KR100912782B1 - 6,7-불포화-7-카르바모일 치환 모르피난 유도체 - Google Patents

6,7-불포화-7-카르바모일 치환 모르피난 유도체 Download PDF

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Publication number
KR100912782B1
KR100912782B1 KR1020077027287A KR20077027287A KR100912782B1 KR 100912782 B1 KR100912782 B1 KR 100912782B1 KR 1020077027287 A KR1020077027287 A KR 1020077027287A KR 20077027287 A KR20077027287 A KR 20077027287A KR 100912782 B1 KR100912782 B1 KR 100912782B1
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substituted
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unsubstituted
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lower alkyl
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KR20080014791A (ko
Inventor
마사나오 이나가끼
신이찌로 하라
노부히로 하가
요시노리 다무라
요시히사 고또
쯔요시 하세가와
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시오노기세야쿠 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020077027287A 2005-05-25 2007-11-23 6,7-불포화-7-카르바모일 치환 모르피난 유도체 Active KR100912782B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JPJP-P-2005-00151864 2005-05-25
JP2005151864 2005-05-25
JP2006065762 2006-03-10
JPJP-P-2006-00065762 2006-03-10
PCT/JP2006/310231 WO2006126529A1 (ja) 2005-05-25 2006-05-23 ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
WOPCT/JP2006/310231 2006-05-23

Publications (2)

Publication Number Publication Date
KR20080014791A KR20080014791A (ko) 2008-02-14
KR100912782B1 true KR100912782B1 (ko) 2009-08-18

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KR1020077027287A Active KR100912782B1 (ko) 2005-05-25 2007-11-23 6,7-불포화-7-카르바모일 치환 모르피난 유도체

Country Status (20)

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US (4) US8084460B2 (enExample)
EP (1) EP1889848B8 (enExample)
JP (1) JP4323547B2 (enExample)
KR (1) KR100912782B1 (enExample)
CN (1) CN101228172B (enExample)
AU (1) AU2006250390B2 (enExample)
BE (1) BE2019C533I2 (enExample)
BR (1) BRPI0610343B8 (enExample)
CA (1) CA2609733C (enExample)
DK (1) DK1889848T3 (enExample)
ES (1) ES2525215T3 (enExample)
FR (1) FR19C1042I2 (enExample)
HU (1) HUS1900034I1 (enExample)
MX (1) MX2007014588A (enExample)
NL (1) NL300996I2 (enExample)
PL (1) PL1889848T3 (enExample)
PT (1) PT1889848E (enExample)
RU (1) RU2403255C2 (enExample)
TW (1) TWI311056B (enExample)
WO (2) WO2006126529A1 (enExample)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
KR101486686B1 (ko) * 2010-11-12 2015-01-26 시오노기세야쿠 가부시키가이샤 6,7-불포화-7-카르바모일 모르피난 유도체의 결정 및 그의 제조 방법

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WO2006126529A1 (ja) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
EP3090743A1 (en) * 2008-01-09 2016-11-09 Charleston Laboratories, Inc. Pharmaceutical compositions for treating headache and eliminating nausea
JP5252391B2 (ja) * 2008-02-21 2013-07-31 学校法人北里研究所 オキサビシクロ［２．２．２］オクタンを有するモルヒナン誘導体およびその医薬用途
CA2734333A1 (en) * 2008-09-16 2010-03-25 Nektar Therapeutics Pegylated opioids with low potential for abuse
BR112012006069A8 (pt) * 2009-09-18 2017-10-10 Adolor Corp Método para tratar ou prevenir constipação induzida e disfunção intestinal induzida por opióide em um humano, e, uso de uma quantidade terapeuticamente efetiva de composto
WO2011142620A2 (en) * 2010-05-13 2011-11-17 Green Cross Corporation (+)-3-hydroxymorphinan-based polycycle derivatives as neuroprotectants
ES2903149T3 (es) 2012-05-14 2022-03-31 Shionogi & Co Preparación que contiene derivado de 7-carbamoilmorfinano 6,7-insaturado
CN110325178B (zh) * 2016-12-26 2022-05-13 盐野义制药株式会社 改善含量均一性的制剂的制造方法
EP3773573B1 (en) 2018-04-12 2026-03-18 Morphic Therapeutic, Inc. Antagonists of human integrin (alpha4)(beta7)
KR102201609B1 (ko) 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
JP7437490B2 (ja) 2019-10-16 2024-02-22 モーフィック セラピューティック，インコーポレイテッド ヒトインテグリン（アルファ－４）（ベータ－７）の阻害
EP4062973A4 (en) 2019-11-20 2023-11-29 Shionogi & Co., Ltd 6,7-unsaturated-7-carbamoyl morphinan derivative-containing solid formulation
CN111905111B (zh) * 2020-09-16 2023-03-31 地奥集团成都药业股份有限公司 一种评价复方谷氨酰胺组方对腹泻型肠易激综合征疗效的方法
IT202300009864A1 (it) * 2023-05-16 2024-11-16 Procos Spa Processo per la preparazione di naldemedina
CN121534059A (zh) * 2024-08-09 2026-02-17 盐野义有限公司 一种治疗帕金森综合征或帕金森病的方法和药物组合物

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101486686B1 (ko) * 2010-11-12 2015-01-26 시오노기세야쿠 가부시키가이샤 6,7-불포화-7-카르바모일 모르피난 유도체의 결정 및 그의 제조 방법

Also Published As

Publication number Publication date
US8084460B2 (en) 2011-12-27
FR19C1042I2 (fr) 2020-06-19
PL1889848T3 (pl) 2015-04-30
EP1889848B1 (en) 2014-10-15
BE2019C533I2 (enExample) 2025-12-10
US8536192B2 (en) 2013-09-17
MX2007014588A (es) 2008-01-24
CN101228172A (zh) 2008-07-23
US20120135978A1 (en) 2012-05-31
TW200726470A (en) 2007-07-16
CA2609733C (en) 2011-07-19
NL300996I1 (nl) 2019-07-03
FR19C1042I1 (enExample) 2019-08-09
CN101228172B (zh) 2013-04-03
EP1889848A1 (en) 2008-02-20
AU2006250390A1 (en) 2006-11-30
BRPI0610343B1 (pt) 2020-03-10
BRPI0610343B8 (pt) 2021-05-25
PT1889848E (pt) 2014-12-09
NL300996I2 (nl) 2019-07-30
BRPI0610343A2 (pt) 2010-06-15
HUS1900034I1 (hu) 2019-07-29
KR20080014791A (ko) 2008-02-14
TWI311056B (en) 2009-06-21
JPWO2006126637A1 (ja) 2008-12-25
ES2525215T3 (es) 2014-12-19
EP1889848B8 (en) 2014-12-17
DK1889848T3 (en) 2014-12-01
US20090203723A1 (en) 2009-08-13
AU2006250390B2 (en) 2010-07-08
USRE46375E1 (en) 2017-04-25
RU2403255C2 (ru) 2010-11-10
CA2609733A1 (en) 2006-11-30
EP1889848A4 (en) 2011-08-10
JP4323547B2 (ja) 2009-09-02
WO2006126637A1 (ja) 2006-11-30
WO2006126529A1 (ja) 2006-11-30
RU2007148412A (ru) 2009-06-27
USRE46365E1 (en) 2017-04-11

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