CA2529742C - Composition of a vegf antagonist and an anti-proliferative agent - Google Patents

Composition of a vegf antagonist and an anti-proliferative agent Download PDF

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Publication number
CA2529742C
CA2529742C CA2529742A CA2529742A CA2529742C CA 2529742 C CA2529742 C CA 2529742C CA 2529742 A CA2529742 A CA 2529742A CA 2529742 A CA2529742 A CA 2529742A CA 2529742 C CA2529742 C CA 2529742C
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CA
Canada
Prior art keywords
vegf
antagonist
agent
paclitaxel
trap
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2529742A
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English (en)
French (fr)
Other versions
CA2529742A1 (en
Inventor
Jocelyn Holash
Robert Jaffe
Limin Hu
George D. Yancopoulos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Regeneron Pharmaceuticals Inc
University of California San Diego UCSD
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34118812&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2529742(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharmaceuticals Inc, University of California San Diego UCSD filed Critical Regeneron Pharmaceuticals Inc
Publication of CA2529742A1 publication Critical patent/CA2529742A1/en
Application granted granted Critical
Publication of CA2529742C publication Critical patent/CA2529742C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2529742A 2003-07-25 2004-07-23 Composition of a vegf antagonist and an anti-proliferative agent Expired - Lifetime CA2529742C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US49000203P 2003-07-25 2003-07-25
US60/490,002 2003-07-25
US49397103P 2003-08-08 2003-08-08
US60/493,971 2003-08-08
PCT/US2004/023815 WO2005011734A2 (en) 2003-07-25 2004-07-23 Composition of a vegf antagonist and an anti-proliferative agent and its use for the treatment of cancer

Publications (2)

Publication Number Publication Date
CA2529742A1 CA2529742A1 (en) 2005-02-10
CA2529742C true CA2529742C (en) 2012-09-18

Family

ID=34118812

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2529742A Expired - Lifetime CA2529742C (en) 2003-07-25 2004-07-23 Composition of a vegf antagonist and an anti-proliferative agent

Country Status (17)

Country Link
US (1) US7354579B2 (https=)
EP (1) EP1648428A2 (https=)
JP (1) JP5355856B2 (https=)
KR (1) KR101175990B1 (https=)
AR (1) AR046510A1 (https=)
AU (1) AU2004261165C1 (https=)
BR (1) BRPI0412798A (https=)
CA (1) CA2529742C (https=)
IL (1) IL172406A (https=)
MX (1) MXPA05013642A (https=)
MY (1) MY149169A (https=)
NO (1) NO20060924L (https=)
NZ (1) NZ544570A (https=)
RU (1) RU2353353C2 (https=)
TW (1) TWI351953B (https=)
UY (1) UY28438A1 (https=)
WO (1) WO2005011734A2 (https=)

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US9321832B2 (en) * 2002-06-28 2016-04-26 Domantis Limited Ligand
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Also Published As

Publication number Publication date
AR046510A1 (es) 2005-12-14
US20050032699A1 (en) 2005-02-10
RU2006105496A (ru) 2006-06-10
MY149169A (en) 2013-07-31
US7354579B2 (en) 2008-04-08
KR101175990B1 (ko) 2012-08-23
TW200524589A (en) 2005-08-01
KR20060028654A (ko) 2006-03-30
CA2529742A1 (en) 2005-02-10
AU2004261165B2 (en) 2009-07-16
AU2004261165C1 (en) 2009-12-17
JP5355856B2 (ja) 2013-11-27
TWI351953B (en) 2011-11-11
BRPI0412798A (pt) 2006-09-26
AU2004261165A1 (en) 2005-02-10
IL172406A (en) 2016-04-21
NO20060924L (no) 2006-04-25
EP1648428A2 (en) 2006-04-26
MXPA05013642A (es) 2006-03-10
WO2005011734A2 (en) 2005-02-10
IL172406A0 (en) 2006-04-10
RU2353353C2 (ru) 2009-04-27
JP2007500131A (ja) 2007-01-11
UY28438A1 (es) 2004-11-08
WO2005011734A3 (en) 2005-04-14
NZ544570A (en) 2008-08-29

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