CN100558354C - 用作免疫调节药和抗癌药的雷公藤内酯醇内酯环衍生物 - Google Patents

用作免疫调节药和抗癌药的雷公藤内酯醇内酯环衍生物 Download PDF

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Publication number
CN100558354C
CN100558354C CNB2005800068751A CN200580006875A CN100558354C CN 100558354 C CN100558354 C CN 100558354C CN B2005800068751 A CNB2005800068751 A CN B2005800068751A CN 200580006875 A CN200580006875 A CN 200580006875A CN 100558354 C CN100558354 C CN 100558354C
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chemical compound
alkyl
compound according
triptolide
aryl
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Expired - Lifetime
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CNB2005800068751A
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English (en)
Chinese (zh)
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CN1925852A (zh
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H·袁
J·H·马瑟
D·戴
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Pharmagenesis Inc
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Pharmagenesis Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CNB2005800068751A 2004-03-02 2005-03-02 用作免疫调节药和抗癌药的雷公藤内酯醇内酯环衍生物 Expired - Lifetime CN100558354C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54976904P 2004-03-02 2004-03-02
US60/549,769 2004-03-02

Publications (2)

Publication Number Publication Date
CN1925852A CN1925852A (zh) 2007-03-07
CN100558354C true CN100558354C (zh) 2009-11-11

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CNB2005800068751A Expired - Lifetime CN100558354C (zh) 2004-03-02 2005-03-02 用作免疫调节药和抗癌药的雷公藤内酯醇内酯环衍生物

Country Status (10)

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US (2) US7863464B2 (enExample)
EP (1) EP1732536B1 (enExample)
JP (1) JP5057966B2 (enExample)
CN (1) CN100558354C (enExample)
AT (1) ATE554758T1 (enExample)
AU (1) AU2005218610B2 (enExample)
CA (1) CA2557260C (enExample)
DK (1) DK1732536T3 (enExample)
ES (1) ES2385716T3 (enExample)
WO (1) WO2005084365A2 (enExample)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN107663225A (zh) * 2016-07-29 2018-02-06 欣凯医药化工中间体（上海）有限公司 一种氟代雷公藤内酯醇内酯环衍生物

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US8048914B2 (en) 2004-02-09 2011-11-01 Pharmagenesis, Inc. Methods for isolation of triptolide compounds from Tripterygium wilfordii
ES2385716T3 (es) 2004-03-02 2012-07-30 Pharmagenesis, Inc. Derivados en el anillo de lactona de triptolida como inmunomoduladores y agentes anticáncer
US8617906B2 (en) * 2004-10-13 2013-12-31 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
CN102307881B (zh) * 2009-02-05 2014-12-24 药物起源公司 作为抗癌药和免疫调制剂的雷公藤内酯 c-环衍生物
US9150600B2 (en) 2009-05-07 2015-10-06 Regents Of The University Of Minnesota Triptolide prodrugs
CA2760953C (en) 2009-05-07 2017-05-30 Regents Of The University Of Minnesota Triptolide prodrugs
JP2016515530A (ja) * 2013-03-15 2016-05-30 ファーマジェネシス， インコーポレイテッド 免疫調節薬および抗がん剤としてのトリプトリドの静脈内乳剤
WO2015127011A1 (en) 2014-02-21 2015-08-27 Institute Of Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center C-myc as a biomarker for tumor sensitivity to treatment with rna polymerase ii inhibition
WO2016181312A1 (en) * 2015-05-11 2016-11-17 Versitech Limited Polycyclic epoxides and compositions thereof with anti-cancer activities
CN106749496A (zh) * 2016-12-05 2017-05-31 张奇军 新型雷公藤甲素衍生物、及其制备和用途
CN108530511B (zh) * 2017-03-02 2021-06-22 欣凯医药化工中间体（上海）有限公司 一种c19-酰基化雷公藤甲素衍生物
CN108530510A (zh) * 2017-03-02 2018-09-14 欣凯医药化工中间体（上海）有限公司 一种c19-酰基化雷公藤甲素的制备方法
WO2018222351A1 (en) * 2017-05-27 2018-12-06 Pharmagenesis, Inc. Triptolide lactone derivatives as immunomodulators and anticancer agents
CN109942665B (zh) 2018-04-02 2021-04-06 欣凯医药化工中间体（上海）有限公司 雷公藤内酯醇衍生物及其制备方法和应用
CN110551170B (zh) * 2018-05-31 2022-04-22 欣凯医药化工中间体（上海）有限公司 一种c-19位单酰基化雷公藤内酯醇衍生物的合成方法
CN110551171B (zh) * 2018-05-31 2021-07-27 欣凯医药化工中间体（上海）有限公司 一种雷公藤内酯醇衍生物的制备方法
CN110551172B (zh) * 2018-05-31 2021-08-27 欣凯医药化工中间体（上海）有限公司 一种c-19位双键化雷公藤内酯醇衍生物的合成方法
CN111909119B (zh) * 2020-08-25 2023-06-16 上海诗丹德标准技术服务有限公司 雷公藤来源化合物及其应用和制备方法、药物组合物、杀虫剂

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107663225A (zh) * 2016-07-29 2018-02-06 欣凯医药化工中间体（上海）有限公司 一种氟代雷公藤内酯醇内酯环衍生物

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WO2005084365A2 (en) 2005-09-15
ES2385716T3 (es) 2012-07-30
CA2557260A1 (en) 2005-09-15
ATE554758T1 (de) 2012-05-15
EP1732536A4 (en) 2009-06-10
AU2005218610B2 (en) 2011-08-18
EP1732536B1 (en) 2012-04-25
EP1732536A2 (en) 2006-12-20
WO2005084365A3 (en) 2005-11-10
US7863464B2 (en) 2011-01-04
US20080287530A1 (en) 2008-11-20
JP5057966B2 (ja) 2012-10-24
DK1732536T3 (da) 2012-06-25
US20100331554A1 (en) 2010-12-30
AU2005218610A1 (en) 2005-09-15
US8426616B2 (en) 2013-04-23
JP2007526331A (ja) 2007-09-13
CA2557260C (en) 2013-02-12
CN1925852A (zh) 2007-03-07

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