BRPI0515832A - processo estereosseletivo e formas cristalinas de uma camptotecina - Google Patents
processo estereosseletivo e formas cristalinas de uma camptotecinaInfo
- Publication number
- BRPI0515832A BRPI0515832A BRPI0515832-0A BRPI0515832A BRPI0515832A BR PI0515832 A BRPI0515832 A BR PI0515832A BR PI0515832 A BRPI0515832 A BR PI0515832A BR PI0515832 A BRPI0515832 A BR PI0515832A
- Authority
- BR
- Brazil
- Prior art keywords
- crystalline forms
- camptothecin
- stereoselective process
- gimatecan
- stereo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCESSO ESTEREOSSELETIVO E FORMAS CRISTALINAS DE UMA CAMPTOTECINA. A presente invenção refere-se a um processo estéreo - seletivo para preparação de 7-¢(E)-t-butilóxi imino metil! camptotecina (também conhecida como gimatecano) é aqui mostrado. Com a adição de ainda etapas de dissolução e precipitação realizadas em misturas de solventes diferentes apropriadas, quatro novas formas cristalinas de gimatecana também são obteníveis através do uso de mesmo processo estéreo - seletivo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04030246 | 2004-12-21 | ||
PCT/EP2005/056849 WO2006067092A2 (en) | 2004-12-21 | 2005-12-16 | Stereoselective process and crystalline forms of a camptothecin |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0515832A true BRPI0515832A (pt) | 2008-08-05 |
Family
ID=34927884
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0515832-0A BRPI0515832A (pt) | 2004-12-21 | 2005-12-16 | processo estereosseletivo e formas cristalinas de uma camptotecina |
Country Status (19)
Country | Link |
---|---|
US (3) | US7799921B2 (pt) |
EP (1) | EP1828196B1 (pt) |
JP (2) | JP5491699B2 (pt) |
KR (1) | KR101355121B1 (pt) |
CN (1) | CN101084221B (pt) |
AU (1) | AU2005318227B2 (pt) |
BR (1) | BRPI0515832A (pt) |
CA (1) | CA2590756C (pt) |
CY (1) | CY1117243T1 (pt) |
DK (1) | DK1828196T3 (pt) |
ES (1) | ES2395930T3 (pt) |
HK (1) | HK1113487A1 (pt) |
HR (1) | HRP20120926T1 (pt) |
ME (1) | ME01495B (pt) |
PL (1) | PL1828196T3 (pt) |
PT (1) | PT1828196E (pt) |
RS (1) | RS52585B (pt) |
SI (1) | SI1828196T1 (pt) |
WO (1) | WO2006067092A2 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1828196T3 (da) * | 2004-12-21 | 2012-11-26 | Sigma Tau Ind Farmaceuti | Stereospecifik fremgangsmåde og krystallinske former af en camptothecin |
ITRM20050418A1 (it) * | 2005-08-04 | 2007-02-05 | Sigma Tau Ind Farmaceuti | Sistemi terapeutici a rilascio immediato per il migliorato assorbimento orale di 7-[(e)-t-butilossimminometil] camptotecina. |
FR2938534B1 (fr) | 2008-11-14 | 2012-10-26 | Sanofi Aventis | Procede de preparation de l'hemifumarate d'eplivanserine |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03271278A (ja) * | 1990-03-16 | 1991-12-03 | Nissan Chem Ind Ltd | 2―アニリノピリミジン誘導体および農園芸用殺菌剤 |
JP3046401B2 (ja) * | 1991-06-18 | 2000-05-29 | イハラケミカル工業株式会社 | 6−〔1−(n−アルコキシイミノ)エチル〕サリチル酸誘導体及びその製造法 |
IL106786A (en) * | 1992-09-10 | 1997-02-18 | Basf Ag | Substituted pyridine derivatives and fungicidal compositions containing them |
DE69901379T2 (de) * | 1999-03-09 | 2002-11-07 | Sigma Tau Ind Farmaceuti | Camptothecin-Derivate mit Antitumor-Wirkung |
KR20040091083A (ko) * | 2002-03-01 | 2004-10-27 | 파마시아 이탈리아 에스.피.에이. | 이리노테칸 히드로클로라이드의 결정성 다형체 |
DK1828196T3 (da) * | 2004-12-21 | 2012-11-26 | Sigma Tau Ind Farmaceuti | Stereospecifik fremgangsmåde og krystallinske former af en camptothecin |
-
2005
- 2005-12-16 DK DK05849781.9T patent/DK1828196T3/da active
- 2005-12-16 CA CA2590756A patent/CA2590756C/en not_active Expired - Fee Related
- 2005-12-16 JP JP2007547467A patent/JP5491699B2/ja not_active Expired - Fee Related
- 2005-12-16 EP EP05849781A patent/EP1828196B1/en active Active
- 2005-12-16 WO PCT/EP2005/056849 patent/WO2006067092A2/en active Application Filing
- 2005-12-16 AU AU2005318227A patent/AU2005318227B2/en not_active Ceased
- 2005-12-16 CN CN2005800440829A patent/CN101084221B/zh active Active
- 2005-12-16 SI SI200531610T patent/SI1828196T1/sl unknown
- 2005-12-16 PT PT05849781T patent/PT1828196E/pt unknown
- 2005-12-16 KR KR1020077016814A patent/KR101355121B1/ko active IP Right Grant
- 2005-12-16 BR BRPI0515832-0A patent/BRPI0515832A/pt not_active Application Discontinuation
- 2005-12-16 PL PL05849781T patent/PL1828196T3/pl unknown
- 2005-12-16 ES ES05849781T patent/ES2395930T3/es active Active
- 2005-12-16 RS RS20120505A patent/RS52585B/en unknown
- 2005-12-16 US US11/721,282 patent/US7799921B2/en not_active Expired - Fee Related
- 2005-12-16 ME MEP-2012-128A patent/ME01495B/me unknown
-
2008
- 2008-04-02 HK HK08103639.3A patent/HK1113487A1/xx unknown
-
2010
- 2010-08-17 US US12/857,776 patent/US8101758B2/en not_active Expired - Fee Related
- 2010-08-17 US US12/857,743 patent/US8124769B2/en not_active Expired - Fee Related
-
2012
- 2012-10-30 CY CY20121101034T patent/CY1117243T1/el unknown
- 2012-11-09 JP JP2012247587A patent/JP5982261B2/ja not_active Expired - Fee Related
- 2012-11-16 HR HRP20120926TT patent/HRP20120926T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
KR20070097535A (ko) | 2007-10-04 |
ES2395930T3 (es) | 2013-02-18 |
PL1828196T3 (pl) | 2013-02-28 |
AU2005318227A1 (en) | 2006-06-29 |
JP2008524306A (ja) | 2008-07-10 |
CN101084221A (zh) | 2007-12-05 |
JP2013067629A (ja) | 2013-04-18 |
US8124769B2 (en) | 2012-02-28 |
KR101355121B1 (ko) | 2014-01-24 |
CN101084221B (zh) | 2011-05-11 |
EP1828196B1 (en) | 2012-10-17 |
HRP20120926T1 (hr) | 2012-12-31 |
CA2590756A1 (en) | 2006-06-29 |
SI1828196T1 (sl) | 2012-12-31 |
JP5491699B2 (ja) | 2014-05-14 |
CA2590756C (en) | 2014-09-02 |
CY1117243T1 (el) | 2017-04-05 |
AU2005318227B2 (en) | 2011-08-18 |
DK1828196T3 (da) | 2012-11-26 |
US7799921B2 (en) | 2010-09-21 |
ME01495B (me) | 2014-04-20 |
PT1828196E (pt) | 2012-11-19 |
WO2006067092A2 (en) | 2006-06-29 |
RS52585B (en) | 2013-04-30 |
EP1828196A2 (en) | 2007-09-05 |
JP5982261B2 (ja) | 2016-08-31 |
US20100311783A1 (en) | 2010-12-09 |
HK1113487A1 (en) | 2008-10-03 |
US20090239893A1 (en) | 2009-09-24 |
US8101758B2 (en) | 2012-01-24 |
WO2006067092A3 (en) | 2006-11-02 |
US20100311784A1 (en) | 2010-12-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0821440A2 (pt) | Derivados de tetra-hidro-imidazo[1,5-a] pirazina, processo de preparação e uso medicinal dos mesmos | |
CY1108742T1 (el) | Κρυσταλλικη μορφη της μηλεϊνικης ασεναπινης | |
NZ579997A (en) | PROCESS FOR PREPARATION OF N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | |
BRPI0818630A2 (pt) | Estrutura de núcleo celular capaz de ser usada em painel acústico para nacela de motor turbojato, método de preparação de estrutura de núcleo celular, painel acústico de nacela de motor turbojato | |
BRPI0506858A (pt) | composto, métodos de preparação de monoidrato de gaboxadol cristalino e de anidrato de gaboxadol cristalino, composição farmacêutica, e, uso de um composto | |
ZA200805989B (en) | Taxane pharmaceutical formulation, solid taxane composition, method for preparing the solid taxane composition, composition for solubilising said solid taxane composition and set of elements (kit) for the injectable taxane formulation | |
HK1094215A1 (en) | Process for the preparation of stable polycarbodiimide dispersions in water, which are free of organic solvents and may be used as crosslinking agent | |
WO2008074719A8 (en) | Disperse dyes mixtures | |
CR11827A (es) | Activadores de glucoquinasa | |
BRPI0914682B8 (pt) | compostos de heteroarila e composições compreendendo os referidos compostos | |
BR112013014599A2 (pt) | composição imunogênica, uso de uma composição imunogênica, processo para preparar uma composição imunogênica, método para a fabricação de uma composição imunogênca estável, e, kit | |
MY149705A (en) | Pyridino-pyridinone derivatives, preparation therof, and therapeutic use thereof | |
BRPI0718706B8 (pt) | métodos para a preparação de hexa-hidrofuro[2,3- b]furan-3-ol | |
ZA200805247B (en) | Quinazoline derivatives, process for their preparation and their use as anti-cancer agents | |
EA200800595A1 (ru) | Композиции политиоуретана и способы получения и применения композиций политиоуретана | |
MX2009004435A (es) | Tinturas dispersas, su preparacion y su uso. | |
NO20081365L (no) | Ny krystallinsk form av et pyridazino[4,5-b]indolderivat | |
EE05536B1 (et) | N-karbamoüülmetüül-4-(R)-fenüül-2-pürrolidinoon, selle valmistamise meetod ja farmatseutiline kasutamine | |
BR0212341A (pt) | Processo para a preparação de hexaidro-furo[2,3-b]furan-3-ol | |
IL218539A0 (en) | Pregnane derivatives condensed in the 16, 17 position with an n-substituted isoxazolidin ring as anti-inflammatory agents | |
BRPI0515832A (pt) | processo estereosseletivo e formas cristalinas de uma camptotecina | |
DE602005016282D1 (de) | Verfahren zur herstellung von camptothecin-derivaten | |
ECSP078011A (es) | DERIVADOS DE PIRIDO[2,3-d]PIRIMIDINA, SU PREPARACION, SU APLICACION EN TERAPEUTICA | |
DK1870460T3 (da) | Fremgangsmåder til fremstilling af proteiner med tripelhelixstruktur | |
IL219116A (en) | 5h– oxo- (Theo / oxa) Zulu [a – 2,3] ortho-compressed pyrimidine with other rings and their use for treating anemia and tissue damage caused by ischemic diseases |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 491/22 Ipc: C07D 491/22 (2006.01), A61P 35/00 (2006.01), A61P |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |