-21 | Galderma Sa | Nouvelles compositions sous forme d'onguent sans vaseline comprenant un derive de vitamine d et eventuellement un anti-inflammatoire steroidien |
| MX2009009557A (es) * | 2007-03-08 | 2010-08-10 | Crescendo Therapeutics Llc | Formulaciones de aposito para prevenir o reducir la cicatrizacion. |
| EP2167036B1 (en) * | 2007-07-11 | 2013-09-18 | Dow Corning Corporation | Compositions for delivering a drug |
| BR112012001098A2 (pt) * | 2009-07-09 | 2015-09-01 | Crescendo Therapeutics Llc | Método de cicatrização de feridas e modulação de cicatriz |
| US9254296B2 (en) | 2009-12-22 | 2016-02-09 | Leo Pharma A/S | Pharmaceutical composition comprising vitamin D analogue and cosolvent-surfactant mixture |
| AU2009357263B2 (en) * | 2009-12-22 | 2015-04-09 | Leo Pharma A/S | Pharmaceutical composition comprising vitamin D analogue and cosolvent-surfactant mixture |
| US20160095876A1 (en) | 2014-10-01 | 2016-04-07 | Rochal Industries, Llp | Composition and kits for inhibition of pathogenic microbial infection and methods of using the same |
| TW201636025A (zh) * | 2015-04-15 | 2016-10-16 | Maruho Kk | 皮膚用之醫藥組成物 |
| KR20190026397A (ko) | 2017-09-05 | 2019-03-13 | 안준배 | 노이즈 필터링 장치 및 방법 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0410099A1 (en) * | 1989-06-27 | 1991-01-30 | American Cyanamid Company | Stable, cosmetically acceptable topical gel formulation and method of treatment for acne |
| WO2000072817A1 (en) * | 1999-05-28 | 2000-12-07 | Neutrogena Corporation | Water-in-oil emulsion comprising a silicone gel containing vitamin c |
| WO2000073374A1 (en) * | 1999-05-28 | 2000-12-07 | Neutrogena Corporation | Silicone gel containing salicylic acid |
| WO2001078661A2 (de) * | 2000-04-18 | 2001-10-25 | Wella Aktiengesellschaft | Aerosolschaum zur haarbehandlung |
| EP1163951A2 (en) * | 2000-06-14 | 2001-12-19 | Dow Corning Corporation | Water-in-oil-polar solvent emulsions |
| WO2004103323A1 (en) * | 2003-05-16 | 2004-12-02 | The Procter & Gamble Company | Personal care products comprising active agents in a gel network |
| WO2005053666A1 (en) * | 2003-11-21 | 2005-06-16 | Galderma Research & Development, S.N.C. | Sprayable composition for the administration of vitamin d derivatives |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03275619A (ja) * | 1990-03-23 | 1991-12-06 | Nitsusui Seiyaku Kk | 外用剤組成物 |
| JP3251717B2 (ja) * | 1992-06-29 | 2002-01-28 | 花王株式会社 | 皮膚外用剤 |
| JP3573803B2 (ja) * | 1994-02-16 | 2004-10-06 | ポーラ化成工業株式会社 | 皮膚外用剤 |
| BR9708081A (pt) * | 1996-03-16 | 1999-07-27 | Hoechst Ag | Formulações tópicas para tratamento de psóriase de unhas |
| GB9902812D0 (en) * | 1998-06-18 | 1999-03-31 | Dow Corning Sa | Composition for delivering pharmaceutically active agents |
| US6365670B1 (en) * | 2000-03-10 | 2002-04-02 | Wacker Silicones Corporation | Organopolysiloxane gels for use in cosmetics |
| PL212660B1 (pl) * | 2000-10-27 | 2012-11-30 | Leo Pharma As | Zasadniczo niewodna zelowa kompozycja farmaceutyczna do podawania na skóre oraz jej zastosowanie |
| JP2004189639A (ja) * | 2002-12-09 | 2004-07-08 | Pola Chem Ind Inc | 乳化組成物 |
| FR2871697B1 (fr) * | 2004-06-17 | 2007-06-29 | Galderma Sa | Composition sous forme de spray comprenant une association d'actifs pharmaceutiques, une phase alcoolique, au moins un silicone volatile et une phase huileuse non volatile |
-
2006
- 2006-05-22 JP JP2008515155A patent/JP2008542423A/ja active Pending
- 2006-05-22 MX MX2007015672A patent/MX2007015672A/es not_active Application Discontinuation
- 2006-05-22 EP EP06754427A patent/EP1901709A2/en not_active Withdrawn
- 2006-05-22 RU RU2008100037/14A patent/RU2008100037A/ru unknown
- 2006-05-22 CA CA002610755A patent/CA2610755A1/en not_active Abandoned
- 2006-05-22 BR BRPI0613230-8A patent/BRPI0613230A2/pt not_active IP Right Cessation
- 2006-05-22 AU AU2006256860A patent/AU2006256860B2/en not_active Expired - Fee Related
- 2006-05-22 KR KR1020077028565A patent/KR20080016612A/ko not_active Application Discontinuation
- 2006-05-22 WO PCT/EP2006/005831 patent/WO2006131401A2/en active Application Filing
- 2006-05-22 CN CN2006800204905A patent/CN101247787B/zh not_active Expired - Fee Related
- 2006-06-08 AR ARP060102384A patent/AR054381A1/es unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0410099A1 (en) * | 1989-06-27 | 1991-01-30 | American Cyanamid Company | Stable, cosmetically acceptable topical gel formulation and method of treatment for acne |
| WO2000072817A1 (en) * | 1999-05-28 | 2000-12-07 | Neutrogena Corporation | Water-in-oil emulsion comprising a silicone gel containing vitamin c |
| WO2000073374A1 (en) * | 1999-05-28 | 2000-12-07 | Neutrogena Corporation | Silicone gel containing salicylic acid |
| WO2001078661A2 (de) * | 2000-04-18 | 2001-10-25 | Wella Aktiengesellschaft | Aerosolschaum zur haarbehandlung |
| EP1163951A2 (en) * | 2000-06-14 | 2001-12-19 | Dow Corning Corporation | Water-in-oil-polar solvent emulsions |
| WO2004103323A1 (en) * | 2003-05-16 | 2004-12-02 | The Procter & Gamble Company | Personal care products comprising active agents in a gel network |
| WO2005053666A1 (en) * | 2003-11-21 | 2005-06-16 | Galderma Research & Development, S.N.C. | Sprayable composition for the administration of vitamin d derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006256860A1 (en) | 2006-12-14 |
| JP2008542423A (ja) | 2008-11-27 |
| RU2008100037A (ru) | 2009-07-20 |
| BRPI0613230A2 (pt) | 2011-01-04 |
| WO2006131401A2 (en) | 2006-12-14 |
| MX2007015672A (es) | 2008-02-20 |
| CN101247787A (zh) | 2008-08-20 |
| WO2006131401A3 (en) | 2007-03-15 |
| EP1901709A2 (en) | 2008-03-26 |
| AR054381A1 (es) | 2007-06-20 |
| CN101247787B (zh) | 2011-10-05 |
| KR20080016612A (ko) | 2008-02-21 |
| CA2610755A1 (en) | 2006-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |