AU2006230413B8 - Fc variants with optimized properties - Google Patents

Fc variants with optimized properties Download PDF

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Publication number
AU2006230413B8
AU2006230413B8 AU2006230413A AU2006230413A AU2006230413B8 AU 2006230413 B8 AU2006230413 B8 AU 2006230413B8 AU 2006230413 A AU2006230413 A AU 2006230413A AU 2006230413 A AU2006230413 A AU 2006230413A AU 2006230413 B8 AU2006230413 B8 AU 2006230413B8
Authority
AU
Australia
Prior art keywords
antibody
variant
polypeptide
variants
parent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006230413A
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English (en)
Other versions
AU2006230413B2 (en
AU2006230413A1 (en
Inventor
Wei Dang
John R. Desjarlais
Sher Bahadur Karki
Gregory Alan Lazar
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Xencor Inc
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/124,620 external-priority patent/US8188231B2/en
Application filed by Xencor Inc filed Critical Xencor Inc
Publication of AU2006230413A1 publication Critical patent/AU2006230413A1/en
Application granted granted Critical
Publication of AU2006230413B2 publication Critical patent/AU2006230413B2/en
Publication of AU2006230413B8 publication Critical patent/AU2006230413B8/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2006230413A 2005-03-31 2006-03-31 Fc variants with optimized properties Ceased AU2006230413B8 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US66719705P 2005-03-31 2005-03-31
US60/667,197 2005-03-31
US11/124,620 2005-05-05
US11/124,620 US8188231B2 (en) 2002-09-27 2005-05-05 Optimized FC variants
US70537805P 2005-08-03 2005-08-03
US60/705,378 2005-08-03
US72329405P 2005-10-03 2005-10-03
US72333505P 2005-10-03 2005-10-03
US60/723,294 2005-10-03
US60/723,335 2005-10-03
PCT/US2006/011752 WO2006105338A2 (fr) 2005-03-31 2006-03-31 Variants fc presentant des proprietes optimisees

Publications (3)

Publication Number Publication Date
AU2006230413A1 AU2006230413A1 (en) 2006-10-05
AU2006230413B2 AU2006230413B2 (en) 2010-09-23
AU2006230413B8 true AU2006230413B8 (en) 2011-01-20

Family

ID=37054149

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006230413A Ceased AU2006230413B8 (en) 2005-03-31 2006-03-31 Fc variants with optimized properties

Country Status (5)

Country Link
EP (1) EP1871808A2 (fr)
AU (1) AU2006230413B8 (fr)
CA (1) CA2602663A1 (fr)
IL (1) IL186145A0 (fr)
WO (1) WO2006105338A2 (fr)

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* Cited by examiner, † Cited by third party
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WO2006105338A2 (fr) 2006-10-05
AU2006230413B2 (en) 2010-09-23
AU2006230413A1 (en) 2006-10-05
CA2602663A1 (fr) 2006-10-05

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