AU2004272485B2 - 2-pyridone derivatives as neutrophil elastase inhibitors and their use - Google Patents

2-pyridone derivatives as neutrophil elastase inhibitors and their use Download PDF

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Publication number
AU2004272485B2
AU2004272485B2 AU2004272485A AU2004272485A AU2004272485B2 AU 2004272485 B2 AU2004272485 B2 AU 2004272485B2 AU 2004272485 A AU2004272485 A AU 2004272485A AU 2004272485 A AU2004272485 A AU 2004272485A AU 2004272485 B2 AU2004272485 B2 AU 2004272485B2
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AU
Australia
Prior art keywords
alkyl
oxo
phenyl
trifluoromethyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004272485A
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English (en)
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AU2004272485A1 (en
Inventor
Peter Hansen
Karolina Lawitz
Hans Lonn
Antonios Nikitidis
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AstraZeneca AB
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AstraZeneca AB
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29212489&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2004272485(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of AU2004272485A1 publication Critical patent/AU2004272485A1/en
Application granted granted Critical
Publication of AU2004272485B2 publication Critical patent/AU2004272485B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2004272485A 2003-09-18 2004-09-15 2-pyridone derivatives as neutrophil elastase inhibitors and their use Ceased AU2004272485B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0302487A SE0302487D0 (sv) 2003-09-18 2003-09-18 Novel compounds
SE0302487-4 2003-09-18
PCT/SE2004/001336 WO2005026124A1 (en) 2003-09-18 2004-09-15 2-pyridone derivatives as netrophil elastase inhibitors and their use

Publications (2)

Publication Number Publication Date
AU2004272485A1 AU2004272485A1 (en) 2005-03-24
AU2004272485B2 true AU2004272485B2 (en) 2008-03-13

Family

ID=29212489

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004272485A Ceased AU2004272485B2 (en) 2003-09-18 2004-09-15 2-pyridone derivatives as neutrophil elastase inhibitors and their use

Country Status (25)

Country Link
US (1) US20070043036A1 (enExample)
EP (1) EP1663974B1 (enExample)
JP (1) JP2007505902A (enExample)
KR (1) KR20060096995A (enExample)
CN (1) CN100439339C (enExample)
AR (1) AR046083A1 (enExample)
AT (1) ATE420861T1 (enExample)
AU (1) AU2004272485B2 (enExample)
BR (1) BRPI0414570A (enExample)
CA (1) CA2538410A1 (enExample)
CO (1) CO5670357A2 (enExample)
DE (1) DE602004019110D1 (enExample)
ES (1) ES2319300T3 (enExample)
IL (1) IL173986A0 (enExample)
IS (1) IS8394A (enExample)
MX (1) MXPA06002723A (enExample)
NO (1) NO20061700L (enExample)
RU (1) RU2348617C2 (enExample)
SA (1) SA04250300B1 (enExample)
SE (1) SE0302487D0 (enExample)
TW (1) TW200526579A (enExample)
UA (1) UA84878C2 (enExample)
UY (1) UY28513A1 (enExample)
WO (1) WO2005026124A1 (enExample)
ZA (1) ZA200602262B (enExample)

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EP1940458A4 (en) * 2005-09-29 2010-03-03 Univ Alberta COMPOSITIONS AND METHODS OF INHIBITING GRANZYME B
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TW200808763A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
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Also Published As

Publication number Publication date
BRPI0414570A (pt) 2006-11-07
IL173986A0 (en) 2006-07-05
UA84878C2 (ru) 2008-12-10
TW200526579A (en) 2005-08-16
EP1663974B1 (en) 2009-01-14
RU2348617C2 (ru) 2009-03-10
NO20061700L (no) 2006-04-18
CO5670357A2 (es) 2006-08-31
ATE420861T1 (de) 2009-01-15
MXPA06002723A (es) 2006-06-06
UY28513A1 (es) 2005-04-29
AR046083A1 (es) 2005-11-23
HK1089167A1 (en) 2006-11-24
JP2007505902A (ja) 2007-03-15
SE0302487D0 (sv) 2003-09-18
IS8394A (is) 2006-03-31
WO2005026124A1 (en) 2005-03-24
DE602004019110D1 (de) 2009-03-05
RU2006112427A (ru) 2007-11-10
SA04250300B1 (ar) 2008-09-07
ZA200602262B (en) 2007-07-25
ES2319300T3 (es) 2009-05-06
AU2004272485A1 (en) 2005-03-24
CN100439339C (zh) 2008-12-03
US20070043036A1 (en) 2007-02-22
KR20060096995A (ko) 2006-09-13
CA2538410A1 (en) 2005-03-24
EP1663974A1 (en) 2006-06-07
CN1856467A (zh) 2006-11-01

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ 2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE

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