AU2005278962C1 - Isoindolin-1-one derivatives - Google Patents
Isoindolin-1-one derivatives Download PDFInfo
- Publication number
- AU2005278962C1 AU2005278962C1 AU2005278962A AU2005278962A AU2005278962C1 AU 2005278962 C1 AU2005278962 C1 AU 2005278962C1 AU 2005278962 A AU2005278962 A AU 2005278962A AU 2005278962 A AU2005278962 A AU 2005278962A AU 2005278962 C1 AU2005278962 C1 AU 2005278962C1
- Authority
- AU
- Australia
- Prior art keywords
- mmol
- nmr
- substituted
- phenyl
- dihydroisoindolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/50—Iso-indoles; Hydrogenated iso-indoles with oxygen and nitrogen atoms in positions 1 and 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0419481.7 | 2004-09-02 | ||
| GBGB0419481.7A GB0419481D0 (en) | 2004-09-02 | 2004-09-02 | Isoindolin-1-one derivatives |
| PCT/GB2005/003345 WO2006024837A1 (en) | 2004-09-02 | 2005-08-26 | Isoindolin-1-one derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2005278962A1 AU2005278962A1 (en) | 2006-03-09 |
| AU2005278962B2 AU2005278962B2 (en) | 2012-03-01 |
| AU2005278962C1 true AU2005278962C1 (en) | 2012-10-25 |
Family
ID=33155907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005278962A Expired AU2005278962C1 (en) | 2004-09-02 | 2005-08-26 | Isoindolin-1-one derivatives |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8258175B2 (https=) |
| EP (1) | EP1786773B1 (https=) |
| JP (1) | JP5057273B2 (https=) |
| AU (1) | AU2005278962C1 (https=) |
| CA (1) | CA2578955A1 (https=) |
| GB (1) | GB0419481D0 (https=) |
| WO (1) | WO2006024837A1 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2346157T3 (es) * | 2006-03-22 | 2010-10-11 | Janssen Pharmaceutica N.V. | Derivados de alquilaminas ciclicas como inhibidores de la interaccion entre mdm2 y p53. |
| WO2007107545A1 (en) * | 2006-03-22 | 2007-09-27 | Janssen Pharmaceutica N.V. | Cyclic-alkylaminederivatives as inhibitors of the interaction between mdm2 and p53 |
| WO2007139499A1 (en) * | 2006-05-31 | 2007-12-06 | Aprea Ab | Compounds for use as a medicament |
| AU2007332493A1 (en) | 2006-12-14 | 2008-06-19 | Daiichi Sankyo Company, Limited | Imidazothiazole derivatives |
| WO2009151069A1 (ja) | 2008-06-12 | 2009-12-17 | 第一三共株式会社 | ４，７－ジアザスピロ［２．５］オクタン環構造を有するイミダゾチアゾール誘導体 |
| GB0811643D0 (en) * | 2008-06-25 | 2008-07-30 | Cancer Rec Tech Ltd | New therapeutic agents |
| UA107814C2 (uk) | 2009-11-12 | 2015-02-25 | Дзе Ріджентс Оф Дзе Юніверсіті Оф Мічіган | Спірооксіндольні антагоністи мdм2 |
| CU24130B1 (es) | 2009-12-22 | 2015-09-29 | Novartis Ag | Isoquinolinonas y quinazolinonas sustituidas |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| JP2014500870A (ja) | 2010-11-12 | 2014-01-16 | ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、ミシガン | スピロ−オキシインドールｍｄｍ２アンタゴニスト |
| SG193002A1 (en) | 2011-03-10 | 2013-09-30 | Daiichi Sankyo Co Ltd | Dispiropyrrolidine derivative |
| WO2012155066A2 (en) | 2011-05-11 | 2012-11-15 | Shaomeng Wang | Spiro-oxindole mdm2 antagonists |
| WO2013056015A1 (en) | 2011-10-14 | 2013-04-18 | Incyte Corporation | Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors |
| EP2855483B1 (en) | 2012-05-24 | 2017-10-25 | Novartis AG | Pyrrolopyrrolidinone compounds |
| TWI586668B (zh) | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
| KR102196882B1 (ko) | 2012-12-20 | 2020-12-30 | 머크 샤프 앤드 돔 코포레이션 | Hdm2 억제제로서의 치환된 이미다조피리딘 |
| WO2014115077A1 (en) | 2013-01-22 | 2014-07-31 | Novartis Ag | Substituted purinone compounds |
| US9556180B2 (en) | 2013-01-22 | 2017-01-31 | Novartis Ag | Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction |
| EP3412675A1 (en) | 2013-05-27 | 2018-12-12 | Novartis AG | Imidazopyrrolidinone derivatives and their use in the treatment of disease |
| AU2014272700B2 (en) | 2013-05-28 | 2016-12-01 | Novartis Ag | Pyrazolo-pyrrolidin-4-one derivatives and their use in the treatment of disease |
| MX2015016421A (es) | 2013-05-28 | 2016-03-03 | Novartis Ag | Derivados de pirazolo-pirrolidin-4-ona como inhibidores de bet y su uso en el tratamiento de enfermedades. |
| EA029269B1 (ru) | 2013-11-21 | 2018-02-28 | Новартис Аг | Производные пирролопирролона и их применение для лечения заболеваний |
| CA2976752C (en) | 2015-02-20 | 2019-12-17 | Daiichi Sankyo Company, Limited | Method for treating cancer by combined use |
| JP6823587B2 (ja) | 2015-04-13 | 2021-02-03 | 第一三共株式会社 | Ｍｄｍ２阻害剤とｂｔｋ阻害剤との併用治療法 |
| GB201517216D0 (en) | 2015-09-29 | 2015-11-11 | Cancer Res Technology Ltd And Astex Therapeutics Ltd | Pharmaceutical compounds |
| GB201517217D0 (en) | 2015-09-29 | 2015-11-11 | Astex Therapeutics Ltd And Cancer Res Technology Ltd | Pharmaceutical compounds |
| TWI734715B (zh) | 2015-11-19 | 2021-08-01 | 美商卡默森屈有限公司 | 趨化因子受體調節劑 |
| TWI724056B (zh) | 2015-11-19 | 2021-04-11 | 美商卡默森屈有限公司 | Ｃｘｃｒ２抑制劑 |
| US10759808B2 (en) | 2016-04-06 | 2020-09-01 | The Regents Of The University Of Michigan | Monofunctional intermediates for ligand-dependent target protein degradation |
| SG11201808728QA (en) | 2016-04-06 | 2018-11-29 | Univ Michigan Regents | Mdm2 protein degraders |
| EP3527226A4 (en) | 2016-10-17 | 2020-06-17 | Daiichi Sankyo Company, Limited | COMBINATION THERAPY PROCEDURE WITH MDM2 INHIBITOR AND DNA METHYL TRANSFERASE INHIBITOR |
| GB201704966D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| GB201704965D0 (en) | 2017-03-28 | 2017-05-10 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| CN107286074B (zh) * | 2017-08-16 | 2019-08-20 | 厦门华厦学院 | 3-羟基异吲哚-1-酮衍生物及其制备方法 |
| EP3737366B1 (en) | 2018-01-08 | 2026-02-25 | ChemoCentryx, Inc. | Methods of treating generalized pustular psoriasis with an antagonist of ccr6 or cxcr2 |
| CN109053546B (zh) | 2018-07-05 | 2021-04-27 | 中国科学院兰州化学物理研究所 | 一种苯酞类衍生物及其制备方法和应用 |
| CN112912143A (zh) | 2018-10-08 | 2021-06-04 | 美国密歇根州立大学试剂中心 | 小分子mdm2蛋白降解剂 |
| EP3659964A1 (en) | 2018-11-28 | 2020-06-03 | Hysilabs, SAS | Catalysed process of production of hydrogen from silylated derivatives as hydrogen carrier compounds |
| HRP20241159T1 (hr) | 2020-02-07 | 2024-12-06 | Gasherbrum Bio, Inc. | Heterociklički agonisti za glp-1 |
| KR20230005160A (ko) | 2020-03-19 | 2023-01-09 | 카이메라 쎄라퓨틱스 인코포레이티드 | Mdm2 분해제 및 이의 용도 |
| CN116368140A (zh) | 2020-09-10 | 2023-06-30 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
| CN120957993A (zh) | 2023-02-16 | 2025-11-14 | 加舒布鲁姆生物公司 | 杂环glp-1激动剂 |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1325066A (en) * | 1970-02-12 | 1973-08-01 | American Home Prod | Phthalimidine compounds |
| US3763178A (en) * | 1968-09-05 | 1973-10-02 | American Home Prod | Imidazolinyl phenyl carbonyl acid addition salts and related compounds |
| US4200759A (en) * | 1978-07-20 | 1980-04-29 | Delmar Chemicals, Limited | Preparation of imidazo[2,1-a]isoindole compounds |
| US4244966A (en) * | 1979-09-24 | 1981-01-13 | American Home Products Corporation | 1,3-Dihydro-3-(2-hydroxy-, 2-bromo- or 2-chloroethyl)-2H-isoindol-1-one derivatives |
| GB1601701A (en) * | 1977-07-22 | 1981-11-04 | Delmar Chem | Production of heterocyclic benzamide compounds |
| US4331600A (en) * | 1980-10-31 | 1982-05-25 | Usv Pharmaceutical Corporation | Intermediates for the synthesis of phthalimidines |
| US4505921A (en) * | 1982-09-23 | 1985-03-19 | Adir, S.A.R.L. | Sulfonylurea compounds and their use in treating diabetes |
| US6344468B1 (en) * | 1998-02-21 | 2002-02-05 | Aventis Pharma Deutschland Gmbh | Substituted isoindolones and their use as cyclic GMP modulators in medicaments |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3466298A (en) * | 1967-03-14 | 1969-09-09 | American Home Prod | Process for the preparation of 2-(2-aminoethyl)isoindolines |
| AR203996A1 (es) * | 1972-03-16 | 1975-11-12 | Rhone Poulenc Sa | Procedimiento para preparar derivados de(hidroxi-2-amino-3-propoxi)-3-isoindolinona-1 |
| FR2217000B1 (https=) * | 1973-02-08 | 1976-04-09 | Rhone Poulenc Ind | |
| DE2840800C2 (de) * | 1978-09-20 | 1980-02-14 | Mannesmann Demag Ag, 4100 Duisburg | Kanalbaumaschine |
| JP2001106673A (ja) * | 1999-07-26 | 2001-04-17 | Banyu Pharmaceut Co Ltd | ビアリールウレア誘導体 |
| WO2001032928A2 (en) * | 1999-11-05 | 2001-05-10 | Phase-1 Molecular Toxicology | Methods of determining individual hypersensitivity to an agent |
| PL370823A1 (en) * | 2001-12-18 | 2005-05-30 | F.Hoffmann-La Roche Ag | Cis-2,4,5- triphenyl-imidazolines and their use in the treatment of tumors |
| JP2004217591A (ja) | 2003-01-16 | 2004-08-05 | Dai Ichi Seiyaku Co Ltd | シス選択的フルオロシクロプロパン誘導体の製造方法 |
| JP2005255660A (ja) | 2004-03-10 | 2005-09-22 | Katsuhiko Tomooka | 多官能基を有するラクタム類とその製法 |
| WO2005112932A2 (en) * | 2004-05-07 | 2005-12-01 | Exelixis, Inc. | Raf modulators and methods of use |
-
2004
- 2004-09-02 GB GBGB0419481.7A patent/GB0419481D0/en not_active Ceased
-
2005
- 2005-08-26 CA CA002578955A patent/CA2578955A1/en not_active Abandoned
- 2005-08-26 WO PCT/GB2005/003345 patent/WO2006024837A1/en not_active Ceased
- 2005-08-26 JP JP2007528986A patent/JP5057273B2/ja not_active Expired - Lifetime
- 2005-08-26 US US11/574,531 patent/US8258175B2/en active Active
- 2005-08-26 AU AU2005278962A patent/AU2005278962C1/en not_active Expired
- 2005-08-26 EP EP05782577.0A patent/EP1786773B1/en not_active Expired - Lifetime
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3763178A (en) * | 1968-09-05 | 1973-10-02 | American Home Prod | Imidazolinyl phenyl carbonyl acid addition salts and related compounds |
| GB1325066A (en) * | 1970-02-12 | 1973-08-01 | American Home Prod | Phthalimidine compounds |
| GB1601701A (en) * | 1977-07-22 | 1981-11-04 | Delmar Chem | Production of heterocyclic benzamide compounds |
| US4200759A (en) * | 1978-07-20 | 1980-04-29 | Delmar Chemicals, Limited | Preparation of imidazo[2,1-a]isoindole compounds |
| US4244966A (en) * | 1979-09-24 | 1981-01-13 | American Home Products Corporation | 1,3-Dihydro-3-(2-hydroxy-, 2-bromo- or 2-chloroethyl)-2H-isoindol-1-one derivatives |
| US4331600A (en) * | 1980-10-31 | 1982-05-25 | Usv Pharmaceutical Corporation | Intermediates for the synthesis of phthalimidines |
| US4505921A (en) * | 1982-09-23 | 1985-03-19 | Adir, S.A.R.L. | Sulfonylurea compounds and their use in treating diabetes |
| US6344468B1 (en) * | 1998-02-21 | 2002-02-05 | Aventis Pharma Deutschland Gmbh | Substituted isoindolones and their use as cyclic GMP modulators in medicaments |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1786773A1 (en) | 2007-05-23 |
| US20080261917A1 (en) | 2008-10-23 |
| AU2005278962B2 (en) | 2012-03-01 |
| EP1786773B1 (en) | 2017-03-01 |
| US8258175B2 (en) | 2012-09-04 |
| AU2005278962A1 (en) | 2006-03-09 |
| JP2008511601A (ja) | 2008-04-17 |
| GB0419481D0 (en) | 2004-10-06 |
| WO2006024837A1 (en) | 2006-03-09 |
| CA2578955A1 (en) | 2006-03-09 |
| JP5057273B2 (ja) | 2012-10-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2005278962C1 (en) | Isoindolin-1-one derivatives | |
| RU2155187C2 (ru) | Производные индола, их таутомеры, смеси их изомеров или отдельные изомеры и фармацевтически приемлемые соли, фармацевтическая композиция с антиопухолевой или ингибирующей протеин-тирозинкиназу активностью и способ торможения зависящего от протеин-тирозинкиназы заболевания или борьбы с аберрантным ростом клеток млекопитающего или человека. | |
| CA2766328C (en) | Isoindolin-1-one derivatives | |
| EP0673937B1 (en) | Bicyclic heterocyclic sulfonamide and sulfonic ester derivatives | |
| CA2598788C (en) | Indoline-sulfonamides compounds | |
| US20030153507A1 (en) | HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis | |
| AU2002345644A1 (en) | HV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis | |
| HU213605B (en) | Process for producing amide composition and pharmaceutical compositions comprising same as active ingredient | |
| BG109688A (bg) | Карбоксиарил заместени дифенил уреи като инхибитори на raf киназа | |
| JP5778297B2 (ja) | 癌治療用のｈｄａｃ阻害剤としての新規４−アミノ−ｎ−ヒドロキシ−ベンズアミド | |
| HK1203943A1 (en) | Quinazolinedione derivative | |
| US7750019B2 (en) | Pyrimidine compound having benzyl(pyridylmethyl)amine structure and medicament comprising the same | |
| KR100686531B1 (ko) | 히스톤 디아세틸라제 저해활성을 갖는 아릴아미노메틸프로페닐 벤즈하이드록시아마이드 유도체 및 그의 제조방법 | |
| JPS609716B2 (ja) | １，２―ベンズインチアゾリン―３―オン類、それらの製造法および医薬としての使用 | |
| CN111763180A (zh) | 苯并氮杂环类化合物及其制法和药物用途 | |
| CA2787860C (en) | Substituted 2-imidazolidones and analogs and their use against cancer | |
| US20250026741A1 (en) | Inhibitors of the oncogenic shp2 phosphatase and uses thereof | |
| JPH06220044A (ja) | ベンズアミド誘導体 | |
| KR20240051859A (ko) | Yap-tead 상호작용 억제를 위한 신규한 헤테로비시클릭 화합물 및 이를 포함하는 약학적 조성물 | |
| JPH07149722A (ja) | 縮合複素環化合物、その製造法および剤 | |
| JPH059429B2 (https=) | ||
| JPH0328425B2 (https=) | ||
| AU2006235964A1 (en) | HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DA2 | Applications for amendment section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ HARDCASTELE, IAN ROBERT; GOLDING, BERNARD THOMAS; CALVERT, ALAN H.; NOBEL, MARTIN E. M.; WILLEMS, HENDRIKA MARIA GERARDA; GRIFFIN, ROGER JOHN; LUNEC, JOHN; NEWELL, DAVID R. AND KALLBLAD, PER. |
|
| DA2 | Applications for amendment section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 29 MAY 2012 . |
|
| DA2 | Applications for amendment section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ WILLEMS, HENDRIKA MARIA GERARDA; KALLBLAD, PER; HARDCASTLE, IAN ROBERT; GRIFFIN, ROGER JOHN; GOLDING, BERNARD THOMAS; LUNEC, JOHN; NOBEL, MARTIN E. M.; NEWELL, DAVID R. AND CALVERT, ALAN H. . |
|
| TH | Corrigenda |
Free format text: IN VOL 26 , NO 22 , PAGE(S) 2980 UNDER THE HEADING AMENDMENTS - APPLICATION FOR AMENDMENTS DELETE ALL REFERENCE TO 2005278962 |
|
| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 29 MAY 2012 |
|
| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ WILLEMS, HENDRIKA MARIA GERARDA; KALLBLAD, PER; HARDCASTLE, IAN ROBERT; GRIFFIN, ROGER JOHN; GOLDING, BERNARD THOMAS; LUNEC, JOHN; NOBEL, MARTIN E. M.; NEWELL, DAVID R. AND CALVERT, ALAN H. |
|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |