AU2005218610B2 - Triptolide lactone ring derivatives as immunomodulators and anticancer agents - Google Patents
Triptolide lactone ring derivatives as immunomodulators and anticancer agents Download PDFInfo
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- AU2005218610B2 AU2005218610B2 AU2005218610A AU2005218610A AU2005218610B2 AU 2005218610 B2 AU2005218610 B2 AU 2005218610B2 AU 2005218610 A AU2005218610 A AU 2005218610A AU 2005218610 A AU2005218610 A AU 2005218610A AU 2005218610 B2 AU2005218610 B2 AU 2005218610B2
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- compound
- triptolide
- alkyl
- aryl
- alkenyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US54976904P | 2004-03-02 | 2004-03-02 | |
| US60/549,769 | 2004-03-02 | ||
| PCT/US2005/006952 WO2005084365A2 (en) | 2004-03-02 | 2005-03-02 | Triptolide lactone ring derivatives as immunomodulators and anticancer agents |
Publications (2)
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|---|---|
| AU2005218610A1 AU2005218610A1 (en) | 2005-09-15 |
| AU2005218610B2 true AU2005218610B2 (en) | 2011-08-18 |
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| AU2005218610A Ceased AU2005218610B2 (en) | 2004-03-02 | 2005-03-02 | Triptolide lactone ring derivatives as immunomodulators and anticancer agents |
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|---|---|
| US (2) | US7863464B2 (enExample) |
| EP (1) | EP1732536B1 (enExample) |
| JP (1) | JP5057966B2 (enExample) |
| CN (1) | CN100558354C (enExample) |
| AT (1) | ATE554758T1 (enExample) |
| AU (1) | AU2005218610B2 (enExample) |
| CA (1) | CA2557260C (enExample) |
| DK (1) | DK1732536T3 (enExample) |
| ES (1) | ES2385716T3 (enExample) |
| WO (1) | WO2005084365A2 (enExample) |
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| EP2468277A1 (en) * | 2002-05-31 | 2012-06-27 | Pharmagenesis, Inc. | Triptolide derivatives for modulation of apoptosis and immunosuppression |
| US7820834B2 (en) | 2003-12-24 | 2010-10-26 | Pharmagenesis, Inc. | Triptolide 5,6-derivatives as immunomodulators and anticancer agents |
| US8048914B2 (en) | 2004-02-09 | 2011-11-01 | Pharmagenesis, Inc. | Methods for isolation of triptolide compounds from Tripterygium wilfordii |
| ES2385716T3 (es) | 2004-03-02 | 2012-07-30 | Pharmagenesis, Inc. | Derivados en el anillo de lactona de triptolida como inmunomoduladores y agentes anticáncer |
| US8617906B2 (en) * | 2004-10-13 | 2013-12-31 | Pharmagenesis, Inc. | Identification and screening of triptolide target molecules |
| CN102307881B (zh) * | 2009-02-05 | 2014-12-24 | 药物起源公司 | 作为抗癌药和免疫调制剂的雷公藤内酯 c-环衍生物 |
| US9150600B2 (en) | 2009-05-07 | 2015-10-06 | Regents Of The University Of Minnesota | Triptolide prodrugs |
| CA2760953C (en) | 2009-05-07 | 2017-05-30 | Regents Of The University Of Minnesota | Triptolide prodrugs |
| JP2016515530A (ja) * | 2013-03-15 | 2016-05-30 | ファーマジェネシス， インコーポレイテッド | 免疫調節薬および抗がん剤としてのトリプトリドの静脈内乳剤 |
| WO2015127011A1 (en) | 2014-02-21 | 2015-08-27 | Institute Of Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | C-myc as a biomarker for tumor sensitivity to treatment with rna polymerase ii inhibition |
| WO2016181312A1 (en) * | 2015-05-11 | 2016-11-17 | Versitech Limited | Polycyclic epoxides and compositions thereof with anti-cancer activities |
| CN107663225A (zh) * | 2016-07-29 | 2018-02-06 | 欣凯医药化工中间体（上海）有限公司 | 一种氟代雷公藤内酯醇内酯环衍生物 |
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- 2005-03-02 CN CNB2005800068751A patent/CN100558354C/zh not_active Expired - Lifetime
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| WO2005084365A2 (en) | 2005-09-15 |
| ES2385716T3 (es) | 2012-07-30 |
| CA2557260A1 (en) | 2005-09-15 |
| ATE554758T1 (de) | 2012-05-15 |
| EP1732536A4 (en) | 2009-06-10 |
| EP1732536B1 (en) | 2012-04-25 |
| EP1732536A2 (en) | 2006-12-20 |
| WO2005084365A3 (en) | 2005-11-10 |
| US7863464B2 (en) | 2011-01-04 |
| US20080287530A1 (en) | 2008-11-20 |
| JP5057966B2 (ja) | 2012-10-24 |
| CN100558354C (zh) | 2009-11-11 |
| DK1732536T3 (da) | 2012-06-25 |
| US20100331554A1 (en) | 2010-12-30 |
| AU2005218610A1 (en) | 2005-09-15 |
| US8426616B2 (en) | 2013-04-23 |
| JP2007526331A (ja) | 2007-09-13 |
| CA2557260C (en) | 2013-02-12 |
| CN1925852A (zh) | 2007-03-07 |
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