AU2005318227B2 - Stereoselective process and crystalline forms of a camptothecin - Google Patents

Stereoselective process and crystalline forms of a camptothecin Download PDF

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Publication number
AU2005318227B2
AU2005318227B2 AU2005318227A AU2005318227A AU2005318227B2 AU 2005318227 B2 AU2005318227 B2 AU 2005318227B2 AU 2005318227 A AU2005318227 A AU 2005318227A AU 2005318227 A AU2005318227 A AU 2005318227A AU 2005318227 B2 AU2005318227 B2 AU 2005318227B2
Authority
AU
Australia
Prior art keywords
camptothecin
compound
ray diffraction
process according
degrees
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005318227A
Other languages
English (en)
Other versions
AU2005318227A1 (en
Inventor
Marco Alpegiani
Walter Cabri
Paolo Carminati
Paolo Ghetti
Fabrizio Giorgi
Mauro Marzi
Maria Ornella Tinti
Domenico Vergani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of AU2005318227A1 publication Critical patent/AU2005318227A1/en
Application granted granted Critical
Publication of AU2005318227B2 publication Critical patent/AU2005318227B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
AU2005318227A 2004-12-21 2005-12-16 Stereoselective process and crystalline forms of a camptothecin Ceased AU2005318227B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04030246 2004-12-21
EP04030246.5 2004-12-21
PCT/EP2005/056849 WO2006067092A2 (en) 2004-12-21 2005-12-16 Stereoselective process and crystalline forms of a camptothecin

Publications (2)

Publication Number Publication Date
AU2005318227A1 AU2005318227A1 (en) 2006-06-29
AU2005318227B2 true AU2005318227B2 (en) 2011-08-18

Family

ID=34927884

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005318227A Ceased AU2005318227B2 (en) 2004-12-21 2005-12-16 Stereoselective process and crystalline forms of a camptothecin

Country Status (18)

Country Link
US (3) US7799921B2 (enExample)
EP (1) EP1828196B1 (enExample)
JP (2) JP5491699B2 (enExample)
KR (1) KR101355121B1 (enExample)
CN (1) CN101084221B (enExample)
AU (1) AU2005318227B2 (enExample)
BR (1) BRPI0515832A (enExample)
CA (1) CA2590756C (enExample)
CY (1) CY1117243T1 (enExample)
DK (1) DK1828196T3 (enExample)
ES (1) ES2395930T3 (enExample)
HR (1) HRP20120926T1 (enExample)
ME (1) ME01495B (enExample)
PL (1) PL1828196T3 (enExample)
PT (1) PT1828196E (enExample)
RS (1) RS52585B (enExample)
SI (1) SI1828196T1 (enExample)
WO (1) WO2006067092A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1828196B1 (en) * 2004-12-21 2012-10-17 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Stereoselective process and crystalline forms of a camptothecin
ITRM20050418A1 (it) * 2005-08-04 2007-02-05 Sigma Tau Ind Farmaceuti Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina.
FR2938534B1 (fr) 2008-11-14 2012-10-26 Sanofi Aventis Procede de preparation de l'hemifumarate d'eplivanserine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1044977A1 (en) * 1999-03-09 2000-10-18 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Camptothecin derivatives having antitumor activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03271278A (ja) * 1990-03-16 1991-12-03 Nissan Chem Ind Ltd ２―アニリノピリミジン誘導体および農園芸用殺菌剤
JP3046401B2 (ja) * 1991-06-18 2000-05-29 イハラケミカル工業株式会社 ６−〔１−（ｎ−アルコキシイミノ）エチル〕サリチル酸誘導体及びその製造法
IL106786A (en) * 1992-09-10 1997-02-18 Basf Ag Substituted pyridine derivatives and fungicidal compositions containing them
AU2003215594A1 (en) * 2002-03-01 2003-09-16 Pharmacia Italia S.P.A. Crystalline polymorphic form of irinotecan hydrochloride
EP1828196B1 (en) * 2004-12-21 2012-10-17 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. Stereoselective process and crystalline forms of a camptothecin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1044977A1 (en) * 1999-03-09 2000-10-18 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Camptothecin derivatives having antitumor activity

Also Published As

Publication number Publication date
US20100311783A1 (en) 2010-12-09
HK1113487A1 (en) 2008-10-03
WO2006067092A3 (en) 2006-11-02
EP1828196A2 (en) 2007-09-05
RS52585B (sr) 2013-04-30
US7799921B2 (en) 2010-09-21
CN101084221B (zh) 2011-05-11
PL1828196T3 (pl) 2013-02-28
AU2005318227A1 (en) 2006-06-29
EP1828196B1 (en) 2012-10-17
ES2395930T3 (es) 2013-02-18
KR101355121B1 (ko) 2014-01-24
JP5982261B2 (ja) 2016-08-31
CN101084221A (zh) 2007-12-05
US8124769B2 (en) 2012-02-28
PT1828196E (pt) 2012-11-19
KR20070097535A (ko) 2007-10-04
CY1117243T1 (el) 2017-04-05
US20090239893A1 (en) 2009-09-24
JP2013067629A (ja) 2013-04-18
ME01495B (me) 2014-04-20
DK1828196T3 (da) 2012-11-26
BRPI0515832A (pt) 2008-08-05
CA2590756C (en) 2014-09-02
US20100311784A1 (en) 2010-12-09
JP5491699B2 (ja) 2014-05-14
JP2008524306A (ja) 2008-07-10
CA2590756A1 (en) 2006-06-29
WO2006067092A2 (en) 2006-06-29
HRP20120926T1 (hr) 2012-12-31
SI1828196T1 (sl) 2012-12-31
US8101758B2 (en) 2012-01-24

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired