AU2004261165C1 - Composition of a VEGF antagonist and an anti-proliferative agent and its use for the treatment of cancer - Google Patents
Composition of a VEGF antagonist and an anti-proliferative agent and its use for the treatment of cancer Download PDFInfo
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- AU2004261165C1 AU2004261165C1 AU2004261165A AU2004261165A AU2004261165C1 AU 2004261165 C1 AU2004261165 C1 AU 2004261165C1 AU 2004261165 A AU2004261165 A AU 2004261165A AU 2004261165 A AU2004261165 A AU 2004261165A AU 2004261165 C1 AU2004261165 C1 AU 2004261165C1
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- vegf
- agent
- antagonist
- proliferative agent
- paclitaxel
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49000203P | 2003-07-25 | 2003-07-25 | |
| US60/490,002 | 2003-07-25 | ||
| US49397103P | 2003-08-08 | 2003-08-08 | |
| US60/493,971 | 2003-08-08 | ||
| PCT/US2004/023815 WO2005011734A2 (en) | 2003-07-25 | 2004-07-23 | Composition of a vegf antagonist and an anti-proliferative agent and its use for the treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2004261165A1 AU2004261165A1 (en) | 2005-02-10 |
| AU2004261165B2 AU2004261165B2 (en) | 2009-07-16 |
| AU2004261165C1 true AU2004261165C1 (en) | 2009-12-17 |
Family
ID=34118812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2004261165A Expired AU2004261165C1 (en) | 2003-07-25 | 2004-07-23 | Composition of a VEGF antagonist and an anti-proliferative agent and its use for the treatment of cancer |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7354579B2 (https=) |
| EP (1) | EP1648428A2 (https=) |
| JP (1) | JP5355856B2 (https=) |
| KR (1) | KR101175990B1 (https=) |
| AR (1) | AR046510A1 (https=) |
| AU (1) | AU2004261165C1 (https=) |
| BR (1) | BRPI0412798A (https=) |
| CA (1) | CA2529742C (https=) |
| IL (1) | IL172406A (https=) |
| MX (1) | MXPA05013642A (https=) |
| MY (1) | MY149169A (https=) |
| NO (1) | NO20060924L (https=) |
| NZ (1) | NZ544570A (https=) |
| RU (1) | RU2353353C2 (https=) |
| TW (1) | TWI351953B (https=) |
| UY (1) | UY28438A1 (https=) |
| WO (1) | WO2005011734A2 (https=) |
Families Citing this family (76)
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| US20050271663A1 (en) * | 2001-06-28 | 2005-12-08 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| DK1399484T3 (da) * | 2001-06-28 | 2010-11-08 | Domantis Ltd | Dobbelt-specifik ligand og anvendelse af denne |
| AU2003244817B2 (en) * | 2002-06-28 | 2010-08-26 | Domantis Limited | Antigen-binding immunoglobulin single variable domains and dual-specific constructs |
| US9321832B2 (en) * | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| EP1578801A2 (en) * | 2002-12-27 | 2005-09-28 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| WO2004110490A2 (en) * | 2003-06-06 | 2004-12-23 | Regeneron Pharmaceuticals, Inc. | Use of vegf inhibitors for tumor regression |
| FR2878749B1 (fr) * | 2004-12-03 | 2007-12-21 | Aventis Pharma Sa | Combinaisons antitumorales contenant en agent inhibiteur de vegt et du 5fu ou un de ses derives |
| EP1853298A2 (en) * | 2005-02-11 | 2007-11-14 | Regeneron Pharmaceuticals, Inc. | Therapeutic combination of a vegf antagonist (vegf trap) and an anti-hypertensive agent |
| US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| US20070166388A1 (en) * | 2005-02-18 | 2007-07-19 | Desai Neil P | Combinations and modes of administration of therapeutic agents and combination therapy |
| KR20070114753A (ko) * | 2005-02-18 | 2007-12-04 | 아브락시스 바이오사이언스 인크. | 치료제의 조합 및 투여 방식, 및 조합 요법 |
| ES2633574T3 (es) | 2005-03-25 | 2017-09-22 | Regeneron Pharmaceuticals, Inc. | Formulaciones de antagonistas de VEGF |
| JP2009519011A (ja) * | 2005-12-01 | 2009-05-14 | ドマンティス リミテッド | インターロイキン１受容体１型に結合する非競合ドメイン抗体フォーマット |
| FR2895258B1 (fr) * | 2005-12-22 | 2008-03-21 | Aventis Pharma Sa | Combinaison comprenant de la combretastatine et des agents anticancereux |
| RU2494108C2 (ru) | 2006-04-07 | 2013-09-27 | Аерпио Терапетикс, Инк. | Антитела, которые связывают человеческий белок бета-тирозин фосфатазу (нртрвета), и их использование |
| EP2094268A2 (en) * | 2006-05-26 | 2009-09-02 | Bayer HealthCare, LLC | Drug combinations with substituted diaryl ureas for the treatment of cancer |
| CA2654510C (en) | 2006-06-16 | 2015-03-17 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations suitable for intravitreal administration |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
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| RU2021128415A (ru) | 2016-09-06 | 2021-11-08 | Мэйо Фаундейшн Фор Медикал Эдьюкейшн Энд Рисерч | Композиции с паклитакселом, альбумином и связывающим средством и способы их применения и получения |
| KR20230011473A (ko) | 2016-09-06 | 2023-01-20 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | Ｐｄ－ｌ１ 발현 암의 치료 방법 |
| EP3509635A1 (en) | 2016-09-06 | 2019-07-17 | Vavotar Life Sciences LLC | Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins |
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| AU2019212622B2 (en) | 2018-01-26 | 2024-05-23 | The Regents Of The University Of California | Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents |
| EP3758737A4 (en) | 2018-03-02 | 2022-10-12 | Kodiak Sciences Inc. | IL-6 ANTIBODIES AND FUSION CONSTRUCTS AND CONJUGATES THEREOF |
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| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| BR112022010113A2 (pt) | 2019-11-25 | 2022-09-06 | Univ California | Inibidores de vegf de longa ação para neovascularização intraocular |
| AU2021268026A1 (en) | 2020-05-08 | 2023-01-19 | Regeneron Pharmaceuticals, Inc. | VEGF traps and mini-traps and methods for treating ocular disorders and cancer |
| KR20240008821A (ko) | 2021-05-17 | 2024-01-19 | 리제너론 파아마슈티컬스, 인크. | 혈관신생성 눈 장애 치료를 위한 연장된 고용량 vegf 길항제 요법 |
| IL315347A (en) | 2022-03-15 | 2024-11-01 | Regeneron Pharma | Prolonged high-dose VEGF antagonist regimens for the treatment of angiogenic ocular disorders |
| IL315374A (en) | 2022-03-15 | 2024-11-01 | Regeneron Pharma | Prolonged high-dose VEGF antagonist regimens for the treatment of angiogenic ocular disorders |
| CN121712520A (zh) | 2023-06-23 | 2026-03-20 | 瑞泽恩制药公司 | 用于治疗血管生成性眼病的延长的高剂量vegf拮抗剂方案 |
| WO2025217334A1 (en) | 2024-04-09 | 2025-10-16 | Regeneron Pharmaceuticals, Inc. | Low concentration vegf receptor fusion protein containing formulations |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2000075319A1 (en) * | 1999-06-08 | 2000-12-14 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
| US6342219B1 (en) * | 1999-04-28 | 2002-01-29 | Board Of Regents, The University Of Texas System | Antibody compositions for selectively inhibiting VEGF |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6811779B2 (en) * | 1994-02-10 | 2004-11-02 | Imclone Systems Incorporated | Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy |
| US6100071A (en) * | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| WO2004110490A2 (en) * | 2003-06-06 | 2004-12-23 | Regeneron Pharmaceuticals, Inc. | Use of vegf inhibitors for tumor regression |
-
2004
- 2004-07-21 AR ARP040102585A patent/AR046510A1/es unknown
- 2004-07-23 RU RU2006105496/15A patent/RU2353353C2/ru active
- 2004-07-23 NZ NZ544570A patent/NZ544570A/en not_active IP Right Cessation
- 2004-07-23 CA CA2529742A patent/CA2529742C/en not_active Expired - Lifetime
- 2004-07-23 MX MXPA05013642A patent/MXPA05013642A/es not_active Application Discontinuation
- 2004-07-23 AU AU2004261165A patent/AU2004261165C1/en not_active Expired
- 2004-07-23 TW TW093121978A patent/TWI351953B/zh not_active IP Right Cessation
- 2004-07-23 KR KR1020067000521A patent/KR101175990B1/ko not_active Expired - Lifetime
- 2004-07-23 WO PCT/US2004/023815 patent/WO2005011734A2/en not_active Ceased
- 2004-07-23 JP JP2006521281A patent/JP5355856B2/ja not_active Expired - Lifetime
- 2004-07-23 MY MYPI20042968A patent/MY149169A/en unknown
- 2004-07-23 EP EP04779050A patent/EP1648428A2/en not_active Withdrawn
- 2004-07-23 BR BRPI0412798-6A patent/BRPI0412798A/pt not_active Application Discontinuation
- 2004-07-23 US US10/897,802 patent/US7354579B2/en not_active Expired - Lifetime
- 2004-07-26 UY UY28438A patent/UY28438A1/es not_active Application Discontinuation
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2005
- 2005-12-06 IL IL172406A patent/IL172406A/en not_active IP Right Cessation
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2006
- 2006-02-24 NO NO20060924A patent/NO20060924L/no not_active Application Discontinuation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6342219B1 (en) * | 1999-04-28 | 2002-01-29 | Board Of Regents, The University Of Texas System | Antibody compositions for selectively inhibiting VEGF |
| WO2000075319A1 (en) * | 1999-06-08 | 2000-12-14 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
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| Title |
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| Journal of Clinical Oncology 21(1) (2003) pp60-65 * |
| Proc Nat Acad Sci USA 100(13) (2003) pp 7785-7790 * |
| Proc Nat Acad Sci USA 98(13) (2001) pp 7481-7486 * |
| Proc Nat Acad Sci USA 99(17) (2002) pp 11393-11298 * |
| Proc Nat Acad Sci USA 99(17) (2002) pp 11399-11404 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AR046510A1 (es) | 2005-12-14 |
| US20050032699A1 (en) | 2005-02-10 |
| RU2006105496A (ru) | 2006-06-10 |
| MY149169A (en) | 2013-07-31 |
| US7354579B2 (en) | 2008-04-08 |
| KR101175990B1 (ko) | 2012-08-23 |
| TW200524589A (en) | 2005-08-01 |
| KR20060028654A (ko) | 2006-03-30 |
| CA2529742A1 (en) | 2005-02-10 |
| AU2004261165B2 (en) | 2009-07-16 |
| JP5355856B2 (ja) | 2013-11-27 |
| TWI351953B (en) | 2011-11-11 |
| BRPI0412798A (pt) | 2006-09-26 |
| AU2004261165A1 (en) | 2005-02-10 |
| IL172406A (en) | 2016-04-21 |
| NO20060924L (no) | 2006-04-25 |
| EP1648428A2 (en) | 2006-04-26 |
| CA2529742C (en) | 2012-09-18 |
| MXPA05013642A (es) | 2006-03-10 |
| WO2005011734A2 (en) | 2005-02-10 |
| IL172406A0 (en) | 2006-04-10 |
| RU2353353C2 (ru) | 2009-04-27 |
| JP2007500131A (ja) | 2007-01-11 |
| UY28438A1 (es) | 2004-11-08 |
| WO2005011734A3 (en) | 2005-04-14 |
| NZ544570A (en) | 2008-08-29 |
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