CN1809531B - 作为鞘氨醇-1-磷酸受体调节剂的氨基丙醇衍生物 - Google Patents

作为鞘氨醇-1-磷酸受体调节剂的氨基丙醇衍生物 Download PDF

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Publication number
CN1809531B
CN1809531B CN2004800171527A CN200480017152A CN1809531B CN 1809531 B CN1809531 B CN 1809531B CN 2004800171527 A CN2004800171527 A CN 2004800171527A CN 200480017152 A CN200480017152 A CN 200480017152A CN 1809531 B CN1809531 B CN 1809531B
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alkyl
phenyl
methyl
replaces
group
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Expired - Fee Related
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CN2004800171527A
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Chinese (zh)
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CN1809531A (zh
Inventor
R·阿尔贝特
C·埃尔哈特
P·埃特迈尔
K·欣特尔丁
K·赫根诺伊尔
P·努斯鲍默
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Novartis AG
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Novartis AG
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Priority claimed from GB0329501A external-priority patent/GB0329501D0/en
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Oncology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
CN2004800171527A 2003-04-30 2004-04-29 作为鞘氨醇-1-磷酸受体调节剂的氨基丙醇衍生物 Expired - Fee Related CN1809531B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0309946 2003-04-30
GB0309946.2 2003-04-30
GB0329501.1 2003-12-19
GB0329494A GB0329494D0 (en) 2003-12-19 2003-12-19 Organic compounds
GB0329501A GB0329501D0 (en) 2003-12-19 2003-12-19 Organic compounds
GB0329494.9 2003-12-19
PCT/EP2004/004572 WO2004096757A1 (en) 2003-04-30 2004-04-29 Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators

Publications (2)

Publication Number Publication Date
CN1809531A CN1809531A (zh) 2006-07-26
CN1809531B true CN1809531B (zh) 2010-05-26

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CN2004800171527A Expired - Fee Related CN1809531B (zh) 2003-04-30 2004-04-29 作为鞘氨醇-1-磷酸受体调节剂的氨基丙醇衍生物

Country Status (10)

Country Link
US (1) US7825260B2 (enExample)
EP (1) EP1622866B1 (enExample)
JP (1) JP4638410B2 (enExample)
CN (1) CN1809531B (enExample)
AU (1) AU2004234067B2 (enExample)
BR (1) BRPI0409977A (enExample)
CA (1) CA2523677A1 (enExample)
ES (1) ES2392167T3 (enExample)
MX (1) MXPA05011597A (enExample)
WO (1) WO2004096757A1 (enExample)

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CA2515638A1 (en) * 2003-02-11 2004-08-26 Shifeng Pan Novel bicyclic compounds and compositions
US7399765B2 (en) * 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
WO2005041899A2 (en) 2003-11-03 2005-05-12 University Of Virginia Patent Foundation Orally available sphingosine 1-phosphate receptor agonists and antagonists
GB0411929D0 (en) * 2004-05-27 2004-06-30 Novartis Ag Organic compounds
US8039674B2 (en) 2004-06-23 2011-10-18 Ono Pharmaceutical Co., Ltd. Compound having S1P receptor binding potency and use thereof
PL1772145T3 (pl) 2004-07-16 2011-08-31 Kyorin Seiyaku Kk Sposób skutecznego stosowania leku i sposób dotyczący zapobiegania efektom ubocznym
BRPI0514316A (pt) 2004-08-13 2008-06-10 Praecis Pharm Inc métodos e composições para modulação de atividade de receptor de esfingosina-1-fosfato (s1p)
RU2376285C2 (ru) 2004-10-12 2009-12-20 Киорин Фармасьютикал Ко., Лтд. Процесс получения гидрохлорида 2-амино-2-[2-[4-(3-бензилоксифенилтио)-2-хлорфенилэтил]-1,3-пропандиола] и его гидратов, а также промежуточные продукты их получения
JP2008522977A (ja) 2004-12-06 2008-07-03 ユニバーシティ オブ バージニア パテント ファンデーション スフィンゴシン＝１−リン酸のアリールアミドアナログ
GB0504544D0 (en) * 2005-03-04 2005-04-13 Novartis Ag Organic compounds
CA2604042C (en) 2005-04-13 2016-06-21 Astex Therapeutics Limited Pharmaceutical compounds
DK1932522T3 (da) * 2005-10-07 2012-07-02 Kyorin Seiyaku Kk Terapeutisk middel mod leversygdom indeholdende 2-amino-1,3-propandiolderivat som aktiv bestanddel
KR100773765B1 (ko) 2005-11-24 2007-11-12 재단법인서울대학교산학협력재단 개선된 스핑고신 유사체의 제조 방법
JP2009528274A (ja) 2006-01-27 2009-08-06 ユニバーシティ オブ バージニア パテント ファンデーション 神経因性疼痛の治療法
TWI389683B (zh) * 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
EP1987013A1 (en) * 2006-02-09 2008-11-05 University Of Virginia Patent Foundation Bicyclic sphingosine 1-phosphate analogs
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
WO2007112322A2 (en) * 2006-03-28 2007-10-04 Allergan, Inc. Indole compounds having sphingosine-1-phosphate (s1p) receptor agonist and/or antagonist biological activity
LT2799427T (lt) 2006-07-05 2018-11-26 Fibrotech Therapeutics Pty Ltd Terapiniai junginiai
RU2458044C2 (ru) * 2006-08-08 2012-08-10 Киорин Фармасьютикал Ко., Лтд. Производное аминоспирта и иммунодепрессивное средство, содержащее его в качестве активного ингредиента
CN101501049B (zh) 2006-08-08 2013-04-24 杏林制药株式会社 氨基磷酸酯衍生物以及将它们作为有效成分的s1p受体调节剂
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