AU2006250390B2 - 6,7-unsaturated-7-carbamoyl substituted morphinan derivative - Google Patents

6,7-unsaturated-7-carbamoyl substituted morphinan derivative Download PDF

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Publication number
AU2006250390B2
AU2006250390B2 AU2006250390A AU2006250390A AU2006250390B2 AU 2006250390 B2 AU2006250390 B2 AU 2006250390B2 AU 2006250390 A AU2006250390 A AU 2006250390A AU 2006250390 A AU2006250390 A AU 2006250390A AU 2006250390 B2 AU2006250390 B2 AU 2006250390B2
Authority
AU
Australia
Prior art keywords
optionally substituted
compound
chiral
lower alkyl
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006250390A
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English (en)
Other versions
AU2006250390A1 (en
Inventor
Yoshihisa Goto
Nobuhiro Haga
Shin-Ichiro Hara
Tsuyoshi Hasegawa
Masanao Inagaki
Yoshinori Tamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of AU2006250390A1 publication Critical patent/AU2006250390A1/en
Application granted granted Critical
Publication of AU2006250390B2 publication Critical patent/AU2006250390B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2006250390A 2005-05-25 2006-05-25 6,7-unsaturated-7-carbamoyl substituted morphinan derivative Ceased AU2006250390B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP2005-151864 2005-05-25
JP2005151864 2005-05-25
JP2006065762 2006-03-10
JP2006-065762 2006-03-10
PCT/JP2006/310231 WO2006126529A1 (ja) 2005-05-25 2006-05-23 ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
AUPCT/JP2006/310231 2006-05-23
PCT/JP2006/310454 WO2006126637A1 (ja) 2005-05-25 2006-05-25 ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体

Publications (2)

Publication Number Publication Date
AU2006250390A1 AU2006250390A1 (en) 2006-11-30
AU2006250390B2 true AU2006250390B2 (en) 2010-07-08

Family

ID=37451954

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006250390A Ceased AU2006250390B2 (en) 2005-05-25 2006-05-25 6,7-unsaturated-7-carbamoyl substituted morphinan derivative

Country Status (20)

Country Link
US (4) USRE46365E1 (enExample)
EP (1) EP1889848B8 (enExample)
JP (1) JP4323547B2 (enExample)
KR (1) KR100912782B1 (enExample)
CN (1) CN101228172B (enExample)
AU (1) AU2006250390B2 (enExample)
BE (1) BE2019C533I2 (enExample)
BR (1) BRPI0610343B8 (enExample)
CA (1) CA2609733C (enExample)
DK (1) DK1889848T3 (enExample)
ES (1) ES2525215T3 (enExample)
FR (1) FR19C1042I2 (enExample)
HU (1) HUS1900034I1 (enExample)
MX (1) MX2007014588A (enExample)
NL (1) NL300996I2 (enExample)
PL (1) PL1889848T3 (enExample)
PT (1) PT1889848E (enExample)
RU (1) RU2403255C2 (enExample)
TW (1) TWI311056B (enExample)
WO (2) WO2006126529A1 (enExample)

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WO2006126529A1 (ja) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
WO2009089494A2 (en) * 2008-01-09 2009-07-16 Charleston Laboratories, Inc. Pharmaceutical compositions
JP5252391B2 (ja) * 2008-02-21 2013-07-31 学校法人北里研究所 オキサビシクロ［２．２．２］オクタンを有するモルヒナン誘導体およびその医薬用途
AU2009292631A1 (en) * 2008-09-16 2010-03-25 Nektar Therapeutics Pegylated opioids with low potential for abuse
CA2774021A1 (en) * 2009-09-18 2011-03-24 Adolor Corporation Use of opioid receptor antagonist for gastrointestinal tract disorders
WO2011142620A2 (en) * 2010-05-13 2011-11-17 Green Cross Corporation (+)-3-hydroxymorphinan-based polycycle derivatives as neuroprotectants
US9108975B2 (en) * 2010-11-12 2015-08-18 Shionogi & Co., Ltd. Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same
JP5818219B2 (ja) * 2012-05-14 2015-11-18 塩野義製薬株式会社 ６，７−不飽和−７−カルバモイルモルヒナン誘導体含有製剤
US11135217B2 (en) 2016-12-26 2021-10-05 Shionogi & Co., Ltd. Manufacturing process of formulation having improved content uniformity
EP3773573A4 (en) 2018-04-12 2022-04-06 Morphic Therapeutic, Inc. ANTAGONISTS OF HUMAN INTEGRIN (ALPHA4) (BETA7)
KR102201609B1 (ko) 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
RS66976B1 (sr) 2019-10-16 2025-07-31 Morphic Therapeutic Inc Inhibiranje ljudskog integrina alfa4beta7
JP7582961B2 (ja) 2019-11-20 2024-11-13 塩野義製薬株式会社 ６，７－不飽和－７－カルバモイルモルヒナン誘導体含有固形製剤
CN111905111B (zh) * 2020-09-16 2023-03-31 地奥集团成都药业股份有限公司 一种评价复方谷氨酰胺组方对腹泻型肠易激综合征疗效的方法
IT202300009864A1 (it) * 2023-05-16 2024-11-16 Procos Spa Processo per la preparazione di naldemedina

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WO2001037785A2 (en) * 1999-11-29 2001-05-31 Adolor Corporation Novel methods and compositions involving opioids and antagonists thereof
JP2004501094A (ja) * 2000-05-05 2004-01-15 ペイン・セラピューティクス・インコーポレイテッド オピオイドアゴニストの効力を増強するか、またはオピオイドアゴニストの有害な副作用を減弱するための新規な組成物および方法

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Also Published As

Publication number Publication date
PL1889848T3 (pl) 2015-04-30
JPWO2006126637A1 (ja) 2008-12-25
AU2006250390A1 (en) 2006-11-30
EP1889848B1 (en) 2014-10-15
US20120135978A1 (en) 2012-05-31
USRE46365E1 (en) 2017-04-11
US8084460B2 (en) 2011-12-27
CA2609733A1 (en) 2006-11-30
FR19C1042I1 (enExample) 2019-08-09
RU2007148412A (ru) 2009-06-27
JP4323547B2 (ja) 2009-09-02
US8536192B2 (en) 2013-09-17
RU2403255C2 (ru) 2010-11-10
CN101228172A (zh) 2008-07-23
BRPI0610343B1 (pt) 2020-03-10
NL300996I1 (nl) 2019-07-03
PT1889848E (pt) 2014-12-09
US20090203723A1 (en) 2009-08-13
WO2006126529A1 (ja) 2006-11-30
FR19C1042I2 (fr) 2020-06-19
DK1889848T3 (en) 2014-12-01
EP1889848A4 (en) 2011-08-10
USRE46375E1 (en) 2017-04-25
EP1889848B8 (en) 2014-12-17
BRPI0610343A2 (pt) 2010-06-15
CN101228172B (zh) 2013-04-03
EP1889848A1 (en) 2008-02-20
CA2609733C (en) 2011-07-19
BE2019C533I2 (enExample) 2025-12-10
HUS1900034I1 (hu) 2019-07-29
TWI311056B (en) 2009-06-21
KR100912782B1 (ko) 2009-08-18
WO2006126637A1 (ja) 2006-11-30
ES2525215T3 (es) 2014-12-19
MX2007014588A (es) 2008-01-24
TW200726470A (en) 2007-07-16
NL300996I2 (nl) 2019-07-30
KR20080014791A (ko) 2008-02-14
BRPI0610343B8 (pt) 2021-05-25

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired