AU2006248825B2 - Fluorene derivatives, composition containing said derivatives and the use thereof - Google Patents

Fluorene derivatives, composition containing said derivatives and the use thereof Download PDF

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Publication number
AU2006248825B2
AU2006248825B2 AU2006248825A AU2006248825A AU2006248825B2 AU 2006248825 B2 AU2006248825 B2 AU 2006248825B2 AU 2006248825 A AU2006248825 A AU 2006248825A AU 2006248825 A AU2006248825 A AU 2006248825A AU 2006248825 B2 AU2006248825 B2 AU 2006248825B2
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AU
Australia
Prior art keywords
fluoren
imidazo
pyridin
carboxylic acid
amide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006248825A
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English (en)
Other versions
AU2006248825A1 (en
Inventor
Didier Benard
Luc Bertin
Chantal Carrez
Helene Goulaouic
Thierry Guyon
Patrick Mailliet
Herve Minoux
Fabienne Pilorge
Jean-Marie Ruxer
Fabienne Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of AU2006248825A1 publication Critical patent/AU2006248825A1/en
Application granted granted Critical
Publication of AU2006248825B2 publication Critical patent/AU2006248825B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
AU2006248825A 2005-05-19 2006-05-19 Fluorene derivatives, composition containing said derivatives and the use thereof Ceased AU2006248825B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0505037 2005-05-19
FR0505037A FR2885904B1 (fr) 2005-05-19 2005-05-19 Nouveaux derives du fluorene, compositions les contenant et utilisation
PCT/FR2006/001137 WO2006123061A2 (fr) 2005-05-19 2006-05-19 Derives du fluorene, compositions les contenant et utilisation

Publications (2)

Publication Number Publication Date
AU2006248825A1 AU2006248825A1 (en) 2006-11-23
AU2006248825B2 true AU2006248825B2 (en) 2012-02-23

Family

ID=36036699

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006248825A Ceased AU2006248825B2 (en) 2005-05-19 2006-05-19 Fluorene derivatives, composition containing said derivatives and the use thereof

Country Status (31)

Country Link
US (1) US7674795B2 (pt)
EP (1) EP1888579B1 (pt)
JP (1) JP4964874B2 (pt)
KR (1) KR101288696B1 (pt)
CN (1) CN101203518B (pt)
AR (1) AR054125A1 (pt)
AT (1) ATE518859T1 (pt)
AU (1) AU2006248825B2 (pt)
BR (1) BRPI0611424A2 (pt)
CA (1) CA2608378C (pt)
CR (1) CR9515A (pt)
DO (1) DOP2006000112A (pt)
EA (1) EA019027B1 (pt)
FR (1) FR2885904B1 (pt)
GT (1) GT200600206A (pt)
HN (1) HN2006018410A (pt)
IL (1) IL187163A (pt)
JO (1) JO2753B1 (pt)
MA (1) MA29493B1 (pt)
MX (1) MX2007014443A (pt)
MY (1) MY149037A (pt)
NO (1) NO20076460L (pt)
NZ (1) NZ563239A (pt)
PA (1) PA8675701A1 (pt)
PE (1) PE20061367A1 (pt)
TN (1) TNSN07389A1 (pt)
TW (1) TWI386406B (pt)
UA (1) UA93203C2 (pt)
UY (1) UY29549A1 (pt)
WO (1) WO2006123061A2 (pt)
ZA (1) ZA200709856B (pt)

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JP5270571B2 (ja) * 2007-11-22 2013-08-21 出光興産株式会社 有機ｅｌ素子
AU2009233324B2 (en) * 2008-03-31 2015-01-22 Council Of Scientific & Industrial Research Donor-acceptor fluorene scaffolds : a process and uses thereof
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FR2932484B1 (fr) * 2008-06-16 2010-06-18 Sanofi Aventis Nouveaux derives de pyrroloindole inhibiteurs d'hsp90, compositions les contenant et utilisation
RU2015107733A (ru) * 2008-07-02 2015-06-27 Бритиш Коламбиа Кэнсер Эйдженси Бранч Терапевтические средства на основе производных диглицилиловых простых эфиров и способы их применения
AR074797A1 (es) 2008-10-10 2011-02-16 Japan Tobacco Inc Compuesto de fluoreno , composiciones farmaceuticas , inhibidores de pdhk y pdhk2 , metodos de tratamiento , usos de los mismos y kit comercial
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
CA2786319C (en) 2010-01-06 2019-03-12 British Columbia Cancer Agency Branch Bisphenol derivatives and their use as androgen receptor activity modulators
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WO2012145330A1 (en) * 2011-04-18 2012-10-26 The University Of British Columbia Fluorene-9-bisphenol compounds and methods for their use
CN102442973A (zh) * 2011-09-22 2012-05-09 华东理工大学 催化氧化伯醇闭环合成苯并咪唑和苯并噻唑化合物的方法
KR102020083B1 (ko) * 2012-01-31 2019-09-09 캠브리지 디스플레이 테크놀로지 리미티드 중합체
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US9533002B2 (en) 2012-05-25 2017-01-03 Berg Llc Methods of treating a metabolic syndrome by modulating heat shock protein (HSP) 90-β
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GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
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KR102280686B1 (ko) 2014-02-11 2021-07-22 삼성전자주식회사 카바졸계 화합물 및 이를 포함한 유기 발광 소자
WO2015160845A2 (en) * 2014-04-14 2015-10-22 Arvinas, Inc. Imide-based modulators of proteolysis and associated methods of use
WO2015188198A2 (en) 2014-06-06 2015-12-10 Berg Llc Methods of treating a metabolic syndrome by modulating heat shock protein (hsp) 90-beta
AU2015357489A1 (en) 2014-12-05 2017-07-06 Case Western Reserve University Compositions and methods of modulating S-nitrosylation
US11426386B2 (en) 2014-12-05 2022-08-30 Case Western Reserve University Compositions and methods of modulating S-nitrosylation
AU2016206412B2 (en) 2015-01-13 2020-10-08 British Columbia Cancer Agency Branch Heterocyclic compounds for cancer imaging and treatment and methods for their use
US10471023B2 (en) 2015-03-12 2019-11-12 British Columbia Cancer Agency Branch Bisphenol ether derivatives and methods for using the same
CN108136044B (zh) * 2015-06-04 2021-08-10 阿尔维纳斯运营股份有限公司 基于酰亚胺的蛋白水解调节剂和相关使用方法
US20170298033A1 (en) 2016-04-15 2017-10-19 The University Of British Columbia Bisphenol derivatives and their use as androgen receptor activity modulators
EP3492452B1 (en) 2016-07-29 2022-08-31 Japan Tobacco Inc. Production method for pyrazole-amide compound
CA3076889A1 (en) 2017-09-25 2019-03-28 Case Western Reserve University Compositions and methods of reducing serum cholesterol and pcsk9
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BR112021007222A8 (pt) 2018-10-18 2022-11-22 Provincial Health Services Authority Moduladores de receptor de androgênio e métodos para seu uso
CN109574917B (zh) * 2018-12-03 2020-12-08 武汉尚赛光电科技有限公司 一种芴酮衍生物及其制备和应用
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Also Published As

Publication number Publication date
FR2885904B1 (fr) 2007-07-06
UA93203C2 (ru) 2011-01-25
DOP2006000112A (es) 2007-01-31
BRPI0611424A2 (pt) 2010-09-08
WO2006123061A2 (fr) 2006-11-23
HN2006018410A (es) 2010-03-05
IL187163A0 (en) 2008-02-09
EA200702531A1 (ru) 2008-04-28
MX2007014443A (es) 2008-02-11
TWI386406B (zh) 2013-02-21
KR101288696B1 (ko) 2013-07-22
US20080153837A1 (en) 2008-06-26
EP1888579B1 (fr) 2011-08-03
CA2608378C (fr) 2013-12-31
ZA200709856B (en) 2009-12-30
GT200600206A (es) 2006-12-26
AU2006248825A1 (en) 2006-11-23
PE20061367A1 (es) 2007-01-08
MA29493B1 (fr) 2008-05-02
NO20076460L (no) 2008-02-19
CA2608378A1 (fr) 2006-11-23
JO2753B1 (en) 2014-03-15
ATE518859T1 (de) 2011-08-15
MY149037A (en) 2013-07-15
NZ563239A (en) 2011-01-28
CR9515A (es) 2008-02-21
JP2008540620A (ja) 2008-11-20
US7674795B2 (en) 2010-03-09
EP1888579A2 (fr) 2008-02-20
CN101203518B (zh) 2013-07-24
TW200716633A (en) 2007-05-01
PA8675701A1 (es) 2006-12-07
WO2006123061A3 (fr) 2007-01-11
JP4964874B2 (ja) 2012-07-04
UY29549A1 (es) 2006-12-29
IL187163A (en) 2014-07-31
KR20080025375A (ko) 2008-03-20
FR2885904A1 (fr) 2006-11-24
CN101203518A (zh) 2008-06-18
TNSN07389A1 (en) 2009-03-17
EA019027B1 (ru) 2013-12-30
AR054125A1 (es) 2007-06-06

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