EA200702531A1 - Новые производные флуорена, содержащие их композиции и применение - Google Patents
Новые производные флуорена, содержащие их композиции и применениеInfo
- Publication number
- EA200702531A1 EA200702531A1 EA200702531A EA200702531A EA200702531A1 EA 200702531 A1 EA200702531 A1 EA 200702531A1 EA 200702531 A EA200702531 A EA 200702531A EA 200702531 A EA200702531 A EA 200702531A EA 200702531 A1 EA200702531 A1 EA 200702531A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- alkyl
- aryl
- halogen
- heteroaryl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Изобретение относится к новым продуктам формулы (I), в которой А1, А2, A3 и А4 означают CRa или N; R1 и R1' являются такими, что один означает Н, галоген, C1-С3-алкил, С1-С3-алкоксил, алкил-ОН, CF3, цианогруппу, карбоксил и карбоксамидогруппу; а другой означает Н; галоген; CF3; ОН; SH; нитрогруппу; аминогруппу; NH-OH; NH-CO-H; NH-CO-OH; NH-CO-Оалкил; NH-CO-NH2; карбоксил; CN; CO-NH2; Х-(СН2)m-алкил; X-(СН2)m-циклоалкил; Х-(СН2)m-гетероциклоалкил; Х-(СН2)m-арил или Х-(СН2)m-гетероарил, где Х - простая связь, СН2, СН=СН, СН2-O, CH2-NH, СН2-С(O), СН2-С(O)-O, СН2-С(О)-NH, CH2-NH-(СО), CH2-NH-S(O), CH2-NH-S(O)2, О, S, NH, O-C(O), C(O)-NH, -NH-C(O), -NH-С(O)-С(O)-, -NH-C(O)-NH; NH-CS, NH-S(О) или NH-S(O)2; m=0, 1 или 2; либо R1 и R'1 вместе с С, с которым они связаны, образуют или радикал =O; =S; =N-OH; =N-NH2; =N-NH-CO-NH2; =CH-OH; =Y1-(CH2)m-арил, или =Y1-(CH2) m-гетероарил, где Y1 означает CH, CH-CO, CH-CO-NH, N, N-O или N-NH-, где m=0, 1 или 2, или цикл; R2 и R'2 означают Н, галоген, CF3, нитрогруппу, цианогруппу, алкил, гидроксил, меркаптогруппу, аминогруппу, алкиламиногруппу, диалкиламиногруппу, алкоксил, алкилтиогруппу, свободный или этерифицированный карбоксил, карбоксамидогруппу, CO-NH(алкил) и CO-N(алкил)2; р = 1-3 и р' = 1-4; Ra означает Н; галоген; CF3; гидроксил; меркаптогруппу, нитрогруппу; аминогруппу; NH-OH; NH-CO-H; NH-CO-NH2; карбоксил; CN; CO-NH2; Y-(CH2)n-алкил; Y-(CH2)n-циклоалкил; Y-(CH2)n-гетероциклоалкил; Y-(CH2)n-арил или Y-(CH2)n-гетероарил, где Y=O, S, NH, О-С(О), C(O)-NH, NH-C(O); NH-S(О) или NH-S(О)2, где n=0, 1, 2 или 3; причем все алкильные радикалы, алкоксильные радикалы, алкилтиогруппы, циклоалкильные, гетероциклоалкильные, арильные и гетероарильные радикалы возможно замещены; и причем эти продукты находятся в любых таутомерных и изомерных формах и в виде солей; в качестве лекарственных средств.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0505037A FR2885904B1 (fr) | 2005-05-19 | 2005-05-19 | Nouveaux derives du fluorene, compositions les contenant et utilisation |
| PCT/FR2006/001137 WO2006123061A2 (fr) | 2005-05-19 | 2006-05-19 | Derives du fluorene, compositions les contenant et utilisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200702531A1 true EA200702531A1 (ru) | 2008-04-28 |
| EA019027B1 EA019027B1 (ru) | 2013-12-30 |
Family
ID=36036699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200702531A EA019027B1 (ru) | 2005-05-19 | 2006-05-19 | Производные флуорена, содержащие их композиции и применение |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US7674795B2 (ru) |
| EP (1) | EP1888579B1 (ru) |
| JP (1) | JP4964874B2 (ru) |
| KR (1) | KR101288696B1 (ru) |
| CN (1) | CN101203518B (ru) |
| AR (1) | AR054125A1 (ru) |
| AT (1) | ATE518859T1 (ru) |
| AU (1) | AU2006248825B2 (ru) |
| BR (1) | BRPI0611424A2 (ru) |
| CA (1) | CA2608378C (ru) |
| CR (1) | CR9515A (ru) |
| DO (1) | DOP2006000112A (ru) |
| EA (1) | EA019027B1 (ru) |
| FR (1) | FR2885904B1 (ru) |
| GT (1) | GT200600206A (ru) |
| HN (1) | HN2006018410A (ru) |
| IL (1) | IL187163A (ru) |
| JO (1) | JO2753B1 (ru) |
| MA (1) | MA29493B1 (ru) |
| MX (1) | MX2007014443A (ru) |
| MY (1) | MY149037A (ru) |
| NO (1) | NO20076460L (ru) |
| NZ (1) | NZ563239A (ru) |
| PA (1) | PA8675701A1 (ru) |
| PE (1) | PE20061367A1 (ru) |
| TN (1) | TNSN07389A1 (ru) |
| TW (1) | TWI386406B (ru) |
| UA (1) | UA93203C2 (ru) |
| UY (1) | UY29549A1 (ru) |
| WO (1) | WO2006123061A2 (ru) |
| ZA (1) | ZA200709856B (ru) |
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| US8362268B2 (en) | 2008-05-30 | 2013-01-29 | University Of Notre Dame Du Lac | Anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria |
| FR2932484B1 (fr) * | 2008-06-16 | 2010-06-18 | Sanofi Aventis | Nouveaux derives de pyrroloindole inhibiteurs d'hsp90, compositions les contenant et utilisation |
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| AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| US9388112B2 (en) | 2010-01-06 | 2016-07-12 | The University Of British Columbia | Bisphenol derivatives and their use as androgen receptor activity modulators |
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| KR102280686B1 (ko) | 2014-02-11 | 2021-07-22 | 삼성전자주식회사 | 카바졸계 화합물 및 이를 포함한 유기 발광 소자 |
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| MXPA05008335A (es) | 2003-02-11 | 2006-05-04 | Vernalis Cambridge Ltd | Compuestos de isoxazol como inhibidores de las proteinas de choque por calor. |
| GB0309637D0 (en) | 2003-04-28 | 2003-06-04 | Cancer Rec Tech Ltd | Pyrazole compounds |
| JP4575294B2 (ja) * | 2003-06-27 | 2010-11-04 | 協和発酵キリン株式会社 | Ｈｓｐ９０ファミリー蛋白質阻害剤 |
| GB0315111D0 (en) | 2003-06-27 | 2003-07-30 | Cancer Rec Tech Ltd | Substituted 5-membered ring compounds and their use |
| NZ546044A (en) | 2003-08-29 | 2009-09-25 | Vernalis Cambridge Ltd | Pyrimidothiophene compounds |
| GB0323810D0 (en) * | 2003-10-10 | 2003-11-12 | Cancer Rec Tech Ltd | Pyridothiophene compounds |
| JPWO2005063222A1 (ja) * | 2003-12-26 | 2007-07-19 | 協和醗酵工業株式会社 | Ｈｓｐ９０ファミリー蛋白質阻害剤 |
| FR2884252B1 (fr) * | 2005-04-08 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90 |
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2005
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