AU2004234067B2 - Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators - Google Patents

Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators Download PDF

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Publication number
AU2004234067B2
AU2004234067B2 AU2004234067A AU2004234067A AU2004234067B2 AU 2004234067 B2 AU2004234067 B2 AU 2004234067B2 AU 2004234067 A AU2004234067 A AU 2004234067A AU 2004234067 A AU2004234067 A AU 2004234067A AU 2004234067 B2 AU2004234067 B2 AU 2004234067B2
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Australia
Prior art keywords
substituted
phenyl
optionally substituted
compound according
title compound
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Ceased
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AU2004234067A
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AU2004234067A1 (en
Inventor
Rainer Albert
Claus Ehrhardt
Peter Ettmayer
Klaus Hinterding
Klemens Hogenauer
Peter Nussbaumer
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Novartis AG
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Novartis AG
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Priority claimed from GB0329494A external-priority patent/GB0329494D0/en
Priority claimed from GB0329501A external-priority patent/GB0329501D0/en
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2004234067A1 publication Critical patent/AU2004234067A1/en
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Publication of AU2004234067B2 publication Critical patent/AU2004234067B2/en
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Ceased legal-status Critical Current

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    • C07—ORGANIC CHEMISTRY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
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    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
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    • C—CHEMISTRY; METALLURGY
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/141—Esters of phosphorous acids
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539—Five-membered rings
    • C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
AU2004234067A 2003-04-30 2004-04-29 Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators Ceased AU2004234067B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0309946 2003-04-30
GB0309946.2 2003-04-30
GB0329501.1 2003-12-19
GB0329494A GB0329494D0 (en) 2003-12-19 2003-12-19 Organic compounds
GB0329501A GB0329501D0 (en) 2003-12-19 2003-12-19 Organic compounds
GB0329494.9 2003-12-19
PCT/EP2004/004572 WO2004096757A1 (en) 2003-04-30 2004-04-29 Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators

Publications (2)

Publication Number Publication Date
AU2004234067A1 AU2004234067A1 (en) 2004-11-11
AU2004234067B2 true AU2004234067B2 (en) 2008-02-28

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ID=33424536

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Application Number Title Priority Date Filing Date
AU2004234067A Ceased AU2004234067B2 (en) 2003-04-30 2004-04-29 Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators

Country Status (10)

Country Link
US (1) US7825260B2 (enExample)
EP (1) EP1622866B1 (enExample)
JP (1) JP4638410B2 (enExample)
CN (1) CN1809531B (enExample)
AU (1) AU2004234067B2 (enExample)
BR (1) BRPI0409977A (enExample)
CA (1) CA2523677A1 (enExample)
ES (1) ES2392167T3 (enExample)
MX (1) MXPA05011597A (enExample)
WO (1) WO2004096757A1 (enExample)

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US7399765B2 (en) * 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
WO2005041899A2 (en) 2003-11-03 2005-05-12 University Of Virginia Patent Foundation Orally available sphingosine 1-phosphate receptor agonists and antagonists
GB0411929D0 (en) * 2004-05-27 2004-06-30 Novartis Ag Organic compounds
US8039674B2 (en) 2004-06-23 2011-10-18 Ono Pharmaceutical Co., Ltd. Compound having S1P receptor binding potency and use thereof
PL1772145T3 (pl) 2004-07-16 2011-08-31 Kyorin Seiyaku Kk Sposób skutecznego stosowania leku i sposób dotyczący zapobiegania efektom ubocznym
BRPI0514316A (pt) 2004-08-13 2008-06-10 Praecis Pharm Inc métodos e composições para modulação de atividade de receptor de esfingosina-1-fosfato (s1p)
RU2376285C2 (ru) 2004-10-12 2009-12-20 Киорин Фармасьютикал Ко., Лтд. Процесс получения гидрохлорида 2-амино-2-[2-[4-(3-бензилоксифенилтио)-2-хлорфенилэтил]-1,3-пропандиола] и его гидратов, а также промежуточные продукты их получения
JP2008522977A (ja) 2004-12-06 2008-07-03 ユニバーシティ オブ バージニア パテント ファンデーション スフィンゴシン＝１−リン酸のアリールアミドアナログ
GB0504544D0 (en) * 2005-03-04 2005-04-13 Novartis Ag Organic compounds
CA2604042C (en) 2005-04-13 2016-06-21 Astex Therapeutics Limited Pharmaceutical compounds
DK1932522T3 (da) * 2005-10-07 2012-07-02 Kyorin Seiyaku Kk Terapeutisk middel mod leversygdom indeholdende 2-amino-1,3-propandiolderivat som aktiv bestanddel
KR100773765B1 (ko) 2005-11-24 2007-11-12 재단법인서울대학교산학협력재단 개선된 스핑고신 유사체의 제조 방법
JP2009528274A (ja) 2006-01-27 2009-08-06 ユニバーシティ オブ バージニア パテント ファンデーション 神経因性疼痛の治療法
TWI389683B (zh) * 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
EP1987013A1 (en) * 2006-02-09 2008-11-05 University Of Virginia Patent Foundation Bicyclic sphingosine 1-phosphate analogs
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
WO2007112322A2 (en) * 2006-03-28 2007-10-04 Allergan, Inc. Indole compounds having sphingosine-1-phosphate (s1p) receptor agonist and/or antagonist biological activity
LT2799427T (lt) 2006-07-05 2018-11-26 Fibrotech Therapeutics Pty Ltd Terapiniai junginiai
RU2458044C2 (ru) * 2006-08-08 2012-08-10 Киорин Фармасьютикал Ко., Лтд. Производное аминоспирта и иммунодепрессивное средство, содержащее его в качестве активного ингредиента
CN101501049B (zh) 2006-08-08 2013-04-24 杏林制药株式会社 氨基磷酸酯衍生物以及将它们作为有效成分的s1p受体调节剂
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
EP2073804B1 (en) 2006-10-12 2017-09-13 Astex Therapeutics Limited Hydroxy-substituted benzoic acid amide compounds for use in the treatment of pain
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044029A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
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